) in 1962 under the code BTS 13621.
The drug was registered on January 12, 1962 by the British Patent Office under the name Brufen. It began to be used as a prescription drug to treat rheumatoid arthritis.
Since 1974, ibuprofen has been used in the United States under the trade name Motrin as an analgesic and antipyretic drug.
In 1983, in the UK, Nurofen (ibuprofen) received over-the-counter drug status for the first time. The success of Nurofen was truly amazing - by the end of 1985, more than 100 million people were using this drug.
The biggest moment in the history of ibuprofen was in 1985, when Boots was awarded the Queen's Award in recognition of its scientific and technological achievements in developing the drug.
Today, ibuprofen is available in more than 120 countries around the world and is effectively used in the treatment of various types of pain and fever by millions of people.
At the Pediatric Pain Symposium (Vancouver, Canada, August 2006), the manufacturer of the original ibuprofen admitted that the drug was less effective than paracetamol in therapeutic doses, which means ibuprofen, both according to the recommendations of the World Health Organization and the recommendations of the Russian Ministry of Health, remains the second choice drug for the treatment of fever and pain in children (paracetamol was and remains the first choice drug for the treatment of fever and pain in adults and children from 2 months of life ).
It so happened that my treasure Seryozhka fell ill on his birthday
in the evening he had a fever and his mother gave him Nurofen, it was terrible mistake, it had no effect, the temperature did not drop at all, then I took a basin with warm water and a diaper in the old fashioned way, wrapping Sergei in a wet diaper was not difficult, he was still small, so we sat all night, rinsing the hot diaper in water , and from time to time using the “titkavrot” method, in the morning, i.e. eight hours later, my bad head gave me another dose of this poison, either Nurofen still worked, or rubbing helped, the fever subsided a little and we both fell asleep, and on the afternoon of December 31, leaving my son with daddy, I went shopping, well, I really wanted to meet New Year, like a normal family with a decorated Christmas tree, tangerines and Olivier (I managed to cook fruit juice while Sergei Sr. was at work), I arrive loaded three hours later, I am greeted by panicking people.
Grandma is running around with the phone calling an ambulance, Sarochka is crying and rushing in and out of the bathroom, Sergei Sr. holds Sergei Jr. in the bath and washes his nose cold water- the child has a fever, blood from the nose and was vomiting blood before the nose began to bleed.
Mom first reassured her daughter that her brother would not die and nothing would happen to him, then they called the grandmother an ambulance, everything would be fine, then I came to my husband!
Two hours later, the ambulance arrived, the doctor, a calm young girl, liked the younger one so much during the examination =) he wheeled his vehicles to her, sat side by side with his legs dangling and inspiredly told her about his adventures =)
The doctor reassured me with the assurance that the bleeding was caused by the action of Nurofen, recommended changing the prescribed treatment and in general it would be great to have a nebulizer, which is what grandfather did - on the next working day, grandfather went to the pharmacy and now we have this miracle of technology.
I looked through the information on the Internet and this is what I found:
95% of sick children with acute respiratory infections and acute respiratory viral infections require the use of antipyretics. Antipyretic drugs, which are classified as non-opioid analgesics (analgesics-antipyretics), are widely used. They are divided into non-steroidal anti-inflammatory drugs (NSAIDs) and “simple analgesics” (paracetamol or acetaminaphen). Paracetamol has almost no anti-inflammatory effect, unlike NSAIDs (ibuprofen).
Nurofen or paracetamol?
Today, only paracetamol and ibuprofen meet the criteria of strict safety and high effectiveness. Therefore, they are officially recommended by the National Programs of the Russian Federation in pediatric practice and by WHO as antipyretics. The antipyretic effects of paracetamol and ibuprofen are comparable.
Paracetamol acts mainly in the central nervous system, affecting the centers of thermoregulation and pain, inhibiting the synthesis of prostaglandins. This explains the pronounced analgesic, antipyretic effect and low anti-inflammatory effect.
Ibuprofen inhibits the biosynthesis of prostaglandins not so much in the central nervous system as in peripheral inflamed tissues, which adds an anti-inflammatory effect to the antipyretic and analgesic effect. When peripheral inflammation is severe, the effectiveness of paracetamol is insufficient. Here it is more advisable to use NSAIDs based on ibuprofen.
Ibuprofen is effective in reducing fever. Its antipyretic effect begins quickly (15-25 minutes), simultaneously with paracetamol, and lasts longer (6-8 hours). Ibuprofen is re-prescribed to control hyperthermia much less frequently than paracetamol. Ibuprofen is better than paracetamol, it reduces critically high temperature. The antipyretic effect of ibuprofen at a dose of 10 mg/kg is more pronounced than that of the same dose of paracetamol.
When choosing an antipyretic, you need to pay attention to the ease of administration and the availability of dosage forms for children of all ages. Taste properties, appearance and the method of administering the drug is very important to the child. In pediatrics, dosage forms of suppositories, syrups and suspensions are most often used. Ibuprofen and paracetamol come in all of these forms.
Thus, ibuprofen and paracetamol have their advantages in different clinical situations when for various reasons temperature. In the event of a sudden critical temperature, the emergency use of any of these drugs (taking into account contraindications) will be justified, and subsequent treatment should be agreed upon with a pediatrician who will help make the right choice.
Why is Nurofen dangerous?
Ibuprofen is well tolerated, but has side effects, which are usually associated with exceeding recommended doses and long-term unnecessary therapy. Can appear:
dyspepsia (nausea, vomiting or diarrhea) and intestinal erosions; headache, dizziness, sleep disturbances; increased blood pressure, tachycardia; changes in the blood count (cytopenic conditions); skin allergies, Quincke's edema, bronchospasm, anaphylaxis; dysfunction of the kidneys, liver, etc.
When taking the recommended dosage of the drug, complications practically do not develop. At the slightest side effects, ibuprofen is discontinued. If accidental poisoning occurs (for example, a child drank syrup), you need to call ambulance, and before her arrival induce vomiting drinking plenty of fluids water.
When is Nurofen contraindicated?
in case of hypersensitivity to the components of the drug or any NSAIDs; with allergic bronchospasms and rhinitis, allergic history after using aspirin or other NSAIDs; for bleeding and coagulopathies with coagulation disorders; for ulcers of any part of the intestine (including healed ones); if you are allergic to fructose. The suspension is contraindicated for up to 3 months. Suppositories are contraindicated in children ≤ 6 kg.
What else do you need to know about Nurofen?
When taken simultaneously with aspirin or anticoagulants, the risk of side effects increases. They potentiate each other's action.
Simultaneous use with drugs that lower blood pressure and diuretics reduces their effectiveness.
Increases the concentration of methotrexate and lithium drugs in the blood plasma.
Compound
One film-coated tablet contains the active substance:
200 mg ibuprofen;
excipients: croscarmellose sodium 30 mg, sodium lauryl sulfate 0.5 mg, sodium citrate dihydrate 43.5 mg, stearic acid 2.0 mg, colloidal silicon dioxide
Shell composition: carmellose sodium 0.7 mg, talc 33.0 mg, acacia gum 0.6 mg, sucrose 116.1 mg, titanium dioxide 1.4 mg, macrogol 6000 0.2 mg, black ink [Opacode S-1 - 277001JND*.
*(The inscription Nurofen is applied in black ink [Opacode S-1-277001JND - (shellac, black iron oxide dye (E172), propylene glycol, isopropanol**, butanol**, ethanol**, purified water**.
** Solvents evaporated after the printing process)
Description
Round, biconvex, white or almost white film-coated tablets white with black Nurofen imprint on one side of the tablet.
pharmachologic effect
The drug belongs to non-steroidal anti-inflammatory drugs (NSAIDs). Nurofen® has analgesic, antipyretic and anti-inflammatory effects. Indiscriminately blocks COX1 and COX2. The mechanism of action of ibuprofen is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction.
The decrease in temperature during fever begins 30 minutes after administration, its maximum effect appears after 3 hours.
The leading analgesic mechanism is a decrease in the production of prostaglandins of classes E, F and I, biogenic amines, which leads to the prevention of the development of hyperalgesia at the level of changes in the sensitivity of nociceptors. The analgesic effect is most pronounced for inflammatory pain. The pain-relieving effect is felt within 15 minutes after taking ibuprofen.
The anti-inflammatory effect is due to inhibition of cyclooxygenase (COX) activity. As a result, the synthesis of prostaglandins in inflammatory foci. This leads to a decrease in the secretion of inflammatory mediators and a decrease in the activity of the exudative and proliferative phases of the inflammatory process.
Pharmacokinetics
Absorption is high, binding to plasma proteins (mainly albumin) is more than 90%. The high degree of protein binding results in a relatively low volume of distribution (0.1 l/kg). Although ibuprofen binds actively to albumin, this does not affect drug interactions.
Time to reach maximum plasma concentration T max - 1-2 hours. Half-life - 2 hours. In elderly people (over 65 years of age), the half-life of the drug increases and overall clearance decreases. According to some data, infants aged 6-18 months have a higher Tmax (3 hours). It is believed that in children the half-life of ibuprofen does not differ significantly from the value established for adults.
Eating slows down the absorption of ibuprofen, but does not reduce its bioavailability. When taken with food, Tmax increases by 30-60 minutes compared to taking on an empty stomach and is 1.5-3 hours.
Ibuprofen slowly penetrates into the joint cavity, lingers in the synovial tissue, creating higher concentrations in it than in plasma; the maximum concentration is observed 5-6 hours after administration. Lower concentrations of ibuprofen are found in cerebrospinal fluid compared to plasma. After absorption, about 60% of the pharmacologically inactive R form is slowly transformed into the active S form in the gastrointestinal tract and liver. Metabolized in the liver to form 4 metabolites. It is excreted by the kidneys (70-90% of the administered dose in the form of ibuprofen and its metabolites; unchanged, no more than 1%) and, to a lesser extent, with bile (less than 2%). Excretion of metabolites in urine is usually complete within 24 hours of the last dose. The complete urinary excretion of ibuprofen and its metabolites is linear dependence on dosage. After 2 months of age, the kidneys are well developed enough to cope with the elimination of ibuprofen through glomerular filtration. The study, which included 49 children aged 3 months to 12 years, showed no age-related differences in the rate of absorption and elimination of ibuprofen.
Indications for use
Nurofen is used for headaches and toothaches, migraines, painful menstruation, neuralgia, back pain, muscle and rheumatic pain; as well as in case of fever due to influenza and colds.
Contraindications
Erosive and ulcerative lesions gastrointestinal tract in the acute phase, including peptic ulcer of the stomach and duodenum in the acute stage and/or recurrent form, ulcerative colitis, peptic ulcer, Crohn's disease;
Gastrointestinal bleeding or perforation associated with NSAIDs;
Severe heart failure;
Severe arterial hypertension;
Hypersensitivity to ibuprofen or to the components of the drug;
Complete or incomplete acetylsalicylic acid intolerance syndrome (rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma); - diseases of the optic nerve; violation color vision, amblyopia, scotoma;
Glucose-6-phosphate dehydrogenase deficiency, hemophilia and other bleeding disorders, hemorrhagic diathesis, hypocoagulation conditions;
Pregnancy III trimester, period of breastfeeding;
Severe liver dysfunction;
Severe renal failure (creatinine clearance less than 30 ml/min);
Hearing loss, pathology of the vestibular apparatus;
Gastrointestinal bleeding in acute and recurrent form;
Intracranial hemorrhages;
Hemophilia and other bleeding disorders, hemorrhagic diathesis;
Children under 6 years of age;
Carefully: elderly age, ischemic disease heart disease, cerebrovascular diseases, dyslipidemia, diabetes mellitus, peripheral artery disease, smoking, frequent use alcohol, long-term use of NSAIDs, severe somatic diseases, simultaneous use of oral corticosteroids (including prednisolone), anticoagulants (including warfarin, clopidogrel, acetylsalicylic acid), taking selective inhibitors recapture serotonin, diseases when taking the drug in patients with a history of gastric and duodenal ulcers, gastritis, enteritis, colitis, with anamnestic information about bleeding from the gastrointestinal tract; in the presence of concomitant diseases liver and/or kidneys; for liver cirrhosis with portal hypertension, nephrotic syndrome, chronic heart failure; arterial hypertension; for blood diseases of unknown etiology (leukopenia and anemia); for bronchial asthma, for hyperbilirubinemia; pregnancy (I, II trimesters); age under 12 years.
Pregnancy and lactation
The use of the drug during pregnancy is possible only under the supervision of a physician. Use of the drug during the 1st and 2nd trimesters is undesirable, but possible with caution. If Nurofen is used by a woman planning a pregnancy, or by a woman in the first and second trimesters of pregnancy, the lowest effective dose and shortest treatment period should be selected.
Use during the third trimester is contraindicated.
The use of the drug during lactation is not recommended. In a number of studies, ibuprofen was found in breast milk in very low concentrations and its effects on infants are unlikely.
Directions for use and doses
The drug is intended for short-term use.
NUROFEN® is prescribed to adults and children over 12 years of age orally, after meals, in tablets of 200 mg 3-4 times a day. The tablets should be taken with water.
To achieve a rapid therapeutic effect in adults, the dose can be increased to 400 mg (2 tablets) 3 times a day.
The minimum effective dose should be used for the shortest time necessary to relieve symptoms.
Do not take more than 6 tablets in 24 hours. The maximum daily dose is 1200 mg. If symptoms persist after taking the drug for 2-3 days, you should stop treatment and consult a doctor.
It is recommended to exercise extreme caution when prescribing the drug to patients with reduced renal function. If this function is significantly reduced, it is recommended periodic control creatinine clearance or serum creatinine concentration.
Use of the drug in patients with chronic diseases liver, in older people should be carried out under the supervision of a physician.
If you miss the next dose of the drug, it is recommended to take the dose in accordance with the prescribed dosage regimen, without doubling the amount of the drug.
In exceptional cases (in the absence of children's forms of ibuprofen), as prescribed and under the supervision of a doctor, the drug can be prescribed to children aged 6 to 12 years: 1 tablet no more than 3-4 times a day; the drug can only be used if the child’s body weight is more than 20 kg. The interval between taking tablets is at least 6 hours.
For children aged 6-9 years (average child weight 20-29 kg) maximum dose no more than 600 mg of ibuprofen per day (3 tablets per day).
For children aged 10-12 years (average child weight 30-40 kg), the maximum dose is no more than 800 mg of ibuprofen per day (4 tablets per day).
Side effect
When using the drug NUROFEN® for 2-3 days side effects are practically not observed. In case of long-term use, the following side effects may occur:
From the gastrointestinal tract: nausea, vomiting, heartburn, anorexia, pain and discomfort in the epigastrium, diarrhea, flatulence, possible erosive and ulcerative lesions of the gastrointestinal tract (in some cases complicated by perforation and bleeding), abdominal pain, irritation , dryness of the oral mucosa or pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis, constipation, hepatitis.
From the nervous system: headache, dizziness, insomnia, agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases).
From the outside of cardio-vascular system: heart failure, increased blood pressure(BP), tachycardia.
From the urinary system: nephrotic syndrome (edema), acute renal failure, allergic nephritis, polyuria, cystitis.
From the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
From the senses: hearing loss, ringing or noise in the ears, reversible toxic optic neuritis, blurred vision or diplopia, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), scotoma.
Allergic reactions: skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions, anaphylactic shock, fever, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.
From the respiratory system: bronchospasm, shortness of breath.
Other: increased sweating.
With long-term use in large doses - ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (impaired color vision, scotoma, amblyopia). If side effects occur, the doctor should stop taking the drug.
Overdose
Symptoms: abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, metabolic acidosis, coma, acute renal and liver failure, gastrointestinal bleeding, decreased blood pressure (BP), bradycardia, tachycardia, atrial fibrillation, arrest breathing, increased prothrombin time, convulsions are rarely possible.
Treatment: within the first hour after taking the drug, gastric lavage and administration activated carbon
In case of frequent or prolonged convulsions, it is necessary to use anticonvulsants(diazepam or lorazepam intravenously).
Interaction with other drugs
Concomitant use of NUROFEN tablets with acetylsalicylic acid (aspirin) is not recommended unless taking low-dose aspirin (not exceeding 75 mg per day) is recommended by your doctor, as it increases the risk of adverse side effects. When taken concomitantly, ibuprofen may inhibit the effect of low-dose aspirin on platelet aggregation.
You should also avoid taking two or more NSAIDs at the same time, including selective cyclooxygenase-2 inhibitors, as this may increase the risk of side effects.
When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding simultaneously increases. Cefamandole, cefaperazone, cefotetan, valproic acid, plicamycin, increase the incidence of hypoprothrombinemia.
Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increased risk of nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.
NSAIDs should not be used for 8 to 12 days after taking mifepristone because NSAIDs may reduce the effect of mifepristone.
Concomitant use of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
When NSAIDs and zidovudine are taken concomitantly, the risk of hematological toxicity increases.
Patients taking NSAIDs and quinolones have an increased risk of seizures. Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.
Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Inhibitors of microsomal oxidation - reduce the risk of hepatotoxicity.
Reduces the hypotensive activity of vasodilators, natriuretic in furosemide and hydrochlorothiazide.
Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics.
Increases the side effects of mineralocorticosteroids, glucocorticosteroids, estrogens, ethanol.
Enhances the effect of oral hypoglycemic drugs, sulfonylurea derivatives and insulin. Antacids and cholestyramine reduce absorption.
Increases the blood concentration of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.
Precautionary measures
Nurofen is prescribed with caution to patients with heart failure, arterial hypertension, with blood clotting disorders, with impaired renal and/or liver function. Caution should be exercised when using the drug in patients with bronchial asthma and other obstructive pulmonary diseases due to the risk of bronchospasm. Patients with diseases of the gastrointestinal tract (ulcerative colitis, Crohn's disease) should be prescribed NSAIDs with caution due to a possible exacerbation of these diseases.
The drug is prescribed with caution to elderly patients, as they are more likely to experience adverse side reactions to NSAIDs, mainly gastrointestinal bleeding and perforation, which can lead to a sharp deterioration of the condition. Patients with a history of gastrointestinal toxicity, especially the elderly, should report any unusual abdominal symptom (especially gastrointestinal bleeding), especially if the symptom occurs on initial stage taking the drug.
If patients develop gastrointestinal bleeding while taking the drug, the drug should be stopped immediately.
The simultaneous use of Nurofen and other NSAIDs, including selective cyclooxygenase-2 inhibitors, should be avoided.
Systemic lupus erythematosus and mixed diseases connective tissue contribute to an increased risk of aseptic meningitis.
There is some evidence that drugs that inhibit cyclogenase/prostaglandin synthesis may impair fertility in women by affecting ovulation. This phenomenon reversible upon discontinuation of the drug.
The drug should not be prescribed to patients with fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltase deficiency.
Two Nurofen tablets contain 25.3 mg sodium, which should be taken into account in patients on a sodium-controlled diet.
During long-term treatment it is necessary to monitor the peripheral blood picture and functional state liver and kidneys.
If symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, general analysis blood (hemoglobin determination), stool analysis occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Patients should refrain from all activities related to driving vehicles and working with moving machinery, as well as from other potentially dangerous species activities associated with concentration and increased speed of psychomotor reactions.
During the treatment period you should refrain from drinking alcoholic beverages.
When used in children aged 6 to 12 years, it should be borne in mind that the tablets cannot be divided, and therefore can only be used in those children whose single dose is at least 1 tablet.
Compound
| Film-coated tablets | 1 table |
| active substance: | |
| ibuprofen | 200 mg |
| Excipients: croscarmellose sodium - 30 mg; sodium lauryl sulfate - 0.5 mg; sodium citrate dihydrate - 43.5 mg; stearic acid - 2 mg; colloidal silicon dioxide – 1 mg | |
| shell composition: carmellose sodium - 0.7 mg; talc - 33 mg; acacia gum - 0.6 mg; sucrose - 116.1 mg; titanium dioxide - 1.4 mg; macrogol 6000 - 0.2 mg; black ink [Opacode S-1-277001] (shellac - 28.225%, black iron oxide dye (E172) - 24.65%, propylene glycol - 1.3%, isopropanol* - 0.55%, butanol* - 9.75 %, ethanol* - 32.275%, purified water* - 3.25%) | |
| *Solvents evaporated after the printing process |
Description of the dosage form
Film-coated tablets: round, biconvex, white or almost white film-coated tablet with a black overprint “Nurofen” on one side of the tablet.
On the cross section of the tablet, the core is white or almost white, the shell is white or almost white.
pharmachologic effect
pharmachologic effect- anti-inflammatory, antipyretic, analgesic.Pharmacodynamics
The mechanism of action of ibuprofen, a derivative of propionic acid from the NSAID group, is due to inhibition of the synthesis of PG - mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks COX-1 and COX-2, as a result of which it inhibits the synthesis of PG. It has a rapid, targeted effect against pain (painkiller), antipyretic and anti-inflammatory. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect of the drug lasts up to 8 hours.
Pharmacokinetics
Absorption is high, quickly and almost completely absorbed from the gastrointestinal tract. After taking the drug on an empty stomach, the Cmax of ibuprofen in the blood plasma is achieved after 45 minutes. Taking the drug with food can increase T max by up to 1-2 hours.
Communication with blood plasma proteins - 90%. Slowly penetrates into the joint cavity, lingers in the synovial fluid, creating higher concentrations in it than in the blood plasma. Lower concentrations of ibuprofen are found in cerebrospinal fluid compared to blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into active S-form. Metabolized in the liver.
T1/2 - 2 hours. Excreted in urine (unchanged form, no more than 1%) and, to a lesser extent, in bile. In limited studies, ibuprofen has been found in breast milk at very low concentrations.
Indications for the drug Nurofen ®
headache;
toothache;
painful menstruation;
neuralgia;
backache;
muscle pain;
rheumatic pain;
joint pain;
febrile conditions with influenza and colds.
Contraindications
hypersensitivity to ibuprofen or any of the components included in the drug;
complete or incomplete combination bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history);
erosive and ulcerative diseases of the gastrointestinal tract (including gastric and duodenal ulcers, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or history (two or more confirmed episodes peptic ulcer or ulcer bleeding);
a history of bleeding or perforation of a gastrointestinal ulcer caused by the use of NSAIDs;
severe liver failure or active liver disease;
severe renal failure (Cl creatinine<30 мл/мин), подтвержденная гиперкалиемия;
decompensated heart failure;
period after coronary artery bypass surgery;
cerebrovascular or other bleeding;
fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency;
hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis;
pregnancy (III trimester);
children under 6 years of age.
Carefully: simultaneous use of other NSAIDs, a history of a single episode of gastric and duodenal ulcers or gastrointestinal ulcer bleeding; gastritis, enteritis, colitis, infection Helicobacter pylori, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or history - the development of bronchospasm is possible; systemic lupus erythematosus or mixed connective tissue disease (Sharpe's syndrome) - increased risk of aseptic meningitis; renal failure, incl. when dehydrated (Cl creatinine<30-60 мл/мин), нефротический синдром, печеночная недостаточность, цирроз печени с портальной гипертензией, гипербилирубинемия, артериальная гипертензия и/или сердечная недостаточность, цереброваскулярные заболевания, заболевания крови неясной этиологии (лейкопения и анемия), тяжелые соматические заболевания, дислипидемия/гиперлипидемия, сахарный диабет, заболевания периферических артерий, курение, частое употребление алкоголя, одновременное применение ЛС , которые могут увеличить риск возникновения язв или кровотечения, в частности, пероральных ГКС (в т.ч. преднизолона), антикоагулянтов (в т.ч. варфарина), СИОЗС (в т.ч. циталопрама, флуоксетина, пароксетина, сертралина) или антиагрегантов (в т.ч. ацетилсалициловой кислоты, клопидогрела), беременность I-II триместры, период грудного вскармливания, пожилой возраст, возраст младше 12 лет.
Use during pregnancy and breastfeeding
The use of the drug is contraindicated in the third trimester of pregnancy. You should avoid using the drug in the first and second trimesters of pregnancy; if you need to take the drug, you should consult your doctor.
There is evidence that ibuprofen can pass into breast milk in small quantities without any adverse effects on the health of the nursing infant, so there is usually no need to stop breastfeeding when taken for a short period of time. If long-term use of the drug is necessary, you should consult a doctor to decide whether to stop breastfeeding for the period of use of the drug.
Side effects
The risk of side effects can be minimized if the drug is taken in a short course, at the minimum effective dose required to eliminate symptoms.
Elderly people experience an increased incidence of adverse reactions with the use of NSAIDs, especially gastrointestinal bleeding and perforation, in some cases fatal. Side effects are predominantly dose-dependent. The following adverse reactions were observed with short-term use of ibuprofen in doses not exceeding 1200 mg/day (Table 6). When treating chronic conditions and long-term use, other adverse reactions may occur.
The incidence of adverse reactions was assessed based on the following criteria: very often (≥1/10); often (from ≥1/100 to<1/10); нечасто (от ≥1/1000 до <1/100); редко (от ≥1/10000 до <1/1000); очень редко (<1/10000); частота неизвестна (данные по оценке частоты отсутствуют).
From the blood and lymphatic system: very rarely - hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.
From the immune system: uncommon - hypersensitivity reactions, nonspecific allergic reactions and anaphylactic reactions, reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia; very rarely - severe hypersensitivity reactions, incl. swelling of the face, tongue and larynx, shortness of breath, tachycardia, arterial hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock).
From the gastrointestinal tract: uncommon - abdominal pain, nausea, dyspepsia (including heartburn, bloating); rarely - diarrhea, flatulence, constipation, vomiting; very rarely - peptic ulcer, perforation or gastrointestinal bleeding, melena, hematemesis, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis; frequency unknown - exacerbation of colitis and Crohn's disease.
From the liver and biliary tract: very rarely - liver dysfunction, increased activity of liver transaminases, hepatitis and jaundice.
From the kidneys and urinary tract: very rarely - acute renal failure (compensated and decompensated), especially with long-term use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.
From the nervous system: infrequently - headache; very rarely - aseptic meningitis.
From the SSS side: frequency unknown - heart failure, peripheral edema, with long-term use there is an increased risk of thrombotic complications (for example, myocardial infarction), increased blood pressure.
From the respiratory system and mediastinal organs: frequency unknown - bronchial asthma, bronchospasm, shortness of breath.
Laboratory indicators: hematocrit or Hb (may decrease); bleeding time (may increase); plasma glucose concentration (may decrease); creatinine clearance (may decrease); plasma creatinine concentration (may increase); liver transaminase activity (may increase).
If side effects occur, you should stop taking the drug and consult a doctor.
Interaction
The simultaneous use of ibuprofen with the following drugs should be avoided
Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (no more than 75 mg/day) prescribed by a doctor, since combined use may increase the risk of side effects. With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent is possible after starting ibuprofen).
Other NSAIDs, in particular selective COX-2 inhibitors: The simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increased risk of side effects.
Use with caution simultaneously with the following drugs
Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, in particular warfarin and thrombolytic drugs.
Antihypertensive drugs (ACE inhibitors and ARA II) and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. In some patients with impaired renal function (eg, dehydrated patients or elderly patients with impaired renal function), coadministration of ACE inhibitors or ARB II and COX-inhibiting agents may lead to deterioration of renal function, including the development of acute renal failure (usually reversible).
These interactions should be considered in patients taking coxibs concomitantly with ACE inhibitors or ARB II. In this regard, the combined use of the above drugs should be prescribed with caution, especially in elderly people. Patients should be prevented from dehydration and consideration should be given to monitoring renal function upon initiation of this combination treatment and periodically thereafter.
Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.
GKS: increased risk of gastrointestinal ulcers and gastrointestinal bleeding.
Antiplatelet agents and SSRIs: increased risk of gastrointestinal bleeding.
Cardiac glycosides: simultaneous administration of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in GFR and an increase in the concentration of cardiac glycosides in the blood plasma.
Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma during the use of NSAIDs.
Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.
Cyclosporine: increased risk of nephrotoxicity with simultaneous administration of NSAIDs and cyclosporine.
Mifepristone: NSAIDs should be started no earlier than 8-12 days after taking mifepristone, since NSAIDs may reduce the effectiveness of mifepristone.
Tacrolimus: with simultaneous administration of NSAIDs and tacrolimus, the risk of nephrotoxicity may increase.
Zidovudine: simultaneous use of NSAIDs and zidovudine may lead to increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen.
Quinolone antibiotics: in patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may increase.
Myelotoxic drugs: increased hematotoxicity.
Cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin: increased incidence of hypoprothrombinemia.
Drugs that block tubular secretion: decreased excretion and increased plasma concentrations of ibuprofen.
Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants): increased production of hydroxylated active metabolites, increased risk of developing severe intoxications.
Microsomal oxidation inhibitors: reducing the risk of hepatotoxicity.
Oral hypoglycemic drugs and insulin, sulfonylurea derivatives: enhancing the effect of drugs.
Antacids and colestyramics: decreased absorption.
Uricosuric drugs: decreased effectiveness of drugs.
Caffeine: enhancing the analgesic effect.
Directions for use and doses
Inside with water. Patients with hypersensitivity of the stomach are recommended to take the drug with meals. For short term use only. Before taking the drug, you should carefully read the instructions.
Adults and children over 12 years of age: 1 tablet orally. (200 mg) up to 3-4 times a day. To achieve a faster therapeutic effect in adults, the dose can be increased to 2 tablets. (400 mg) up to 3 times a day.
Children from 6 to 12 years old: 1 tablet. (200 mg) up to 3-4 times a day; The drug can only be taken if the child weighs more than 20 kg.
The interval between taking tablets should be at least 6 hours.
The maximum daily dose for adults is 1200 mg (6 tablets).
The maximum daily dose for children from 6 to 18 years is 800 mg (4 tables).
If symptoms persist or worsen after taking the drug for 2-3 days, you should stop treatment and consult a doctor.
Overdose
In children, overdose symptoms may occur after taking a dose exceeding 400 mg/kg. In adults, the dose-dependent effect of overdose is less pronounced. T1/2 of the drug in case of overdose is 1.5-3 hours.
Symptoms: nausea, vomiting, epigastric pain or, less commonly, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, manifestations from the central nervous system are observed: drowsiness, rarely - agitation, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and increased PT, renal failure, liver tissue damage, decreased blood pressure, respiratory depression and cyanosis may develop. In patients with bronchial asthma, exacerbation of this disease is possible.
Treatment: symptomatic, with mandatory maintenance of airway patency, monitoring of ECG and vital signs until the patient’s condition is normalized. Oral use of activated charcoal or gastric lavage is recommended within 1 hour after taking a potentially toxic dose of ibuprofen. If ibuprofen has already been absorbed, an alkaline drink may be prescribed in order to eliminate the acidic derivative of ibuprofen by the kidneys, forced diuresis. Frequent or prolonged seizures should be treated with IV diazepam or lorazepam. If bronchial asthma worsens, the use of bronchodilators is recommended.
special instructions
It is recommended to take the drug for the shortest possible course and in the minimum effective dose necessary to eliminate symptoms. If you need to take the drug for more than 10 days, you should consult a doctor.
In patients with bronchial asthma or an allergic disease in the acute stage, as well as in patients with a history of bronchial asthma/allergic disease, the drug may provoke bronchospasm. Use of the drug in patients with systemic lupus erythematosus or mixed connective tissue disease is associated with an increased risk of developing aseptic meningitis.
During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a complete blood count (Hb determination), and a stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. During the treatment period, ethanol intake is not recommended.
Patients with renal failure should consult a doctor before using the drug, as there is a risk of deterioration in the functional state of the kidneys.
Patients with hypertension, incl. history, and/or CHF, it is necessary to consult a doctor before using the drug, since the drug can cause fluid retention, increased blood pressure and edema.
Information for women planning pregnancy: the drug suppresses COX and PG synthesis, affects ovulation, disrupting female reproductive function (reversible after discontinuation of treatment).
Influence on the ability to drive vehicles and machinery. Patients who experience dizziness, drowsiness, lethargy, or blurred vision while taking ibuprofen should avoid driving or operating machinery.
Release form
Film-coated tablets, 200 mg. 6, 8, 10 or 12 tablets each. in a blister (PVC/PVDC/aluminum). One blister (6, 8, 10 or 12 tablets each) or two blisters (6, 8, 10 or 12 tablets each) or three blisters (10 or 12 tablets each) or four blisters (12 tablets each) or eight blisters (12 tablets each) are placed in a cardboard box.
Manufacturer
Reckitt Benckiser Healthcare International Ltd., Thane Road, Nottingham, NG90 2DB, UK.
Legal entity in whose name the registration certificate is issued: Reckitt Benckiser Healthcare International Ltd., Thane Road, Nottingham, NG90 2DB, UK.
Representative in Russia/organization receiving consumer complaints: Reckitt Benckiser Healthcare LLC. 115114, Russia, Moscow, st. Kozhevnicheskaya, 14.
Tel.: 8-800-505-1-500 (calls within Russia are free).
Conditions for dispensing from pharmacies
Over the counter.
Storage conditions for the drug Nurofen ®
At a temperature not exceeding 25 °C.Keep out of the reach of children.
Shelf life of the drug Nurofen ®
3 years.Do not use after the expiration date stated on the package.
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| G43 Migraine | Migraine pain |
| Hemicrania | |
| Hemiplegic migraine | |
| Migraine headache | |
| Migraine | |
| Migraine attack | |
| Serial headache | |
| J06 Acute upper respiratory tract infections of multiple and unspecified localization | Bacterial infections of the upper respiratory tract |
| Bacterial respiratory infections | |
| Viral respiratory disease | |
| Viral respiratory tract infections | |
| Inflammatory disease of the upper respiratory tract | |
| Inflammatory diseases of the upper respiratory tract | |
| Inflammatory diseases of the upper respiratory tract with difficult to separate sputum | |
| Inflammatory diseases of the respiratory tract | |
| Secondary infections with influenza | |
| Secondary infections due to colds | |
| Influenza conditions | |
| Difficulty secreting sputum in acute and chronic respiratory diseases | |
| Upper respiratory tract infections | |
| Upper respiratory tract infections | |
| Respiratory tract infections | |
| Respiratory and lung infections | |
| ENT infections | |
| Infectious and inflammatory diseases of the upper respiratory tract | |
| Infectious and inflammatory diseases of the upper respiratory tract and ENT organs | |
| Infectious and inflammatory diseases of the upper respiratory tract in adults and children | |
| Infectious and inflammatory diseases of the upper respiratory tract | |
| Infectious inflammation of the respiratory tract | |
| Respiratory tract infection | |
| Qatar of the upper respiratory tract | |
| Catarrhal inflammation of the upper respiratory tract | |
| Catarrhal disease of the upper respiratory tract | |
| Catarrhal phenomena from the upper respiratory tract | |
| Cough in diseases of the upper respiratory tract | |
| Cough with a cold | |
| ARVI | |
| acute respiratory infections | |
| Acute respiratory infection with symptoms of rhinitis | |
| Acute respiratory infection | |
| Acute infectious-inflammatory disease of the upper respiratory tract | |
| Acute cold | |
| Acute respiratory disease | |
| Acute respiratory disease of influenza nature | |
| Sore throat or nose | |
| Cold | |
| Colds | |
| Colds | |
| Respiratory infection | |
| Respiratory viral infections | |
| Respiratory diseases | |
| Respiratory infections | |
| Recurrent respiratory tract infections | |
| Seasonal colds | |
| Seasonal colds | |
| Frequent colds and viral diseases | |
| J11 Influenza, virus not identified | Flu pain |
| Flu | |
| Flu in the initial stages of the disease | |
| Flu in children | |
| Influenza condition | |
| Influenza | |
| Beginning flu state | |
| Acute parainfluenza disease | |
| Parainfluenza | |
| Parainfluenza condition | |
| Influenza epidemics | |
| K08.8.0* Toothache | Anesthesia in dentistry |
| Pain syndromes in dental practice | |
| Dentin pain | |
| Pulp pain | |
| Pain after tartar removal | |
| Pain after dental procedures | |
| Pain during tooth extraction | |
| Dentin pain | |
| Toothache | |
| M13.9 Arthritis, unspecified | Arthritis |
| Arthritis non-purulent (non-infectious) | |
| Arthritis acute | |
| Osteoarthritis pain | |
| Inflammation in osteoarthritis | |
| Inflammatory arthropathy | |
| Inflammatory and degenerative joint diseases | |
| Inflammatory disease of the musculoskeletal system | |
| Inflammatory joint disease | |
| Inflammatory diseases of the musculoskeletal system | |
| Destructive arthritis | |
| Musculoskeletal disease | |
| Diseases of the musculoskeletal system | |
| Diseases of the musculoskeletal system and connective tissue | |
| Musculoskeletal infections | |
| Monoarthritis | |
| Non-infectious arthritis | |
| Non-rheumatic arthritis | |
| Osteoarthritis | |
| Acute inflammation of musculoskeletal tissue | |
| Acute inflammatory disease of the musculoskeletal system | |
| Acute inflammatory condition of the musculoskeletal system | |
| Acute arthritis | |
| Acute osteoarthritis | |
| Post-traumatic osteoarthritis | |
| Reactive arthritis | |
| Chronic inflammatory joint diseases | |
| Chronic arthritis | |
| Chronic inflammatory arthritis | |
| Chronic inflammation of the inner layer of the joint capsule | |
| Chronic inflammation of the joint capsule | |
| Chronic inflammatory joint disease | |
| Exudative arthritis | |
| M25.5 Joint pain | Arthralgia |
| Pain syndrome in osteoarthritis | |
| Pain syndrome in osteoarthritis | |
| Pain syndrome in acute inflammatory diseases of the musculoskeletal system | |
| Pain syndrome in chronic inflammatory diseases of the musculoskeletal system | |
| Pain in the joints | |
| Joint pain | |
| Joint pain during heavy physical activity | |
| Painful inflammatory joint lesions | |
| Painful joint conditions | |
| Painful traumatic joint lesions | |
| Shoulder pain | |
| Joint pain | |
| Joint pain | |
| Joint pain due to injury | |
| Musculoskeletal pain | |
| Osteoarthritis pain | |
| Pain due to joint pathology | |
| Rheumatoid arthritis pain | |
| Pain in chronic degenerative bone diseases | |
| Pain in chronic degenerative joint diseases | |
| Osteoarticular pain | |
| Rheumatic pain | |
| Rheumatic pains | |
| Joint pain | |
| Joint pain of rheumatic origin | |
| Joint pain syndrome | |
| Joint pain | |
| M35.3 Polymyalgia rheumatica | Pain syndrome in rheumatic diseases |
| Muscle pain due to rheumatism | |
| Extra-articular rheumatism | |
| Extra-articular rheumatic syndrome | |
| Extra-articular rheumatic diseases | |
| Extra-articular rheumatic soft tissue lesions | |
| Extra-articular forms of rheumatism | |
| Polymyalgia rheumatica | |
| Pseudoarthritis rhizomelic | |
| Soft tissue rheumatism | |
| Rheumatic diseases of soft tissues | |
| Rheumatic diseases of periarticular soft tissues | |
| Rheumatic collagen diseases | |
| Rheumatic soft tissue lesions | |
| Rheumatic soft tissue lesions | |
| M54 Dorsalgia | Pain in the musculoskeletal system |
| Pain in the spine | |
| Back pain | |
| Back pain | |
| Spinal pain | |
| Pain in various parts of the spine | |
| Backache | |
| Spine pain syndrome | |
| M54.5 Pain in the lower back | Painful conditions of the spinal column |
| Lower back pain | |
| Lower back pain | |
| Lower back pain | |
| Lower back pain | |
| Lumbar pain | |
| Lumbodynia | |
| Low back pain syndrome | |
| M79.1 Myalgia | Pain syndrome in muscular and joint diseases |
| Pain syndrome in chronic inflammatory diseases of the musculoskeletal system | |
| Pain in the muscles | |
| Muscle soreness | |
| Muscle soreness during heavy physical activity | |
| Painful conditions of the musculoskeletal system | |
| Pain in the musculoskeletal system | |
| Muscle pain | |
| Pain at rest | |
| Muscle pain | |
| Muscle pain | |
| Musculoskeletal pain | |
| Myalgia | |
| Myofascial pain syndromes | |
| Muscle pain | |
| Muscle pain at rest | |
| Muscle pain | |
| Muscle pain of non-rheumatic origin | |
| Muscle pain of rheumatic origin | |
| Acute muscle pain | |
| Rheumatic pain | |
| Rheumatic pains | |
| Myofascial syndrome | |
| Fibromyalgia | |
| M79.2 Neuralgia and neuritis, unspecified | Pain syndrome with neuralgia |
| Brachialgia | |
| Occipital and intercostal neuralgia | |
| Neuralgia | |
| Neuralgic pain | |
| Neuralgia | |
| Neuralgia of the intercostal nerves | |
| Neuralgia of the posterior tibial nerve | |
| Neuritis | |
| Traumatic neuritis | |
| Neuritis | |
| Neurological pain syndromes | |
| Neurological contractures with spasms | |
| Acute neuritis | |
| Peripheral neuritis | |
| Post-traumatic neuralgia | |
| Severe neurogenic pain | |
| Chronic neuritis | |
| Essential neuralgia | |
| N94.0 Pain in the middle of the menstrual cycle | Algomenorrhea |
| Painful periods | |
| Pain during menstruation | |
| Menalgia | |
| N94.6 Dysmenorrhea, unspecified | Algomenorrhea |
| Algomenorrhea | |
| Pain during menstruation | |
| Pain during menstruation | |
| Dysalgomenorrhea | |
| Dysmenorrhea | |
| Dysmenorrhea (essential) (exfoliative) | |
| Menstrual disorder | |
| Menstrual crumpies | |
| Menstruation is painful | |
| Metrorrhagia | |
| Menstrual irregularities | |
| Menstrual irregularities | |
| Primary dysalgomenorrhea | |
| Prolactin-dependent menstrual disorder | |
| Prolactin-dependent menstrual dysfunction | |
| Menstrual disorder | |
| Spasmodic dysmenorrhea | |
| Functional disorders of the menstrual cycle | |
| Functional disorders of the menstrual cycle | |
| R50.0 Fever with chills | High fever |
| Heat | |
| Hyperthermia | |
| Prolonged fever | |
| Fever | |
| Fever during pregnancy | |
| Fever in infectious and inflammatory diseases | |
| Fever with ARVI | |
| Fever due to cold | |
| Fever due to colds | |
| Fever with thrombocytopenia | |
| Feverish state | |
| Feverish reactions during blood transfusion | |
| Feverish conditions | |
| Fever due to influenza | |
| Feverish conditions in infectious and inflammatory diseases | |
| Fever in infectious diseases and in the postoperative period | |
| Fever due to colds | |
| Feverish conditions of various origins | |
| Fever syndrome | |
| Feverish syndrome due to infectious diseases | |
| Feverish syndrome in infectious and inflammatory diseases | |
| Feverish syndrome due to colds | |
| Feverish syndrome of various origins | |
| Chills | |
| Fever | |
| Increased temperature due to colds | |
| Fever due to colds and infectious-inflammatory diseases | |
| Increased body temperature | |
| Increased body temperature in infectious and inflammatory diseases | |
| Increased body temperature due to colds, etc. | |
| Increased body temperature with colds and other infectious and inflammatory diseases | |
| Symptoms of fever | |
| Febrile syndrome | |
| Febrile conditions | |
| R51 Headache | Head pain |
| Pain due to sinusitis | |
| Pain in the back of the head | |
| Headache | |
| Headache of vasomotor origin | |
| Headache of vasomotor origin | |
| Headache with vasomotor disturbances | |
| Headache | |
| Neurological headache | |
| Serial headache | |
| Cephalgia | |
| R52.9 Pain, unspecified | Obstetric and gynecological pain |
| Pain syndrome | |
| Pain syndrome in the postoperative period | |
| Pain syndrome in the postoperative period after orthopedic surgery | |
| Pain syndrome of inflammatory origin | |
| Pain syndrome of non-oncological origin | |
| Pain syndrome after diagnostic procedures | |
| Pain syndrome after diagnostic interventions | |
| Pain syndrome after surgery | |
| Pain syndrome after surgical interventions | |
| Pain syndrome after orthopedic surgery | |
| Pain syndrome after injuries | |
| Pain syndrome after removal of hemorrhoids | |
| Pain syndrome after surgery | |
| Pain syndrome due to inflammation of non-rheumatic nature | |
| Pain syndrome in inflammatory lesions of the peripheral nervous system | |
| Pain syndrome in diabetic neuropathy | |
| Pain syndrome in acute inflammatory diseases of the musculoskeletal system | |
| Pain syndrome due to tendon pathology | |
| Pain syndrome due to smooth muscle spasms | |
| Pain syndrome due to smooth muscle spasms (renal and biliary colic, intestinal spasms, dysmenorrhea) | |
| Pain syndrome due to spasms of smooth muscles of internal organs | |
| Pain syndrome due to spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasms, dysmenorrhea) | |
| Pain syndrome due to injuries | |
| Pain syndrome in chronic inflammatory diseases of the musculoskeletal system | |
| Pain syndrome in duodenal ulcer | |
| Pain syndrome with gastric ulcer | |
| Pain syndrome in gastric and duodenal ulcers | |
| Painful sensations | |
| Pain during menstruation | |
| Pain syndromes | |
| Painful conditions | |
| Painful tired legs | |
| Sore gums when wearing dentures | |
| Tenderness of cranial nerve exit points | |
| Painful, irregular periods | |
| Painful dressings | |
| Painful muscle spasm | |
| Painful tooth growth | |
| Pain | |
| Pain in the lower extremities | |
| Pain in the area of the surgical wound | |
| Pain in the postoperative period | |
| Body pain | |
| Pain after diagnostic interventions | |
| Pain after orthopedic surgery | |
| Pain after surgery | |
| Pain after cholecystectomy | |
| Flu pain | |
| Pain due to diabetic polyneuropathy | |
| Pain from burns | |
| Pain during sexual intercourse | |
| Pain during diagnostic procedures | |
| Pain during therapeutic procedures | |
| Pain due to colds | |
| Pain due to sinusitis | |
| Pain from injuries | |
| Shooting pains | |
| Pain | |
| Pain in the postoperative period | |
| Pain after diagnostic interventions | |
| Pain after sclerotherapy | |
| Pain after surgery | |
| Postoperative pain | |
| Post-traumatic pain | |
| Pain when swallowing | |
| Pain in infectious and inflammatory diseases of the upper respiratory tract | |
| Pain from burns | |
| Pain from traumatic muscle injury | |
| Pain from injuries | |
| Pain during tooth extraction | |
| Pain due to smooth muscle spasm | |
| Severe pain syndrome | |
| Non-malignant pain syndrome | |
| Polyarthralgia with polymyositis | |
| Postoperative pain | |
| Postoperative pain | |
| Postoperative pain syndrome | |
| Postoperative pain | |
| Post-traumatic pain | |
| Post-traumatic pain syndrome | |
| Torpid pain syndrome | |
| Traumatic pain | |
| Traumatic pain | |
| Moderate pain | |
| Moderate pain syndrome | |
| Moderate pain syndrome | |
| T14.3 Dislocation, sprain and damage to the capsular-ligamentous apparatus of a joint of an unspecified area of the body | Painful muscle strains |
| Pain and inflammation when stretched | |
| Reduction of dislocation | |
| Degenerative changes in the ligamentous apparatus | |
| Swelling due to sprains and bruises | |
| Swelling after interventions for dislocations | |
| Damage and rupture of ligaments | |
| Damage to the musculo-ligamentous apparatus | |
| Ligament damage | |
| Joint damage | |
| Habitual sprains and tears | |
| Ligament rupture | |
| Ligament tears | |
| Tendon ruptures | |
| Muscle tendon ruptures | |
| Joint injuries | |
| Stretching | |
| Crick | |
| Muscle strain | |
| Sprain | |
| Ligament sprain | |
| Tendon sprain | |
| Sprains | |
| Muscle strains | |
| Sprains | |
| Ligament sprains | |
| Tendon sprains | |
| Musculo-ligamentous injury | |
| Joint injuries | |
| Injuries to capsuloarticular tissues | |
| Injuries of the osteoarticular system | |
| Ligament injuries | |
| Joint injuries | |
| T14.9 Injury, unspecified | Pain syndrome after injuries |
| Pain syndrome due to injuries | |
| Pain syndrome during injuries and after surgery | |
| Pain from injuries | |
| Traumatic pain | |
| Joint pain due to injury | |
| Postoperative and post-traumatic pain | |
| Pain from injuries | |
| Pain of traumatic origin | |
| Severe pain syndrome of traumatic origin | |
| Deep tissue damage | |
| Deep scratches on the body | |
| Closed injury | |
| Minor domestic injuries | |
| Minor skin damage | |
| Violations of the integrity of soft tissues | |
| Uncomplicated injuries | |
| Extensive traumatic injury | |
| Acute pain syndrome of traumatic origin | |
| Swelling due to injuries | |
| Previous sports injuries | |
| Post-traumatic pain | |
| Soft tissue injuries | |
| Joint injuries | |
| Sports injuries | |
| Injury | |
| Traumatic pain | |
| Traumatic pain | |
| Traumatic infiltration | |
| Sports injuries |
Nurofen is a drug that has a pronounced anti-inflammatory, antipyretic and analgesic effect. Its active ingredient is ibuprofen from the group of non-steroidal anti-inflammatory drugs. The drug is widely used both for the treatment of adults and pediatrics. If the recommended doses are accidentally or intentionally exceeded, an overdose of Nurofen may develop.
Source: nurofen.ru
General information about the drug
Nurofen is a drug that has pronounced anti-inflammatory, antipyretic and analgesic properties. The active component of this product is ibuprofen. It belongs to the group of non-steroidal anti-inflammatory drugs and is actively used not only in the treatment of adult patients, but also in pediatric practice.
An overdose of Nurofen can occur when the recommended doses of the drug are intentionally or accidentally exceeded.
Is it possible to use Nurofen during pregnancy?
Nurofen is one of the most popular drugs due to its effectiveness, and many women, having become pregnant, are interested in whether this medicine can be used while carrying a child.
According to the drug's annotation, it can only be used in the first and second trimester of pregnancy, and only in cases where the benefit from it outweighs the risk of the baby's development.
At a later date, it can affect the development of the fetus and provoke premature birth.
Taking Nurofen during lactation is contraindicated. If there is no choice, then you should stop feeding the drug for the duration of treatment, or give preference to other drugs, for example, Paracetamol or No-shpe.
Pharmacological action of the drug
Nurofen is capable of providing a rapid, targeted analgesic effect, as well as fighting fever and exhibiting anti-inflammatory properties.
The active substance of the drug in question, ibuprofen, is a derivative of propionic acid. Its principle of action is associated with inhibition of the synthesis of prostaglandins - mediators of inflammation, pain and hyperthermic reaction. The drug indiscriminately blocks COX-2 and COX-1, and also reversibly reduces the rate of platelet aggregation.
The analgesic effect after taking Nurofen lasts up to 8 hours.
Brief description of the drug
The drug Nurofen is available in the form of capsules, tablets, gel, as well as children's rectal suppositories and oral suspension. The medication contains ibuprofen, which is used as an active ingredient (see). Also in some types of the product codeine is added to enhance the therapeutic power.
Auxiliary components and dosage active substance depend solely on the form of release of the drug.
Read what to do in case of: main manifestations and first aid.
Find out: causes, symptoms of overdose, first aid and treatment.
Nurofen has the ability to relieve pain, inflammatory processes of various origins, and also quickly reduce temperature and feelings of heat. When applying the medication in the form of a gel, local relief of unpleasant symptoms occurs. Ibuprofen, which is the active substance of the drug, inhibits the synthesis of prostaglandins, which cause all of the above symptoms.
Possible causes of overdose
An overdose of Nurofen is uncommon. As a rule, the reasons for such situations are:
Why should children not be given Nurofen?
We often observe situations where a child is forced to take Nurofen, whether necessary or not. As for Europe, there they consider this medicine dangerous for the child’s body and try not to take it unless absolutely necessary. On the contrary, when a pediatrician prescribes medications, he focuses on the undesirable use of Nurofen, because it entails painful consequences. Paracetamol tablets are preferred for older children, and suppositories are good for infants.
Side effects from using this medicine
Very often, the symptoms of an overdose of Nurofen are confused with the side effects of this drug. Therefore, before using the mentioned medicine, you should definitely study the attached instructions.
Nurofen is a drug that is prescribed not only to adults, but also to children of different age groups. This product may cause the following side effects:
Side effects
Adverse reactions are manifestations of the consequences of an overdose of Nurofen. Their appearance is associated with the individual characteristics of the course of the disease and the patient’s body. In case of Nurofen poisoning, side effects increase many times over. Among them are:
- inflammatory processes in the pancreas;
- intestinal disorder;
- flatulence;
- pain in the mouth;
- increase or decrease in blood pressure;
- accelerated heart rate;
- feeling of heartburn;
- rapid weight loss;
- shortness of breath;
- nausea;
- depression;
- anemia (anemia);
- sleep disorders;
- hallucinations;
- bleeding of various nature;
- irritability;
- Quincke's edema;
- various allergic reactions on the skin.
How much drug is needed for an overdose?
The maximum dose of the drug in question for adult patients is 1.6–2.4 g (per day). For children, this value should not exceed 30 mg per 1 kg of child weight. An overdose of Nurofen develops if a person has taken the mentioned medication in an amount significantly exceeding the specified amount. daily dose.
In children, a dose of the drug up to 100 mg/kg body weight does not contribute to the development of serious consequences. But a dosage above 400 mg/kg will certainly cause severe symptoms.
The amount of NSAIDs that can lead to an overdose in adult patients is determined individually and depends on the characteristics of the body.
Prevention
To prevent a possible overdose of Nurofen for children or medication for adult patients, you must follow these rules:
- do not use the product that has expired;
- Avoid using medications with damaged packaging;
- do not change the dosage regimen prescribed by your doctor;
- keep the product away from children;
- do not let your child take the medicine himself;
- exclude home self-medication.
Conclusion
Nurofen has a strong analgesic property, the ability to relieve inflammation, as well as a feeling of heat. It is successfully used to treat children and adults. Systematic or accidental excess of the drug leads to the development of a number of dangerous pathologies due to an overdose.
Nurofen is the most popular drug that has an antipyretic and anti-inflammatory effect, but childhood poisoning with this drug is also possible.
Children's Nurofen is available in syrup and tablets
It is produced in the form of syrup, tablets, suppositories, and gels. But children's ones only come in syrups. It has an analgesic effect. Children's age for using this medicine is from 3 months to 12 years. To treat infectious diseases, after vaccinations, when teething, acute respiratory infections and acute respiratory viral infections. Like all medications, it has universal contraindications for liver, kidney and heart failure. And also for diseases of the stomach and blood. Use with caution during pregnancy and lactation.
Important! The instructions for use must be strictly followed. An overdose for children can be fatal.
The main component of this medication is ibuprofen. Auxiliary ingredients: dimofen bromite, polysorbate, chloride, saccharinate, glycerin, citric acid, water, flavorings 2M16014 or 500244E, maltitol syrup, glycerol, xanthan gum.
Consult a doctor before use
The amount of medication is calculated based on the child’s body weight. For pain or fever, a single dose should be from 5 mg to 10 mg per kg. Taking into account the weight and age of the patient. Use no more than 4 times a day. Duration of use is 3 - 5 days. In case of heat and fever, use no more than 3 days. And with pain relief, no more than 5 days. The duration of action of one dose is 8 hours.
- From 3 to 6 months, 2.5 ml 3 times a day.
- From 6 to 12 months, 2.5 ml 3-4 times a day, but not to exceed 200 ml per day.
- From one to three years, 5.0 ml 3 times a day, the norm is 300 ml per day.
- From 4 to 6 years, 7.5 ml three times a day, the daily norm is 450 ml per day.
- From 7 to 9 years, 10 ml 3 times a day, no more than 600 ml per day.
- From 10 - 12 to 15 ml 3 times a day, not exceeding 900 ml per day.
It is advisable to take it during or after meals.
Use with caution with other drugs. Only with the consultation of a doctor. Compatibility with diuretics and antihypertensives reduces its effectiveness.
Nurofen and pregnancy
Pregnant women should avoid taking Nurofen
Every expectant mother is very careful about her health. After all, her health is the health of her baby. During such an important period, all women treat medications with fear and caution. The instructions that come with each bottle contain information by trimester.
Children's Nurofen during pregnancy:
- 1st and 2nd trimester. The use of the drug is possible if the benefit outweighs the risk for normal fetal development.
- 3rd trimester. Absolutely forbidden
. The components may cause premature birth.
You can take the drug while breastfeeding. But at the same time, it is necessary to stop feeding so as not to harm the baby’s health.
Limiting the use of the medicine
Age up to three months and body weight should be from 5 kg.
Syrup has many contraindications such as:
- Intolerance to the components included in the composition.
- For liver, kidney and heart failure.
- Nasal polyposis.
- Bronchial asthma.
- For blood diseases.
- Anemia.
- Intestinal diseases.
- For hypokalemia.
Side effects of Nurofen
To avoid side effects, you must strictly adhere to the instructions and recommendations of the doctor.
Various side effects:
- Vomiting, nausea, loose stools, pain in the animal.
- Bleeding in the gastrointestinal tract.
- Allergic reactions ranging from urticaria to Lyell's syndrome.
- Headache, overexcitement, nausea, dizziness.
- Insomnia.
- Renal dysfunction, inflammatory diseases of the bladder.
- Hepatitis.
- Rapid weight loss.
- Shortness of breath.
- Cystitis.
- Tachycardia.
- Increased pressure.
It is necessary to closely monitor the child’s behavior and his health. If you detect any signs, immediately contact an ambulance.
Giving children Nurofen or its analogues should be used for no more than 5 days. Because the body gets used to it very quickly.
Children's Nurofen is indicated for use as an antipyretic
Drug overdose in children
Important! If you take the medicine correctly, there will be no overdose. But if, nevertheless, there is an overdose, then you need to consult a doctor.
You can identify an overdose by the following symptoms:
- pallor,
- vomit,
- dizziness,
- pain in the stomach and ears,
- a sharp decrease in pressure,
- heart diseases,
- coma,
- heart failure,
- renal failure,
- bradycardia,
- metabolic acidosis.
It is best not to risk the health and life of the child.
First aid for overdose
The main thing is to act quickly without panic. The baby’s further well-being depends on the correct assistance provided. It is necessary to give the child warm, boiled water in small sips. Adult children (over 5 years old) are induced to vomit to rid the body of the drug.
Important! Small babies should not be vomited.
Parents should strictly follow the instructions and not exceed the dosage
Then take the sorbent and wait for specialists. The child should be given a compress (of cool water) and allowed to rest. At this time, parents must collect all the necessary things for hospitalization. For complex symptoms, self-medication at home will not help.
- When buying a drug at a pharmacy, you need to pay attention to the date of manufacture and expiration date.
- Do not exceed the dose without consulting a doctor. Take as directed.
- If you need to take other medications, you first need to find out about compatibility.
- Important! Store syrup correctly.
- If for some reason the stage is clear that the medication is not suitable for the baby. You must stop using it immediately. Children's poisoning with Nurofen is very rare. Even less often - in severe form. You need to take your medication seriously. The responsibility and prudence of parents is, first of all, the health and long life of their children.
Overdose symptoms
The symptoms of an overdose of Nurofen in a child and an adult are no different. The main signs of this condition are:
- abdominal pain, double vision, nausea, drowsiness;
- vomiting, spasm of masticatory muscles, lethargy, heart rhythm disturbances;
- transient hearing impairment, headache, ringing or tinnitus, depression, decreased blood pressure, bradycardia, tachycardia.
In case of severe overdose of Nurofen, symptoms in a child and an adult may be as follows:
- metabolic acidosis;
- atrial fibrillation;
- acute renal failure;
- respiratory arrest;
- coma.
Video: Nurofen description and instructions
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First aid
An overdose of Nurofen (tablets or syrup) requires mandatory medical intervention. If no more than one hour has passed since taking the increased dose of the medicine, then emergency assistance should be provided by gastric lavage. For this purpose, the victim needs to drink a large amount of ordinary water or a weak solution of potassium permanganate. Next, you need to provoke vomiting (by irritating the root of the tongue). A similar procedure is carried out until the water that comes out no longer contains particles of previously eaten food.
It should be remembered that children 3-4 years old are not allowed to rinse their stomach in this way! If you overdose on Nurofen for children, you should immediately call an ambulance. Gastric lavage for babies is carried out only with the help of a tube in a hospital setting.
The next step in first aid is the use of enterosorbent. It can be drugs such as activated carbon, Atoxil, Polysorb, Smecta, etc. Such medications are necessary to bind ibuprofen that has managed to penetrate the small intestine. They prevent its further absorption into the bloodstream and also prevent the development of intoxication.
In case of an overdose of Nurofen (syrup or tablets), it is extremely important to ensure that the victim drinks plenty of fluids. Drinking large amounts of water will reduce the concentration of the medication in the blood and speed up its elimination from the body.
Nurofen overdose: signs in a child, first aid
The actions of adults are complicated by the age of the child. Washing is not done if the child is under 5 years old. A child of three or four years old must be taken to a medical facility, where a special gastric tube will be used to cleanse the small intestine of any remaining toxic substances and food.
Drinking alkaline mineral water will speed up the elimination of the active substance. The child needs to be wrapped in a blanket. To reduce the toxic effects on the central nervous system, place a towel and an ice pack on the head.
Drinking plenty of fluids is alternated with taking diuretics to speed up the elimination of toxins and reduce the load on the kidneys.
Nurofen for children is sold in the form of syrup, the maximum volume is 200 ml. This is 4000 mg of substance. For an overdose, a child weighing 10 kg needs to drink the entire bottle. Imported analogues are equipped with protection mechanisms so that a small child cannot open the bottle on his own.
When is specialist help needed?
In all cases, in case of an overdose of NSAIDs, you should seek medical help, especially if an increased amount of medication was taken by a child, an elderly person or a pregnant woman.
To speed up the process of removing the drug from the human body, forced diuresis is performed, which involves alkalization of the plasma. To do this, intravenous infusion of electrolytes, glucose solutions and sodium bicarbonate is carried out. The patient may also be prescribed oral diuretics.
The use of other methods of extracorporeal detoxification is not provided due to their low efficiency.
Earlier studies on the harm of Ibuprofen for men
Previously, a similar ]]>study of painkillers had already been conducted]]> on 90 thousand men aged 45 to 69 years and it showed that people who regularly took aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Anaprox, Naprosyn) and other NSAIDs 38% more likely to suffer from erection problems.
The study was conducted on 31 healthy young people aged 18 to 35 years. Fourteen men took two 600-milligram doses of ibuprofen over six weeks, the amount many athletes take for pain relief. The remaining 17 people took placebo pills.
Possible consequences
A mild overdose of Nurofen usually does not cause negative consequences. However, the prognosis when taking large doses of the drug mentioned is much more serious. In such cases, acute renal failure (and then chronic) and even death can become a complication.
The consequences of an overdose of NSAIDs can be extremely severe if a person has taken an excessively large dose of Nurofen. Such acute poisoning necessarily affects all important human systems and organs. In this case, the following diseases may develop:
Indications for use
Regardless of the form of release, the use of the drug is justified for the treatment of the following pathologies:
- pain syndrome of various nature;
- brachial plexopathy of an idiopathic nature;
- elevated temperature due to infectious diseases;
- gout;
- malignant tumors accompanied by pain;
- ankylosing spondylitis;
- various forms of arthritis.
Indications for the use of children's Nurofen in the form of a suspension or suppositories are:
- negative reactions to childhood vaccinations;
- painful sensations of various origins;
- high temperature due to infectious lesions.
Precautions when using the drug
What do patients need to know in order to prevent possible cases of overdose with such an analgesic and antipyretic drug as Nurofen? Experts say that in order to avoid intoxication of the body with anti-inflammatory drugs, it is necessary to follow a few simple rules:
- It is prohibited to use medications expired, as they develop a chemical reaction that contributes to the appearance of toxic substances.
- Do not exceed the dosage of the medication recommended by your doctor. All medications for the treatment of certain diseases must be calculated strictly based on the severity of the disease and the patient’s body weight.
- It is prohibited to use drugs whose packaging has been damaged. When exposed to oxygen, some products can decompose, releasing toxic substances.
- Medicines should be kept out of the reach of small children.
- Do not leave Nurofen in an easily accessible place until next appointment.
- Children should not be shown how to open a container with medicinal syrup.
"Nurofen" is an excellent drug for providing first aid to children and adults with severe pain of various types, as well as elevated body temperature. However, you should always remember that excessive and uncontrolled use of any medications can lead to dire consequences.
When not to use Nurofen
The medicine has contraindications that act as an obstacle to taking:
- individual intolerance to components;
- increased sensitivity of the body to acetylsalicylic acid drugs, other non-steroidal anti-inflammatory drugs (in the presence of allergic rhinitis, urticaria and other negative reactions in the anamnesis);
- the presence of erosive and ulcerative neoplasms on the mucous membranes of the gastrointestinal tract, exacerbation of relevant diseases (Crohn's disease, ulcerative colitis, etc.);
- violation of the blood coagulation system (hemophilia, hypocoagulation, hemorrhagic diathesis);
- recovery period after coronary artery bypass surgery;
- gastrointestinal bleeding and intracranial hemorrhage;
- development of liver failure, severe kidney disease;
- development of hyperkalemia;
- gestation period;
- children under 12 years of age.
Situations when monitoring the condition when using the medicine is required:
- simultaneous use of other non-steroidal anti-inflammatory drugs;
- a history of ulcerative tumors in the stomach or intestines;
- ulcerative bleeding;
- gastritis, enteritis, colitis due to Helicobacter pylori bacteria;
- bronchial asthma or acute allergic diseases;
- systemic lupus erythematosus and connective tissue pathologies;
- general dehydration;
- nephrotic syndrome;
- cirrhosis of the liver;
- arterial hypertension;
- heart failure;
- diseases of the cerebral region;
- pathologies of the hematopoietic system of unknown origin;
- alcoholism;
- concomitant therapy with drugs that increase the risk of internal bleeding (anticoagulants, hormonal agents, antiplatelet agents).
Take Nurofen with caution in old age.
Analogues of the drug according to ATC codes:
DEBLOC IBUPROFEN-HEMOPHARM IBUFEN MIG 400 NUROFEN NUROFEN FOR CHILDREN NUROFEN ULTRACAP NUROFEN FORTE FASPIK FASPIK All
Causes of temperature during intoxication
Poor quality food often causes food poisoning. One of the symptoms that a person has eaten a dangerous product is fever.
When a person’s temperature increases, the following changes are observed in the body:
- Metabolism is greatly accelerated.
- Blood circulation is stimulated.
- Fluid circulation improves in all tissues and organs.
- Decomposition and removal of toxic derivatives from the body occurs.
- Sweating is stimulated and skin pores dilate, which helps remove toxins.
The following factors contribute to Nurofen intoxication:
- Overdose. More often, the problem is caused by non-compliance with medical recommendations, violation of instructions, or independent use. When calculating the required amount of medicine, the patient’s weight is taken into account, so be sure to weigh the baby before use.
- Improper storage. If you leave the drug in plain sight, a child can easily reach it. The syrup is especially dangerous in this case, as it contains flavorings and fruit additives, which makes the taste attractive.
- Using expired Nurofen.
- Treatment of a newborn. The instructions clearly indicate that therapy for up to 3 months is prohibited.
results
Both groups of men had blood tests and hormonal tests throughout the study. After 14 days of using ibuprofen, the researchers observed higher levels of luteinizing hormone in the blood, which regulates the production of testosterone and other hormones. After 44 days, levels were even higher. However, testosterone production did not increase at the same time, resulting in a lower testosterone-to-luteinizing hormone ratio, a sign of testicular failure, according to the article.
The researchers also observed other hormonal disorders on days 14 and 44 of ibuprofen consumption, indicating widespread consequences of testicular suppression.
The researchers then tested the substance's direct effects on the testicles using samples that were taken from organ donors. When exposed to levels of ibuprofen similar to those taken orally, testicular samples produced less testosterone after 24 hours. The researchers found that the higher and longer the exposure, the more dramatic the effect. It was found that also gene function is disrupted associated with the conversion of cholesterol into steroid hormones.
]]>Guardian magazine on the topic]]>
]]>
The dangers of taking painkillers for pregnant women, men and children
Previous research by the lead author also showed that boys born to mothers who took ibuprofen during the first trimester of pregnancy may have impaired testicular development. This means that, at least in some scenarios, the drug may negatively impact boys' masculinity later in life.
This is confirmed by ]]>earlier publications]]>. In them, taking ibuprofen, aspirin and paracetamol during pregnancy by 2,300 Finnish and Danish women increased the risk of cryptorchidism (testicular pathology) in boys by 16 times. Taking painkillers in the second trimester of pregnancy is especially unfavorable: they disrupt the formation of the genital organs and the production of testosterone. And if left untreated, it can subsequently cause infertility in men, and possibly influence the phenomenon of “transgenderness.”
In addition, there are studies showing an increased risk of heart disease and heart attack in connection with taking the drug.
Most often, drugs are used in excess of the norm by children. To prevent this from happening:
- keep Nurofen out of the reach of children;
- strictly follow the proportions of the drug recommended by the treating specialist when using it internally;
- do not administer additional medications yourself, they may enhance the effect of those that you or your child are already taking, and there is also a risk of drug incompatibility with each other;
- Take Nurofen for children and tablets for adults during breakfast, lunch, dinner or immediately after, so that the drug is more easily absorbed by the body;
- Do not unscrew the difficult-to-open lid of the syrup in front of a child, and especially do not demonstrate to him how to do it correctly. This will be one of the guarantors of his safety.
Nurofen is one of the most popular drugs in the world, which is available without a prescription. Despite the small percentage of severe consequences in case of an overdose of the drug, strictly follow the doses recommended by the manufacturer and doctor.
Release form
Nurofen comes in several forms:
- Rectal suppositories. They are white or almost white and shaped like a torpedo. Candles have a smooth surface; the cut may have an air core or a funnel-shaped cavity. The package contains 10 suppositories, each of which contains 60 mg of ibuprofen. Nurofen suppositories are recommended for children from 3 months to 2 years.
- Suspension for oral administration. It is white or almost white and may smell like orange or strawberry. The suspension has a syrupy consistency. 5 ml of the dosage form contains 100 mg of the medicinal component. The suspension is designed for children from 3 months to 12 years.
- Tablets for children from 6 years old. They are round, convex on both sides. The tablets have a white or almost white shell and core; on one side the name of the medication is written in Latin.
Colds of an infectious, viral nature are accompanied by elevated temperature joining general symptoms. The flu is especially difficult to tolerate; with this disease, the temperature can reach 39-40 degrees. The patient needs to take antipyretic and anti-inflammatory medications. Nurofen for adults effectively fights fever and pain, which helps improve the patient’s well-being.
Composition, release form and types of drug
There are a number of medicines of this name on sale, which differ in composition and form.
So in pharmacies there are:
- Nurofen for children;
- Nurofen Ultracap;
- Nurofen;
- Nurofen Forte;
- Nurofen Plus.
Regular Nurofen is produced in the form of tablets containing 200 mg of the main component (ibuprofen). In one package, packaging can vary between 6-24 pcs. Adult effervescent tablets contain 200 mg of ibuprofen. There are 10 pcs in one pack.
Nurofen Ultracap is produced in the form of capsules, packaged in 4-10 pieces. The inner part is liquid and contains 200 mg of ibuprofen (the dose for adults is calculated based on personal data). Nurofen Forte is presented in tablets packaged from 6 to 24 pcs. In 1 piece I take 400 mg of ibuprofen.
The manufacturer produces children's Nurofen in the form of a syrup suspension. Vials of medicine have a volume of 50-150 ml; the drug is packaged at the factory in 5 ml portions (8-16 sachets per package). The medicine can also come with a dosing spoon (5 and 2.5 ml) or a dosing syringe. The children's medicine contains ibuprofen 100 mg. Rectal suppositories contain 60 mg of ibuprofen.
Nurofen Plus is packaged in blister packs. The number of tablets varies. The composition contains 10 mg of codeine phosphate and 200 mg of ibuprofen. Nurofen gel (5% concentration) is sold in tubes from 20 to 100 g. 1 g of gel contains 50 mg of ibuprofen.
General information
Registration number: P N013012/01–090117. Clinical and pharmacological group: NSAIDs (non-steroidal anti-inflammatory drugs).
Release form, packaging and composition
White round biconvex tablet with black one-sided overprint Nurofen. Covered with a protective shell. The packaging is a cardboard block containing several foil blisters, each containing 10 tablets. detailed instructions instructions for using Nurofen 200 mg tablets are included with each package.
One tablet contains 200 mg of ibuprofen - active substance(in the drug “Nurofen Forte” - 400 mg, and in “Nurofen Plus” another 10 mg of codeine is added). There are also auxiliary components: silicon dioxide in colloidal form - 1 mg, sodium dodecyl sulfate - 0.5 mg, cetylacetic acid - 2 mg, sodium citric acid - 43.5 mg, croscarmellose sodium - 30 mg.
Additional substances contained in the shell: gum arabic - 0.6 mg, sugar - 116.1 mg, titanium dioxide - 1.4 mg, black coloring matter [Opacode S-1–277001] (shellac - 28, 225%, isopropyl alcohol - 0.55%, water - 3.25%, iron oxide (E-172 - food additive) - 24.65%, ethyl alcohol - 9.75%, E-1520 - 1.3%, butyl alcohol - 9, 75%), cellulose gum - 0.7 mg, talc - 33 mg, polyethylene glycol - 0.2 mg. Solvents that evaporate after printing.
Pharmacological properties
Nurofen is an express anti-inflammatory drug of non-hormonal nature. It has an antipyretic and analgesic effect by blocking Cyclooxygenase-1 and 2, which causes inhibition of the connection of prostaglandins, the so-called pain mediators. It is worth noting that ibuprofen (the active ingredient) also inhibits platelet aggregation. The medicine works for up to 8 hours.
It has high absorption - quickly and almost everything is absorbed from the intestines. If you take the medicine on an empty stomach, the active substance will reach its maximum concentration in the blood after 3/4 hours. In the case of food intake, the time can be increased to 1.5 hours.
In blood plasma, proteins have a good connection with Nurofen - 90%. The drug is absorbed into all tissues and cavities of the joints, especially retaining in the synovial fluid, where it reaches its highest concentration. It can be found in very small quantities in the liquor.
The tablets are then broken down in the liver and removed naturally by the kidneys within 4 hours.
Dispensed in pharmacies without a doctor's prescription.
Action and properties of the drug
The main effects of ibuprofen:
- analgesic;
- antipyretic;
- anti-inflammatory.
The active components help inhibit the synthesis of prostaglandins, which are mediators of heat, inflammation and pain. The duration of the influence of the main substance from the moment of a single use or use of the product lasts approximately 8 hours, which depends on the drugs used in parallel, medications and on the characteristics of a particular organism.
Efficiency of drug forms
Nurofen Ultracap contains the main component in liquid equivalent. The capsules are developed using modern technologies, so ibuprofen enters the body more quickly, beginning to be absorbed and providing the desired effect in an accelerated manner. The shape and size make it easier for adults to take the medicine.
Effervescent Nurofen tablets, which must first be dissolved in a certain amount of water, also differ in their speed of action. Taking only the prepared solution promotes faster absorption. This type of medicine is distinguished by its rapid solubility, pleasant taste and speed of absorption into the body.
Children's Nurofen syrup is produced for children. Applicable from 3 months to 12 years. The composition does not contain potential allergens such as dyes or alcohol, which ensures the relative safety of taking the product even by infants. The drug has a pleasant fruity taste, which makes it easier for the child to take.
The principle of action of Nurofen as an anesthetic
Ibuprofen is synthesized from propionic acid. Contacting the cells of the human body, the active substance blocks the enzyme cyclooxygenase (forms 1 and 2), and also stops the production of prostaglandins, due to which a pronounced analgesic effect occurs for pain of inflammatory origin.
The mechanism that provides the analgesic effect of the drug has several stages:
- after being absorbed from the gastrointestinal tract, the drug is transported by the blood to places of increased synthesis of prostaglandins;
- ibuprofen stops the production of prostaglandins;
- swelling is relieved;
- compression on nerve endings is reduced;
- pain disappears.
After what time Nurofen begins to act depends on the form of the drug used. For example, the analgesic effect of taking a Nurofen Express Neo tablet will be noticeable after 15 minutes, and after half an hour maximum pain relief will occur. It will take 35-40 minutes to feel the pain-relieving effect of the medicine in the form of a gel.
The analgesic and antipyretic effect lasts depending on the dose of the medicine taken. So, 200 mg of the drug will provide relief from pain for a period of 4 to 6 hours. A Nurofen Forte tablet containing 400 mg of ibuprofen exhibits an analgesic effect for up to 12 hours (with painful sensations medium intensity).
Indications for use
Nurofen tablets and other forms are used as an antipyretic drug:
- influenza and ARVI;
- childhood infections;
- post-vaccination reactions;
- other febrile conditions arising from infectious diseases of various types.
Medicine of this type It is also used as a pain reliever.
How is an analgesic used for:
- neuralgia;
- arthralgia;
- pain caused by injuries;
- back pain;
- migraine;
- sore throat or ears;
- myalgia;
- toothache;
- algodismenorrhea;
- headache;
- other types of pain.
Nurofen is taken for headaches caused by for various reasons: from colds, flu to migraines. The tablet form is used in the treatment of toothache, joint pain, muscle pain, and menstrual pain. The drug actively fights the symptoms of flu and colds.
Nurofen express
Nurofen Express is available in capsules with liquid contents. This dosage form ensures rapid absorption and onset of effect – 10 minutes after administration. This has little effect on the duration of action.
Capsules should be taken in the same way as tablets - with plenty of water, preferably after or during meals.
Indications for use
Effervescent tablets are used for dental pain, headaches, back pain, migraines, periodic pain in women, and so on. This type of remedy helps to quickly relieve fever and symptoms of infectious diseases. Nurofen capsules help with pain of various origins. Forte can eliminate pain in muscles, teeth, and head. The medicine is effective for neuralgia, myalgia, and fever.
When treating children, Nurofen syrup is used. It will not only quickly relieve fever, but will also eliminate pain caused by infection or other reasons. Helps with post-vaccination reactions, during teething, eliminates the main symptoms of flu and colds. Relieves pain of various types, if it is part of the symptomatology infectious disease like ARVI. The suspension (syrup) is effective if used from 3 months to 12 years. The dosage of Nurofen for adolescents is taken as for adults.
Nurofen gel is used topically for pain caused by injuries or degenerative joint and muscle diseases. It relieves not only pain, but also swelling, reducing inflammation in the affected area. The sooner the remedy is used, the sooner the symptoms will be relieved.
When to take Nurofen
For headaches, the dosage of Nurofen for children and adults is according to the instructions or prescription of the doctor. Efficiency is higher if you use the product immediately after the development of the first symptoms. Timely administration helps reduce the duration of pain intensity during migraine. By clinical research A significant reduction in pain during a migraine attack occurs approximately an hour after using the drug.
Algodismenorrhea, which is also called periodic pain in women, is easily relieved with the tablet form of Nurofen. It should be taken until the peak of pain is reached. If it is already strong enough, then it is better to take Nurofen Plus.
Treatment regimen
Nurofen dosage at any time pharmacological form depends on the disease, the patient’s age, and individual condition. For an adult, the maximum daily dose is 1200 mg of ibuprofen in any form, for children - 800 mg. One single dose should not exceed 200 mg, for children under 12 months - 60 mg. The time interval between doses is 6-7 hours. Increasing the single and daily dose to 300-400 mg is allowed only on the recommendation of a doctor under the supervision of medical personnel.
Nurofen use and dosage
Nurofen is taken based on the patient’s age and body weight. For children, the volume of syrup is calculated according to the age table, which is in the instructions and on the packaging of the drug. The adult version involves the use of Nurofen according to the instructions, taking into account the weight. How to take Nurofen is indicated in the instructions, although the attending physician is able, at his own discretion, to adjust the regimen for using the drug.
Children's Nurofen
The dosage of Nurofen for children depends largely not only on the age, but also on the patient’s body weight. Per 1 kg of body weight, about 5-10 mg of the substance is expected. This volume is given 3-4 times a day. But the daily volume should not exceed 30 mg/kg. Before taking the syrup, you need to shake it thoroughly. To calculate the dose, use either a measuring spoon or a special syringe that comes with the medicine.
- six months to a year, 2.5 ml up to 4 times a day (maximum 200 mg per day);
- 1-3 years 5 ml (maximum 300 mg per day);
- 4-6 years, 7.5 ml (no more than 450 mg per day);
- 7-9 years old, 10 ml (no more than 600 mg per day);
- 10-12 years: 15 mg (not more than 900 mg per day).
How often can children over 3 months take the medicine is written in the instructions. Starting from a year, the medication is taken a maximum of 3 times a day, every 7-8 hours. If symptoms appear after immunization, then the dose of Nurofen prescribed in the instructions is given once for up to a year. For children over one year old, the same dosage is assumed (2.5 ml), but it is allowed to take another 2.5 ml if necessary after 6 hours.
The use of suppositories (Nurofen suppositories) is carried out rectally. For fever and pain, patients weighing from 5.5 to 8 kg (approximately 3 to 9 months) use 1 suppository per day three times maximum every 6 hours. Patients weighing from 8 to 12.5 kg (about 9 months) use Nurofen in suppositories 4 times. During postimmunization, 1 suppository is used once for children under one year old and twice every 6 hours for children over one year old. It is necessary to differentiate Nurofen suppositories for adults from children, since the dosage of ibuprofen is different for them.
Important! The drug is used without prescription by a specialist for no longer than 3 days in case of fever, and also for no longer than 5 days as an analgesic. If symptoms continue to persist, it is recommended to consult a doctor for a diagnosis or change of remedy.
Nurofen for adults
Nurofen tablets, capsules and other forms of the drug are prescribed for adults, dividing the daily dose into 4 doses. It is assumed to take 200 mg at a time. The effervescent form should be dissolved in 200 ml of still water. To achieve the effect more quickly, the dose is doubled. For children and adolescents, the daily maximum was 1000 mg. It cannot be exceeded. For adults, the daily maximum was 1200 mg. If symptoms persist for 3 days or there is a clear deterioration, consult a specialist.
Gel Nurofen is prescribed exclusively from 12 years of age. The daily maximum was 50-125 mg, which in volume is expressed as 4-10 cm of medicine squeezed out of the tube. Rub in until absorbed. Re-application is provided no earlier than after 5 hours. The composition is used no more than 4 times per day. If after a month there is no improvement, then use of the drug is discontinued.
Nurofen for children
There are the following types of Nurofen for children:
- Suspension for oral administration in vials of 50, 100 and 150 ml;
- Suspension for oral administration in the form of 5 ml sachets. Available in packs of 8 or 16 units;
- Rectal suppositories contain 60 mg of ibuprofen, available in 10 units per package.
For ease of measuring dosage, suspensions have measuring spoons and syringes. This form has a pleasant strawberry or orange flavor and is free of alcohol and sugar. Therefore, children do not refuse such treatment. The effect of the suspension and suppositories lasts up to 8 hours. All forms of release for children relieve pain and fever well.
Previously, Nurofen was produced in the form of syrup, patch and chewable tablets, but currently this type of release is not available.
Overdose
The manifestation of negative reactions during an overdose develops extremely rarely, but if they make themselves felt, you should consult a doctor.
- bradycardia, tachycardia;
- decreased blood pressure, accompanied by noise, ringing in the ears, headache, even migraine;
- epigastric pain, nausea, which is accompanied by vomiting or the urge to vomit;
- coma;
- respiratory arrest;
- metabolic acidosis;
- lethargic, drowsy state;
- constriction of the pupil;
- acute renal failure;
- atrial fibrillation.
The last point applies more to Nurofen Plus. In such situations, you need to call an ambulance. Treatment consists of gastric lavage (effective in the first hour after taking an excessive dose of the drug), the use of adsorbents such as activated carbon, white coal, Enteros-gel, Polysorb MP and so on. The patient is given an alkaline drink. Then treatment is carried out according to the existing symptoms. For shortness of breath, asphyxia and depressed breathing, naloxone is used. An overdose of the gel has not been observed to this day.
Composition, active substance and principle of action
The active ingredient is ibuprofen. This is a drug from the NSAID group, i.e. anti-inflammatory drugs that are not based on steroid hormones.
The mechanism of action of ibuprofen and related drugs is that it interferes with the activity of the enzyme cyclooxygenase, which is involved in the regulation of the inflammatory process.
By suppressing COX, ibuprofen reduces the severity of inflammation, relieves pain, swelling and temperature.
This mechanism of action also causes a number of side effects common to all NSAIDs. The fact is that there are two types of COX: COX-1, which regulates the production of protective compounds on the gastric mucosa, and COX-2, which is involved in the inflammatory process.
A distinctive feature of Nurofen is that its effect on COX-1 is quite low, and in terms of safety it is close to selective COX-2 inhibitors.
Contraindications
Nurofen for adults and children has factors that are contraindications for use that cannot be ignored.
These include:
- hypersensitivity;
- traumatic brain injuries and consequences of such injuries;
- increased intracranial pressure;
- dysfunction of the vestibular apparatus, hearing impairment;
- respiratory failure;
- up to 6 years for tablet form;
- up to 12 for gel, capsules, effervescent tablets and Nurofen Plus;
- up to 3 months for any form of the drug;
- hyperkalemia;
- deficiency of glucose-phosphate dehydrodenase;
- Visual impairment, complex ophthalmological diseases, pathologies;
- allergic reactions caused by taking the medicine;
- gastrointestinal ulcer in the acute phase;
- hemophilia, leukopenia, hypocoagulation;
- active liver disease;
- impaired kidney function;
- severe heart disease;
- heart surgery, bypass surgery;
- chronic constipation;
- lactation period, pregnancy in the 3rd trimester;
- for Nurofen Plus – pregnancy from beginning to end.
The drug is prescribed with caution to people with helicobacteriosis, enteritis, colitis, gastritis, gastrointestinal ulcers, hyperbilirubinemia, diabetes mellitus, polyps on the nasal mucosa, diseases of the liver, heart, blood, kidneys, and severe somatic conditions. Also, intake is limited or reduced to an effective minimum if there have been allergic reactions to the drug such as rhinitis, urticaria, rhinitis, bronchial asthma, and so on. The dosage is limited/reduced for adults with dys- or hyperlipidemia, cerebrovascular diseases, diseases of the peripheral arteries, and thyroid gland.
Take with extreme caution with glucocorticoids, anticoagulants, antiplatelet agents and other similar drugs, as well as if NSAIDs are used for a sufficiently long period. Elderly people use the minimum daily dose of the drug whenever possible. Smoking and frequent consumption of alcoholic beverages while taking medications is not recommended.
How long does it take for Nurofen to work?
The drug is considered quite effective in reducing hyperthermia. The effect of the drug appears 15-20 minutes after administration. Patients with diseases of the gastrointestinal tract are not recommended to take the medicine on an empty stomach, as this may cause irritation of the gastric mucosa. It is best to take it 10-15 minutes after eating.
Nurofen: instructions for use of tablets (official)
Overdose of Nurofen
Often the patient, in order to quickly improve his health and get back on his feet, tries to take a “load” dose of the medicine. But this often leads to the opposite effect; overdose symptoms may develop:
- Reduced blood pressure;
- Stomach ache;
- Depression, lethargy, drowsiness;
- Depression of kidney function;
- Vomiting, nausea;
- Noise in ears;
- Tachycardia;
- Respiratory depression;
- Acidosis;
- Fibrillation;
- Coma.
To avoid such troubles, before you start taking Nurofen, you should read the instructions for the drug and carefully monitor the dosage. It is extremely important to pay attention to the expiration dates of Nurofen - the old drug is contraindicated for use.
Does the drug help?
To eliminate pain associated with joint diseases, soft tissue bruises and sprains, there are currently a huge number of drugs available. The most popular are those that are applied topically. The Nurofen gel has pronounced therapeutic effectiveness. Reviews from people who have used it to relieve pain indicate that the drug allows you to quickly restore motor activity. The most effective remedy will be for mild and moderate pain.
You should not rely on the drug to help with exacerbations of pathologies of the musculoskeletal system, accompanied by severe pain. In such cases, it is recommended to use more powerful drugs in the form of injections.
Side effects
In most cases, a local ibuprofen-based drug is well tolerated by patients and does not cause any negative reactions in the body. Experts usually associate the occurrence of side effects with the presence of hypersensitivity to the components or improper use of the drug. The development of an undesirable reaction is indicated by symptoms such as the appearance of rashes on the skin, burning, itching, numbness, dizziness, tachycardia, Quincke's edema, bronchospasm.
Some symptoms occur with long-term use of Nurofen gel. Instructions for use in such cases recommend discontinuing further treatment with the drug and consulting with a specialist.
general description
To relieve pain and relieve swelling, the modern pharmaceutical industry offers a huge number of different products. Drugs from the NSAID category will help restore freedom of movement. They effectively suppress development discomfort, eliminate pain and inflammation. For external use, many experts recommend using Nurofen gel. The price of the drug is quite reasonable, despite the fact that it is produced by pharmaceutical companies from Spain and the UK.
Most often, topical nonsteroidal anti-inflammatory drugs are used in the treatment of diseases of the musculoskeletal system. They can be prescribed as part of complex therapy or as monopreparations. Gel "Nurofen" has proven itself to be quite effective local remedy, capable of coping with pain syndrome of any etiology.
Candles
Another pediatric form of the drug, intended for children under 5 years of age. It is especially convenient in cases where the baby cannot take tablets or syrup due to toothache.
The suppository acts somewhat slower than oral forms (the effect occurs after half an hour), but it usually lasts longer - it relieves pain for up to 7-8 hours.
This is an ideal remedy for toothache in a small child who is teething.
"Diclofenac"
Another popular and inexpensive medicine with an analgesic effect is Diclofenac. Available in various forms and is used for a huge number of pathologies of the musculoskeletal system. Diclofenac sodium is used as the active substance.
The drug has been used for quite a long time in medical practice and helps eliminate pain caused by neuralgia, lumbago, inflammatory processes in the joints, various types arthritis.
Children can be prescribed the drug for external use from the age of 6 years. The cost of the analogue is 40-80 rubles. The price will depend on the dosage of the active component in the gel.
"Apizartron" or "Nurofen"?
What is better to use for pain – Apizartron ointment or Nurofen gel? The instructions for using the first product indicate that this is a fairly effective local drug that has a pronounced analgesic and anti-inflammatory effect due to the presence of bee venom in the composition.
In addition, one of active ingredients is methyl salicylate, a substance from the NVPS group. You can use the ointment for pain in soft tissues, joints, radiculitis, osteoarthritis, myalgia. The average cost of Apizartron is 230-250 rubles.
How quickly does children's Nurofen work?
The manufacturer of the medicine conducted studies, based on which it can be argued that a clear positive effect can be seen from the product within 30-40 minutes after use. This is an average because a lot depends on individual qualities body. In most children, the temperature drops, on average, within twenty minutes from the start of administration.
How quickly the fever subsides largely depends on the quantity, dosage, and drug taken. For different ages, there is a “own” recommended dose, which must be followed. The product should be effective for eight hours, according to the manufacturer. In reality, most often this period is much shorter, the temperature begins to rise again. When the disease is serious, the effect of the medicine can be no more than three hours. And when the drug brings down the temperature much faster than expected, you should pay attention to this, as this may be a sign of an overdose.
How many days can Nurofen be given to a child?
The instructions say that if symptoms of the disease persist for more than five days, you should urgently consult a doctor. We recommend not to wait so long, but to promptly seek an examination and diagnosis from a pediatrician. After all, this will help to avoid many problems in the future. How many days Nurofen can be taken by children should be decided by the attending physician in dialogue with parents, based on clinical picture and the condition of the little patient.
Features of application
If the product gets into the eyes, mucous membranes of the mouth or nose, a burning sensation occurs. To eliminate it, rinse under running clean water. If you accidentally ingest the drug, you should consult a doctor. This is especially true for young children, as the likelihood of overdose and poisoning increases. To their clinical manifestations the following symptoms include:
- nausea, vomiting;
- weakness, apathy.
To neutralize the ingredients, gastric lavage with detoxification solutions is required.
The external product is combined with bandages and fixing bandages made from natural fabrics. Using the gel with airtight orthoses will cause severe skin irritation. Nurofen is also not used for occlusive sealed dressings.
The drug does not affect the reaction rate. It is used while driving vehicles and performing work that requires concentration and attention.
Nurofen should not be used before visiting a solarium or the beach due to the likelihood of skin discoloration at the application sites under the influence of ultraviolet radiation.
Nurofen gel is available over-the-counter from pharmacies. Despite this, its use without a doctor’s prescription is inappropriate. The drug is intended to reduce the severity of symptoms, but it cannot eliminate the cause of the disease. Only highly specialized doctors - rheumatologists, vertebrologists, neurologists - can correctly treat joint pathology. After conducting a series of diagnostic studies, the doctor will draw up a treatment regimen that will help speed up recovery and avoid irreversible complications.
How often can Nurofen be given?
So, medicine has a pronounced antipyretic and analgesic effect. It can be prescribed almost from birth to eliminate severely disturbing and severe symptoms during infections or teething. If a baby has a significant increase in temperature, this is always accompanied by particular concern on the part of the parents. Then, of course, you should not neglect the use of the tool in question. After all, this is a non-steroidal anti-inflammatory drug that will relieve pain and relieve fever in a short time.
The product will stimulate the formation of natural interferon, increase defensive reaction body. The absorption of the drug is high, the main active ingredient is absorbed into the blood after an hour.
Based on the form of release of the drug, one can expect the speed of its effect. As a rule, symptom relief occurs within a quarter of an hour after taking the required dosage. And your body temperature will drop in no more than forty minutes. The syrup works faster than tablets. Its effect will occur in the child within ten minutes from the moment of use.
Doctors insist that medications to lower body temperature should be given when the readings on the thermometer reach 38.5 degrees or more. At lower temperatures the drug should not be given. If, for example, a child has a temperature of 37-38 degrees, there is no point in bringing it down, because such a symptom indicates the work of the body’s defenses with pathogenic flora. At this moment, the formation of immune protection occurs, which is so necessary for the growing organism in the future.
When the child has already taken the medicine, and the temperature has risen again, the question arises: how often can Nurofen be given to the child? After taking the drug, your child should wait at least four hours before the next dose. There are rare cases, and only after consulting with a doctor, when it is permissible to re-give the medicine after three hours. But, as a rule, over the next four hours, the temperature will be stable, not requiring immediate subsequent medication.
If there is no improvement after taking the drug, and the temperature continues to persist, doctors recommend trying to give the baby another remedy for fever, for example Panadol, with the active ingredient in the form of paracetomol.
General characteristics of the drug
Since the medicine is presented in several forms, it is worth identifying each category of its use separately.
- acute respiratory infections, acute respiratory viral infections, influenza, with fever, pain;
- pain in the gums and teeth;
- lumbar pain;
- headache;
- for migraines;
- joint and muscle pain and inflammation, bruises, injuries, fractures;
- rheumatic pains;
- neuralgia.
The maximum daily dosage can be 6 tablets. Children over 12 years of age and adults are recommended to take 1-2 tablets 3-4 times a day.
Children under 12 years of age can take no more than 4 tablets per day, 1 tablet per dose.
You can take the drug for 2-3 days, then, if the condition does not improve, you need to find a more effective remedy. To do this, you should consult a doctor.
Indications for taking Nurofen express
- inflammation of the upper respiratory tract;
- acute respiratory infections, acute respiratory viral infections, influenza, other viral diseases with fever, pain;
- pain in the gums and teeth;
- lumbar pain;
- headache (you can take Nurofen for migraines);
- pain and inflammation in joints and muscles, injuries;
- rheumatic pains;
- neuralgia.
Daily dose of Express remedy for adults: from 1200-2400 mg per day for 3-4 doses. The dosage should be discussed with your doctor. It is recommended to take the medicine after meals.
Overdose, side effects and contraindications
Excessive use of the drug may cause the following symptoms:
- pain occurs in the abdominal area;
- may feel nauseous to the point of vomiting;
- mood worsens, you want to sleep, you feel lethargic and apathetic;
- noise in ears;
- headache;
- decreased blood pressure;
- dysfunction genitourinary system up to renal failure syndrome;
- cardiac dysfunction.
An overdose of the drug can lead to coma and respiratory arrest.
Side effect
Before using the drug, you should consult your doctor. Despite the fact that Nurofen is generally accepted well, in some cases it may have Negative influence on the functioning of the kidneys, heart, gastrointestinal tract, respiratory system, cause allergic reactions.
The drug can provoke changes in the microflora of the stomach and duodenum and cause the formation of ulcers in these organs.
After treatment with the drug, heartburn, nausea, vomiting, and bloating may occur.
You should be careful with the use of the medicine for kidney disease, as it may cause functional renal failure, inflammatory process in the kidneys and bladder.
There may be a disturbance in the functioning of the heart and blood vessels, which is manifested by an increase or decrease in blood pressure and swelling.
The drug may cause bronchospasm, but only if possible allergic reaction for ibuprofen and other components of the dosage form. There may also be allergic dermatitis.
Contraindications for use
The presence of diseases of the gastrointestinal tract, such as ulcerative process in the stomach and duodenum, ulcerative colitis.
Heart failure. Hypertension.
Depression of hematopoiesis or inhibition of the growth of new blood cells, diseases of the circulatory and hematopoietic system, for example, hemorrhagic diathesis.
Diseases of the optic nerve.
Do not apply the gel to skin that has wounds, ulcers, damage, or rashes.
The appointment must be made by a doctor. Self-medication can cause deterioration in the health of not only the mother, but also her baby.
Does the drug interact with other medications?
When treating hypertension or taking diuretics, taking Nurofen may lead to a decrease in the effectiveness of such treatment.
The simultaneous use of Nurofen and anticoagulants increases the risk of hemorrhages, bleeding and other complications. Drinking alcohol during treatment with Nurofen can lead to the development of diseases of the stomach and intestines or seriously complicate them.
Caring for health does not tolerate negligence and amateurism. Self-medication often causes complications of the process and the appearance of additional problems. Sometimes such an attitude towards one’s health can cost a person his life. Pain, inflammation, increased body temperature are serious reasons to go to the hospital or call a doctor at home.
Side effects
Nurofen has a certain number of side effects, and if the permissible dosage is exceeded, the risk of their occurrence only increases.
These side effects include:
- Digestive system – abdominal pain, heartburn, nausea, flatulence, vomiting, diarrhea, constipation, diarrhea and others;
- Central nervous system – depression, insomnia, headaches, tinnitus, decreased hearing acuity, hallucinations;
- Visual organs – decreased visual acuity, dry eye syndrome, inflammation of the conjunctiva;
- Cardiovascular system - tachycardia, blood pressure fluctuations, bradycardia;
- Allergies – rhinitis, urticaria, skin itching, Quincke's edema;
- Respiratory system – shortness of breath, bronchospasm.
Frequent and prolonged excess of permissible doses of Nurofen provoke irritation of the gastric mucosa, which over time leads to the appearance of peptic ulcers, and ulcers appear not only on the walls of the duodenum and stomach, but also spread to the mucous membranes of the esophagus.
Nurofen's analogs
Analogues according to active substance and therapeutic effect are:
- Dolgit;
- Arviprox-200;
- Advansd Remides;
- Arviprox-400;
- Advansd Remides;
- Farmea;
- Arofen;
- Affida Max;
- Apotex;
- No pain;
- Gofen;
- Marxans;
- Brufen;
- Affida Max;
- Eurofast;
- Ibunorm Baby;
- Ibufen;
- Marxans;
- Ibuprex;
- Zentiva;
- Berlin-Chemie;
- Nurosan;
- Ibuprom;
- Ibutex Max;
- Nurofen Forte.
Plisov Vladimir, dentist, medical columnist
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Analogs
The table shows the closest analogues:
Reaction with other pharmacological drugs
The hypotensive activity of vasodilators decreases while taking ibuprofen.
Nurofen potentiates the effect of fibrinolytics, anticoagulants and antiplatelet agents.
This drug can enhance the effect of oral hypoglycemic drugs, sulfonylurea derivatives and insulin
Thrombolytics and anticoagulants significantly increase the risk of bleeding. Cyclosporine can provoke toxic effects of Nurofen on the liver.
When taking medications that reduce tubular secretion, the plasma concentration of ibuprofen in the blood plasma increases markedly.
Severe hepatotoxic reactions can be provoked by phenytoin, the antibiotic rifampicin, the NSAID phenylbutazone and tricyclic antidepressants.
Concurrent consumption of caffeine can enhance the analgesic effect of ibuprofen.
You cannot combine ibuprofen and ethanol (including pharmaceutical tinctures).
Pharmacokinetics
The maximum therapeutic concentration of ibuprofen in all layers of the epidermis is detected after a day. 5% of the active ingredient penetrates into inflammatory foci. It accumulates in the synovial capsule and periarticular soft tissues. Only trace amounts of ibuprofen are found in the systemic circulation.
After the gel is absorbed by the skin, more of the inactive form of the NSAID is transformed into the active form, which exhibits pharmachologic effect. 90% of the components of the drug are metabolized in liver cells. Inactive and active metabolites are excreted by the urinary organs. About 20% is evacuated with bile acids during bowel movements.
