Chronic pyelonephritis, symptoms and treatment. Treatment of pyelonephritis in traditional ways. Application in children

The number of patients suffering from violations from the urinary system, is growing steadily every year. Such diseases cause pain and discomfort, as well as threaten hazardous complications, threatening Life. In order to prevent it, you need timely treatment. It is not enough to deal with the symptoms of urological diseases, it is necessary to eliminate the reason for their appearance, this can help Uroantisceptic.

Such drugs are a separate group of preparations with pronounced antimicrobial properties. Their activity applies to most causative agents of urological diseases. These funds are used as part complex therapy urethritis, cystitis, pyelonephritis and even chronic renal failure.

Before proceeding with treatment, it is necessary to hand over bacteriological analysis, which will help identify the pathogen and reveal its sensitivity to antibacterial agents. Uroantispets, according to experts, are approved, they are reduced to no inflammatory response, struggling with the infectious process and prevent the transition to a chronic form.

Uroantistetics at cystitis

Uroantisseptics are divided into such groups:

• pipe emidic acid-based preparations;
• nitrofuran medications;
• nitroxolin-based funds;
• combined drugs;
• vegetable medicines.

Furadonin

This is an antimicrobial tool to which such pathogens are sensitive:

• proteus;
• enterobacter;
• klebsiella;
• intestinal wand.

Furadonin is prescribed for infectious and inflammatory processes caused by microorganisms that are sensitive to active substance drug. Typically, the course of treatment is seven days, but to secure the result recommended a couple of days to continue receiving the tablets.

The drug is not prescribed in the presence of severe kidney diseases, as well as during pregnancy. Sometimes Furadonin can cause side effects in the form of the following symptoms: drowsiness, dizziness, cough, chest pain, dyspeptic disorders, allergies.

Palin.

It refers to the quinolone row and its composition includes peemeidic acid. Palin is produced in the form of capsules for oral application. It is sensitive to gram-positive and gram-negative microflora. The dosage and duration of treatment is determined individually.

Palina can be recommended for the treatment of uncomplicated forms of acute and chronic cystitis only as a reserve drug, if for any reason it is impossible to use such modern antibiotics, like, digital, xenavin, etc.

Nitroxoline

The preparation has a wide range of antibacterial action. Such pathogens are sensitive:

• fungi;
• gram-positive and gram-negative bacteria;
• mycoplasma;
• mycobacteria;
• trichomonas.

Nitroxoline can lead to the appearance of such side Effects: headache, nausea, vomiting, allergic.

Furagin

This is a synthetic antimicrobial preparation, which is available in the form of tablets and capsules. The medical course is ten days. Sometimes they may appear adverse reactions From the digestive tract, but to reduce the likelihood of their appearance can be sufficiently consuming natural water. In individual intolerance, during pregnancy and lactation, Furagin is not accepted.

Biseptol.

The combined drug has not only a bactericidal, but also a bacteriostatic action, slowing down growth, the vital activity of pathogens and leading to their inevitable death. Patients are not recommended to stay under the influence of direct sun ray, as well as consume green parts of the plants.

UROANTISPETTICS in pyelonephritis

It is the most common nephrological disease. Such drugs help to suspend the infectious process and prevent the chronization of the disease. Preparations for pyelonephritis take strictly to appoint a doctor, adhering to instructions in connection with the dosages and the duration of therapeutic process.

We highlight the list of popular Urictionptics:

• Ampicillin;
• Ciprofloxacin;
• Offloxacin;
• Vancomycin;
• Ceftriaxone.

Fluoroquinolones

Uroanthisteptic fluoroquinolone rows are destructive effect on such pathogens:

• siegnaya and intestinal wand;
• streptococcus and staphylococcus;
• enterobacter.

Typically, treatment is from three to ten days. In severe cases, preparations are entered by parenterally. Juvenile children are prohibited by fluoroquinolone treatment.

Penicillins

Compared to others antibacterial agentsPenicillins are most secure. They are even used in the therapy of young children. But there are Penicillins and negative sidesassociated with high risks of the appearance of an allergic reaction.

Derivatives naphthyridine

The composition of such funds includes nodium acid, which neutralizes viruses and bacteria, and also prevents cellular division. Preparations are able to have a toxic effect on the kidneys and the liver, so the long-lasting reception is unacceptable.

Cephalosporins

WHAT DO THE DOCTOR'S SAY?

Doctor of Medical Sciences, Honored Doctor Russian Federation and honorary member of the Russian Academy of Sciences, Anton Vasilyev:

"I am engaged in treating diseases gOOD SYSTEM many years. According to statistics, the Ministry of Health cystitis in 60% of cases goes into a chronic form.

Main error - tightening! The earlier begin treatment of cystitis, the better. There is a means that is recommended for self-treatment and prevention of cystitis at home, since many patients do not seek help due to lack of time or shame. This is Ureferon. He is most versatile. There are no synthetic components in it, the action is soft, but tangible after the first day of reception. He removes inflammation, strengthens the walls bladderHis mucous, restores general immunity. It is suitable for both women and men. For men there will be a pleasant bonus - strengthening potency. "

We highlight the four main features of Uroanthisteptic cephalosporine rows:

• pronounced bactericidal properties;
• mathoxicity;
• the possibility of continuous two-week reception;
• low probability of side effects.

Uricticsptics of plant origin

Essential plants will help to get rid of infectious inflammatory processes:

• toloknyanka;
• birch buds;
• corn silk;
• lingonberry;
• calendula;
• smudge
• ortosif.

Such medicinal plants contribute to the removal of viral and bacterial infection. They eliminate stagnant processes in which pathogens are actively developing.

Kanefron.

Composite parts of the plant preparation are such components:

• lovers (rhizomes);
• rosemary (leaves);
• glott breeder (grass).

The multicomponent Uroantispetik has a wide range of therapeutic effects:

• anti-inflammatory;
• antimicrobial;
• spasmolytic.

Can use for a long period of time. Even after the disappearance of clinical symptoms, the drug is accepted within a few weeks to secure the therapeutic effect. A peculiarity of the vegetable uroantispetics is its ability to strengthen the antibacterial effect of antibiotics.

Remedies are produced in the form of dragees and oral solutions. it safe tool Allowed to use pregnant women. Sometimes the canofron causes dyspeptic disorders, as well as allergic reactions. Contraindications include individual intolerance, as well as acute processes of the digestive tract.

Uriassian

This is another vegetable preparation, which includes such elements:

• wild carrots;
• hop cones;
• oregano;
• fir oil;
• peppermint.

It has such an impact on the body:

• antispasmodic action;
• diuretic effect;
• litholithic impact;
• choleretic action.

The tool is produced in various dosage forms: Capsules, solution, syrup. It is important to clearly observe accurate dosages, otherwise dizziness, nausea, vomiting may occur. In this case, the use of adsorbing agents will take.

Phytolizin

The drug is known for its diverse effect on the body, it is due to the presence of grasses and essential oils. Consider the features of therapeutic effects depending on the availability of specific components:

• long husk - antimicrobial effect;
• fire root - Normalization of metabolism;
• bird Highlander - anti-inflammatory effect;
• field Host - Diuretic and Hemostatic Action;
• birch leaves - swelling;
• seeds of the fenugreek - removal of irritation;
• golden - immunostimulation;
• parsley leaves - disinfection.

In addition to the above-mentioned phytolizin, a number of essential oils are included:

• sage;
• mint;
• orange;
• pines.

A drug is produced in the form of a paste, which makes a suspension. For its preparation, the preparation is bred with warm sweetened water. Take phytolysin follows after meals.

The tool is well tolerated by patients, but in rare cases causes allergic reactions and dyspeptic disorders. Contraindicated drug with acute processes in the kidneys, digestive tract, as well as in the presence of allergic reactions. Renal failure is an absolute contraindication to the use of phytolizin.

Scientific tests did not pass on the application in pediatrics, but despite this, he is prescribed by doctors even newborns. It is used at the second stage of therapeutic process after applying antimicrobial means. The dosage for children is usually half a teaspoon.

Conclusion

Urictionptics are medicinal products that act in the fight against the infectious processes of the urinary system. Preparations are used in accordance with the exact prescription of the doctor and manufacturer's recommendations.

Uroantisptics are not used as self-medication. A qualified specialist is engaged in the selection of medicines. If against the background of taking UROANTISEptics, you do not have improvements, and the clinical picture is only aggravated, be sure to consult a doctor.

Each means is distinguished by the dosage and duration of the course of treatment. If you want to reduce the likelihood of complications, examine your body in a timely manner and follow all medical destinations.

Chronic pyelonephritis - inflammatory disease, affecting, above all, chescho-laughter system kidney. It can develop at any age, in men and women can be as an independent disease and complication of other diseases or developmental abnormalities.

According to statistics, up to 20% of the population suffer from this disease, but experts believe that in fact his prevalence is even higher.

What clinical symptoms are typical of chronic pyelonephritis?

In case of chronic pyelonephritis, the inflammatory process is localized in the area of \u200b\u200bthe cups and luggles of the kidneys.

• Pain in the lower back is more often non-intensive, noving, usually asymmetrical. It is noted that the pain often appear on the affected side, but on the opposite. There may be a sense of discomfort, gravity in the lower back, especially when walking or long standing. Patients complain that the waist is frowning, seek warmer to get dressed. Strong or grapple-shaped pains are more typical for urolithiasis. With low or mobile kidney, as well as in children up to 10-12 years old, pain can be localized in the stomach.
• Temperature increase, not higher than 38 s, usually in the evening, without visible reasons.
• , especially at night.
• Raising arterial pressure. During the remission, it may be the only symptom.
• Detergence of well-being, brunce and weakness, more pronounced in the morning, decline in mood, headaches.
• A small swelling of the face, brushes, more in the morning, stop and legs - by the end of the day.

Laboratory signs of chronic pyelonephritis

• Reducing hemoglobin B. general Analysis blood.
• With a three-time study of urine tests, an increased number of leukocytes is detected (no more than 4-6 in the field of view); bacteriuria more than 50-100 thousand microbial bodies in 1 ml.; erythrocytes (especially with urolithiasis,); Sometimes - protein, but not more than 1 g / l, and the cylinders do not happen at all.
• In the Sample Zimnitsky often decreases the proportion (in any portion it does not exceed 1018).
• IN biochemical analysis Blood Common protein within the normal range, can slightly decrease albumin, and when signs of renal failure appear creatinine and urea.

Treatment of pyelonephritis

Liquidation of the causative agent of the disease. For this, antibiotics and solaries are used. Main requirements for drugs: minimal nephrotoxicity and maximum efficiency in relation to the most typical pathogens of infection: E. coli, protea, klebseyella, staphylococcus, and blue stick, etc.

Optimally, before the start of treatment, sowing urine with the definition of sensitivity to antibiotics - then the choice will become more accurate. Most often assigned

• penicillins (amoxicillin, carbenicillin, azlocylin) - with minimal nephrotoxicity, they have a wide range of action;
• cefalosporins 2 and 3 generations are not inferior to the first in efficiency, but the main part of the drugs is intended for injections, therefore are used more often in the hospital, and supraks and cestem are most often used in an outpatient practice;
• fluoroquinolones (Levofloxacin, Ciprofloxacin, Ofloxacin, Norfloxacin) - effective in relation to most infections pathogens urinary tract, non-toxic, but they are forbidden to use in pediatric practice, pregnant and nursing. One of the side effects is photosensitivity, so during the reception it is recommended to refuse to visit a solarium or hikes to the beach;
• sulfonamide drugs (in particular Bispetol) were so often used in our country at the end of the 20th century for the treatment of literally any infections, which now most bacteria are small to them, so it is worth using it if sowing confirmed the sensitivity of the microorganism;
• nitrofurans (Furadonin, Furamag) are still very effective in pyelonephritis. However, sometimes side effects - nausea, bitterness in the mouth, even vomiting - forcing patients to refuse to treat them;
• oxychinolines (5-bed, nitroxoline) - is usually well tolerated, but sensitivity to these drugs, unfortunately, has recently decreased recently.

The duration of treatment during chronic pyelonephritis is at least 14 days, and while maintaining complaints and changes in urine analyzes can last up to a month. It is advisable to change the drugs 1 time in 10 days, repeating urine sowing and taking into account when choosing the next medicine, their results.

Disinfection

If not high pressure and pronounced edema, it is recommended to increase the amount of fluid from up to 3 liters per day. You can drink water, juices, frosts, and when high temperatures and symptoms of intoxication - a regidron or citrotrushosolyan.

Phytotherapy

Most effective tool Phytotherapy in chronic pyelonephritis is a tolokany leaf.

These folk remedies treatment of pyelonephritis is effective as an addition to antibacterial therapyBut do not replace it, and should not be used during the period of exacerbation. Herbal fees should be taken for a long time, monthly courses after the completion of antibacterial treatment or during remission period, for prophylaxis. It is optimal to do it 2-3 times a year, in the autumn-spring period. Undoubtedly, phytotherapy should be abandoned if there is a tendency to allergic reactions, especially polynomy.
Examples of fees:

• Taspberry (sheet) - 3 parts, cornflowers (flowers), licorice (root) - 1 parts. Raw in the ratio of 1 tablespoon on a glass of boiling water, insisted 30 minutes, drink on the tablespoon 3 times a day.
• Birch leaf, corn storks, field hat 1 part, Rosehip fruits 2 parts. A tablespoon of collection to pour 2 glasses of boiling water, to insist half an hour, drinking half a cup 3-4 times a day.

Funds that improve renal blood flow:

• antiagregants (Trental, Kuraltil);
• preparations that improve the venous outflow (Eskusan, Trokevazin) are assigned to courses from 10 to 20 days.

Spa treatment

It makes sense, since the healing effect mineral water Quickly lost when bottling. Truskavets, Zheleznovodsk, Obukhovo, Cook, Karlovy Vary - Which of these (or other) Balneological resorts choose is a question of geographic proximity and financial opportunities.

Website - Medical portal online consultation of children's and adult doctors of all specialties. You can ask a question on the topic "Biseptol with pyelonephritis" And get free online advice of the doctor.

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Questions and Answers: Biseptol with Pyelonephritis

2013-01-24 15:21:06

Olga asks:

Hello, Doctor! I was disturbed by a strong itching, allocation, dryness of mucous membranes, cracks on the mucous membrane outside, once there were even some "loss" near the anus. Cracks passed after Bepanten. There are no venereal diseases, and bacterial sowing showed fecal enterococcus or staphylococcus - I do not have the results of the analysis, and I am abroad. I can not say what an infection was found in exactly the quantity, but the gynecologist said that he would not give me antibiotics, but only the vaginal Ecovag capsules, which I had just finished using and could not say that all the symptoms were gone. Itching it appears, it disappears, a little redness can be seen in a small sexual lip. Tell me, please, the appointment of antibiotics is not always necessary with this infection, depends on the growth indicators of this infection? And whether this infection is transmitted, i.e. Can I infect my partner? How effective is the use of media microflora recovery in the presence of such an infection? Can I take advantage of Biseptol, which I have with me now? And such a question. My doctor said that this infection does not essentially need treatment. But the situation was not clear to me, did not reveal anything, and the discomfort remains. By the way, the problem began after exacerbation chronic pyelonephritis. Uzi showed a stone in the kidney. I then drank the course of antibiotics and drink until now Cyston. What would you advise others to be examined or to continue to use the means to restore microflora, since I did not find anything else? Thanks in advance.

Replies Ostroder Elena Ivanovna:

In your situation, the appointment of antibiotics is not justified. This infection is not transferred to the sexual way. I would like to know how old you have and saved menstrual cycle. Biseptol does not need to drink. But to put the candles for rehanging the vagina, such as fluomesin or hexicone, or candles with polyvidone-iodine (betadine). And then, the candles of the hynoflor (estriol with lactobacteriums). And I advise you to examine the partner on the STI. Be healthy.

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Popular articles on the topic: Biseptol with pyelonephritis

The subject of acute discussions so far is the question of the principles of anti-infliction therapy and its effectiveness in children, patients with pyelonephritis. There is no single point of view in clinical pediatrics on this problem, and often opposite ...

Treatment of pyelonephritis is a long process that should pass under the close observation of the doctor. All drugs that are prescribed with the inflammation of the kidney cup, are aimed at eliminating the pathogen, the restoration of normal urine outflows and have anti-inflammatory activity.

In addition to etiotropic treatment, acting directly to the cause of the disease (antibacterial tablets and injections), with pyelonephritis, drugs acting pathogenetically use: eliminate the factors of the development of the disease and eliminate the symptoms.

Kanefron-N.

Kanefron-H is a powerful revolving preparation. Available in the form of dragee and a solution for receiving inside.

The active ingredient is a water-alcohol extract of plant biocomponents (the root of loving, the gold male, rosemary).

Mechanism of action

If you get inside, Kanefron-H reaches a maximum concentration in the excretory kidney system, where there is a local anti-inflammatory, antimicrobial and antiseptic effect. He removes the spasm of urinary tract due to the soft effect on the smooth muscles of the kidneys. Also, the agent has an easy diuretic effect.

Cysteon is a multicomponent vegetative antiseptic preparation. Produced in the form of tablets.

Active ingredient - plant extracts:

• flowers of the stalk bobbling;
• standing Camery;
• stem garments;
• rhizomes of the film satisfying;
• solomocet seeds;
• onosmo bractor;
• basil scented;
• seeds of horse beans;
• mimosa seeds;
• mountain mummy.

Mechanism of action

Couston, like many other plant preparations, after entering the body, accumulates in kidney tissues. Treatment of pyelonephritis occurs at the expense of local antiseptic effect: Cyston tablets enhance the effect of antibiotics and sanitize a cup of kidney and urinary tract.

5-NOC

5-NOC - a synthetic agent with antibacterial activity. Release form - tablets with a dosage of 50 mg.

The active ingredient is nitroxoline from the group of oxicinolines. Due to the large number of unwanted reactions, the expediency of its purpose is currently considered for the treatment of pyelonephritis.

Mechanism of action

Treatment of urinary diseases is based on antibacterial action of the means: nitroxoline is able to bind to metal-containing microbial catalyst enzymes and block the metabolism in it. This stops the reproduction and pathological activity of bacteria. Like other drugs from the group of oxychinolines, 5-nct are active in relation to both gram-positive and gram-negative microorganisms. With it, it is possible to treat not only kidney inflammation, but also other bacterial infections of the urinary system (cystitis, urethritis, etc.).

Biseptol.

Biseptol is a combined antimicrobial agent, active in relation to the main pathogens of pyelonephritis. Produced form - tablets (120, 480 mg).

The active ingredient is a combination of trimethopril and sulfometoxazole (co-trimoxazole).

Mechanism of action

The active ingredients that are included in the drug, when entering the inside, absorbed into the blood and concentrate in the tissues of the kidneys. Sulfetometoxazole, similar on the structure of the PABK (para-aminobenzoic acid), interferes with the synthesis of dihydro folic acid And prevents the PABK embedding in the causative agent cells. Biseptol is able to treat inflammatory processes even high activity.

Nolysin is a means from a group of fluoroquinolones, which has antibacterial activity. Available in the form of tablets with a dosage of 400 mg medication.

The active ingredient is Norfloxacin.

Mechanism of action

Nolysin concentrates in the kidneys and has a bactericidal effect. The active substance blocks the enzyme DNA gyrase and destabilizes the genetic chain of microorganisms. Currently, fluoroquinolone rows are means of choosing in the therapy of inflammatory diseases of the urinary system. Nolysin and its analogues allow you to get rid of the causative agent of pyelonephritis for 7-10 days.

Furamag.

Furamag is an antimicrobial remedy from the group of nitrofuran. The form of the release of medication - capsules (25, 50 mg).

The active ingredient is Furazidine Potassium.

Mechanism of action

Acting at the kidney level, Furamag suppresses the main biochemical processes in the causative agent cell, which leads to his death. Treatment to the means is actively with respect to the broad group of pathogens (gram-positive, gram-negative, protetes, klebseyella, simplest, mycoplasma, etc.).

Phytolizin is a complex vegetable preparation. Produced in the form of thick paste for intake.

Active substance - extracts:

• golden
• escapes of the Highlander bird;
• fields of Field Horsetail;
• onion husk;
• rhizomy dusty;
• family root;
• parsley;
• as well as a mixture of essential oils (peppermint, sage, orange, pine ordinary).

Mechanism of action

Vegetable preparations, including phytolysin, have a local anti-inflammatory, antiseptic effect. Such additional treatment of pyelonephritis eliminates the symptoms of the disease in 10-14 days from the start of therapy.

Furadonin is a synthetic antimicrobial agent. The release form is a tablet 50 or 100 mg.

The active ingredient is nitrofurantoin.

Mechanism of action

The active ingredient of the drug has a bactericidal effect, destroys the cell wall and contributes to the death of microorganisms.

Furazolidon is a means of antibacterial activity from a group that is classified as preparations with a wide antimicrobial effect. Release form of medicine - Tablets 0.05

The active ingredient is Furazolidon, the drugs of its groups belong to the nitrofuran derivatives.

Mechanism of action

If you get into the body, it is capable of penetrating into all organs and systems. Exported by the kidneys, here also has a basic therapeutic effect. The active ingredients of the drug are able to inhibit some protective enzyme systems of the body and block the reproduction of microbial cells.

The treatment of furazolidone is effective in relation to inflammatory processes in the kidneys and the urinary system caused by bacterial flora (Streptococcus Saprophyticus, Staphylococcus SPP., Escherichia coli, etc.), salmonella, mycoplasmas, klebseyella and some simplest.

But-shp.

But-shpa is a well-known antispasmodic agent. Produced in the form of tablets of 40 mg.

The active ingredient is drootserin hydrochloride, which is derived from isoquinoline.

Mechanism of action

As well as similar antispasmodic drugs, but-SPAP inhibits the phosphodiesterase enzyme, which participates in the energy metabolism of the muscle. Thanks to this, the smooth muscles of the whole organism, including organs urinary system, relaxes.

Attention! Treatment of but-spasp and other muscle relaxants is possible only in the absence of a mechanical barrier, disturbing urine outflow from the kidneys (for example, tumors, prostate adenoma, ureteral stenosis).

Diclofenac - anti-inflammatory agent wide spectrum Applications. The release form is a tablet 25, 50 mg and an injection solution 75 mg / 3 ml.

The active ingredient is diclofenac sodium, from a group of non-steroidal anti-inflammatory funds.

Pyelonephritis action mechanism

The drugs of the NSAID group, including diclofenac, suppress cyclooxygenase is a key enzyme that runs the cascade of response. Due to this, the production of basic inflammation proteins is inhibited - PGA, protoclines, leukotrienes.

Diclofenac treatment is shown in active inflammatory process in kidney tissues, bright clinical picture Diseases I. pronounced symptoms intoxication. The appointment of NSAIDs without etiotropic therapy with antibiotics is not recommended.

Immunotherapy of inflammatory diseases of the kidneys

Inflammation is the response of the body to introduce the pathogen. In order to activate protective forces and treat possible immunodeficiency, immunomodulators are prescribed.

• Viferon - rectal candles, the active component of which is the recombinant human interferon. It has an immunostimulating, antiviral action, possess minimal side effects.
• Genferon is another means based on interferon. The clinical efficacy of the product is to reduce the phenomena of intoxication and accelerate the healing of the inflammatory focus in the kidney tissue, which contributes to rapid recovery.

Pyelonephritis treatment with interferon drugs reduces the course of antibiotic therapy by an average of 7-10 days.

Vegetables for the treatment of pyelonephritis

Phytopreparations that have antiseptic and light diuretic effects are often prescribed as supportive pyelonephritis therapy. The renal collection includes:

• the shoots of the Zverboy;
• toloknyanka;
• rootier parsley;
• a series;
• strawberry leaves;
• lovers;
• violet;
• sage.

Long-term use of the means is possible as anti-edema, solar therapy, but recommended regular control of urine tests (1 time in 3 months).

Analgesic

Anesthetic drugs are prescribed for symptomatic treatment of the disease. Remove pain syndrome (With pyelonephritis, it is more often associated with the spasm of urinary tract) with the help of drugs:

• Ketanov (active component - ketorolac) - NSPIDs with an anesthetic effect, which is produced in the form of tablets 10 mg and a solution for injection 3% 1 ml;
• Analgine (sodium metamizole) - analgesic from the pyrozolone group, produced in the form of tablets 500 mg and a solution of 50% 2 ml.

Vascular drugs

For treatment acute pyelonephritis In the hospital, vascular means are sometimes prescribed. This allows you to improve blood circulation in the vessels of the mycocirculatory bed, and reduce the risk of renal tissue necrosis. Preparations of choice are:

• Trental use intravenously drip: 20 mg / 5 ml of preparation + 400 ml of physical. solution to one introduction.
• Kuraltil (remedy with anti-aggregate action) - 25 mg tablets are available.

Therapy acute inflammation Renal tissue should be carried out in the hospital under the control of the nephron physicianExacerbation chronic form Diseases can be treated at home according to the algorithm compiled by a district doctor.

Pathogenetic I. symptomatic treatment Pyelonephritis, together with antibiotic therapy, ensures a quick sanation of the infection, eliminates the phenomena of inflammation and reduces the risk of developing exacerbations and chronic renal failure.

This article allows you to familiarize yourself with the instructions for use. medicinal preparation Biseptol.. There are reviews of site visitors - consumers of this medicine, as well as the opinions of doctors of specialists in the use of Biseptol in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of Biseptol in the presence of available structural analogues. Use for the treatment of angina, colds, cystitis and other infectious diseases In adults, children, as well as in pregnancy and breastfeeding.

Biseptol. - The combined antibacterial drug contains sulfamethoxazole and trimethopris.

Sulfamethoxazole, similar in structure with PABK, disrupts the synthesis of dihydrofolya acid in bacterial cells, preventing the inclusion of the PABK in its molecule.

Trimethoprium enhances the effect of sulfamethoxazole, disrupting the reduction of dihydrofoliic acid into the tetrahydrofolya - the active form of folic acid responsible for protein exchange and division of the microbial cell.

It is a bactericidal preparation of a wide range of action.

Active with respect to gram-positive aerobic bacteria, gram-negative aerobic bacteria, with respect to gram-positive anaerobov, with respect to the simplest: Plasmodium SPP., TOXOPLASMA GONDII; Pathogenic fungi: Coccidioides Immitis, Histoplasma Capsulatum, Pneumocystis Carinii, Leishmania SPP.

To the drug is stable: Corynebacterium SPP., Pseudomonas Aeruginosa, Mycobacterium Tuberculosis, Treponema SPP., Leptospira SPP., Viruses.

Inhibits the life of the intestinal stick, which leads to a decrease in the synthesis of thiamine, riboflavin, nicotinic acid and other group vitamins in the intestine.

The duration of the therapeutic action is 7 hours.

Pharmacokinetics

After taking the drug inside active substances Quickly and completely absorbed from the gastrointestinal tract. Timetoprix penetrates well in the tissue and biological environment of the body: light, kidneys, prostate, bile, saliva, wet, spinal fluid. The binding of trimethopris with plasma proteins is 50%; Sulfamethoxazole - 66%. The main way of removal - kidney; In this case, trimethopris is excreted in unchanged form to 50%; Sulfamethoxazole - 15-30% in active form.

Indications

Treatment of infectious inflammatory diseases caused by microorganisms sensitive to the drug:

• infection respiratory tract (including bronchitis, pneumonia, abscess light, Empiama pleura);
• otitis, sinusitis;
• infections of the urogenital system (including pyelonephritis, urethritis, salpingitis, prostatitis);
• gonorrhea;
• pCT infection (incl. typhoid fever, paratif bacterial dysentery, cholera, diarrhea);
• infectilation of the skin and soft tissues (including furunculosis, piederma).

Forms of release

Tablets 120 mg and 480 mg.

Suspension or syrup for oral administration.

Concentrate for the preparation of a solution for infusion (injections) Biseptol 480.

Instructions for use and dosage

Install individually. The drug is accepted after eating, drinking with sufficient liquid.

Children aged 3 to 5 years, the drug is prescribed 240 mg (2 tablets of 120 mg) 2 times a day; Children aged from 6 to 12 years old - 480 mg (4 tablets of 120 mg or 1 tablet of 480 mg) 2 times a day.

With pneumonia, the drug is prescribed at the rate of 100 mg of sulfamethoxazole per 1 kg of body weight per day. The interval between receptions is 6 hours, the duration of the reception is 14 days.

Dose the dose of the drug is 2 g (in terms of sulfamethoxazole) 2 times a day with an interval between receptions of 12 hours.

Adults and children over 12 years old are prescribed 960 mg 2 times a day, with long therapy - 480 mg 2 times a day.

The duration of the course of treatment is from 5 to 14 days. With severe disease and / or when chronic infections It is possible to increase the one-time dose by 30-50%.

With the duration of the course of therapy more than 5 days and / or increase the dose of the drug, it is necessary to control the picture of peripheral blood; When appearance pathological changes Foliic acid should be prescribed at a dose of 5-10 mg per day.

Side effect

• headache
• dizziness
• depression
• apathy
• tremor
• bronchospasm
• suffocation
• cough
• nausea, vomiting
• reduced appetite
• diarrhea
• gastritis
• abdominal pain
• stomatitis
• leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia, aplastic and hemolytic anemia, eosinophilia
• polyuria
• interstitial nephritis
• violation of kidney function
• hematuria
• arthralgia
• malgy
• photosensitization
• hives
• drug Fever
• multiform exudative erythema (incl. Stevens-Johnson syndrome)
• increase body temperature
• angioedema swelling
• hyperemia Scler
• hypoglycemia, hypercalemia, hyponatremia.

The drug is usually well tolerated.

Contraindications

• mounted damage to the liver parenchyma;
• pronounced disorders of the kidney function in the absence of the possibility of controlling the concentration of the drug in blood plasma;
• renal failure of severe (QC less than 15 ml / min);
• severe blood diseases (aplastic anemia, B12 deficient anemia, agranulocytosis, leukopenia, megaloblastic anemia, anemia associated with folic acid deficiency);
• hyperbilirubinemia in children;
• deficiency of glucose-6-phosphate dehydrogenase (risk of hemolysis);
• pregnancy;
• lactation;
• children's age up to 3 years (for this dosage form);
• increased sensitivity to the components of the drug;
• increased sensitivity to sulfanimamides.

Application in pregnancy and breastfeeding

Biseptol is contraindicated for use during pregnancy and during lactation (breastfeeding).

special instructions

Caution prescribed the drug with a burdened allergological history.

With a long (more than a month) treatment courses, regular blood tests are needed, since there is a likelihood of hematological changes (most often asymptomatic). These changes can be reversible when prescribing folic acid (3-6 mg per day), which does not significantly violate the antimicrobial activity of the drug. Special caution is necessary in the treatment of elderly patients or patients with suspicion of the original lack of folates. The purpose of folic acid is also suitable with long-term treatment with a drug in high doses.

It is also impractical on the background of treating food productscontaining a large number of PABK - green parts of plants ( cauliflower, spinach, legumes), carrots, tomatoes.

Excessive solar and UV irradiation should be avoided.

The risk of side effects is significantly higher in patients with AIDS.

Timetoprix can change the results of determining the level of methotrexate in serum conducted by the enzymatic method, but does not affect the result when choosing a radioimmunological method.

Medicinal interaction

With the simultaneous use of bispetol with thiazide diuretics, there is a risk of thrombocytopenia and bleeding (the combination is not recommended).

Co-trimoxazole increases the anticoagulant activity of indirect anticoagulants, as well as the effect of hypoglycemic drugs and methotrexate.

Co-trimoxazole reduces the intensity of the hepatic metabolism of phenytoin (increases itst1 / 2 by 39%) and warfarin, reinforcing their action.

With the simultaneous use of pyrimetamine in doses exceeding 25 mg / weeks, increases the risk of developing megaloblastic anemia.

With the simultaneous use of diuretics (more often, thiazida) increase the risk of thrombocytopenia.

Benzocaine, procaine, procainamide (like other drugs, as a result of the hydrolysis of which PABK is formed) reduce the effectiveness of bispetol.

Between diuretics (including with thiazidami, furosemide) and oral hypoglycemic drugs (sulfonylurea derivatives) on the one hand, and antibacterial means of a group of sulfonamide - on the other hand, the development of a cross-allergic reaction is possible.

Phenytoin, barbiturates, Pasca enhance the manifestations of folic acid deficiency while simultaneously use with bispetol.

Derivatives salicylic acid Enhance the effect of bispetol.

Ascorbic acid, hexamethyleneteremin (like other drugs whining the urine) increase the risk of crystalluria's development against the background of the use of bispetol.

Kolistramin reduces absorption while taking effect with other drugs, so it should be taken after 1 hour after or 4-6 hours before receiving co-trimoxazole.

With simultaneous use with drugs, inhibiting bone marrowing, increases the risk of myelosuppression.

In some cases, Biseptol can increase the concentration of digoxin in the blood plasma in elderly patients.

Biseptol can reduce the effectiveness of tricyclic antidepressants.

In patients after kidney transplantation, with the simultaneous use of co-trimoxazole and cyclosporine, there is a passing disruption of the transplanted kidney function, manifested by an increase in serum creatinine concentrations, which is probably caused by trimethopril.

Reduces the effectiveness of oral contraception (inhibits the intestinal microflora and reduces the intestinal and hepatic circulation of hormonal means).

Analogs of the drug Biseptol

Structural analogues for the acting substance:

• Bactrim;
• Bactrim Forte;
• Berlocide 240;
• Berlocide 480;
• Bi-septin;
• Biseptol 480;
• Briffideptol;
• Grosptol;
• Twispetol;
• Duo-septol;
• Co-trimoxazole;
• Co-trimoxazol-acry;
• Co-trimoxazole-rivofarm;
• Co-trimoxazole-sie;
• Kotrifarm 480;
• Metosulfabol;
• Orifim;
• Halfcptol;
• Septrine;
• Syneursul;
• Sulling;
• SMETROLIM;
• Trimepsol.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.