Macmiror is a remedy for combating infectious diseases of the genitourinary tract. Macmiror instructions for use, properties, indications and contraindications, reviews of what Macmiror helps with

Instructions

Macmiror represents antibacterial drug from the group of nitrofurans. The medication is intended to combat fungal and bacterial infections. At the same time, it is characterized by high efficiency and a wide range of bactericidal (toxic) effects on pathogenic microorganisms. Due to its original properties, the drug is in demand in narrow medical fields. In this case, like any antibiotic, the drug must be taken in accordance with the recommendations of the attending physician.

Composition and action

The medication has an antiprotozoal, antibacterial and antifungal effect against infectious and inflammatory processes. Dosage forms of the drug contain nifuratel as active substance.

Release form

The drug is available in 2 dosage forms:

suppositories (suppositories for vaginal administration);
pills.

Candles

Vaginal gelatin suppositories are elliptical in shape and yellow with a brown tint. The candles contain a suspension yellow color; oily to the touch. The antimicrobial effect is based on a combination of 500 mg of nifuratel and 200,000 units of nystatin. Dimethicone 1000 is used as an auxiliary component in production.

The shell consists of glycerin, sodium propyl parahydroxybenzoate and ethyl parahydroxybenzoate, gelatin, titanium dioxide. The color of the preparation is given by a yellow iron-based dye. Suppositories are packaged in blister packs of 8 or 12 pieces. A cardboard box contains 1 blister.

Pills

The tablet form contains 200 mg of nifuratel. The biconvex round units of the preparation are colored in White color. Auxiliary components include:

corn and rice starch;
magnesium stearate;
acacia gum;
macrogol 6000;
gelatin;
talc.

The film shell consists of magnesium carbonate, wax, sucrose and titanium dioxide. Tablets are contained in 10 pieces in 2 blisters, which are packaged in cardboard boxes.

Pharmacological properties of the drug Macmiror

The drug is a derivative of nitrofurans and is classified as an antimicrobial agent.

Pharmacodynamics

The bactericidal effect against fungal and bacterial structures is due to the high antimicrobial activity of nifuratel against pathogenic strains of microorganisms. Chemical compound belongs to the group of nitrofurans - acceptors of oxygen molecules.

The antibacterial mechanism of action is to disrupt the cellular respiration of microorganisms and suppress the formation of genetic material during the development of bacteria. When the drug penetrates the pathogen cell during intracellular metabolism, toxic nitro groups are restored under the influence of the microbe's flavoproteins. As a result, active nitrofuran metabolites are formed, which have a cytotoxic effect.

Resistance of bacterial structures develops gradually over a long time. The drug is highly effective against gram-positive and gram-negative microorganisms. The medicine is used to eliminate staphylococci, salmonella, shigella, Helicobacter pylori, resistant to metronidazole.

Pharmacokinetics

When administered orally, the drug is rapidly absorbed into small intestine. Food intake does not affect the absorption rate. When it enters the bloodstream, the active compound is bound by plasma proteins, thanks to which it begins to be distributed in the tissues of the body. It can penetrate the blood-brain barrier only if there is an inflammatory process in the latter. Nifuratel is able to pass through the hematoplacental barrier and accumulate in the mammary glands.

The active substance of the drug is transformed in hepatocytes and muscle tissue. The drug is excreted from the body through the urinary system. In this case, 30-50% of the drug is excreted in its original form and has a strong antibacterial effect in the urinary tract.

Indications for use

The drug is intended for the treatment and prevention of inflammatory processes of an infectious nature, provoked by microorganisms sensitive to the drug, in the following cases:

in the presence of vaginal diseases caused by chlamydia, trichomonas and other pathogenic bacteria;
for the treatment of chronic diseases of the upper gastrointestinal tract accompanied by inflammation (ulcerative-erosive lesions of the stomach and duodenum, chronic form gastritis, gastroesophageal reflux disease caused by Helicobacter pylori);
to eliminate vaginal candidiasis, giardiasis, amebiasis in the intestinal lumen, worms;
necessary for ureaplasma, gardnerellosis.

The drug is also used for the treatment of urinary system infections in gynecology (chronic and acute pyelonephritis, urethritis, cystitis).

For cystitis

The drug is used to treat cystitis of various etiologies. High activity is observed against the following microorganisms:

Trichomonas;
yeast-like fungi;
chlamydia.

For urethritis

Applicable for both men and women. Candles help eliminate inflammatory process V soft tissues and promote the removal of bacterial metabolic products from the macroorganism. The course of treatment is 7 days when taking 400 mg per day.

For pyelonephritis

The drug is taken regardless of gender. It is allowed to take tablets and suppositories. It is recommended to take 2 tablets 2 times a day for a week.

How to take Macmiror

Tablets are intended for oral administration inside. It is not recommended to chew the drug, because grinding dosage form may lead to a decrease in therapeutic effect.

It is important to remember that the dosage and duration of therapy is established only by a medical specialist based on the individual characteristics of the patient, data laboratory research and medical examination.

When determining the treatment regimen, the attending physician plays a key role in the severity, nature and localization of the infectious process.

Approximate treatment regimens are as follows:

Disease	Therapy model
Vulvovaginal infections	The duration of therapy is 7 days, during which you need to take 1 tablet 3 times a day. The drug should be taken by all sexual partners.
Diseases digestive tract caused by Helicobacter pylori	You need to take 4 tablets throughout the week. The dosage is divided into 2 doses.
Intestinal amoebiasis	2-3 times a day you need to take 2 tablets for 10 days.
Giardiasis	The course of therapy is 1 week. Daily dosage - 4-6 tablets, divided into 2-3 doses.
Urinary tract infections	The daily norm is established depending on the severity of the infectious process. The standard treatment regimen is 3-6 tablets daily for 1-2 weeks. If necessary, the course can be repeated.

Before or after meals

How many days to drink

The duration of use is determined by the attending physician on an individual basis, depending on the type, location and severity of the infection.

Contraindications to the use of Macmiror

The only contraindication to the use of Macmiror is the increased sensitivity of tissues to structural components drug.

Side effects

When taking it, the following may occur: negative effects:

Overdose

No evidence of abuse of the drug clinical manifestations overdose. High dosages of antibiotics can lead to the development of intestinal dysbiosis.

special instructions

When carrying out monotherapy with Macmiror for the treatment of infectious process with thrush, vaginal candidiasis, chlamydia, it is recommended to increase the daily dosage to 4-6 tablets. This is necessary to enhance the antibacterial effect. During the period of drug therapy, you should abstain from sexual intercourse.

The drug does not affect the work nervous system, therefore, when taking the drug, it is allowed to drive a car, interact with complex mechanisms and other work that requires concentration and speed of reaction.

Can I take it during pregnancy and lactation?

The chemical compound nifuratel freely penetrates the placental barrier, therefore the drug is contraindicated for use during embryonic development. Taking an antibiotic is allowed only in emergency situations, when the danger to the life of a pregnant woman exceeds the risk of the fetus developing intrauterine pathologies.

Nifuratel can accumulate in the mammary glands and be excreted in breast milk, so lactation must be stopped during drug therapy.

Use in childhood

Schemes for using the product in children:

For impaired renal function

The drug leaves the body unchanged and has an antibacterial effect against microorganisms in the urinary system, so no additional dose adjustment is required.

For liver dysfunction

Alcohol compatibility

When drinking alcohol during drug therapy, a weakening of the therapeutic effect against pathogenic microorganisms is observed. In some cases, nifuratel precipitates from inactive metabolites, which are excreted from the body without providing an antibacterial effect. In cases of severe intoxication, ethyl alcohol increases the toxicity of the drug.

Nifuratel and ethanol are deactivated in the liver, but hepatocytes can only deactivate 1 toxin at a time. Under conditions of high load, cells cannot cope with their function, and massive death of hepatocytes begins. Necrotic areas are replaced connective tissue, which leads to fatty degeneration of the liver. Therefore, drinking alcohol is prohibited when taking Macmiror.

Drug interactions

With the simultaneous use of Macmiror with Nystatin, an increase in the antifungal effect of the latter is observed.

Analogues

Structural analogues of the drug include:

Nemozol;
Nifuratel;
Terzhinan;
Polygynax.

Other substitutes with a similar mechanism of action are Metronidazole, Furazolidone and Furacilin. Such drugs are sold cheaper because they contain only pure active substance.

Terms and conditions of storage

Shelf life - 5 years.

Conditions for dispensing from pharmacies

Tablets are sold with a doctor's prescription; suppositories are commercially available.

Price

The average cost of Macmiror tablets is 914 rubles; vaginal suppositories - from 811 to 868 rubles.

The drug Macmiror has antibacterial properties wide range actions. The active substance Nifuratel has bactericidal and antifungal properties. The scope of application is quite diverse, therefore, for complete familiarization, you should study the instructions for use of the medicine in detail.

The action of the drug is based on the activity of the main component of the nitrofuran series, which provides the main pharmacological property McMirora. The medicine suppresses the development of fungi of various origins and has a depressing effect on the vital activity of amoebas and giardia.

Macmiror is metabolized in the liver, kidneys, and tends to pass into breast milk in small quantities. The process of complete disintegration and removal of the substance from the body takes place within 5–6 hours.

The composition of the medicine consists of the active substance and auxiliary components.

Main components of the drug:

nifuratel in the amount of 0.2 grams;
magnesium stearate;
magnesium carbonate;
starch;
polyethylene glycol;
titanium dioxide;
fructose;
wax.

The drug is produced in the form of white tablets coated in sugar. The blister contains 10 pieces. Cardboard box includes 2 blisters.

Purposes, contraindications, side effects of Macmiror

Macmiror is prescribed for extensive indications for use.

Basic conditions for using the drug:

The medicine has virtually no contraindications, which is a big advantage of the drug. You should not take Macmiror if you hypersensitivity in relation to the active substance.

Side effects may occur when using the medicine:

state of nausea;
allergic manifestations (atypical itching, urticaria);
stomach ache;
spasms, gag reflex.

Instructions for using Macmiror

The best way to use the medicine is to comply with all dosages prescribed by your doctor in each individual case.

According to the official instructions, the medication and dosage are distributed as follows:

Certain data on drug overdose have not been studied. The drug is dispensed at the pharmacy only with a prescription. The shelf life is 5 years. The use of Macmiror after the expiration date is strictly prohibited! Storage conditions at a temperature of no more than 25 degrees in a dry, dark place, protected from children.

Additional instructions and analogues of Macmiror

No negative interactions with the drug were identified. The combination of nystatin with Macmiror causes excessive activity of the drug. Concurrent use of the substance and alcohol is contraindicated, as side effects may occur.

During pregnancy and breastfeeding The prescription of Macmiror should be supervised by a doctor, because the active substance is actively absorbed into the bloodstream and passes into breast milk. During lactation, doctors recommend not using the drug.

The average cost of the drug ranges from 800–900 rubles per package. Price policy The medicine is quite large, so to get an alternative you should consider cheaper analogues of Macmiror. The list below contains close substitutes for the original.

It is worth noting that McMirror has a sufficient number of analogues, similar in structure of action and pharmacological composition. But it is necessary to replace the main drug after consulting a qualified specialist and studying possible side effects and contraindications.

Reviews from the doctor and those who took the drug

Obstetrician-gynecologist in Moscow:

When studying large quantity reviews of the drug Macmiror, we can come to the conclusion that most of them are positive. Quality and popularity depend on professional, consumer-type responses, so below are some recommendations.

I work in the gynecological field as an obstetrician-gynecologist quite long time. My review of the drug Macmiror was assessed from a professional point of view. Since I mainly care for pregnant women, I often prescribe medicine for preventive purposes before the onset of labor.

The active substance Macmirora allows you to delicately fight the causative agents of various infections and has a positive effect on restoring the proper microflora of the vagina. Another advantage of the medication is the short-term use of the drug, which is especially important during pregnancy. Hence I think this medicine one of the optimal and relatively safe antibacterial agents. When prescribing, I take into account all the nuances, so my patients do not feel negative consequences after using McMirror!

Natalya, Severodvinsk:

Two weeks later we completed a follow-up study and Giardia was no longer detected. I'm very glad we chose the right medicine and quickly got rid of this terrible diagnosis. Macmiror fully pays for the money spent on it, as it ensures the high effectiveness of the drug.

Irina, Orel:

While on vacation, I felt discomfort in my lower abdomen. I felt an unpleasant itching and nagging pain. After visiting a gynecologist and undergoing tests, a diagnosis of vulvovaginitis was made. I was prescribed a course of Macmiror for 10 days in the amount of 3 tablets per day.

After using the drug, I did not notice any significant changes in the body. And after a few days, all the unpleasant moments of the gynecological infection disappeared. After a control test, there were no signs of infection. Therefore, I recommend Macmiror as effective and quality drug quick impact!

Victor, Kansk:

It all started with what I felt severe pain in the lower back area. After a clinical urine test, the doctor confirmed the presence of pyelonephritis and kidney inflammation. I was scared by this diagnosis, but the specialist reassured me that the disease can be quickly cured when used effective medicine. This drug turned out to be Macmiror. After taking the first pill I quickly felt relief, and a day later painful sensations disappeared.

Complete treatment with Macmiror had a positive effect; there were no serious contraindications to the body. I was very pleased with the medicine and did not regret buying and using the drug. The high price confirms the quality of McMirror!

Macmiror is an antibiotic of synthetic origin of the nitrofuran group. Intended for use in gynecology (complex) and gastroenterology. It has antibacterial, antiprotozoal and antifungal properties. Due to its low toxicity, the drug can be prescribed to children and expectant mothers. The main advantage of the main component is its selective ability to pathogenic microorganisms. In this case, treatment is accompanied by restoration of the internal ecosystem and population growth beneficial bacteria. Before using Macmiror, read the instructions for use.

Regardless of the form of release produced, the drug Macmiror contains the main component - nifuratel. The dosage and method of administration allow the drug to be used for various diseases patients of different age categories.

Macmiror tablets contain 200 mg of the main component, have a white color, a biconvex shape and a sweetish taste of the shell. The cardboard package contains two blisters of 10 pills.

Macmiror suppositories are available in the form of a complex of suppositories. The main component in them is 500 mg. Excipients: nystatin. The shape is oval, the color is light yellow with a brown tint. The consistency is soft jelly-like. Macmiror is produced in the form of a complex of suppositories of 8 or 12 pieces in one package, designed for one course of treatment.

The cream (ointment), as well as Macmiror suppositories, contains nystatin. The active ingredient is 100 mg per 1 g of the drug. Tubes are available in 30 g. The color is yellow. The size of one candle corresponds to 2.5 g of creamy mass.

Mechanism of action

The medicinal effect of Macmiror extends to gram-positive and gram-negative strains of bacteria resistant to other antibiotics. The drug also has a detrimental effect on protozoan microorganisms and some types of fungi. Does not cause resistance.

The high effectiveness of Macmiror is due to the complex of active substances included in its composition. The antimycotic effect of nifuratel is enhanced by the support of nystatin. This tandem has a devastating effect on cell membranes, penetrates inside and disrupts their morphological structure, resulting in the death of pathogenic microorganisms.

Macmiror complex cream or suppositories inhibit only harmful bacteria and fungi, while beneficial microflora has no negative impact. Nifuratel contained in tablets, when taken orally, is quickly absorbed through the gastrointestinal mucosa and easily overcomes the placental and blood-brain barriers. Some concentrations are found in breast milk.

Macmiror is metabolized in the liver and muscle tissue. It is excreted mainly by the kidneys. Moreover, with urine, approximately 30-50% of the drug composition leaves the body unchanged.

Therapeutic purposes

A synthetic drug consisting of a complex of active substances with bactericidal effects was created for the treatment of diseases caused by acid-dependent bacteria and associated with Helicobacter pylori Macmiror is successfully used for giardiasis and mixed microbial infection.

Macmiror's main indications:

Diseases of the gastrointestinal tract associated with Helicobacter.
Vulvovaginal infections caused by Trichomonas, chlamydia, Candida fungi.
Infectious infections with intestinal protozoa - Giardia, amoeba.
Infections genitourinary system– urethritis, cystitis, pyelitis, pyelonephritis.

For the treatment of gastroenterological diseases, only Macmiror tablets are used; the complex composition is not prescribed in these cases.

Contraindications and negative effects

Macmiror during pregnancy is prescribed only if absolutely necessary. It is taken into account that the infection can cause serious consequences for the mother, so taking an antibiotic is indispensable. At the same time, the danger when using it for a child in the womb is much less.

Also, McMirror's influence is transmitted from mother's milk. Therefore, if treatment with this medicine is necessary, it is better to stop lactation.

According to the annotation, Macmiror has contraindications for:

High sensitivity to the active components of the drug and its auxiliary ingredients.
Severe renal and hepatic pathologies.
Planning to conceive a child for men (nifuratel affects spermatogenesis).
Childhood.

Although Macmiror is a low-toxic drug, side effects may still occur during therapy. They occur either with oral or vaginal use, and when used locally.

Negative manifestations:

Allergic – skin dermatitis, urticaria, itching, swelling.
Gastrointestinal tract disorders - abdominal pain, nausea, belching, heartburn, bitterness in the mouth, stool disorders.
Anaphylactic shock, Quincke's edema.

Macmiror, due to its gentle effect on the human body, can be prescribed as a prophylactic agent. But any use of it must be agreed with a doctor who will help you choose correct dosage and establish the required duration of therapy.

Methods of administration and dosage

The size of a single dose and the length of treatment time are affected by individual characteristics patient and severity of the disease. The choice of the dosage form of Macmiror depends on the location of the infection and the type of pathogen.

Pills

The drug does not contain nystatin. Macmiror is prescribed according to the disease according to the following scheme:

Intestinal infections. Take 2 pills of 200 mg up to 3 times a day. The course of therapy can last up to 10 days. Children's dosage is calculated based on the child's body weight. For 1 kilogram of weight, 10 mg of the substance is used. The result obtained is divided by 3.
Diseases of the gastrointestinal tract. Prescribe 2 tablets of 200 mg 3 times a day. The course lasts a week. For children, the calculation unit increases - 15 mg per kilogram of weight. They also use Macmiror for Giardia.
Diseases of the urinary system. A single dose is 0.4 g 3 times a day. Treatment is extended to 2 weeks. Children's dose - 15 mg/kg, divided into 2 doses.
Sexual infections. Three doses of 200 mg per day. If necessary, treatment is supplemented with cream or vaginal suppositories. Both sexual partners need to undergo therapy. For children, the calculation is based on the treatment plan for gastrointestinal diseases.

In advanced situations or severe diseases, Macmiror can be extended or discontinued repeat course. To do this, you need to consult with your doctor.

Suppositories

Despite the low toxicity, the use of Macmiror complex during pregnancy is allowed only as prescribed by a doctor. The drug in the form of suppositories has a systemic effect, since it contains nystatin. Treatment of vaginitis lasts from 8 to 12 days.

Macmiror candles are used as follows:

Complex 8 is prescribed for mild infections. Suppositories are inserted into the vagina as deeply as possible. The procedure is performed once a day before bedtime. The duration of therapy is 8 days.
Complex 12 is used for more severe clinical picture. Candles are used before bedtime, one per day. Treatment lasts 12 days.

Complex 8 and 12, if necessary, can be repeated at the end of the menstrual period.

Vaginal suppositories not used to treat young girls to avoid damage to the hymen.

Cream

For this form, the drug is equipped with a special graduated syringe. It is used for the convenience of intravaginal administration of Macmiror. A single dosage is 1 full filling of the applicator, which corresponds to 2.5 mg or 1 suppository.

Therapy is carried out according to the same scheme as for Macmiror suppositories, and is prescribed for the treatment of vaginal infections.

Content

For bacterial diseases of the genitourinary system and digestive organs, doctors prescribe antibiotics. The drug Macmiror acts gently without disturbing the balance of microflora. Its active components help cope even with infections mixed type. However, before you start using Macmiror (the international non-proprietary name Nifuratel), you must carefully study the instructions for use.

Medicine Macmiror - what is it

Nifuratel is a derivative of nitrofuran and, like similar substances from this group, has low toxicity. The drug is produced by the Italian pharmaceutical company Polychem. Macmiror shows high effectiveness against most bacteria, while having a minimum of side effects and contraindications. After data therapy antibacterial agent no need to use others medications to restore intestinal or vaginal flora.

Composition and release form

The company produces three versions of the drug: tablets, cream and capsules. The biconvex tablets are coated with sugar and are produced in blisters of 20 pieces. The cream is supplied in boxes with aluminum tubes of 30 grams and a graduated syringe. Soft gelatin capsules are packaged in blisters of 8 or 12 pieces - this form of the drug is used as vaginal suppositories.

The standard tablets are called Macmiror; the cream and capsules have a prefix - Complex. The first are developed on the basis of only one active component - nifuratel, the second also contain nystatin. The detailed composition for each release form is described in the table:

	Active substances	Auxiliary kernel components	Additional shell substances
Tablets, 1 pc.	nifuratel 200 mg	corn and rice starch, macrogol, talc, magnesium stearate, acacia gum, gelatin	sucrose, titanium dioxide, wax, magnesium carbonate
Vaginal cream, 100 g	nifuratel 10 g nystatin 4 million IU (international units)	xalifin, purified water, 70% sorbitol solution, glycerin, carbomer, propylene glycol, 30% triethanolamine, sodium methyl parahydroxybenzoate and propyl parahydroxybenzoate
Suppositories, 1 pc.	nifuratel 500 mg nystatin 20000 IU	dimethicone	gelatin, glycerin, sodium ethyl and propyl parahydroxybenzoate, titanium dioxide, yellow iron oxide

Pharmacokinetics and mechanism of action

The protozoal, antibacterial and antifungal effects of the drug are due to the action of its components. Nifuratel is effective against trichomoniasis, has a negative effect on the accompanying bacterial flora, and shows good results in the treatment of vaginitis and gastrointestinal lesions caused by Helicobacter pylori bacteria. Nystatin is a mycostatic antibiotic that, when attached to the fungal cell membrane, completely destroys its structure. When combined, these two substances enhance pharmacological actions each other.

When taking tablets, the drug does not have a negative effect on the gastrointestinal mucosa, is quickly absorbed from the stomach and enters the systemic bloodstream. The breakdown of active ingredients occurs in the liver tissue and muscles. 30-50% unchanged is excreted from the body by the kidneys, providing a strong antimicrobial effect in the urinary canal.

What bacteria and organisms is it effective against?

Macmiror suppresses the viability of most gram-positive and negative bacteria - enterococci, E. coli, Klebsiella, staphylococci, chlamydia. The drug is effective against harmful microorganisms, which provoke stomach and duodenal ulcers - Helicobacter pylori. The active ingredients can cope with some protozoa (amoebas, trichomonas, giardia) and are active against fungi that disrupt the vaginal microflora - Candida.

Indications for use

Treatment with Macmiror is prescribed for the diagnosis of inflammatory and infectious diseases of the intestines, urinary tract, mucous membranes caused by pathogens sensitive to it. Bacterial resistance is established by passing preliminary laboratory tests. The instructions for use indicate that the drug should be used for:

vulvovaginitis or leucorrhoea – candidiasis, vaginitis, chlamydia and more;
infectious and inflammatory diseases urinary system– cystitis, pyelonephritis, etc.;
helminthic infestations – intestinal amoebiasis and giardiasis;
chronic diseases of the stomach or intestines - chronic gastritis, ulcer, reflux disease.

For children

Prescribed for identifying diseases of the gastrointestinal tract caused by Helicobacter pylori. Macmiror is the drug of choice for the treatment of salmonellosis in children, shigellosis, intestinal amoebiasis, giardiasis or other acute intestinal infections. The medicine is well tolerated by the child’s body, therefore, if necessary, it can be prescribed from the age of 6 years.

For women

Gynecological diseases caused by fungal pathogens are treated with suppositories. Tablets are used in complex therapy of sexually transmitted diseases in combination with other antibiotics. The main indications for prescribing medication to women are:

vaginal candidiasis;
acute cystitis;
trichomoniasis;
chlamydia;
vulvovaginitis.

For men

Scientists from St. Petersburg found that the use of the drug in the treatment of diseases of the genitourinary system in men in 85% of cases gives positive results. Official instructions according to application states that it would be advisable for men to take the medicine when diagnosing pyelonephritis, inflammation urethra and bladder, urethritis. Macmiror tablets are also prescribed for the complex treatment of sexually transmitted diseases.

How to take Macmiror - method of application and dosage

Cream and gelatin capsules are used only intravaginally, tablets are intended for oral administration. It should be noted that for sexually transmitted infections, both sexual partners must undergo treatment, and at the end of therapy, control tests must be taken. The maximum daily dose for adults should not exceed 1.2 grams of the substance per day, for children - 30 ml per 1 kg of weight.

Urinary tract infections

Nifuratel is used in the treatment of cystitis, pyelitis, inflammation Bladder and channel. The duration of therapy is determined individually for each patient. After a while, the course of treatment can be repeated as prescribed by the attending physician. Daily dosages are determined by the patient’s age:

adults are recommended to take 0.2-0.4 grams of the drug up to three times a day;
Children over 10 years old are prescribed 30-60 mg per 1 kg of weight 2-3 times a day.

Vulvovaginitis

Considering that Macmiror has activity against protozoa, the drug is often prescribed for the treatment of inflammatory genital tract infections in women. The release form is determined depending on the severity of the lesion: sharp forms vulvovaginitis is treated with suppositories, chronic diseases- using tablets. The summary of the drug contains the following recommendations:

Tablets for adults are prescribed 0.2 g 3 times a day after meals, for children 10 mg per 1 kg of weight 2 times a day.
Suppositories are administered intravaginally once a day before bedtime. To relieve inflammation, you must undergo an eight-day course of therapy.

Intestinal amebiasis

The choice of treatment tactics for intestinal bacterial infections depends on the severity of the lesion. As a rule, for intestinal amebiasis, adults are prescribed 0.4 grams of the drug 2-3 times a day for 10 days. If the disease has been detected in a child, the dosage is calculated as follows: 10 mg per 1 kg of weight 2 times a day. A month after the end of treatment, patients with amebiasis must undergo control stool tests.

Giardiasis

For rapid absorption, tablets for helminthic infestations are taken immediately before meals. The standard course of treatment for giardiasis in adults and children is 7 days, but can be extended or repeated if tests show ineffective therapy. The recommended dosages are:

adults are prescribed two tablets 2-3 times a day;
Children are recommended to take 30 mg of Macmiror per 1 kg of weight 2 times a day.

Gastrointestinal diseases caused by Helicobacter pylori

Diseases of the stomach and duodenum caused by the bacterium Helicobacter pylori, according to international consensus, must be treated with two drugs - Clarithromycin and Metronidazole. However, recent studies in Russia have shown that this tactic is only 28-50% effective, so doctors decided to include Macmiror in the treatment regimen.

There are several modern options for destroying Helicobacter pylori. In almost all of them, proton pump inhibitors (PPIs) are required in recommended doses: 0.03 g lansoprazole, 0.02 g omeprazole, 0.04 g pantoprazole, 0.02 g esomeprazole or 0.02 g rabmeprazole twice a day. day. Next, each scheme has its own differences:

Option 1. One of the proposed PPIs in combination with 1 g of Amoxicillin and Macmiror 0.4 g 2 times a day. Course duration – 2 weeks.
Option 2. All drugs from the first option with the same dosages, but in combination with Bismuth tripotassium dicitrate, 0.12 g 4 times a day. The course of therapy is 15 days.
Option 3. One of the PPI drugs plus tripotassium bismuth dicitrate 0.12 g 4 times a day, Macmirora 0.4 g 2 times a day.

Monotherapy for vaginal infections

During treatment gynecological diseases With Nifuratel alone, it is recommended to increase the dose of tablets to 0.8-1.2 g per day or 4-6 tablets. For vaginal infections with severe symptoms on the external genitalia, it is recommended to additionally use Macmiror in the form of a cream up to two times a day, 2.5 g each. The duration of such treatment is 1 week.

Features of using the drug during pregnancy and breastfeeding

Clinical studies have shown that substances from the nitrofuran group are able to penetrate the placental barrier and accumulate in breast milk. For these reasons, the drug can be prescribed to pregnant women when the expected benefit to the mother outweighs the possible risks to the child. If necessary, appointments medicine During lactation, the issue of temporarily stopping breastfeeding should be decided.

How much does Macmiror cost?

The average price of an antifungal drug depends on the method of purchase, your region of residence, the form of the drug and pricing. You can buy the medicine at a pharmacy or order it through the catalog of the official manufacturer. If it is not possible to purchase tablets at a real point of sale, the drug can be ordered at an affordable price through an online pharmacy with delivery by mail or to your home. The cost of the drug in Moscow and the Moscow region is indicated in the table:

Release form and volume	Pharmacy name	Price, rubles
tablets 200 mg, 20 pcs.	ZdravCity

	ZdravZone
Vaginal suppositories No. 8	Apteka.ru


	Apteka.ru

Dispensing conditions in pharmacies

The sale of the drug is carried out only upon presentation of a prescription from a doctor. It is recommended to store the medicine in a dark, dry place at a temperature not exceeding 25 degrees. Shelf life – 5 years.

Side effects and contraindications

Treatment with Macmiror is contraindicated in case of individual intolerance to nifuratel or nystatin. The medicine is prescribed with caution to children under 5 years of age and pregnant women. When treated with vaginal suppositories or cream, minor allergic reactions– burning, itching, rash. When taking the tablet form, the following negative reactions occur:

nausea;
vomit;
dyspepsia;
bowel dysfunction;
heartburn;
pain in the epigastric region.

How can you replace Macmiror?

There are still no structural drugs that could replace nifuratel. Any analogue of Macmiror in tablets is only similar to it in the therapeutic effects it provides. In case of intolerance active ingredients, you can replace the medicine with:

Livarol;
Macropen;
Vagilak;
Acylact;
Lactonorm;
Kolposeptim;
Doxycycline;
Amoxicycline;
Furazolidone;
Pimafucin;
Furazolidone.

Video

An antibacterial drug from the nitrofuran group is Macmiror. Instructions for use indicate that 200 mg tablets, cream and suppositories as part of the complex have antiprotozoal, antibacterial and antifungal properties. According to experts, this drug helps in the treatment of chlamydia, giardiasis and other infectious diseases.

Release form and composition

The drug Macmiror is available in the form of tablets for oral administration, covered with a protective film shell in blisters of 10 pieces, packed in a cardboard box. The pack contains 2 blisters with tablets and detailed instructions with a description.

Each Macmiror tablet contains 0.2 g of the active ingredient – Nifuratel, as well as a number of auxiliary components

They also produce vaginal cream and suppositories (Makmiror complex), which in addition to Nifuratel additionally contain.

Indications for use

What does Macmiror help with? Tablets are prescribed if the patient has:

pyelonephritis, cystitis, etc., if the disease is caused by microorganisms sensitive to nitrofuran;
vaginitis, vulvovaginitis;
Giardia and amoebas in the intestines;
diseases of the gastrointestinal tract caused by the bacterium Helicobacter pylori.

Instructions for use

McMiror is appointed to daily dose determined by the doctor individually for each patient and depends on the diagnosis. According to the instructions, tablets are prescribed to patients according to the following scheme:

At inflammatory diseases urinary tract and vaginal infections, 1 tablet of Macmiror is prescribed 3 times a day for 10 days.
For sexually transmitted infections, treatment with the drug should be carried out together with a partner, after which it is necessary to undergo control tests.
For diseases of the digestive canal caused by the bacterium Helicobacter pylori, 2 Macmiror tablets are prescribed 3 times a day. The course of treatment is at least 1 week; for children under 14 years of age, the dose of the drug is calculated individually, depending on body weight.
For intestinal amebiasis and giardiasis, adult patients are prescribed 2 tablets 2 times a day for 10 days.

Vaginal cream

Prescribe 2.5 g of cream 1-2 times a day (morning or evening) for 8 days. The required dose of cream should be administered using a graduated applicator.

Instructions for use of the graduated applicator

Screw the graduated applicator onto the tube of cream. Take the required amount of cream (in accordance with the scale lines indicating the amount in grams) by pressing on the tube.

Disconnect from the tube, insert into the vagina, squeeze out the contents of the applicator, pressing on the rod. The presence of a special nozzle allows you to introduce the cream without damaging the hymen.

To do this, you need to remove the cannula from the top of the shaft and screw it onto the head of the syringe from the opposite side before inserting the cream into the vagina.

Vaginal suppositories

1 vaginal suppository is administered daily in the evening before bed for 8 days or as recommended by your doctor. If necessary, treatment can be repeated after menstruation. To achieve the maximum therapeutic effect, the suppository should be inserted into the upper part of the vagina.

Suppositories are not used for treatment in children. For this category of patients, it is recommended to use vaginal cream complete with an applicator (graduated syringe).

pharmachologic effect

Macmiror is an antimicrobial drug from the nitrofuran group; has antiprotozoal, antibacterial and antifungal effects. It has low toxicity and high efficiency, which determines a wide range of its clinical action.

Highly effective against Helicobacter pylori and Papiliobacter, gram-negative and gram-positive microorganisms. Range of action includes: Enterococcus faecium, Enterococcus faecalis, Staphylococcus aureus, Bacillus subtilis, Shigella flexneri 2a, Shigella flexneri 6, Escherichia coli, Shigella sonnei, Salmonella typhimurium, Salmonella typhi, Salmonella enteritidis, Klebsiella spp., Enterobacter spp., Serratia spp. , Morganella spp., Citrobacter spp., Rettgerella spp., Pragia fontium, Rahnella aquatilis, Budvicia aquatica and Acinetobacter spp., other atypical enterobacteria, as well as protozoa (Trichomonas, Giardia, amoebas); less active against Proteus vulgaris, Proteus mirabilis and Pseudomonas aeruginosa.

It is the drug of choice for the treatment of shigellosis, salmonellosis and other acute intestinal bacterial infections. Highly active against fungi of the genus Candida, active against Trichomonas vaginalis. Particularly effective against Helicobacter pylori strains resistant to metronidazole.

Contraindications

fructose intolerance;
high individual sensitivity to any component of the drug;
isomaltose/sucrose deficiency;
glucose-galactose malabsorption.

Side effects

Nausea, vomiting, allergic skin rashes.

During pregnancy and breastfeeding

The use of the drug during pregnancy is possible only under strict indications, if the expected benefit to the mother outweighs the potential risk to the fetus, because nifuratel penetrates the placental barrier. So it is better not to use this drug during pregnancy.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided, because nifuratel is excreted in breast milk. There are no contraindications to the use of Macmiror Complex suppositories during pregnancy and lactation (breastfeeding).

special instructions

It is recommended to increase the daily dose of the drug to 4-6 tablets when treating vaginal infections if Macmiror tablets are used as monotherapy. While taking the drug, you should abstain from sexual intercourse.

Drug interactions

Almost no interaction. When taking Macmiror and nystatin simultaneously, the effectiveness of the latter increases.

Analogues

Macmiror's analogues have a similar effect:

Amoxicycline.
Livarol vaginal suppositories.
Vagilak.
Macropen.
Pimafucin.
Nystatin.

Vacation conditions and price

The average cost of Macmiror (200 mg tablets No. 20) in Moscow is 816 rubles. The drug can be purchased freely in pharmacies; a prescription from a doctor is not required.

It is recommended to keep the tablets away from children at room temperature not exceeding 25 degrees. The shelf life of the medicine is indicated on the packaging and is 5 years from the date of manufacture. After the expiration date, the tablets cannot be taken orally.

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