Is it possible for pregnant women to take Cetrin? Cetrin and pregnancy: concepts are incompatible Main components and release form

Cetrin is a well-known antihistamine against allergies and other diseases.

The drug is budget-friendly, its approximate cost in pharmacies varies from 150 to 250 rubles.

More details about the product

Cetrin is available in the form of tablets for use by adults, which must be taken before or after meals, without chewing and with water.

The product contains a minimum number of side effects. Cetrin affects only those types of receptors that are involved in the allergic reaction. The effect of the drug can be noticed within 10 - 15 minutes, and after an hour the drug reaches its maximum concentration in the body.

If a woman periodically experiences various factors, it is impossible to say for sure whether an allergy will manifest itself during pregnancy, since during this period great changes occur in the female body.

For some women, during pregnancy it persists and continues to bother, for others, all manifestations and symptoms decrease or disappear altogether.

Allergies during pregnancy usually manifest themselves in the form of conjunctivitis or allergic rhinitis. In more rare cases, there are allergic skin rashes or even bronchial asthma.

With all such manifestations, the attending physician always recommends that a woman, when preparing for pregnancy, be sure to visit an allergist; sometimes it is even necessary to undergo a course of special preparatory therapy.

What is histamine

Cetrin is one of those drugs that, when consumed, block histamine. Histamine is a mediator of allergic reactions.

In a pregnant woman, histamine is a very important hormone; it plays a huge role at the time of fertilization and during the attachment of the fertilized egg to the wall of the uterus. At later stages, histamine helps the development of the fetus and regulates metabolism in the body. The further formation of the organs of the unborn child depends on the amount of this hormone in the female body.

Cetrin during pregnancy

After fertilization, during the first 13 weeks, the process of embryo formation occurs. Fetal cells are very sensitive to various external factors, especially to drug therapy taken during this period.

During pregnancy, women suffering from allergies should think about treatment with less aggressive, more gentle drugs; Cetrin is not one of these drugs.

But if during the treatment period it turns out that other medications do not help cope with the problem, doctors prescribe Cetrin during pregnancy, but on the condition that the use will be carried out with extreme caution and under the constant supervision of specialists.

According to the instructions for the drug Cetrin, pregnancy and lactation are indicated as contraindications for use. Doctors confirm that medications that suppress the action of the hormone histamine can cause extreme Negative consequences, such as serious impairment of the mental and physical development of the fetus.

In addition, the condition of a pregnant woman may worsen; most often they complain of Negative influence funds for the functioning of the liver and kidneys. The body of a woman in an interesting position can react quite strangely to this or that phenomenon, to certain foods, to the time of year outside the window.

Therefore, even if the symptoms of an allergic reaction are severe, be sure to seek advice from a specialist; you should not take the drug yourself, the consequences can be unpredictable.

Indications for the expectant mother

Indications for use of the drug Cetrin:

• itching of various origins;
• rhinitis (allergic inflammation of the nasal mucosa, sneezing);
• allergic conjunctivitis;
• Quincke's edema;
• hives.

Cetrin prevents the development of inflammatory processes. His active substance– Cetrizine is absorbed from the gastrointestinal tract, food intake does not affect this process in any way, so the time of taking the tablet does not matter much - this can be done before and after meals.

Admission by trimester

During the period up to and including the 12th week of pregnancy, the drug is strictly contraindicated; this is the time when female body extremely important processes take place that contribute to proper development fetus

In the 2nd trimester, the organs and vital activity systems of the embryo actively develop; metabolic processes, with the help of which the fetus can receive everything it needs from the mother’s body.

The hormone histamine is also involved in these processes, so blocking this hormone can subsequently lead to a lack of nutrients that the baby needs at this stage of development.

In the 3rd semester, the child’s body has practically formed, but this does not mean that you can take this drug without fear. You especially shouldn't do it yourself.

The drug Cetrin is prescribed only as an exception, and only in special cases. Treatment in this case is carried out under the strict and constant supervision of the attending physician.

Reception medicines, suppressing the effect of histamine during pregnancy can negatively affect the development of the unborn child.

It is also very important to know that the components included in antihistamines can be excreted along with milk during breastfeeding, therefore such medications are prohibited for use during lactation.

Pregnancy is a special period in the life of any woman. It is important not to forget that any external factors, including therapy, also affect the child’s growing body.

Be sure to remember that taking any medications during pregnancy and while breastfeeding always requires consultation with a specialist.

Do not self-medicate under any circumstances. A woman’s body at such a moment can behave extremely unpredictably, and the use of contraindicated medications can lead to adverse consequences. And this, in turn, will have a detrimental effect on the development of the embryo. If you have experienced allergy attacks already at the stage of preparation for pregnancy, you should definitely visit an allergist who will give you all the necessary instructions.

Cetrin has few side effects, however, it is contraindicated during pregnancy. It is especially undesirable to take this drug in the first 12 weeks of pregnancy, when the organs and tissues of the fetus are being formed. But at later stages, the use of this drug is also contraindicated.

Allergies in pregnant women

If a woman suffers from any allergic disease, then it is sometimes impossible to predict in advance how the allergy will “behave” during pregnancy due to numerous, sometimes very individual changes in metabolism. Metabolism: the basis of the life activity of all living things.

, which occur in her body during pregnancy.

During pregnancy, first of all, a woman's hormonal background changes. A woman's hormonal background - how does it affect the body as a whole? , and under its influence - the speed of blood flow and metabolism. We improve metabolism and lose weight without dieting . Due to the heavy load (two organisms - mother and child), the cleansing abilities of the liver and kidneys are reduced. As a result, all organs and tissues of a woman undergo significant and varied changes, which in turn can change the effect on the body of habitual and previously easily tolerated medications beyond recognition.

All of these changes can significantly increase the risk drug allergies and cause an exacerbation of allergic diseases that began before pregnancy. In some women, during pregnancy, the allergic disease continues to occur as usual, in others, all manifestations disappear or decrease. But the worsening of allergic diseases during pregnancy is especially dangerous - it is very rare, but it does happen.

Allergies in pregnant women most often manifest themselves in the form of allergic rhinitis or conjunctivitis. Less common are skin rashes and bronchial asthma. In all these cases, obstetricians-gynecologists recommend preparing for pregnancy, visiting an allergist in advance and, if necessary, conducting a course of specific treatment.

What to do if allergies get worse during pregnancy

First of all, no amateur activity: all treatment should take place only under the supervision of a doctor. First, the doctor will try to cope with allergies using non-drug methods: a hypoallergenic diet. A hypoallergenic diet is a salvation for the stomach. , excluding possible household allergens (including dust, particles of animal hair, fish scales, and so on).

If it is not possible to help a woman in this way, then drug treatment is prescribed, including the use of the safest antihistamines.

What are the dangers of antihistamines during pregnancy?

Antihistamines are used during pregnancy, but only under strict indications. The fact is that drugs of this group block the action of histamine - biologically active substance, which is not completely superfluous in the body of a pregnant woman.

With the assistance of histamine, the fertilized egg is implanted into the wall of the uterus and the embryo develops in it. In later stages of pregnancy, histamine easily passes through the placenta and regulates the metabolism between the mother and fetus. The process of tissue laying and development of fetal organs depends on its influence.

The use of antihistamines can disrupt all these processes. And since practically no clinical trials are conducted on pregnant women, no one can say for sure how this or that antihistamine will affect the condition of the woman and the fetus.

In the first 12 weeks of pregnancy, these drugs cannot be used categorically, but subsequently they are sometimes used with caution, taking into account all indications and contraindications, the condition of the woman and the fetus. But since there are no thoroughly tested and absolutely safe antihistamines, their use should be under the constant supervision of a doctor.

How does tsetrin affect pregnancy?

Cetrin lacks many of the disadvantages of its predecessors, but, like them, cetrin suppresses the action of histamine, so it cannot be absolutely safe. Manufacturers of the drug (Indian pharmaceutical company Dr. Redi's Laboratories LTD) takes into account the possible consequences of using this antihistamine on a pregnant woman and fetus and therefore does not recommend its use during pregnancy.

How dangerous is cetrin for a pregnant woman and fetus? No one can answer this question, since there are no adequate clinical trials This drug has not been tested in pregnant women. IN clinical practice Also, there is not yet sufficient experience with its use in pregnant women, since it is a relatively new drug.

The main thing that a pregnant woman should know is that she can take any pills only as prescribed by a doctor, but not on her own.

Galina Romanenko

www.womenhealthnet.ru

1. Pharmacological action

The active substance Cetrin has a blocking effect on histamine receptors, thereby reducing the severity and manifestation of allergic reactions. In addition, Cetrin reduces the secretion of secretions and the synthesis of chemicals that promote inflammation, eliminates spasm of smooth muscles, reduces capillary permeability and cell movement immune system throughout the body, eliminates the causes of itching.

2. indications for use

• Seasonal and year-round manifestation of allergic rhinitis and conjunctivitis;
• Various skin allergic reactions (as part of a drug complex);
• Quincke's edema and chronic urticaria.

3. Method of application

Children aged 6-12 years take Cetrin half a tablet 2 times a day.

Children over 12 years of age and adults take the drug 1 tablet per day.

In both cases, Cetrin is washed down with a small amount drinking water. The duration of treatment does not exceed 1 month on average, but if necessary it can last up to six months.

Patients suffering from functional renal impairment take the drug at half the dose;
For patients suffering from functional liver disorders, no dose adjustment is made.

Persons whose work is related to active look activities, control of complex mechanisms, including various vehicles, Cetrin should be taken with caution.

When used in patients under 6 years of age, it is recommended to use the drug in syrup form.

Drinking alcoholic beverages during treatment with Cetrin is prohibited!

4. Side effects

• Activity violations nervous system(drowsiness, increased fatigue, increased nervous excitability, trembling limbs, mood changes, insomnia, changes in taste perception);
• Problems may occur when taking Cetrin digestive system(swelling of the tongue, inflammation of the stomach, impaired liver function, stomatitis, dry mouth, stool disorders);
• Violation of cardio-vascular system(persistent increase blood pressure, change heart rate);
• Disturbances of other organs and systems (urinary retention, pain in muscles and blood vessels, inflammation of the pharynx);
• Various allergic reactions.

6. During pregnancy and lactation

Cetrin is contraindicated in pregnant women and nursing mothers. If use is necessary, breastfeeding must be discontinued throughout treatment.

7. Interaction with other drugs

• When used simultaneously with Theophylline, accumulation of Cetrin is possible;
• Concomitant use with sedatives should be under the supervision of a physician.

8. Overdose

Drowsiness, trembling limbs, itchy skin, urinary retention, increased heart rate, urticaria.

There is no antidote to Cetrin. If overdose symptoms occur, the patient undergoes gastric lavage and is prescribed laxatives and drugs that can bind various chemical substances followed by their removal from the body. Monitoring of the cardiovascular and respiratory systems should also be carried out.

9. Release form

Cetrin tablets, 10 mg - 20 or 30 pcs.
Syrup, 1 mg/1 ml - vial. 30 ml or 60 ml.

10. Storage conditions

The drug is stored at room temperature without access to light.

11. Composition

1 ml syrup:

• cetirizine dihydrochloride - 1 mg;
• Excipients: glycerol, sucrose, benzoic acid, disodium edetate, sorbitol solution, sodium citrate, fruit flavoring, purified water

1 tablet of Cetrin:

• cetirizine dihydrochloride - 10 mg;
• Excipients: lactose, corn starch, povidone (K-30), magnesium stearate.

12. Conditions for dispensing from pharmacies

The drug is available without a prescription.

pillsman.org

Composition and release forms

Review: Some people experience drowsiness when taking Cetrin, and others negative effects. It depends on the individual characteristics body

Cetrin for allergies is available in tablets, drops and syrup for children. It is not administered by injection or rectally, it is not applied topically, there are no corresponding release forms.

A careful study of the composition of the drug is necessary only if a person is allergic to one or another component that is standardly included in this form of release, or if there is a high risk of developing this allergy.

Release form	Compound	Photo
Cetrin tablets Registration date: 08/07/2007	One tablet contains: 10 mg cetirizine Auxiliary formative substances: starch, lactose, dimethicone, etc.
Cetrin syrup (“Children’s Cetrin”) Registration date: 12/25/2008	1 ml of syrup contains: 1 mg of active ingredient, additional components. The greatest danger in terms of the risk of developing allergies is fruit flavoring, which can provoke an allergic reaction in young children.
Registration date: 02/26/2016	In 1 ml of the drug: 10 mg of active ingredient, Excipients

Cetrin: indications for use

Doctor's review: An effective antihistamine

Cetrin for allergies can be used to treat adults and children from two years of age. The indications are:

• periodic, seasonal and chronic allergic conjunctivitis (including swelling of the eye mucosa, lacrimation, itching and burning in the eyes);
• rhinitis (including allergic runny nose, sneezing);
• hay fever (itching, sneezing, lacrimation);
• skin itching;
• urticaria (on the face, neck, on the skin of the hands);
• Quincke's edema;
• bronchial asthma (mild severity, as part of complex therapy);
• itchy dermatoses (atopic dermatitis);
• photodermatoses.

Special cases of using Cetrin

Allergy sufferers are often interested in what Cetrin tablets (and other forms of release) help with in particular cases.

• Able to eliminate minor bronchoconstriction (narrowing of the bronchi), which makes it effective for bronchial asthma easy flow.
• It has the property of reducing the skin's reaction to exposure to low temperatures, so cold allergies are one of the indications for its use.

The drug relieves severe itching, eliminates runny nose, swelling of mucous membranes. Therefore, its use will give positive result in the following cases:

• Dermatoses: sun allergy, sunburn, neurodermatitis, atopic dermatitis.
• Insect bites (such as wasps or bees).
• Allergy to pollen.
• Skin manifestations of food and contact allergies (for example, allergies to wool).

Cetrin: instructions for use

How to take Cetrin for allergies depends on the age of the patient.

Taking Cetrin orally is not associated with food intake (therefore, it can be taken both before and after meals). The tablet should be taken with a small amount of water and not chewed. Simply wash down the syrup and drops with water.

Photo: instructions for use of Cetrin tablets

(save the photo to your computer or open it in a new tab to see it in full size)

Side 1 Side 2

Instructions for use of Cetrin for adults

Instructions for use of Cetrin for children

With regular use, Cetrin can prevent atopic march in children younger age(attachment of respiratory allergy symptoms to existing skin symptoms).

Release form	Children under 6 years old	Children over 6 years old
Pills	—	5 mg (half tablet) 2 times a day
Syrup	Children from 2 to 6 years old: 5 ml once a day or 2.5 ml 2 times a day.	The same as for adults: 10 ml once a day or 5 ml 2 times a day There is a dosage adjustment based on the child’s weight: children weighing up to 30 kg take 1 measuring spoon (5 ml) per day, over 30 kg - 2.
Drops	From 6 months up to 1 year: 5 drops 1 time per day From 1 year to 2 years: 5 drops up to 2 times a day From 2 to 6 years: 5 drops 2 times a day or 10 drops. 1 per day	Same as adult dosage: Initial dose - 10 drops/day The maximum daily dose is 20 drops.

How long can you take Cetrin if you have allergies?

Review: A mother talks about her experience of using Cetrin for allergies in her child. Difficulties in reception

The duration of taking the drug depends on the severity of the allergy. For an acute allergic reaction The course of taking the drug is 10-14 days. Once symptoms disappear, you can stop taking it.

For prevention allergies, the duration of treatment increases. Cetrin is used for a month. In addition, it is recommended to use the medicine for the entire period of action of the allergen.

It is possible to use Cetrin as a basic antihistamine in the treatment of bronchial asthma in combination with other drugs. In this case, Cetrin should be taken for 15-20 days, after which a break is taken for a week and the use continues again.

Cetrin is also used for the treatment of dermatitis in young children. The drug is a prophylactic agent. Should be taken 3-4 times a year, for 2 weeks.

Cetrin and vaccinations

The use of this product before vaccination (for example, mantu) is possible. However, if you have an allergy, you must inform your doctor in advance. Depending on the manifestations, he recommends an antihistamine that is suitable for you.

Cetrin during pregnancy and lactation

One of the important questions is whether it is possible to take Cetrin when planning pregnancy, during it, as well as during breastfeeding.

The active ingredient of this drug is cetirizine. There have been no controlled studies on the safety of its use during pregnancy, so the drug should not be used during pregnancy.

However, in an analysis of more than 700 cases of pregnancy outcomes, there were no cases of malformations, embryonic or neonatal toxicity with a clear cause-and-effect relationship with cetirizine use.

When breastfeeding

Cetirizine is excreted in breast milk - from 25 to 90% of its concentration in the blood plasma, depending on the time after administration. During breastfeeding, it is used after consultation with a doctor, if the expected benefit to the mother outweighs the potential risk to the child.

Effect on fertility

Available data on the effects on human fertility are limited, but no negative effects on fertility have been identified.

Side effects

Reviews about Tsetrina are different - even diametrically opposed

The undesirable effects of the drug Cetrin for allergies, the instructions for use highlight the following:

1. On the nervous system: headaches, dizziness, insomnia, tremors, increased excitability of the nervous system, depression.
2. On the digestive system: dyspepsia, impaired liver function, stomatitis, dry mouth may occur.
3. On the cardiovascular system: hypertension (increased blood pressure), tachycardia.
4. Other side effects: arthralgia, myalgia, allergic reactions and individual intolerance are also possible.

There have been no studies on whether Cetrin changes the color of urine (only possible urinary retention is mentioned). There is also no information on whether it can cause weight gain.

Tsetrin and driving

During treatment with the drug, you should be careful when driving a car and other vehicles, as well as when engaging in activities that require increased concentration.

Contraindications

Absolute contraindications are its use during pregnancy (it is believed that the drug can have a negative effect on the development of the fetus) and during lactation (Cetrin is able to penetrate into breast milk, through it enter the child’s body and affect it negative impact, inhibiting the functioning of the liver and kidneys).

Photo: Side view of the package. Please note: the shell contains lactose.

The use of tablets is contraindicated in children under 6 years of age, syrup - up to 2 years, drops - up to 6 months.

Persons with kidney pathology (especially chronic renal failure), as well as the elderly, should be especially careful when using Cetrin.

The drug should be stored in a place protected from direct sun rays and at a temperature of about 25 °C. The shelf life is 2 years.

In the video below you can see the review appearance packaging and blister of the drug Cetrin for allergies.

It is highly not recommended to take a drug that has expired.

Cetrin: price, where to buy the drug

The price for all forms of the drug is quite affordable:

For comparison, below is a list of its analogues and their cost:

All forms of the drug (except for drops, which are just appearing on the market) are easy to purchase at any pharmacy.

How to recognize a fake

Infographics

The administration of the portal has prepared an infographic that provides all the basic information about the drug.

Cetrin's analogs

These are medicines that also contain cetirizine as an active ingredient.

Comparison of Cetrin and other drugs: which is better?

There is a huge range of antiallergic drugs on the market, so allergy sufferers often wonder which drug is best to choose. Below we have tried to compare some popular medications.

Name (active substance, generation)	How long does it take to work?	Use during pregnancy, lactation, children	Sedative effect	Price
(cetirizine, 2nd generation)	20 minutes	tablets - from 6 years old, syrup - from 2 years, drops - from 6 months.	Very rarely	from 150 rub.
(desloratadine, 3rd generation)	30 min	During pregnancy and feeding: contraindicated. tablets - from 12 years old, oral solution - from 1 year.	Very rarely	Tablets 10 pcs - 250 rub. Syrup 100 ml - 340 rub.
Fexadine (fexofenandine, 3rd generation)	1 hour	During pregnancy and feeding: contraindicated. Children from 12 years old	Very rarely	Tablets 10 pcs - 260 rub.
(ebastine, 2nd generation)	1 hour	During pregnancy and feeding: contraindicated. tablets 20 mg - from 12 years, tablets 10 mg, syrup - from 6 years	Rarely	Lyophilized tablets - 450 rub. Tablets 20 mg - 360 rub. Tablets 10 mg - 180 rub.
Suprastinex (levocetirizine, 3rd generation)	From 12 minutes to 1 hour	During pregnancy and feeding: contraindicated. tablets - from 6 years, drops - from 2 years	Often	Tablets - 230 rub. Drops — 240 rub.
(clemastine, 1st generation)	15-30 minutes, maximum effect - after 2-4 hours	During pregnancy and breastfeeding: contraindicated. tablets - from 6 years, IM solution - from 1 year.	Often	Tablets 20 pcs - 190 rub. Ampoules 5 pcs - 200 rub.
Claritin (loratadine, 2nd generation)	30 min	tablets - from 3 years old, syrup - from 2 years.	Very rarely	Tablets 10 pcs = 210 rub. Syrup 60 ml - 250 rub.
(desloratadine, 3rd generation)	30 min	Safety of use during pregnancy and lactation has not been established. tablets - from 12 years old, syrup - from 6 months.	Very rarely	Tablets 10 pcs - 560 rub.

Which is better for allergies: Zodak or Cetrin? Zyrtec or Cetrin?

Zodak, Zirtek and Cetrin are analogue drugs, because they contain the same active substance. Therefore, there is no fundamental difference between them. In choosing a drug, subjective opinion, release form and price play a role.

Producing countries

1. Tsetrin - India,
2. Zodak - Czech Republic,
3. Zyrtec - Switzerland.

Pharmacists believe that the active substance is of a higher degree of purification in Zyrtec and Zodak, which is why there should be fewer side effects, but, as practice shows, their frequency is the same.

Table: Comparison of Zodak, Zirtec and Cetrin according to some parameters

What is better for allergies: Tavegil or Cetrin?

Tavegil is a 1st generation drug, therefore it has all the inherent side effects, namely:

• dry mouth,
• drowsiness,
• inhibition of reactions,
• headache.

In addition, Tavegil must be taken 3 times a day, while Cetrin - 1 time.

It is preferable to take Cetrin. (Another useful information You can see the comparison of these two drugs in the table above).

Which is better: Cetrin or Erius?

Erius is a 3rd generation drug, and its use is preferable - it is more effective and has fewer side effects.

However, the lower cost of Cetrin and the good effectiveness of the drug often play a decisive role in the choice, tipping the scales in its favor.

Advertising Cetrin - video

We think that many allergy sufferers will remember the bright advertising video “Allergies are not scary for me.” The girl actress who played the main role hides her name under the pseudonym “Pearl”.

year 2014

Check out other cool ideas - allergy medication presentation. You can see the work of the advertising creator at the link.

Cetrin: reviews from allergy sufferers and doctors

A large number of allergy sufferers respond positively to the drug

When the drug Cetrin for allergies is discussed, reviews are both positive and negative. Among the advantages are the speed of its action and duration - it saves you from allergies for a long time. In addition, Cetrin is more economical than, for example, Zodak or Erius.

Popular among users is the use of Cetrin to relieve symptoms such as itching and flaking of the skin caused by non-allergic factors. These actions are wrong, but in this case there are no fewer reviews about the effectiveness of the drug.

Negative reviews are usually limited to describing the phenomena of individual intolerance. This reaction cannot be predicted and calculated, and cannot be prevented. In addition, among negative reviews There are stories that Cetrin causes a side effect in the form of nasal congestion.

allergy-center.ru

Cetrin ( Cetrine) - a modern antihistamine drug that has antiallergic, antiexudative, antipruritic effects. Medicine produced by the Indian pharmaceutical company Dr. Reddy's Laboratories Ltd.

In the pharmacy chain, Cetrin is presented in the form of tablets containing 10 mg of Cetirizine, 20 tablets in blister packs and in the form of syrup containing 1 mg of Cetirizine in 1 ml.

How does Cetrin work for allergies?

The active substance of Cetrin is cetirizine (hydroxyzine metabolite), which is a blocker of H1-histamine receptors and a competitive histamine antagonist. Ceterizine effectively relieves allergy symptoms and also prevents its development. Having an antiexudative and antipruritic effect, Ceterizine helps limit the release of inflammatory mediators, prevents the release of histamine, serotonin, and bradykinin by mast cells, reduces capillary permeability, prevents the migration of neutrophils, basophils, eosinophils, and relieves smooth muscle spasm. When treating bronchial mild asthma degree of severity, Cetrin reduces histamine-induced bronchospasm.

When taking therapeutic doses of Cetrin, no sedative effect is observed. The therapeutic effect after taking 10 mg of the drug is observed after 30-60 minutes and lasts 1 day. At therapeutic dosages, addiction to the antihistamine effect does not develop. After stopping taking Cetrin, the effect lasts for 3 days.

Cetrin contains active components:

• Tablets: the active substance is cetirizine dihydrochloride (10 milligrams); excipients: starch, povidone, lactose, magnesium stearate, macrogol 6000, hypromellose, talc, titanium dioxide, polysorbate.
• Syrup: 1 ml contains 1 mg of cetirizine dihydrochloride; excipients: sucrose, glycerol, disodium edetate, benzoic acid, sodium citrate, sorbitol solution 70%, purified water, flavoring.

Ceterizine is absorbed fairly quickly after oral administration, with maximum plasma concentrations observed after 60 minutes. It is recommended to take the drug before meals, as digestive processes slow down its absorption.

A small amount of Cetirizine is metabolized in the liver. The medicine does not have a cumulative effect (does not accumulate in organs and tissues), penetrates into breast milk, and is excreted from the body primarily by the kidneys.

If the excretory function of the kidneys is impaired, the half-life of the drug increases.

For what diseases is Cetrin prescribed?

Indications for the use of Cetrin are allergic diseases:

• Seasonal and year-round rhinitis, conjunctivitis;
• Drug and food allergies;
• Dermatoses of allergic origin (in complex treatment);
• Chronic recurrent urticaria;
• Quincke's edema;
• Atopic dermatitis (in complex treatment).

Contraindications and side effects

When treated with Cetrin, side effects may occur: headaches, dizziness, drowsiness, insomnia, hand tremors, depression. Also possible: dry mouth, nausea, vomiting, increased heart rate, increased blood pressure, allergic reactions.

Contraindications to the use of Cetrin are:

• Intolerance to the components of the drug;
• Pregnancy and lactation;
• For children under 6 years of age, Cetrin is prescribed in the form of syrup.

Methods of using Cetrin

Cetrin tablets are taken orally before meals with a small amount of water.

Adults and children over 12 years of age are prescribed 1 tablet. (10 milligrams) once daily.

For children over 6 years of age, give half a tablet (5 milligrams) twice a day.

Cetrin syrup is prescribed for adults and children over six years of age from 1 to 2 teaspoons (5-10 milligrams) once a day. For children from two to five years old, give ½ teaspoon. spoon once a day.

For liver and kidney failure, adults are prescribed half a tablet (5 milligrams) once a day.

The course duration of treatment is 1-4 weeks. When treating chronic allergic diseases, the duration of therapy can increase to 6 months. Before taking Cetrin, read the instructions for use.

Can Cetrin be prescribed during pregnancy and breastfeeding?

The active substance Cetirizine penetrates the placental barrier and is found in breast milk, having a negative effect on the condition of the fetus and newborn, therefore the drug is contraindicated during pregnancy and breastfeeding.

Interaction with other drugs

Cetrin should be used with caution concomitantly with sedatives. When administered simultaneously with theophylline, accumulation of Cetirizine and overdose may occur.

An overdose of the drug is possible if the recommended dose is accidentally exceeded; it is accompanied by drowsiness, increased heart rate, hand tremors, itchy skin, and urinary retention. It is recommended to discontinue the drug, gastric lavage, and also take enterosorbents: Polysorb, Enterosgel, Enterosorb, Laktofiltrum, Activated carbon. There is no specific antidote.

Are there analogues of Cetrin?

Similar pharmacological properties have antihistamines: Zyrtec, Zodak, which include Cetirizine, as well as Loratadine, Clarotadine, Claritin, the main active ingredient of which is Loratadine, Erius (Desloratadine), Ketotifen. Medicines of the first group belong to the latest generation of antiallergic drugs; their price in pharmacies is slightly higher. The lowest cost among Cetrin analogues is for the drug Loratadine Verte. The effectiveness of the latest generation of antihistamines is somewhat higher.

How to properly store the medicine?

Cetrin is stored in a place protected from light. Storage temperature is from 15 to 25 degrees Celsius. The shelf life of the medicine is two years.

Price of medicine in a pharmacy chain

Cetrin can be purchased at most pharmacies. The average cost of the drug is:

• Cetrin syrup, 60 ml (1 mg/ml) - 95 - 105 rubles;
• Cetrin tablets (10 mg), No. 20 - 160 - 170 rubles.

Home — Medicines

neboleem-net.ru

Composition and release form of the drug Cetrin

The medicine is available in the form of film-coated tablets. There are 10 tablets in a blister, 2 blisters in a cardboard package.

Composition of the product

1 tablet of Cetrin contains:

Cetrin - instructions for use of the drug

The effect of Cetrin on the body

The medicine has the ability to reduce capillary permeability, prevent tissue swelling, and is an antispasmodic of smooth muscles. Cetrin can also eliminate skin reactions to Histamine, specific allergens, and hypothermia. At mild form bronchial asthma reduces histamine-induced bronchoconstruction. The drug has virtually no anticholinergic or antiserotonin effect.

When used in recommended therapeutic doses, Cetrin has almost no sedative effect. After a single dose of 10 mg, its effect will be in 20-60 minutes. The duration of action of the medicine is 24 hours. The antihistamine effect does not develop addiction. After the course of treatment is completed, the effect of the medicine will last 3 days.

The active ingredient Cetrin is absorbed quite quickly from the gastrointestinal tract. The maximum concentration after taking the medicine orally is reached in approximately an hour. It should be noted that the bioavailability of the active substance does not depend on the dosage form of the drug. Eating does not affect the amount of absorption of the active substance, but lengthens the time for reaching its maximum concentration in the body by an hour. A small amount of Cetrin is metabolized in the liver to form an inactive metabolite. The active substance of the drug does not accumulate in the body. The predominant amount of the drug is excreted by the kidneys in its original form, approximately 10% of the dose is excreted in the feces.

Systemic clearance is 53 ml per minute. When using Cetrin in tablets, the half-life in adults is 10 hours, and syrup - 7-10 hours; for children 6–12 years old this period is 6 hours, 2–6 years old – 5 hours; 6 months – 2 years – approximately 3 hours. In elderly patients, the half-life is 50% longer and systemic clearance is 40% lower. If renal function is impaired (clearance less than 40 ml per minute), clearance decreases and the half-life becomes longer, so a change in Cetrin dosage may be required. The drug cannot be removed by hemodialysis. For liver diseases in chronic form The half-life is increased by 50%, and the total clearance is reduced by 40%.

The active ingredient of the drug can pass into breast milk.

The use of Cetrin in the treatment of diseases

How to take Cetrin

If an increase in dosage is required (10 mg per day), the ability to react quickly decreases. It is for this reason that you need to be careful when doing activities that require increased attention and reaction, as well as when driving.

Indications, contraindications, side effects of Cetrin

Indications for use of Cetrin

According to the instructions, indications for using the drug are:

Contraindications to the use of Cetrin

• during pregnancy and during breastfeeding;
• children under 6 years of age (tablets);
• at hypersensitivity to the substances that make up Citrine.

Side effects when using Cetrin

When using the drug, the following side effects from systems and organs are possible:

• from the gastrointestinal tract: dry mouth, stomatitis, dyspeptic symptoms, gastritis, anorexia, liver dysfunction, swelling of the tongue, change in color of the tongue;
• from the heart and blood vessels: arterial hypertension, tachycardia;
• from the nervous system: headache, dizziness, drowsiness, insomnia, migraine, tremor, depression, increased excitability, change in taste;
• allergic reactions;
• urinary retention, myalgia, pharyngitis, arthralgia.

Cetrin: symptoms of overdose

If there has been an overdose of the drug, either accidentally or intentionally, the following symptoms are possible: drowsiness, urticaria, rapid heart rate, urinary retention, tremor, itching. Treatment begins with an examination of the heart, blood vessels and respiratory system. If Cetrin was taken in high dosage, it is necessary to induce vomiting and perform gastric lavage. Laxatives and enterosorbents may also be prescribed.

If they are observed severe symptoms from the outside respiratory system, heart or blood vessels, is prescribed symptomatic therapy. Cetrin does not have a specific antidote.

How long can you take Cetrin?

As a rule, the course of treatment is from 1 to 4 weeks. If the disease is chronic, the duration of treatment can be up to 6 months. It is recommended to agree on the duration of treatment and dosage with your doctor, which will make it possible to exclude possible adverse reactions of the body and overdose of the drug.

Use of Cetrin during pregnancy

The drug is not prescribed during pregnancy. Cetrin is also not prescribed during breastfeeding because it has the ability to pass into breast milk.

Cetrin in syrup form can be given to children from two years of age. The medicine in tablet form can be prescribed to children over 6 years of age.

Features of using Cetrin

Interaction of Cetrin with other drugs

According to official instructions Cetrin together with sedative medications should be prescribed with caution. An overdose is possible due to the accumulation of cetirizine in combination with theophylline, which is caused by a decrease in the clearance of cetirizine. There is no confirmed data regarding the interaction of Cetrin with other drugs.

Cetrin's analogs

www.medmoon.ru How long does it take for Claritin to start working?

Cetrin ( Cetrine) - a modern antihistamine drug that has antiallergic, antiexudative, antipruritic effects. The medicine is produced by the Indian pharmaceutical company Dr. Reddy's Laboratories Ltd.

In the pharmacy chain, Cetrin is presented in the form of tablets containing 10 mg of Cetirizine, 20 tablets in blister packs and in the form of syrup containing 1 mg of Cetirizine in 1 ml.

How does Cetrin work for allergies?

The active substance of Cetrin is cetirizine (hydroxyzine metabolite), which is a blocker of H1-histamine receptors and a competitive histamine antagonist. Ceterizine effectively relieves allergy symptoms and also prevents its development. Having an antiexudative and antipruritic effect, Ceterizine helps limit the release of inflammatory mediators, prevents the release of histamine, serotonin, and bradykinin by mast cells, reduces capillary permeability, prevents the migration of neutrophils, basophils, eosinophils, and relieves smooth muscle spasm. In the treatment of mild bronchial asthma, Cetrin reduces histamine-induced bronchospasm.

When taking therapeutic doses of Cetrin, no sedative effect is observed. The therapeutic effect after taking 10 mg of the drug is observed after 30-60 minutes and lasts 1 day. At therapeutic dosages, addiction to the antihistamine effect does not develop. After stopping taking Cetrin, the effect lasts for 3 days.

Cetrin contains active components:

• Tablets: the active substance is cetirizine dihydrochloride (10 milligrams); excipients: starch, povidone, lactose, magnesium stearate, macrogol 6000, hypromellose, talc, titanium dioxide, polysorbate.
• Syrup: 1 ml contains 1 mg of cetirizine dihydrochloride; excipients: sucrose, glycerol, disodium edetate, benzoic acid, sodium citrate, sorbitol solution 70%, purified water, flavoring.

Ceterizine is absorbed fairly quickly after oral administration, with maximum plasma concentrations observed after 60 minutes. It is recommended to take the drug before meals, as digestive processes slow down its absorption.

A small amount of Cetirizine is metabolized in the liver. The medicine does not have a cumulative effect (does not accumulate in organs and tissues), penetrates into breast milk, and is excreted from the body primarily by the kidneys.

If the excretory function of the kidneys is impaired, the half-life of the drug increases.

For what diseases is Cetrin prescribed?

Indications for the use of Cetrin are allergic diseases:

• Seasonal and year-round rhinitis, conjunctivitis;
• Drug and food allergies;
• Dermatoses of allergic origin (in complex treatment);
• Chronic recurrent urticaria;
• Quincke's edema;
• Atopic dermatitis (in complex treatment).

Contraindications and side effects

When treated with Cetrin, side effects may occur: headaches, dizziness, drowsiness, insomnia, hand tremors, depression. Also possible: dry mouth, nausea, vomiting, increased heart rate, increased blood pressure, allergic reactions.

Contraindications to the use of Cetrin are:

• Intolerance to the components of the drug;
• Pregnancy and lactation;
• For children under 6 years of age, Cetrin is prescribed in the form of syrup.

Methods of using Cetrin

Cetrin tablets are taken orally before meals with a small amount of water.

Adults and children over 12 years of age are prescribed 1 tablet. (10 milligrams) once daily.

For children over 6 years of age, give half a tablet (5 milligrams) twice a day.

Cetrin syrup is prescribed for adults and children over six years of age from 1 to 2 teaspoons (5-10 milligrams) once a day. For children from two to five years old, give ½ teaspoon. spoon once a day.

For liver and kidney failure, adults are prescribed half a tablet (5 milligrams) once a day.

The course duration of treatment is 1-4 weeks. When treating chronic allergic diseases, the duration of therapy can increase to 6 months.Before taking Cetrin, read the instructions for use.

Can Cetrin be prescribed during pregnancy and breastfeeding?

The active substance Cetirizine penetrates the placental barrier and is found in breast milk, causing a negative effect on the condition of the fetus and newborn, therefore the drug is contraindicated during pregnancy and nursing breast milk.

Interaction with other drugs

Cetrin is used with caution simultaneously with sedatives. When administered simultaneously with theophylline, accumulation of Cetirizine and overdose may occur.

An overdose of the drug is possible if the recommended dose is accidentally exceeded; it is accompanied by drowsiness, increased heart rate, hand tremors, itchy skin, and urinary retention. It is recommended to discontinue the drug, gastric lavage, and also take enterosorbents: Polysorb, Enterosgel, Enterosorb, Laktofiltrum, Activated carbon. There is no specific antidote.

Are there analogues of Cetrin?

Antihistamines have similar pharmacological properties: Zyrtec, Zodak, which contain Cetirizine, as well as Loratadine, Clarotadine, Claritin, the main active ingredient of which is Loratadine, Erius (Desloratadine), Ketotifen. Medicines of the first group belong to the latest generation of antiallergic drugs; their price in pharmacies is slightly higher. The lowest cost among Cetrin analogues is for the drug Loratadine Verte. The effectiveness of the latest generation of antihistamines is somewhat higher.

How to properly store the medicine?

Cetrin is stored in a place protected from light. Storage temperature is from 15 to 25 degrees Celsius. The shelf life of the medicine is two years.

Price of medicine in a pharmacy chain

Cetrin can be purchased at most pharmacies. The average cost of the drug is:

• Cetrin syrup, 60 ml (1 mg/ml) - 95 - 105 rubles;
• Cetrin tablets (10 mg), No. 20 - 160 - 170 rubles.

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The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Medicine Tsetrin represents antihistamine, which is intended to eliminate the symptoms of an allergic reaction in children and adults. Cetrin belongs to the group of selective (selective) antihistamines, which are also called histamine blockers . The drug does not have a strong sedative effect and depression of the central nervous system, so it is used mainly as an antiallergic drug, starting from 2 years.

Release forms

The drug Cetrin is produced by the Indian pharmaceutical corporation DR. REDDY`S LABORATORIES, LTD in the form of tablets and syrup. The syrup is often called “children’s Cetrin”, since this is the form that is used to treat allergy symptoms in a child. You can also find the common name “Cetrin drops” instead of the correct “syrup”, which is used to designate the liquid dosage form of the drug. In this case, “Cetrin drops” = “Cetrin syrup,” that is, we are talking about the same dosage form, just named differently.

Cetrin syrup is available in dark glass bottles of 30 and 60 ml. Each bottle comes with a measuring spoon. The syrup is transparent, uncolored (a slight yellowish tint is allowed), homogeneous, and does not contain suspended particles. Slight opalescence may occur. Has a pleasant fruity smell.

Tablets are sold in packs of 10, 20 and 30 pieces. The tablet itself has a round, biconvex shape and a line on one side. The top is covered with a white film shell.

Composition and dosage

The tablets and syrup contain the chemical cetirizine as the active ingredient. The dosage of cetirizine in one tablet is 10 mg, and in syrup - 1 mg per 1 ml. Therefore, if you need to take Cetrin in small doses (less than 10 mg), it is better to use syrup rather than tablets. In this case, you can always measure the exact amount of syrup in ml, which will contain the required dose of the active substance. And the tablet can only be broken in half.
The syrup contains the following substances as auxiliary components:

• glycerol;
• sucrose;
• benzoic acid;
• sodium edetate;
• sorbitol;
• sodium citrate;
• fruit flavoring.

Tablets contain the following substances as auxiliary components:

• lactose;
• corn starch;
• povidone;
• Magnesium stearate.

Cetrin – generation of antihistamines

To date, there are only three generations of antihistamines. Cetrin belongs to the second. Let's consider general characteristics and the main differences between the three generations of histamine blockers.

First generation of antihistamines(Suprastin, Tavegil, Diazolin, Fenistil, etc.) has a non-selective effect on receptors. That is why medications block histamine receptors located in the central nervous system and digestive tract organs. The consequence of this indiscriminateness is the powerful inhibitory effect of the drugs, which is the most significant side effect (drowsiness). In short, first-generation antihistamines are characterized by a powerful antiallergic effect and a pronounced side effect in the form of drowsiness.

Second generation antihistamines(Zyrtec, Zodak, Cetrin, Cetirizine, Parlazine, etc.) is characterized by a significantly lesser effect on the central nervous system due to its selective effect on receptors. This means that the side effect in the form of central nervous system depression and drowsiness in second-generation drugs is much less pronounced than in the first. Unfortunately, the antiallergic effect of second-generation drugs is also less pronounced than that of the first. Thus, the short characteristic looks like this: less severe drowsiness and less effectiveness against allergy symptoms compared to first-generation drugs.

Third generation of antihistamines(Claritin, Erius, Telfast, etc.) has a highly selective effect on histamine receptors. Therefore, these drugs have virtually no effect on the central nervous system, that is, they do not cause drowsiness. However, the severity of the antiallergic effect of third-generation drugs is no lower than that of the first. Thus, a brief description of these antihistamines is as follows: a powerful antiallergic effect and almost complete absence side effect on the central nervous system in the form of drowsiness.

Cetrin tablets for allergies (therapeutic effects)

The therapeutic effects of Cetrin are due to the active substance - cetirizine, which is a histamine receptor blocker. This means that cetirizine binds to receptors and blocks them. As a result, the released histamine cannot contact its receptors and has no effect. Namely, histamine is responsible for the development of manifestations of an allergic reaction (itching, redness, swelling, rash, etc.). Thus, Cetrin blocks the development of an allergic reaction at the cellular level and, thereby, prevents its formation external manifestations(pain, itching, swelling, etc.).

In addition, Cetrin reduces the amount of histamine released and reduces the migration of eosinophils to the site of the allergic reaction. A decrease in the number of eosinophils in the focus of allergic inflammation leads to a significant decrease in the severity of the late stages of the hypersensitivity reaction. Cetrin also has a general anti-inflammatory effect, inhibiting the production of cytokines that support the inflammatory response.

When used in courses as a prophylactic agent, the drug has the ability to reduce the readiness to develop an allergic reaction in the cells of the bronchi, which leads to a decrease in the frequency of attacks in patients with asthma. In exactly the same way, Cetrin suppresses the development of a skin allergic reaction in people suffering from urticaria and dermographism.

The therapeutic effect of Cetrin begins 20 minutes after taking the drug and lasts up to 24 hours. Therefore, it is enough to take it only once a day. After stopping the use of the drug, readiness to develop allergic reactions is restored after three days.

Thus, the main therapeutic effects of Cetrin are as follows:
1. Eliminates itching.
2. Relieves and prevents swelling.
3. Relieves spasm of smooth muscles.
4. Reduces capillary permeability and fluid release into tissue.

Indications

Syrup and tablets are used to eliminate allergy symptoms in the following conditions:

• seasonal or year-round runny nose;
• allergic conjunctivitis;
• hay fever;
• urticaria of any type;
• dermatoses with severe itching (for example, neurodermatitis, atopic dermatitis, etc.);
• skin itching of any origin, except caused by cholestasis;
• bronchial asthma;

Cetrin - instructions for use (how to take)

Both tablets and Cetrin syrup are taken orally, regardless of food, with a small amount of plain water. Syrup can be given to children from 2 years of age, and tablets - only from 6 years of age. Since the drug has a long-lasting effect, it can only be taken once a day. Moreover, it is better to do this in the evening, before going to bed, so that during the day you do not experience any discomfort associated with possible drowsiness.

How to take Cetrin syrup

The dosage is determined by the person’s age:
1. Children from 2 to 6 years old take 5 ml of syrup (5 mg) once a day, in the evening. If the child does not tolerate this dose well, it can be divided into two doses - 2.5 ml of syrup 2 times a day, morning and evening.
2. Children over 6 years of age and adults take 10 ml of syrup (10 mg) once a day, in the evening, before bed. If necessary, you can distribute a dose of 10 mg into two doses - 5 ml of syrup in the morning and evening.

Older people who do not have kidney disease can take Cetrin at the usual adult dosage.

Patients suffering from renal failure should use Cetrin in doses that depend on the value of the glomerular filtration coefficient, determined using the Rehberg test. The dosage of Cetrin for people suffering from kidney failure is shown in the table:

If a hypersensitivity reaction develops in response to taking Cetrin syrup, you must immediately stop using the drug.

Before conducting allergy tests (Prick test), you must stop taking Cetrin 3 to 4 days in order to avoid getting false negative results.

Adults should refrain from drinking alcohol while using Cetrin. Also, while using the drug, it is necessary, if possible, to abandon any activity that requires increased concentration and high speed of reactions.

Interaction with other medications. Combined use with theophylline leads to an extension of the action of Cetrin by more than 24 hours.

Overdose Cetrina is possible with a single dose of more than 50 ml of syrup. Symptoms of overdose are:

• drowsiness;
• cessation of urine output;
• anxiety and increased irritability.

When treating an overdose, the first thing to do is gastric lavage to remove any remaining drug from the body. Hemodialysis in this case is ineffective. If necessary, apply symptomatic drugs to maintain normal blood pressure, urination, breathing, etc.

How to take Cetrin tablets

Children can take the drug in tablet form only from 6 years of age. The tablets are taken orally, not chewed, but simply swallowed and washed down with a small amount of plain water. Since the drug has a long-lasting effect, the tablet must be taken only once a day. It is best to take Cetrin in the evening to avoid discomfort from possible drowsiness during the day.

The dosage of tablets is the same for adults and children over 6 years of age. Typically, adults take 1 tablet (10 mg) once a day (preferably in the evening). And for the children daily dose 10 mg is divided into two doses - half a tablet (5 mg) twice a day, morning and evening.

Patients with impaired renal function should take Cetrin tablets in half the dosage, that is, half a tablet (5 mg) once a day. If you have kidney failure, the drug may accumulate in the blood, which increases the risk of side effects.

If a hypersensitivity reaction develops while taking the tablets, you should immediately stop using them and consult a doctor. Before conducting allergy tests (Prick test), you must stop using Cetrin tablets at least 3 days in advance.

Alcoholic beverages should be avoided during treatment. Since the drug may cause drowsiness, you should also avoid any activity that requires high concentration and reaction speed.

Overdose Cetrin is possible when taking more than 3 to 4 tablets at a time. Symptoms of this condition include drowsiness, restlessness, itching, rash, urinary retention, fatigue, tremors (shaking limbs), tachycardia (palpitations). To treat an overdose, first of all, you should remove the remaining drug from the body by washing the stomach. Hemodialysis should not be performed because this procedure is ineffective in removing Cetrin from the blood. If necessary, use symptomatic medications to support basic vital functions.

Interaction with other drugs was not identified. However, it is recommended to carefully combine the simultaneous use of Cetrin tablets and drugs that have a sedative effect.

Cetrin for children

Cetrin is allowed to be used in children from 2 years of age. From 2 to 6 years of age, it is allowed to use Cetrin exclusively in the form of syrup, and after 6 years of age, children can also take tablets.

The use of the drug allows you to quickly eliminate painful itching in a child, for whom it causes especially severe discomfort. After all, a child is often simply unable to restrain his desire to “scratch”; he literally scrapes the skin with his nails. As a result, numerous wounds and scratches form on the skin, into which infection easily penetrates. As a result, the allergic reaction is complicated by the infectious process. By relieving painful itching, Cetrin normalizes the child’s sleep and indirectly prevents the development of skin infections.

In addition, the drug has the property of reducing allergic activity of the skin and bronchi. With regular use, this reduces the risk of adding respiratory symptoms (spasm of the bronchi, larynx, difficulty breathing, shortness of breath, swelling of the mucous membranes, etc.) of an allergic reaction to existing skin ones (itching, redness, swelling, rash). That is, Cetrin prevents the transition of dermatitis to serious illness– bronchial asthma or allergic rhinitis. This spread of symptoms of an allergic reaction from the skin to the respiratory system is called atopic march. That is why doctors talk about Cetrin’s ability to prevent atopic march in young children.

The dosage of the drug is determined by the age of the child. Possible options for using Cetrin tablets and syrup in children are shown in the table:

Cetrin tablets must be taken twice a day, since the child cannot be given the entire daily dose at one time.

If the child has impaired renal function, the daily dosage of Cetrin should be reduced by half. This means that children 2–6 years old can take a maximum of 2.5 ml of syrup per day. Children over 6 years old can take a maximum of 5 ml of syrup per day, or one tablet once every two days.

Doctors recommend using Cetrin syrup for children, since it is more convenient to dose and is better accepted by the child. The baby is more willing to drink a pleasant-smelling syrup than a pill that is associated with bitter medicine. Therefore, in order not to cause unnecessary psychological trauma to the child, it is recommended to give him the drug in syrup form.

If one dose of the drug was missed, nothing needs to be done. Just continue to give your child Cetrin at the usual dosage the next day without increasing it.

Use during pregnancy

Both syrup and Cetrin tablets are contraindicated for use during pregnancy and during lactation. This is due to the fact that the drug penetrates the placenta and can have a negative effect on the development of the child’s brain. When breastfeeding, the drug passes into mother's milk in large doses. That is why Cetrin is prohibited for use by pregnant women and nursing mothers.

How many days should I take Cetrin?

The duration of use of Cetrin depends on a number of factors, the determining ones being the severity and nature of the allergic disease.

Thus, Cetrin is used to relieve an acute allergic reaction for a maximum of 10–14 days. If the symptoms of an allergic reaction disappear faster than after 10 days, then stop taking the drug earlier. Thus, when treating an acute allergic reaction, the duration of administration is determined by the rate at which symptoms disappear. As soon as allergy symptoms disappear, you can immediately stop taking the drug. However, in this case, continuous use of Cetrin for more than 14 days is not allowed.

When taking Cetrin as a prophylactic agent to prevent exacerbations of allergic diseases (for example, runny nose, hay fever, dermatitis, etc.), a longer course of treatment is necessary. Typically, the prophylactic course of use of the drug is 1 - 1.5 months. Doctors recommend taking Cetrin for prophylaxis throughout the entire period of presence of a potential allergen in the environment. For example, if you are allergic to flowering plants, you need to take Cetrin in May-June until all the trees have bloomed.

Cetrin can also be used for the treatment of bronchial asthma as a basic antihistamine in combination with other drugs. In this case, the drug is taken in a course lasting 15–20 days, then take a break for 1 week. After a break, the reception is resumed again. This method of taking Cetrin in the treatment of bronchial asthma has been practiced for years.

Children early age(up to 7 years), prone to allergic reactions such as dermatitis, can take Cetrin prophylactically 3 - 4 times a year, in short courses of 10 - 14 days. Such prevention is necessary to prevent the atopic march in children prone to true allergic reactions.

Side effects

Cetrin tablets and syrup have exactly the same side effects, which manifest themselves mainly in the central nervous system. Side effects of both dosage forms of Cetrin on various organs and systems are presented in the table:

Contraindications

Contraindications for the use of Cetrin syrup and tablets are also the same. The drug should not be used in the presence of the following conditions:

• hypersensitivity or allergy to the components of the drug;
• pregnancy period;
• children under 2 years of age (for syrup);
• children under 6 years of age (for tablets).

Relative contraindications to the use of Cetrin are renal failure and elderly age person. In these cases, the drug can be used by reducing the usual adult dose and arranging medical supervision of the patient's condition.

Analogs

Cetrin has both analog and synonym drugs on the domestic pharmaceutical market. Analogs include all drugs from the pharmaceutical group of antihistamines (histamine blockers). Synonyms for Cetrin include antihistamines, which also contain cetirizine as an active ingredient.

So, the following drugs are synonymous with Cetrin:

• Alerza tablets;
• Allertek tablets;
• Levocetirizine-Teva tablets;
• Cetirizine DS tablets;
• Cetirinax tablets;
• Cetirizine-OBL tablets;
• Cetirizine-Teva tablets;
• Zyrtec tablets and drops;
• Zodak drops, syrup and tablets;
• Letizen solution and tablets;
• Parlazin drops and tablets;
• Cetirizine tablets;
• Drops, syrup and tablets Cetirizine Hexal;
• Cetrin syrup and tablets;
• Zetrinal syrup and tablets;
• Zincet syrup and tablets.

Cetrin analogues include the following drugs:

• Alerpriv tablets;
• Allerfex tablets;
• Beksist-sanovel tablets;
• Glencet tablets;
• Histafen tablets;
• Gifast tablets;
• Diacin tablets;
• Dimebon tablets;
• Dimedroquine tablets;
• Dinox tablets;
• Dramamine tablets;
• Desloratadine-Teva tablets;
• Clallergin tablets;
• Clarifer tablets;
• Ketotifen-Ros tablets;
• LoraHexal tablets;
• Loratadine Stada tablets;
• Loratadine-Verte tablets;
• Loratadine-Teva tablets;
• Loratadine-OBL tablets;
• Lordestin tablets;
• Rupafin tablets;
• Ciel tablets;
• Telfast tablets;
• Caeser tablets;
• Fexadin tablets;
• Fexo tablets;
• Fexofast tablets;
• Fexofenadine tablets;
• Xizal drops and tablets;
• Claritin drops and tablets;
• Clargotil syrup and tablets;
• Claridol syrup and tablets;
• Clarisens syrup and tablets;
• Clarotadine syrup and tablets;
• Kestin syrup and tablets;
• Ketotifen syrup and tablets;
• Syrup and tablets Ketotifen Sopharma;
• Loratadine syrup and tablets;
• Syrup and tablets Loratadine-Hemofarm;
• Peritol syrup and tablets;
• Suprastinex drops and tablets;
• Erius syrup and tablets;
• Erolin syrup and tablets;
• Tablets, lozenges and suspension Lomilan;
• Dragees and Diazolin tablets;
• Rapido capsules;
• Semprex capsules.

• Quincke's edema;

Methods of using Cetrin

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Is it possible to drink Cetrin during pregnancy?

Against the background of increased histamine production, nasal congestion, lacrimation are observed, natural breathing is disrupted, and a sensation of itching and burning occurs in the paranasal sinuses. The development of side effects is extremely undesirable during pregnancy.

The therapeutic regimen for pregnant women includes gentle antihistamines of the 3rd generation, among which Cetrin is widely used. The active components are devoid of cardiotoxic sedative effect, have high selectivity, and are not addictive. Is it possible to drink Cetrin during pregnancy, and in what doses/course, so as not to harm the health of the baby and mother?

The advisability of taking Cetrin at different stages of gestation

The drug is presented on the pharmacological market as syrup and tablets coated with a multicomponent soluble coating. Regardless of the form of release, the main composition is formed by the competitive histamine antagonist - cetirizine.

Find out here which drops can be used during pregnancy to restore nasal breathing.

The H1 histamine receptor blocker exhibits antipruritic, antiexudative and antiallergic activity. The therapeutic effect is enhanced by the presence of excipients: corn starch, lactose, povidone KZO.

"Cetrin" relieves the symptoms of an allergic reaction and prevents the development of pathological changes due to the influence of antigens. The action of the drug is aimed at inhibiting the synthesis of irritants, reducing leukocyte lineage cells, and increasing the capacity of capillaries.

The components are quickly absorbed into the gastrointestinal tract, the medical effect occurs within an hour after administration and lasts up to 24 hours.

The productivity and safety of Cetrin is explained by the fact that it does not affect serotonin and cholinergic nerve endings. Research that would prove possible harm health of the mother and unborn child have not been carried out on patients.

For reference! The constituent components can be excreted in milk during breastfeeding, therefore antihistamines are prohibited during lactation.

According to the instructions for use of "Cetrina" during pregnancy, the drug is included in the therapeutic regimen at all stages of gestation, when the threat to the health of the mother and child exceeds potential harm from taking medication.

In order to prevent the risk of side effects, it is necessary to take the allergic drug as recommended by a doctor and under medical supervision.

The use of Cetrin in the 2nd trimester has minimal toxic effects on the fetus. Bookmark internal organs completed, the placenta is formed, the embryo is protected from the effects of the components of the drug.

Contraindications

Due to the fact that the drug is excreted from the body primarily by the kidneys, it is prescribed with caution to patients with a history of renal and liver failure.

For reference! Cetrin is included in the therapeutic regimen for older people in a reduced dosage.

In pediatrics, the pharmaceutical product is approved from the age of six, mainly in the form of syrup. In case of hypersensitivity of the body to individual components or overdose, the development of the following disorders is noted:

• headaches;
• signs of intoxication;
• depression;
• dizziness;
• high blood pressure, tachycardia;
• tremor of the upper extremities;
• feeling of dry mouth.

"Cetrin" during early pregnancy

After fertilization of the egg, the period of embryo formation begins, which covers the first 13 weeks. At this time, the formation of organs and systems occurs. Reproducing fetal cells are sensitive to external factors.

The use of pharmacological products in the early gestational age is fraught with serious pathological disorders.

A weak placental barrier does not provide any hope of protection from the penetration of medicinal components, as a result - the development of fetal hypoxia and spontaneous termination of pregnancy.

The ability of an antihistamine to affect the fetus is determined by physiological characteristics patient and placenta condition, course and dosage.

Contraindications for Cetrina during pregnancy in the 1st trimester indicate an increased likelihood of side effects, but this does not mean that pathological changes characteristic of each clinical case.

Therefore, to prevent the risk of defectiveness of the unborn child, it is advisable to take increased care of your health and that of the baby in order to eliminate the need for drug treatment.

Directions for use and dosage

The tablet form of the antiallergic product has become widespread in ENT practice. 1 tablet contains 10 mg. cetirizine dihydrochloride. This is a one-time rate for adults. With reduced renal function, the dose is halved - half a tablet (5 mg). The daily frequency is limited to two doses.

For reference! For chronic renal failure, Cetrin is prescribed 5 mg. in one day.

Duration drug regimen determines the form of the lesion, the etiology of the pathogen, and the general course of the clinical picture. For prevention purposes, the course of use varies from 2 weeks to a month.

For therapeutic purposes, it is prescribed in a cycle of 14 days to six months. Medicinal effect persists for the next 3 days after discontinuation of the drug.

The digestion process does not slow down the absorption period active ingredients, therefore, it is allowed to take tablets before or after meals with plenty of water.

The regimen for taking the liquid form is no different from the previous variation. From the age of twelve, 10 ml is prescribed. syrup twice a day, provided there are no pathological disorders of the kidneys.

Conclusion

Before using Cetrin, it is recommended to study the instructions to prevent the development of side effects. The 3rd generation antihistamine exhibits a high therapeutic effect in a gentle form for allergic rhinitis, conjunctivitis, hay fever, dermatosis, and in complex therapy for bronchial asthma.

Minimal development risks side effects from the use of the drug are observed in the 2nd trimester of pregnancy. Therefore, early and late periods are contraindications for use.

Directory of main ENT diseases and their treatment

All information on the site is for informational purposes only and does not claim to be absolutely accurate from a medical point of view. Treatment must be carried out by a qualified doctor. By self-medicating you can harm yourself!

Cetrin during pregnancy

The body of a pregnant woman reacts in a unique way to previously familiar foods and phenomena. Therefore, it is not surprising that expectant mothers are susceptible to allergic reactions much more often than others: their allergies manifest themselves in both mild and severe forms and depend on the use of certain medications, the consumption of certain foods, or on a certain period of time when plants bloom or fruits ripen.

Pregnant women try to realize their natural desire to eliminate unpleasant symptoms and live a full life through anti-allergenic drugs, but is it possible to use enough strong drugs, most of which have the ability to block histamine?

Cetrin from a series of antihistamines

Which drug should a pregnant woman suffering from allergies choose? The first thing that comes to mind is Cetrin. The medicine is effective, not very expensive, and advertising is placed in almost all media.

The drug is excreted in the urine.

Indications for use

• allergic rhinitis;
• allergic conjunctivitis;
• itching of various origins;
• hives;
• Quincke's edema.

Cetrin by trimester

1st trimester

2nd trimester

3rd trimester

The baby’s body is practically formed, but this is not a reason to take a drug that is undesirable for pregnant women. Cetrin is prescribed only in exceptional cases and therapy is carried out under the strict supervision of a doctor.

Cetrin: indications for use, analogues

Hello friends! Today I want to tell you about the drug Cetrin, whose indications for use promise to cope with allergies.

It's no secret that there are a lot of medications that stop allergic attacks, but I want to talk about this remedy: its advantages and disadvantages.

In the next article, by the way, you can read why Cetrin tablets are prescribed.

Cetrin indications for use

First, I consider it necessary to write 2 medical facts:

1. Any irritants that get inside are met with powerful resistance from immune cells.
2. There are situations when the immune system weakens and then control over the production of histamines disappears: they begin to form in huge quantities and have a detrimental effect on all human tissues and organs.

Antihistamines come to the rescue in such situations. Today, three generations of antihistamines are used in clinical practice. The first generation includes:

• tavegil,
• fenistil,
• diazolin

Reading the indications for the use of each of them, one can come to the conclusion that they all have a powerful suppressive effect.

But, unfortunately, this results in an equally strong side effect – drowsiness.

Third generation medications (Claritin, Telfast, Erius) have the same strong qualities in suppressing histamine production, and are practically free of side effects.

What specific indications for use do Cetrin have?

It belongs to the second generation of antihistamines and has more wide range actions. It does not have a very pronounced side effect, but it also has a gentler effect on the receptors.

The active ingredient, cetirizine, binds to receptors and prevents histamine from reaching them. This means that such allergic manifestations How:

• Hyperemia,
• Rash,

Moreover, this already happens at the cellular level. In addition, it does not allow eosinophils to accumulate at the site of inflammation, and, accordingly, prevents the development inflammatory process at the site of an allergic reaction.

Due to these qualities and indications, it can be prescribed for the treatment of allergies not only in adults, but also in children over 2 years of age.

Let's now try to figure out what the indications for use say about pregnancy...

Cetrin during pregnancy

Before we talk about the possibility of its use during pregnancy, I want to tell you why, in general, antihistamines are prohibited for expectant mothers.

During pregnancy, histamine becomes a very necessary component. With its assistance, the fertilized egg attaches to the wall of the uterus.

It promotes the development of the embryo, and subsequently regulates the metabolism of the fetus. The formation of the baby’s tissues and organs depends on it.

Taking medications that suppress the production of histamine can have a tragic effect on the child’s condition, physical and mental development.

Here are the indications for use of Cetrin during pregnancy:

if you start using it, it may negatively affect the functioning of your kidneys and liver. Therefore, tsetrin during pregnancy, of course, has advantages over other drugs, but is used with great caution.

It is MANDATORY that you need to consult with a specialist in your area, and then, if you are allowed to use it, do so under the strict supervision of a doctor.

The drug has few side effects and does not affect the quantitative production of histamines.

But, nevertheless, during the first 12 weeks its use is generally prohibited. And in the future, doctors look at the health status of the mother and fetus.

It is also worth mentioning that the medicine is produced by an Indian pharmacological company, but are there any analogues in domestic production?

Cetrin analogues

Comparing the indications for use of Cetrin and looking through reference books, I discovered a number of domestically produced medications that are similar in their effects.

All dosage forms, produced on the basis of cetirizine, and which are histamine blockers can be considered analogues.

If we compare in general the indications for the use of some other drugs, which are sometimes called “synonyms,” this is another separate list.

This includes all medications based on cetirizine, with slightly different additional components.

• Alerza,
• Cetirizine,
• Letizen,
• Zyrtec.

The list can be continued for a very long time. Now, knowing what indications for use Cetrin has, you must decide: do you want to start using it?

Girls, did anyone drink Cetrin during pregnancy?

Need Ginipral tablets!

Comments

Oh, thank you girls for the answers. At least I started to worry less.

The allergist told me that in the first trimester only diazolin is allowed, in the second, suprastin and nothing else, the rest is at your own responsibility

I drank, what should I do? But no longer than 3-4 days in a row. Both in the last pregnancy and in this one.

So, is it normal? Did it affect the baby?

Well, at least I don't know about it

Better go see an allergist. Here you need to find out what you are allergic to and exclude the allergen, and not suppress the pills. They are very undesirable and are drunk only when there is no other choice. Cetrin seems to belong to the latest generation, but it’s still ideal to get by

And for the last generation, does this mean you can drink?

No, this means that if you can’t get anywhere without pills, then these are better than Tavegil or some kind of Suprastin.

I also constantly have allergic blisters all over my body, I have no idea why, I’m allergic in life, enterosgel saves me, the same polysorb, it really helps and is not harmful, I don’t take any anti-allergic drugs and I wouldn’t drink them, it’s scary,

How many days do you drink entorosgel? And how long does everything take? This is the first time I encountered such a problem. The rash looks like hives, my daughter had this 2 times but it went away in 3 days.

I take it for 10 days, and it starts to go away on day 4-5, it also helps with allergies on day 4-5, but not all pills work, some don’t help anymore, I’m getting used to it

Maybe someone took another drug during pregnancy?

Erius (but its price is high) and citrine all the first B. I am allergic, I can be allergic to everything. Now I drink too. A child of almost 4 has no allergies at all, as long as he eats a lot of sweets for 3 days (thanks to my beloved great-grandmother). In general, I think that if the mother feels bad, then the baby in the tummy doesn’t feel good either (my G is of the same opinion). That’s why I drank it and also took a painkiller pill when my tooth hurt for 3 days.

Cetrin says that its use during pregnancy can affect the development of the baby's brain and spinal cord. That's why I'm not scared for him. I've scoured the entire Internet, and reviews from pregnant women are positive about Cetrin.

Girls, before pregnancy I started having hives with itching, I take Diazolin, Claritin, or Cetrin every two or three days. Without them there is crazy itching, you can’t sleep or eat (((Whoever took antihistamines throughout pregnancy, please share your experience.

Girls, please tell me if anyone had this during pregnancy allergic dermatitis? I have spots that itch terribly on my thighs and down to my knees. Today spots began to appear on my hands (so far barely noticeable). About stretch marks in the lower abdomen.

Do you or anyone you know have allergies? What did you do during pregnancy? I drink Cetrin every day, if I don’t drink it, the itching is terrible all over my body. I don’t know what I’m allergic to, but it’s been with me since school. It’s been years.

Hello, there is a sign that during pregnancy you should not embroider, supposedly the baby will get entangled in the umbilical cord. I started embroidering when I was pregnant with my first child. So, as soon as I started sewing, my daughter started kicking me hard and what.

can I take it or not? I didn’t find any contraindications as such, perhaps I didn’t look well. What interests me is the collagen that is taken orally - i.e. in the form of powders and capsules. Because During my first pregnancy (26 years old) I had.

the doctor prescribed herbs and there are contraindications for pregnancy

I thought so, and decided a couple of months before my next pregnancy, I’ll get vaccinated against tetanus, a month before the flu or something, and then I’ll plan. I don’t really believe in the flu shot, I’ll probably just be careful.

I started having allergies before I got pregnant. For a lot. I was saved by antigestamines. As soon as I found out that I was expecting a baby, I immediately stopped taking them (pregnancy is contraindicated for everyone). And now I don’t know how to deal with it.

I started taking Magnesium B6 in the first trimester. Because of the vomiting, the tone of the uterus appeared. I drank for a while. On the trail. When examined by G, she told me to continue drinking, because... There is a slight tone. When was it?

This is how my March 8th ended. After baby sleep We had lunch and went to grandma's for pies. Already on the way I felt bad, I thought I had eaten too much. My grandmother had already started vomiting and diarrhea((I drank coal at home, but I was still vomiting for half the night(((I drank.

Is it possible for pregnant women to take Cetrin?

Cetrine is a modern antihistamine drug that has antiallergic, antiexudative, and antipruritic effects. The medicine is produced by the Indian pharmaceutical company Dr. Reddy's Laboratories Ltd.

In the pharmacy chain, Cetrin is presented in the form of tablets containing 10 mg of Cetirizine, 20 tablets in blister packs and in the form of syrup containing 1 mg of Cetirizine in 1 ml.

How does Cetrin work for allergies?

The active substance of Cetrin is cetirizine (a metabolite of hydroxyzine), which is a blocker of H1-histamine receptors and a competitive histamine antagonist. Ceterizine effectively relieves allergy symptoms and also prevents its development. Having an antiexudative and antipruritic effect, Ceterizine helps limit the release of inflammatory mediators, prevents the release of histamine, serotonin, and bradykinin by mast cells, reduces capillary permeability, prevents the migration of neutrophils, basophils, eosinophils, and relieves smooth muscle spasm. In the treatment of mild bronchial asthma, Cetrin reduces histamine-induced bronchospasm.

When taking therapeutic doses of Cetrin, no sedative effect is observed. The therapeutic effect after taking 10 mg of the drug is observed after a minute and lasts 1 day. At therapeutic dosages, addiction to the antihistamine effect does not develop. After stopping taking Cetrin, the effect lasts for 3 days.

Cetrin contains active components:

• Tablets: the active substance is cetirizine dihydrochloride (10 milligrams); excipients: starch, povidone, lactose, magnesium stearate, macrogol 6000, hypromellose, talc, titanium dioxide, polysorbate.
• Syrup: 1 ml contains 1 mg of cetirizine dihydrochloride; excipients: sucrose, glycerol, disodium edetate, benzoic acid, sodium citrate, sorbitol solution 70%, purified water, flavoring.

Ceterizine is absorbed fairly quickly after oral administration, with maximum plasma concentrations observed after 60 minutes. It is recommended to take the drug before meals, as digestive processes slow down its absorption.

A small amount of Cetirizine is metabolized in the liver. The medicine does not have a cumulative effect (does not accumulate in organs and tissues), penetrates into breast milk, and is excreted from the body primarily by the kidneys.

If the excretory function of the kidneys is impaired, the half-life of the drug increases.

For what diseases is Cetrin prescribed?

Indications for the use of Cetrin are allergic diseases:

• Seasonal and year-round rhinitis, conjunctivitis;
• Drug and food allergies;
• Dermatoses of allergic origin (in complex treatment);
• Chronic recurrent urticaria;
• Quincke's edema;
• Atopic dermatitis (in complex treatment).

Contraindications and side effects

When treated with Cetrin, side effects may occur: headaches, dizziness, drowsiness, insomnia, hand tremors, depression. Also possible: dry mouth, nausea, vomiting, increased heart rate, increased blood pressure, allergic reactions.

Contraindications to the use of Cetrin are:

• Intolerance to the components of the drug;
• Pregnancy and lactation;
• For children under 6 years of age, Cetrin is prescribed in the form of syrup.

Methods of using Cetrin

Cetrin tablets are taken orally before meals with a small amount of water.

Adults and children over 12 years of age are prescribed 1 tablet. (10 milligrams) once daily.

For children over 6 years of age, give half a tablet (5 milligrams) twice a day.

Cetrin syrup is prescribed for adults and children over six years of age from 1 to 2 teaspoons (5-10 milligrams) once a day. For children from two to five years old, give ½ teaspoon. spoon once a day.

For liver and kidney failure, adults are prescribed half a tablet (5 milligrams) once a day.

The course duration of treatment is 1-4 weeks. When treating chronic allergic diseases, the duration of therapy can increase to 6 months. Before taking Cetrin, read the instructions for use.

Can Cetrin be prescribed during pregnancy and breastfeeding?

The active substance Cetirizine penetrates the placental barrier and is found in breast milk, causing a negative effect on the condition of the fetus and newborn, therefore the drug is contraindicated during pregnancy and nursing breast milk.

Interaction with other drugs

Cetrin is used with caution simultaneously with sedatives. When administered simultaneously with theophylline, accumulation of Cetirizine and overdose may occur.

An overdose of the drug is possible if the recommended dose is accidentally exceeded; it is accompanied by drowsiness, increased heart rate, hand tremors, itchy skin, and urinary retention. It is recommended to discontinue the drug, gastric lavage, and also take enterosorbents: Polysorb, Enterosgel, Enterosorb, Laktofiltrum, Activated carbon. There is no specific antidote.

Are there analogues of Cetrin?

Antihistamines have similar pharmacological properties: Zyrtec, Zodak, which contain Cetirizine, as well as Loratadine, Clarotadine, Claritin, the main active ingredient of which is Loratadine, Erius (Desloratadine), Ketotifen. Medicines of the first group belong to the latest generation of antiallergic drugs; their price in pharmacies is slightly higher. The lowest cost among Cetrin analogues is for the drug Loratadine Verte. The effectiveness of the latest generation of antihistamines is somewhat higher.

How to properly store the medicine?

Cetrin is stored in a place protected from light. Storage temperature is from 15 to 25 degrees Celsius. The shelf life of the medicine is two years.

Price of medicine in a pharmacy chain

Cetrin can be purchased at most pharmacies. The average cost of the drug is:

• Cetrin syrup, 60 ml (1 mg/ml) – 95 – 105 rubles;
• Cetrin tablets (10 mg), No. 20 – 160 – 170 rubles.

Cetrin and pregnancy: concepts are incompatible

Allergies in pregnant women most often manifest themselves in the form of allergic rhinitis or conjunctivitis. Less common are skin rashes and bronchial asthma. In all these cases, obstetricians-gynecologists recommend preparing for pregnancy, visiting an allergist in advance and, if necessary, conducting a course of specific treatment.

What to do if allergies get worse during pregnancy

First of all, no amateur activity: all treatment should take place only under the supervision of a doctor. First, the doctor will try to cope with allergies using non-drug methods: a hypoallergenic diet, excluding possible household allergens (including dust, particles of animal hair, fish scales, and so on).

If it is not possible to help a woman in this way, then drug treatment is prescribed, including the use of the safest antihistamines.

What are the dangers of antihistamines during pregnancy?

Antihistamines are used during pregnancy, but only under strict indications. The fact is that drugs in this group block the action of histamine, a biologically active substance that is not entirely superfluous in the body of a pregnant woman.

With the assistance of histamine, the fertilized egg is implanted into the wall of the uterus and the embryo develops in it. In later stages of pregnancy, histamine easily passes through the placenta and regulates the metabolism between the mother and fetus. The process of tissue laying and development of fetal organs depends on its influence.

The use of antihistamines can disrupt all these processes. And since practically no clinical trials are conducted on pregnant women, no one can say for sure how this or that antihistamine will affect the condition of the woman and the fetus.

In the first 12 weeks of pregnancy, these drugs cannot be used categorically, but subsequently they are sometimes used with caution, taking into account all indications and contraindications, the condition of the woman and the fetus. But since there are no thoroughly tested and absolutely safe antihistamines, their use should be under the constant supervision of a doctor.

How does tsetrin affect pregnancy?

Cetrin lacks many of the disadvantages of its predecessors, but, like them, cetrin suppresses the action of histamine, so it cannot be absolutely safe. The manufacturers of the drug (Indian pharmaceutical company Dr. Redi's Laboratories Ltd.) take into account the possible consequences of using this antihistamine on a pregnant woman and fetus and therefore do not recommend its use during pregnancy.

How dangerous is cetrin for a pregnant woman and fetus? No one will answer this question, since adequate clinical studies of this drug have not been conducted on pregnant women. In clinical practice, there is also not yet sufficient experience with its use in pregnant women, since this is a relatively new drug.

The main thing that a pregnant woman should know is that she can take any pills only as prescribed by a doctor, but not on her own.

Questions and answers

• How quickly does Cetrin ® begin to act?

Cetrin ® begins to act within 20 minutes after administration and quickly relieves various symptoms allergies.

Unless the doctor recommends otherwise, Cetrin ® is taken 1 tablet 1 time per day. Swallow the tablet whole, without chewing, with a glass of water. You can take Cetrin ® regardless of meals (both on an empty stomach and during or after meals), which is very convenient.

The duration of use of the drug Cetrin ® is determined in each specific case by the doctor, depending on the symptoms of the disease and its severity. Can be assigned:

Addiction to the drug Cetrin ® does not develop, so if necessary, it can be used for a long time. For such courses, a convenient package containing 30 tablets is enough for a month of regular use.

Yes. Cetrin ® tablets can be used in children from six years of age.

Antihistamines are not included in standard treatment regimens for bronchial asthma, but they are indicated in the presence of concomitant allergic rhinitis. In this case, Cetrin ® not only relieves the symptoms of rhinitis, but also improves bronchial patency in mild asthma*.

* Fedoskova T.G. Cetirizine in the treatment of patients with year-round allergic rhinitis associated with atopic bronchial asthma // Russian Allergological Journal. 2007. No. 6.

Yes, you can. In addition, this combination is preferable for severe and moderate forms of allergic rhinitis*. Thanks to the impact on different mechanisms In case of an allergic reaction, a more pronounced therapeutic effect can be obtained using both external and systemic means.

* Markova T.P. Bulkina O.Z. Prevention and treatment of allergic rhinitis // RMJ. 2011. No. 7.

There are no restrictions for the combined use of Cetrin ® and antibiotics. It is only important that this is the recommendation of your attending physician.

1. Pharmacological action

The active substance Cetrin has a blocking effect on histamine receptors, thereby reducing the severity and manifestation of allergic reactions. In addition, Cetrin reduces the secretion of secretions and the synthesis of chemicals that promote inflammation, eliminates spasm of smooth muscles, reduces capillary permeability and the movement of immune system cells throughout the body, and eliminates the causes of itching.

2. indications for use

• Seasonal and year-round manifestation of allergic rhinitis and conjunctivitis;
• Various skin allergic reactions (as part of a drug complex);
• Quincke's edema and chronic urticaria.

3. Method of application

Children aged 6-12 years take Cetrin half a tablet 2 times a day. Children over 12 years of age and adults take the drug 1 tablet per day. In both cases, Cetrin is washed down with a small amount of drinking water. The duration of treatment does not exceed 1 month on average, but if necessary it can last up to six months. Patients suffering from functional renal impairment take the drug at half the dose; For patients suffering from functional liver disorders, no dose adjustment is made. Persons whose work involves active activities, operating complex mechanisms, including various vehicles, should take Cetrin with caution. When used in patients under 6 years of age, it is recommended to use the drug in syrup form. Drinking alcoholic beverages during treatment with Cetrin is prohibited!

4. Side effects

• Disorders of the nervous system (drowsiness, increased fatigue, increased nervous excitability, trembling of the limbs, mood changes, insomnia, changes in taste perception);
• When taking Cetrin, disorders of the digestive system are possible (swelling of the tongue, inflammation of the stomach, impaired liver function, stomatitis, dry mouth, stool disorders);
• Violation of the cardiovascular system (persistent increase in blood pressure, change in heart rate);
• Disturbances of other organs and systems (urinary retention, pain in muscles and blood vessels, inflammation of the pharynx);
• Various allergic reactions.

6. During pregnancy and lactation

Cetrin is contraindicated in pregnant women and nursing mothers. If use is necessary, breastfeeding must be discontinued throughout treatment.

7. Interaction with other drugs

• When used simultaneously with Theophylline, accumulation of Cetrin is possible;
• Concomitant use with sedatives should be under the supervision of a physician.

8. Overdose

Drowsiness, trembling of limbs, itching, urinary retention, increased heart rate, urticaria. There is no antidote to Cetrin. If overdose symptoms occur, the patient undergoes gastric lavage and is prescribed laxatives and drugs that can bind various chemicals and subsequently remove them from the body. Monitoring of the cardiovascular and respiratory systems should also be carried out.

9. Release form

Cetrin tablets, 10 mg - 20 or 30 pcs. Syrup, 1 mg/1 ml - vial. 30 ml or 60 ml.

10. Storage conditions

The drug is stored at room temperature without access to light.

11. Composition

1 ml syrup:

• cetirizine dihydrochloride - 1 mg;
• Excipients: glycerol, sucrose, benzoic acid, disodium edetate, sorbitol solution, sodium citrate, fruit flavoring, purified water

1 tablet of Cetrin:

• cetirizine dihydrochloride - 10 mg;
• Excipients: lactose, corn starch, povidone (K-30), magnesium stearate.

12. Conditions for dispensing from pharmacies

The drug is available without a prescription.

Which is better: Suprastin or Cetrin

Both drugs are antiallergic drugs, but which one is better? Let's make a small comparison. Instructions for use of the drug Cetrin indicate the main active ingredient is cetirizine dihydrochloride, and for Suprastin it is chloropyramine.

Suprastin is an older drug that more often causes side effects and has a sedative effect. In this case, the drug has a stronger therapeutic effect.

Cetrin more modern drug does not cause drowsiness and is less likely to cause side effects.

The choice of drug depends on the severity of the disease. For severe allergy symptoms and good tolerance, Suprastin is better suited. Cetrin, on the other hand, has a milder effect, while also coping well with allergies.

Compatibility of Cetrin with alcohol

The instructions indicate that you should refrain from drinking alcohol for the entire duration of treatment with Cetrin, and there are reasons for this:

• When alcohol enters the bloodstream, it releases toxins, which in turn can cause allergies. In this regard, treatment of the underlying disease will come to naught;
• If you have a disease such as bronchial asthma, a severe attack may begin while drinking alcohol;
• Alcohol increases the load on the kidneys and liver, and can also cause side effects from taking the drug.

It is unknown what exact consequences will result from the simultaneous use of Cetrin with alcohol, so it is better to avoid alcohol.

How many days can you take Cetrin?

The duration of use of the drug directly depends on the type and severity of the symptoms of the disease, as well as its severity.

To eliminate acute allergies, the course of treatment is no more than a day. Usually, the drug is stopped as soon as allergy symptoms disappear. Continuous treatment with Citrine for acute allergic disease should not be more than 14 days.

For chronic allergic disease, the duration of treatment when prescribed by a doctor can reach up to 6 months.

For bronchial asthma in the composition complex treatment Taking the drug can take up to a day. Then, after a week's break, treatment is continued.

To prevent seasonal allergies, doctors may prescribe the drug for 1-1.5 months.

Cetrin or Loratadine

Both drugs belong to the second generation drugs, have almost the same effectiveness and are prescribed for the treatment of adults and children.

The instructions for Cetrin indicate that its main active ingredient is cetirizine, and Loratadine is loratadine. Despite the different active ingredients, both drugs have a similar effect, blocking H1 receptors, which contribute to the production of histamine.

It is difficult to say which drug is better, because Cetrin and Loratadine cope with their task quite effectively. The choice of drug largely depends on the individual characteristics of the body; Cetrin is more suitable for some, and Loratadine for others.

How long does it take for Cetrin to work?

When using an antihistamine, it is especially important for a person to know when its therapeutic effect will occur.

The time of onset mainly depends on the individual characteristics of the body and may occur earlier in some people and later in others. On average, the drug Cetrin begins its therapeutic effect after a single dose at a concentration of 10 mg, minutes later. The maximum concentration in the blood is reached 1 hour after administration.

The effectiveness of Cetrin continues for more than 24 hours. After a course of treatment, its effectiveness remains for another 3 days.

Take Cetrin before or after meals

The instructions for the drug Cetrine indicate that the drug can be taken regardless of food intake. This is due to the fact that food does not affect the completeness of absorption.

Therefore, Cetrin can be taken on an empty stomach, during or after meals.

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The pharmacokinetic parameters of cetirizine change linearly when the drug is prescribed at a dose of 5-60 mg.

After oral administration, cetirizine is quickly and completely absorbed from the gastrointestinal tract. Food intake does not affect the completeness of absorption, although the rate of absorption decreases and the Cmax value decreases by 23%. In adults, after a single dose of the drug in therapeutic dose Cmax in blood plasma is reached after 1±0.5 hours and is 300 ng/ml.

Plasma protein binding is 93±0.3% and does not change with cetirizine concentrations in the range of ng/ml. Vd is 0.5 l/kg. When taking the drug at a dose of 10 mg for 10 days, no accumulation of cetirizine is observed. Cetirizine is excreted in breast milk.

In small quantities, it is metabolized in the body by O-dealkylation (unlike other histamine H1 receptor antagonists, which are metabolized in the liver with the participation of the cytochrome P450 system), with the formation of a pharmacologically inactive metabolite.

In adults, T1/2 is approximately 10 hours. About 2/3 of the dose taken is excreted unchanged in the urine, 10% in feces. Systemic clearance - 53 ml/min.

Pharmacokinetics in special groups of patients

In elderly patients and patients with chronic diseases liver, with a single dose of 10 mg of the drug, T1/2 increases by approximately 50%, and systemic clearance decreases by 40%.

T 1/2 in children aged 6 to 12 years is 6 hours, from 2 to 6 years old - 5 hours, from 6 months to 2 years old - 3.1 hours.

In patients with mild renal failure (creatinine clearance >40 ml/min), pharmacokinetic parameters are similar to those in patients with normal renal function. In patients with renal failure medium degree severity and in patients on hemodialysis (HD<7 мл/мин), при приеме препарата внутрь в дозе 10 мг Т 1/2 удлиняется в 3 раза, а общий клиренс снижается на 70% (составляет 0.3 мл/мин/кг), относительно пациентов с нормальной функцией почек, что требует соответствующего изменения режима дозирования. Цетиризин практически не удаляется из организма при гемодиализе.

In patients with chronic liver diseases (hepatocellular, cholestatic or biliary cirrhosis), there is an increase in T1/2 by 50% and a decrease in total clearance by 40% (adjustment of the dosage regimen is required only with a concomitant decrease in GFR).

What is histamine and its role in the body of a pregnant woman

In addition to the fact that histamine is a well-known mediator of allergic reactions, it is also an equally well-known regulator of physiological processes. In the pregnant body, histamine becomes a very important hormone; in the very early stages, thanks to this component, the fertilized egg attaches to the wall of the uterus, and in later stages, histamine contributes to the normal development of the fetus and becomes the main regulator of metabolism.

The amount of histamine in the mother’s body determines how adequately the baby’s tissues and organs will be formed.

Cetrin from a series of antihistamines

But such availability of the drug should, at a minimum, make the expectant mother think and consult her doctor.

Only a specialist can dissuade women who are too keen on self-medication from the need for therapy with conventional drugs. During pregnancy, you need to switch to medications that are less aggressive and more appropriate to the woman’s current condition.

Cetrin is excluded from their number, but if other anti-allergenic drugs do not help, doctors make an exception by prescribing Cetrin to pregnant women, subject to taking with great caution and constant monitoring on their part.

Cetrin represents the second generation of antihistamines and differs from the first generation drugs in having a milder effect on receptors and less side effects.

Composition, effects and pharmacokinetics of the drug

The active ingredient in Cetrin is cetirizine.

The active substance binds to receptors at the cellular level and blocks the flow of histamine and prevents the appearance of rash, itching, and hyperemia.

Another feature of the drug’s effect is that it effectively counteracts the accumulation of eosinophils at the site of inflammation and prevents the development of the inflammatory process.

Cetrizine is absorbed from the gastrointestinal tract, and the food intake has virtually no effect on absorption, so there is little difference when to take the tablet: before, after or during meals.

Metabolic processes are concentrated in the liver, the half-life is from 5 to 12 hours, depending on the age of the patient (the older he is, the longer the elimination).

The drug is excreted in the urine.

Indications for use

Allergic reactions that are seasonal or chronic in nature:

• allergic rhinitis;
• allergic conjunctivitis;
• itching of various origins;
• hives;
• Quincke's edema.

Pregnancy as a contraindication

In the instructions for the drug, pregnancy and the lactation period are indicated as contraindications to the use of Cetrin. And any doctor will confirm that taking medications that suppress the effect of histamine in pregnant women can cause such negative consequences as disruption of the mental and physical development of the fetus.

As for the mother's well-being, pregnant women taking Cetrin often complain about the negative effects of the drug on the functioning of the kidneys and liver.

Therefore, even if your allergies are too painful, do not take the drug yourself - an easy solution can later be very expensive.

Cetrin by trimester

1st trimester

Up to and including the 12th week of pregnancy, Cetrin is strictly contraindicated. During this period, such important processes as the implantation of the egg and the development of the embryo take place in the body of a pregnant woman, so histamine levels cannot be reduced.

2nd trimester

The development of fetal organs and systems occurs very actively, as do metabolic processes that allow the baby to fully receive all the essentials from the mother’s body. Histamine is involved in these processes, so blocking this component can lead to the baby not receiving enough nutrients and slow development.