In this article you can find instructions for use medicinal product Diara. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Diara in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogues of Diara in the presence of existing structural analogues. Use for the treatment of diarrhea or diarrhea of infectious or functional origin in adults, children, as well as during pregnancy and lactation. Composition of the drug.
Diara- antidiarrheal drug. Loperamide (the active ingredient of the drug Diara), by binding to opioid receptors of the intestinal wall (modulation of cholinergic and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and prostaglandins). Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes retention feces and reducing the urge to defecate.
The action occurs quickly and lasts for 4-6 hours.
Compound
Loperamide hydrochloride + excipients.
Pharmacokinetics
Loperamide hydrochloride is almost completely metabolized by the liver by conjugation. It is excreted primarily in bile and urine in the form of conjugated metabolites.
Indications
Symptomatic treatment acute and chronic diarrhea:
- allergic, emotional, medicinal, radiation origin;
- when changing the diet and quality of food, when metabolism and absorption are impaired;
- as an adjuvant for diarrhea of infectious origin.
Regulation of bowel movements in patients with ileostomy.
Release forms
Chewable tablets 2 mg.
Capsules 2 mg.
There are no other dosage forms, be it drops or oral solution.
Instructions for use and dosage regimen
The drug should be taken orally with water.
For acute and chronic diarrhea, adults are prescribed an initial dose of 4 mg (2 tablets or 2 capsules), then 2 mg (1 tablet or 1 capsule) after each act of defecation in case of loose stool. Maximum daily dose- 16 mg (8 tablets or 8 capsules).
Children over 6 years of age are prescribed 2 mg (1 tablet or 1 capsule) after each bowel movement in case of loose stools. The maximum daily dose is 6 mg (3 tablets or 3 capsules).
If stool normalizes or there is no stool for more than 12 hours, treatment with Diara should be discontinued.
Side effect
- gastralgia;
- dry mouth;
- intestinal colic;
- nausea, vomiting;
- constipation;
- intestinal obstruction;
- drowsiness;
- dizziness;
- skin rash.
Contraindications
- diverticulosis;
- intestinal obstruction;
- ulcerative colitis in the acute phase;
- diarrhea due to acute pseudomembranous enterocolitis;
- monotherapy for dysentery and other gastrointestinal infections;
- 1st trimester of pregnancy;
- lactation period;
- children under 6 years of age;
- increased sensitivity to the components of the drug.
Use during pregnancy and breastfeeding
The use of Diara is contraindicated in the 1st trimester of pregnancy and during breastfeeding.
Use in children
Contraindicated in children under 6 years of age.
Children over 6 years of age with acute diarrhea prescribed in an initial dose of 2 mg (1 tablet), then 2 mg (1 tablet) after each act of defecation in case of loose stools. The maximum daily dose is 6 mg (3 tablets).
special instructions
If no clinical improvement is observed in acute diarrhea within 48 hours or constipation, bloating, or partial intestinal obstruction develops, Diara should be discontinued.
For chronic diarrhea, loperamide can only be taken as prescribed by a doctor.
Loperamide should be used with caution in children younger age due to greater sensitivity to the opiate-like effects of loperamide - the effect on the central nervous system. During the treatment of diarrhea (especially in children), it is necessary to replace the loss of fluid and electrolytes. Dehydration may contribute to altered response to loperamide.
Use with caution in elderly patients (may mask symptoms of dehydration and variability in response to loperamide).
In patients with liver dysfunction, careful monitoring for signs of toxic damage to the central nervous system is necessary (loperamide metabolism slows down).
In patients with traveler's diarrhea, the decrease in intestinal motility caused by Diara can lead to a prolonged increase in temperature due to slower excretion of microorganisms (Shigella, Salmonella, some strains of Escherichia coli, etc.) and their penetration into the intestinal mucosa.
Impact on the ability to drive vehicles and operate machinery
During the treatment period, you must be careful when driving a car or operating equipment.
Drug interactions
Concomitant use of loperamide with opioid analgesics may increase the risk of severe constipation.
Analogues of the drug Diara
Structural analogues according to active substance:
- Diarol;
- Imodium;
- Imodium Express;
- Laremid;
- Lopedium;
- Loperacap;
- Loperamide;
- Loperamide hydrochloride;
- Superilop;
- Enterobene.
Analogs by pharmacological group (antidiarrheals):
- Bactisporin;
- Hydrasec;
- Diarex Himalaya;
- Diarol;
- Diosmectite;
- Imodium;
- Imodium plus;
- Kaopectate;
- Laremid;
- Lopedium;
- Loperacap;
- Loperamide;
- Mirofuril;
- Neointestopan;
- Neosmectin;
- Nifuroxazide;
- Probifor;
- Racecadotril;
- Smecta;
- Dioctahedral smectite;
- Sporobacterin;
- Stopdiar;
- Superilop;
- Tannacomp;
- Uzara;
- Flonivin BS;
- Ecofuril;
- Elufor;
- Endosorb;
- Enterobene;
- Enterol;
- Enterofuril;
- Entoban;
- Entophyte Diaro;
- Ersefuril.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
Registration number: LS-000845-300518
Tradename: Diara®
International generic name(INN): Loperamide
Dosage form: chewable tablets
Compound:
1 chewable tablet contains:
Active ingredient: loperamide hydrochloride - 2 mg;
Excipients: polymethylsiloxane, potato starch, lactose monohydrate, sugar (sucrose), microcrystalline cellulose, colloidal silicon dioxide (Aerosil), aspartame, povidone (Kollidon 90), xylitol, lactitol, Kollidon SR [polyvinyl acetate, povidone K-30, sodium lauryl sulfate , silicon dioxide], menthol, magnesium stearate, anise oil.
Description: round flat-cylindrical tablets of white or white with a yellowish tint, with a chamfer and a score, with a characteristic odor. Light marbling is allowed.
Pharmacotherapeutic group: Antidiarrheal agent.
ATH CODE:
Pharmacological properties:
Pharmacodynamics:
Loperamide, by binding to opioid receptors of the intestinal wall (modulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and Pg). Slows down peristalsis and increases the transit time of intestinal contents, increases the tone of the anal sphincter, helps retain feces and reduce the urge to defecate.
The action occurs quickly and lasts 4-6 hours.
Pharmacokinetics:
Almost completely metabolized by the liver by conjugation. T1/2 (half-life) - 9-14 hours. Excreted mainly with bile and kidneys (in the form of conjugated metabolites).
Indications for use:
Symptomatic treatment of acute and chronic diarrhea of various origins (allergic, emotional, drug, radiation; with changes in diet and quality food composition, with metabolic and absorption disorders; how aid with diarrhea of infectious origin).
Regulation of bowel movements in patients with ileostomy.
Contraindications:
Hypersensitivity to the drug, diverticulosis, intestinal obstruction, ulcerative colitis in the acute stage, diarrhea against the background of acute pseudomembranous enterocolitis, as monotherapy - dysentery and other infections gastrointestinal tract; pregnancy (first trimester), lactation period, childhood (up to 6 years).
Carefully: liver failure.
Use during pregnancy and breastfeeding
Use during pregnancy
There is no evidence that loperamide has teratogenic or embryotoxic effects.
During the first trimester of pregnancy, taking the drug is contraindicated.
During the II-III trimesters of pregnancy, the use of the drug is possible if the expected benefit of therapy for the mother outweighs the potential risk for the fetus.
Use during breastfeeding
Small amounts of loperamide may penetrate into breast milk Therefore, the drug is not recommended to be taken during breastfeeding.
Directions for use and dosage:
Inside, chewing. For adults with acute and chronic diarrhea, the initial dose is 2 tablets (4 mg); then - 1 tablet (2 mg) after each act of defecation (in the case of loose stools); the maximum daily dose is 8 tablets (16 mg).
For children over 6 years of age with acute diarrhea, an initial dose of 1 tablet (2 mg) is prescribed, then 1 tablet after each act of defecation (in the case of loose stools); the maximum daily dose is 3 tablets (6 mg).
If stool normalizes or there is no stool for more than 12 hours, treatment with the drug should be discontinued.
Side effect:
Gastralgia, dry mouth, allergic reactions (skin rash), drowsiness, dizziness, intestinal colic, nausea, vomiting, constipation. Extremely rare - intestinal obstruction.
Overdose of the drug:
Symptoms: depression of the central nervous system(CNS) (stupor, impaired coordination of movements, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.
Treatment: antidote - naloxone; Given that the duration of action of loperamide is longer than that of naloxone, repeated administration of the latter is possible. Symptomatic treatment: Activated carbon, gastric lavage, artificial pulmonary ventilation (ALV). Medical supervision is required for at least 48 hours.
Special instructions:
If there is no effect within 48 hours, you should stop using the drug and consult a doctor.
Impact on the ability to drive vehicles and machinery
During treatment with the drug, care should be taken when administering vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Obolenskoe Pharmaceutical Enterprise, JSCCountry of origin
RussiaProduct group
Digestive tract and metabolismAntidiarrheal symptomatic drug
Release forms
- 10 pieces. - contour cellular packaging (1) - cardboard packs. 4 - contour cell packaging (2) - cardboard packs. 4 - contour cell packaging (3) - cardboard packs.
Description of the dosage form
- Chewable tablets
pharmachologic effect
Antidiarrheal symptomatic drug. Loperamide, by binding to opioid receptors of the intestinal wall (modulation of cholinergic and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and prostaglandins). Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes fecal retention and reduces the urge to defecate. The action occurs quickly and lasts for 4-6 hours.Pharmacokinetics
After oral administration, the absorption of loperamide is about 40%, and undergoes intensive metabolism during the “first pass” through the liver. A small amount of unchanged loperamide enters the systemic circulation. Does not penetrate the BBB. Metabolized in the liver. T1/2 is 9-14 hours. It is excreted through bile with feces in the form of conjugated metabolites, a small part is excreted in the urine.Special conditions
Use with caution in case of liver failure. Should not be used in clinical situations where inhibition of intestinal motility is required. If there is no effect after 2 days of using loperamide, it is necessary to clarify the diagnosis and exclude the infectious origin of diarrhea. Use with caution in patients with impaired liver function. In case of an overdose of loperamide, naloxone is used as an antidote.Compound
- 1 caps. loperamide hydrochloride 2 mg loperamide hydrochloride 2 mg Excipients: polymethylsiloxane, potato starch, lactose, microcrystalline cellulose, colloidal silicon dioxide (Aerosil), aspartame, povidone (Kollidon 90), xylitol, lactitol, Kollidon SR, menthol, magnesium stearate, anise oil .
Diara indications for use
- Symptomatic treatment of acute and chronic diarrhea of various origins (including allergic, emotional, medicinal, radiation; with changes in diet and quality of food, with metabolic and absorption disorders; as an adjuvant for diarrhea of infectious origin). Regulation of bowel movements in patients with ileostomy.
Diara contraindications
- - diverticulosis; - intestinal obstruction; - ulcerative colitis in the acute phase; - diarrhea due to acute pseudomembranous enterocolitis; - monotherapy for dysentery and other gastrointestinal infections; - I trimester of pregnancy; - lactation period; - children under 6 years of age; - hypersensitivity to the components of the drug. The drug should be used with caution in case of liver failure.
Diara dosage
Diara side effects
- From the outside digestive system: gastralgia, dry mouth, intestinal colic, nausea, vomiting, constipation; very rarely - intestinal obstruction. from the central nervous system: drowsiness, dizziness Allergic reactions: skin rash.
Drug interactions
It is believed that when used concomitantly, cholestyramine may reduce the effectiveness of loperamide. When used simultaneously with co-trimoxazole and ritonavir, the bioavailability of loperamide increases, which is due to inhibition of its metabolism during the “first pass” through the liver. In case of an overdose of loperamide, naloxone is used as an antidote.Overdose
depression of the central nervous system (stupor, loss of coordination of movements, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.Storage conditions
- keep away from children
Eating poor quality food, alcohol, taking antibiotics, and gastrointestinal diseases often cause indigestion. The antidiarrheal drug Diara allows you to get rid of unpleasant symptoms and significantly alleviate the patient’s condition, which should be used according to the instructions for use. What are the main ingredients present in the composition, and are there any contraindications to the use of the medication?
What is it produced in and what does it consist of?
Diara is a product of the Russian pharmaceutical company JSC Pharmaceutical Enterprise Obolenskoye. It is available in capsule and tablet form:
- Diara in capsules contains a white-yellowish powder and is sold in 10 pieces. packaged.
- Diara in chewable tablets has an aniseed odor and is sold in blister pharmaceutical packages of 4, 12, 14, 18, 30 pcs.
The active ingredient is loperamide hydrochloride, 2 mg per tablet/capsule. Also includes:
- Polyvenyl acetate and povidone.
- Microcellulose.
- Laktik.
- Magnesium stearate.
- Starch flour.
- Xylitol.
- L-Aspartyl-L-phenylalanine.
- Aerosil.
- Anise essential oil.
- Polymethylsiloxane polyhydrate.
- Menthol.
The medication Diara does not have any other form of release (injections in injection ampoules, solution, syrup, suspension).
Pharmacodynamics
Loperamide hydrochloride, by binding to certain gastrointestinal tract receptors responsible for pain perception, inhibits the release of pain mediators and fluid secretion, due to which:
- The tone of the smooth muscle fibers of the intestine decreases.
- The wave-like contraction of the walls of the stomach and intestines slows down, as a result of which the time period for the movement of intestinal contents increases.
- The tone of the anorectal valve increases, which significantly reduces the frequency of bowel movements.
The action begins after an hour and lasts for 4-6 hours.
Pharmacokinetics
Active and additional ingredients are metabolized by the liver, binding to endogenous substances, and eliminated naturally.
When is it prescribed?
Diara capsules/tablets are used for acute and chronic diarrhea of various origins:
- Appearing as a result of emotional attacks.
- Occurring after radiation therapy.
- Beginning as a result of allergic food intolerance.
- Medicinal, which is provoked by taking certain drugs.
The pharmaceutical product Diara is used for diarrhea that occurs due to a change in diet, intake of low-quality food, and impaired metabolism.
In addition, chewable tablets and capsules of Diara are actively used for infectious diarrhea, but as an additional treatment. They also regulate stool during ileostomy.
Directions for use and dosage
Before using the antidiarrheal drug Diara, you should carefully read the instructions for use or consult a specialist. The medicine is taken orally without chewing, washed down with plain water.
- Adult patients with acute and chronic diarrhea are prescribed two tablets/capsules. Then it is recommended to take one piece after each attack of diarrhea. The maximum allowed drink is 8 pieces/day.
- Diara is allowed for use by children over 6 years of age, and is prescribed one piece after each attack of diarrhea. You can drink a maximum of 3 pieces/day. During treatment, it is necessary to rehydrate, replenishing fluid volumes lost by the body.
The establishment of normal stool or its long-term absence (about 12 hours) requires discontinuation of chewable tablets or capsules.
Pregnant and lactating
Antidiarrheal symptomatic remedy Diara is not recommended for use during the period of bearing a child up to 12 weeks of pregnancy, when all the internal organs and systems of the fetus are formed. In the future, if necessary, treatment is permitted under the supervision of a specialist if the expected benefit to the mother outweighs the possible danger to the unborn child.
The piperidine derivative (loperamide) is considered an opioid substance and is capable of partially penetrating the systemic circulation. Therefore, taking the drug during lactation is prohibited. If others safe means are not available, breastfeeding is interrupted during treatment by expressing and discarding milk.
Contraindications
There is a certain list of contraindications:
- Hypersensitivity to the components of the drug.
- Diarrhea resulting from the development of acute pseudomembranous colitis.
- Inflammation of the mucous membrane of the large intestine in acute form.
- Formation of diverticula on the intestinal walls.
- Infectious diarrhea, dysentery and other gastrointestinal infections as basic treatment.
- Children under 6 years of age (other medications are suitable for children).
For liver pathologies, the drug is recommended to be taken with extreme caution. Patients need constant laboratory monitoring in order to promptly identify symptoms of possible central nervous system intoxication.
special instructions
For Diara capsules/tablets, instructions must be included with each package. When taking the drug, you need to take into account that the medicine begins to act quickly. If a positive effect is not observed within 48 hours, stop taking the drug and seek medical advice.
- Concomitant treatment with cholestyramine may reduce the therapeutic value of the antidiarrheal drug.
- Tandem with Co-trimoxazole enhances its bioavailability due to slow metabolism in the liver.
- Concomitant use of Diara with opioid analgesics may cause constipation.
Since Diara is a symptomatic antidiarrheal agent, it cannot be used as the only drug for bacteriological diarrhea. The specialist must examine the patient, find out whether there have been attacks of abdominal pain, whether there was blood in the stool, or whether there was a significant increase in body temperature. The presence of such symptoms indicates the development of acute dysentery or another intestinal infection. For example, diarrhea and vomiting are a kind of defense of the body, which tries to eliminate pathogens on its own. In such cases it is prescribed laboratory diagnostics and appropriate treatment.
In older people, loperamide hydrochloride may obscure the clinical symptoms of dehydration, so they are advised to use the medicine with extreme caution.
Side effects
During therapy, the following undesirable effects may develop:
- Sensation preceding vomiting.
- Vomiting.
- Intestinal colic.
- Dry mouth.
- Attacks of dizziness.
- Difficulty with bowel movements.
- Pain in the stomach area.
- Allergic manifestations (itching, skin rash).
Overdose
When using Diara in excessive quantities, symptoms may develop that indicate depression of the nervous system:
- Impaired coordination of movements.
- Miosis (constriction of the pupils).
- Muscle spasticity.
- Malfunctions of the respiratory system.
- Lethargy.
- Apathy.
- Silence.
- Intestinal obstruction.
- Antidote Naloxone.
- Emergency gastric lavage procedures.
- Enterosorbents.
- Strict medical supervision.
The effect of Diara lasts longer than the effect of the antidote, so its secondary administration is possible.
Similar drugs
The pharmaceutical market is rich in various antidiarrheal medications. The drug Diara has analogues that are similar in structure and action.
Structural analogues are:
- Imodium Express– indicated for the development of diarrhea of non-infectious origin.
- Lopedium– not used for dysentery and other infections affecting the gastrointestinal tract, in the first trimester of pregnancy and during lactation.
- Laremid– a medication that inhibits physiological contractions of the intestine.
- Diarol. An antidiarrheal drug to be taken for diarrhea.
- Enterobene. Prescribed after each act of defecation. Failure to comply with recommended doses and the occurrence of an overdose requires urgent administration of the antagonist and medical supervision for at least two to three days.
Drugs belonging to a similar pharmacological group:
- Bactisporin. Indicated when intestinal infections, dysbacteriosis, bacterial vaginosis.
- Kaopectate. Prescribed to adults for acute and chronic diarrhea. It is an antidiarrheal, gastroprotective, adsorbent agent based on attapulgite.
- Mirofuril. Based on nifuroxazide. This antimicrobial agent, used for acute bacterial diarrhea that occurs without deterioration in general condition.
- Neosmectin. Powder for preparing a suspension based on diosmectite. Used as an adsorbent and antidiarrheal agent.
- Eluflor. An antimicrobial medication used for bacterial diarrhea that occurs without fever and sudden deterioration of the condition.
At negative reaction You can use similar drugs for loperamide, but only after consulting your doctor.
Storage conditions
The anti-diarrhea drug Diara is over-the-counter. It can be purchased freely in online pharmacies. Tablets/capsules should be stored in a dry place at a temperature of no more than 25 C. So that the medicine does not cause negative consequences, when purchasing, you must pay attention to the expiration date indicated on the packaging. Basically it does not exceed three years.
Diarrhea may strike at the wrong time. But its symptoms can be suppressed with the help of special antidiarrheal medications. The effect occurs almost immediately after their use. One such remedy is Diara. Let's find out how the drug affects the body and in what cases it should be used.
How the drug works
Diara (Latin name - Diara) is a drug belonging to the group of antidiarrheal drugs. The active component included in its composition reduces the tone of smooth muscles internal organs and intestinal motility. As a result, its peristalsis is inhibited, which helps slow down the movement of feces. As a result, the patient is not bothered by the frequent urge to defecate. The effect of using the drug occurs within a few minutes, and it lasts from 4 to 6 hours.
Composition and release forms
Diara is available in the form of enteric-coated capsules and chewable tablets.
Each capsule contains 2 mg of loperamide, the main substance of the drug. List of auxiliary components for this dosage form:
- corn starch.
The capsule body is painted gray, and its lid is green. Inside the capsule there is a white powdery substance (sometimes with a yellow tint).
Capsules deliver better active substance into the intestines, since their contents are protected from the aggressive environment of the stomach by the membrane
Each tablet contains 2 mg of loperamide. It also includes:
- anise oil;
- silicone oil;
- thickener aerosil;
- sweetener E951;
- povidone;
- potato starch;
- sucrose;
- lactose;
- pentanpentaol;
- alcohol derived from lactose;
- magnesium salt of stearic acid;
- Kollidon SR;
- microcrystalline cellulose;
- menthol.
White or yellowish Diara tablets have a flat-cylindrical shape and smell of anise oil.
Why is the drug prescribed?
Indications for use of Diara are:
- infectious diarrhea (in combination with other drugs);
- sharp or chronic forms non-infectious nature;
- metabolic disorders and absorption processes in the intestines (due to poor quality nutrition or changes in diet).
Diara is also prescribed to regulate stool in patients after ileostomy - surgery to bring the opening of the ileum out through abdominal wall for removal of feces and gases. The product can be used to treat diarrhea in children over 6 years of age and women in the second and third trimester of pregnancy.
Contraindications
Diara should not be taken if the patient has the following diseases or conditions:
- children's age (up to 6 years);
- first 3 months of pregnancy;
- lactation period;
- monotreatment of gastrointestinal tract infections;
- intestinal obstruction;
- diverticulosis (protrusion of the walls) of the colon;
- colitis of ulcerative type in the acute phase;
- individual hypersensitivity to the composition of the product.
You cannot treat diarrhea with Diara if the stool disorder is caused by pseudomembranous inflammation of the colon and small intestine in the acute phase.
special instructions
Most of the loperamide contained in Diara is excreted from the body in bile. Therefore, people suffering from liver failure should be careful when using this device.
You can use Diara without a doctor's instructions for sudden onset diarrhea. But if the drug does not help within two days after taking the first dose, you should consult a doctor.
Treatment with drugs based on loperamide is accompanied by suppression of the central nervous system and a slowdown in mental reactions. Therefore, patients taking Diara should exercise caution during potentially dangerous species work and driving.
When taking opioid analgesics (Morphine, Codeine, Promedol) simultaneously, persistent constipation develops.
How to take Diara correctly for adults and children - instructions
Diara should be taken after each trip to the toilet, regardless of meals. The rules for taking the drug are the same for both children and adults. Capsules must be swallowed whole, and tablets must be chewed thoroughly. Both dosage forms You need to drink plenty of water (1 glass is enough).
IN childhood It is best to use tablets, as they are easier to take if the child does not know how to swallow capsules.
If the stool has returned to normal or has not been present for 12 hours or more, treatment with the drug is stopped.
Possible side effects
During treatment with Diara, the following adverse reactions may occur:
- dry mouth;
- stomach pain;
- skin rashes of an allergic nature;
- lethargy and drowsiness;
- dizziness;
- paroxysmal pain in the intestines (colic);
- constipation;
- nausea and vomiting.
In very rare cases, taking Diara causes patients to develop intestinal obstruction.
Overdose
With excessive use of Diara, signs of overdose develop:
- intestinal obstruction;
- depressed breathing;
- hypertonicity of muscle tissue;
- constriction of the pupils;
- impaired coordination of movements;
- stupor and drowsiness.
If the symptoms described above occur, seek medical attention medical care. Treatment of an overdose of loperamide is based on the administration of an antidote (naloxone), a substance that blocks the effect of the drug. Since the effect of naloxone wears off faster than the effect of taking Diara, the patient is given it twice.
In case of overdose, gastric lavage and taking adsorbents (activated carbon, Polysorb, Smecta, Povidone) are also prescribed. If respiratory depression occurs, the patient is connected to a ventilator (artificial pulmonary ventilation) and left under observation for 2 days.
Prices for the drug and conditions for dispensing from pharmacies
Approximate cost of Diara depending on the form of release:
- capsules (10 pcs.) - about 35 rubles;
- tablets (12 pcs.) - from 90 rubles.
Diara refers to medicines dispensed without a doctor's prescription.
What can be replaced
Diara has many analogues in active component- loperamide. They all have the same indications and contraindications, as well as side properties. But they are released different countries and pharmaceutical companies. Therefore, their prices vary greatly.
Table: brief overview of Diara analogues based on active ingredient
Photo gallery: analogues of Diara based on the active component
Loperamide-Acri is produced by the Russian pharmaceutical company Akrikhin. 
Loperamide Shtad is produced by the Russian company "NIZHFARM" 
Loperamide tablets are produced by the Russian company Ozon. 
Imodium - English analogue of Diara 
Lopedium is produced by the Swiss company Sandoz.
