The drug Claritin occupies a stable position in the line of drugs. Why? Today it is widespread among adults and, which is especially unfortunate, among children. It is not possible to remove the cause of the phenomenon today, because the most common allergens are food products, house dust, animal hair. Therefore, the efforts of pharmaceutical company developers are aimed at creating drugs that can most effectively combat the symptoms of the disease and minimally harm the body.
Today there are 3 generations of antiallergic drugs. The most in demand are 2nd and 3rd generation drugs. Therefore, the question of what antihistamines are, including Claritin, instructions for use, price of the drug, the benefits and harms of using such drugs are quite natural.
One of the most common drugs in this series is Claritin - instructions for use, which contains detailed information about its properties. According to the information contained in this document, the drug is effective and does not have many side effects.
Claritin reviews are positive from approximately 80% of patients who took the drug and expressed their opinion. The price of Claritin, which is about 200 rubles, scares off some allergy sufferers precisely because of its cost. This is one of the main points negative reviews for the drug. Although there is still a certain percentage of patients who note in their reviews that the product is ineffective.
What kind of drug is Claritin?
Claritin - the instructions for this drug classify it as a 2nd or 3rd generation antihistamine. The medical community has not yet agreed on the criteria for classifying drugs that combat allergy symptoms into these two categories. And there are at least three points of view. According to one of them, this is a 2nd generation drug, according to others, it is a 3rd generation drug.
Claritin's active ingredient, loradatin, has a selective blocking effect on histamine receptors (H1). The effect occurs quickly; the active substance does not penetrate the blood-brain barrier, so there is no inhibitory effect on the nervous system.
It means that medicine in the correct dosage does not cause drowsiness and does not inhibit psychomotor processes. During a course of allergy therapy, this drug does not cause changes in the ECG, in particular the QT interval, does not significantly affect the sinus node of the heart and its functional state. Due to its selectivity on H1 receptors, it has virtually no effect on H2 receptors and does not slow down the uptake of norepinephrine.
The instructions for use included in the box of Claritin medicine indicate that the drug begins to have a noticeable effect half an hour after taking the tablet. The maximum effect occurs 12 hours after administration. The effect wears off after 24 hours. After long-term use of the drug, no significant functional disorders in the functioning of organs and systems of the human body were identified. Release form of the drug: Claritin syrup and Claritin tablets - the price for both types of the drug is from 160 to 300 rubles. The syrup is more expensive, it costs about 250 to 300 rubles.
Claritin: instructions for use (official)
In what cases will the drug help?
What is Claritin for? In what cases can his help become invaluable? Most often, the drug is used for seasonal or year-round allergic reactions, manifested in the form of rhinitis (hay fever). For frequent sneezing, swelling of the mucous membrane of the nasal passages, which is accompanied by itching, discharge of mucous contents in large quantities, and nasal congestion, this drug is prescribed.
Allergic conjunctivitis, accompanied by lacrimation, conjunctival hyperemia, itching, containing complex therapy is also an indication for use for Claritin. Decrease skin manifestations Allergies are also possible with this remedy. What else can Claritin help with?
In the case of autoimmune processes that manifest themselves as skin rashes, with idiopathic (unexplained etiology) urticaria. In all of the above cases. Claritin tablets or syrup (if we are talking about a patient childhood) is able to eliminate or reduce the manifestations of an excessive reaction of the patient’s immune system, which significantly reduces his quality of life.
Features of the use of antihistamine
I release the drug in two dosage forms Oh. In the form of tablets and in the form of syrup. Both forms can be prescribed to both children and adults. But usually the syrup is offered for use by children, and the tablet preparation is offered to adults.
Use of tablets
The difference between these two forms is not great. It is more convenient to offer the syrup to the child. He is unlikely to want to swallow the tablet, and crushing the drug is not very convenient. For the drug Claritin, the instructions for using the tablets are very simple: the drug is taken only once a day. The dose is 10 mg - this is equivalent to 1 tablet. At this dose, the drug is prescribed to adults at any age (including elderly allergy sufferers) and to children after they reach 12 years of age.
No dose adjustment is required for people with severe kidney disease (including kidney failure). Claritin for children - instructions for use are not much different from those for adults. The dose of the drug is subject to correction. This remedy is allowed to be prescribed to children from 3 years of age. It is prescribed depending on the body weight of the small patient:
- up to 30 kg - half a tablet;
- from 30 kg – one tablet.
For Claritin tablets, the instructions for use require prescribing the drug to patients with serious liver dysfunction (adults and children weighing over 30 kg) no more than 10 mg once every two days. If the patient's body weight is less than 30 kg, take half a tablet once every two days.
Use of the drug in syrup
The dosage of the drug, regardless of the form of the drug, remains identical. Claritin syrup instructions for use are as simple as the tablet version of the drug. Adults need to take a standard dose of 10 mg of the drug (2 tsp) per day, 1 time. Claritin syrup is approved by the instructions for use for children from the moment the child is 2 years old. From this age and up to 12 years, it is required to dose the drug in the same way as tablets based on weight indicators:
- up to 30 kg - 1 tsp. once a day;
- from 30 kg – 2 tsp. once a day.
Restrictions on use
Claritin instructions for use for children prohibit prescribing the drug in the presence of lactase deficiency and galactose intolerance. This also applies to adults. Reliable information about the effect of the active substance Claritin on fetal development on this moment no, therefore Claritin is prescribed with caution during pregnancy if the doctor believes that the benefit that the mother will receive from using the drug significantly exceeds possible harm for the fetus.
During breastfeeding, if you need to take this antihistamine, the baby is removed from feeding, since the drug is actively excreted in mother's milk. The drug is not prescribed to children under 2 years of age in the form of syrup, and up to 3 years of age in the form of tablets.
Side effects and overdose
The instructions for use available for Claritin warn that, like any substance, loratadite or the components of the shell can cause allergies, including anaphylaxis. May cause headaches and dizziness, indigestion, sleep disturbances, etc. But all these manifestations are observed very rarely.
You should not use the drug in a dose exceeding that specified in the instructions, as an overdose is possible. The main symptoms of receiving an excessive dose are practically the same as the side effects observed when taking the drug (headache, pain, rapid heartbeat, drowsiness). Can Claritin be replaced with another drug?
Drugs with similar effects
Allergy tablets cost about 150-600 rubles, syrups are more expensive. Claritin can be replaced with a drug with another active ingredient, but it also has complete analogues. For Claritin, analogues are the following drugs:
- Loratadine;
- Tevazh;
- Claridol;
- Clarisens;
- Clarotadine.
Of the products listed above, Claritin is far from the cheapest - the price of cheap analogues ranges from 52 (Clarotadin) to 91 rubles (Claridol) approximately. You can't find any cheap antihistamines.
H1-histamine receptor blockers also include drugs based on cetirizine:
- Cetrin;
- Letizen;
- Cetirizine DS.
The cost of these drugs ranges from 51 to 204 rubles, the effect is approximately the same as that of loratadine derivatives. One of the most famous and time-tested histamine H1 receptor blockers is Diazolin; the drug costs about 55 rubles.
Here is a brief description of what Claritin is, instructions for use, price, reviews, analogues of this product. Methods of its use, expected results and possible side effects.
Video: Allergies and how to treat them yourself
Claritin- antihistamine, selective H1 receptor blocker. Active substance drug - loratadine, a tricyclic compound. After taking 10 mg (one dose) or several doses of the drug, based on histamine skin tests, it was found that a pronounced antihistamine effect develops after 1-3 hours and reaches a peak value in the range of 8 to 12 hours from the onset of action. The antihistamine effect continues throughout the day. There was no development of resistance even when taking the drug for 28 days. When studying the effect of the drug on the duration of the QT interval during an electrocardiographic study Claritin used at a dose 4 times higher than the average therapeutic dosage of the drug for 90 days. However, no clinically significant increase in the interval on the ECG was recorded.
Metabolized by hepatocytes using the enzyme CYPZA4 to desloratadine. To a lesser extent, the CYP2D6 isoenzyme takes part in the metabolism of the substance. Eliminated in bile and urine. The half-life of loratadine is 3 to 20 hours (approximately 8.4 hours). The half-life of the desloratadine metabolite is from 8 to 92 hours (on average 28 hours).
Indications for use
. For seasonal (as well as year-round) rhinitis of allergic origin to relieve signs of the disease (itching of the nasal mucosa, sneezing, rhinorrhea, itching and burning in the eyes);. allergic skin diseases, including urticaria (including for children from 2 years of age).
Mode of application
The recommended dose of the drug for children over 12 years of age, elderly and adult patients is 1 tablet (10 mg) once a day (for syrup - 2 teaspoons).Recommended dosage Claritina for children 2-12 years old - 5 ml of syrup (1 teaspoon) or half a tablet (5 mg) provided their body weight does not exceed 30 kg. For weights exceeding 30 kg, it is recommended adult dosage Claritina(syrup or tablets).
If hepatic or renal function is impaired, starting dosage Claritina should be 1 tablet or 10 ml of syrup (10 mg) every other day (with creatinine clearance less than 30 ml/min).
Side effects
Frequency below side effects when taking Claritin did not differ from that when taking placebo.Digestive system (reported in adults): nausea, dry mouth, gastritis; in rare cases - hepatitis.
The immune system(reported in adults): anaphylactic reactions (rare) and rash.
Central nervous system: increased fatigue, headache, drowsiness (in adults); sedative effect, nervousness, headache (in children, rarely).
Skin reactions: isolated cases of alopecia have been identified in adults.
Contraindications
. Intolerance to loratadine or other ingredients Claritina;. period breastfeeding;
. age up to 2 years.
Pregnancy
Prescribed for pregnant women only when absolutely necessary. IN experimental studies no teratogenic effect on the fetus was detected. The active substance of Claritin and its metabolite (descarboethoxyloratadine) pass into breast milk easily, and the concentration of these substances is breast milk is at the plasma level. Therefore, when prescribing the drug to lactating women, breastfeeding must be stopped.Interaction with other drugs
Combination with cimetidine, ketoconazole and erythromycin causes an increase in plasma concentrations of loratadine. However, this does not lead to clinically significant changes in electrocardiography.Overdose
Increased heart rate, headaches, drowsiness in adult patients. Similar symptoms developed only when the dosage was significantly exceeded Claritina(40-180 mg versus recommended 10 mg). When children weighing up to 30 kg took a dosage greater than 10 mg, extrapyramidal disorders and tachycardia developed. Gastric lavage is used to remove Claritin from the gastrointestinal tract. isotonic solution sodium chloride, adsorbents are prescribed. Treatment - supportive and symptomatic therapy. It is not eliminated from the body by hemodialysis. There is no information about the possibility of peritoneal dialysis.Release form
Claritin tabletsTablets of 10 mg, packaged in 7; 10 or 30 pieces (blister pack). The tablets are white or almost white, marked with the number “10” on one side and the manufacturer’s trademark (flask and bowl) on the other, and have a score on one side.
Claritin syrup
Syrup in dark glass bottles of 60 or 120 ml. The kit includes a dosage spoon with markings. Yellowish or colorless syrup without foreign impurities.
Storage conditions
The shelf life of the syrup is 3 years; tablets - 4 years. Store at a temperature of 2-30°C. Claritin approved for sale without a prescription.Synonyms
Vero-Loratadine, Lomilan, Lotharen, Clallergin, Clarisens, Claridol, Loratadine-Hemofarm, Clarifarm, Loratadine-Verte, Clarotadine, Clarifer, Clarfast, Loragexal, Loratadine, Alerpriv, Clargotil, Erolin.Compound
Claritin tabletsActive ingredient (in 1 tablet): loratadine (10 mg).
Excipients: lactose, corn starch, magnesium stearate.
Claritin syrup
Active ingredient (in 5 ml of syrup): loratadine (5 mg).
Excipients: glycerol, propylene glycol, sodium benzoate, lemon acid, granulated sucrose, artificial flavor (peach), water.
Additionally
To avoid distorting the results of skin tests, they are carried out no later than 2 days after the last dose of the drug. There was no increase in the effect of alcohol when taken simultaneously with Claritin.Main settings
| Name: | CLARITIN |
| ATX code: | R06AX13 - |
Nonproprietary name: loratadine
Registered proprietary names of medicines: Alavert, Claritin, Claritin Reditab, Clear-Atadine, Dimetap, Allergy Relief, QlearQuil All Day and Night, Tavist, Wal-itin
What is Claritin?
Claritin (loratadine) is an antihistamine that reduces the effect of inherent histamine in the body. Histamine can cause sneezing, itching, watery eyes and a runny nose.
Claritin is used to treat sneezing, runny nose, epiphora, allergic rashes, skin rashes, skin itching, and other cold or allergy symptoms.
Claritin is also used to treat hives and itching in people with chronic skin reactions.
Important information
Strictly follow the instructions for use of the drug indicated in the insert and on the packaging. Tell each of your healthcare providers about all your illnesses, allergies, and any medications you take.
Claritin Reditab lozenges may contain phenylalanine.
Talk to your doctor before using this type of Claritin if you have phenylketonuria (PKU).
Ask your doctor or pharmacist before using this drug if you have liver or kidney disease.
Before taking this drug
You are not allowed to be treated medical drug Claritin if you are allergic to loratadine or desloratadine (Clarinex).
Ask your doctor or pharmacist if it is safe for you to use this medicine if you have any of the following:
- suffocation;
- kidney disease; or
- liver disease.
Claritin will not harm an unborn baby. Tell your doctor if you are pregnant or planning to become pregnant.
Loratadine can pass into human milk and may harm the baby. Tell your doctor if you are breastfeeding.
Do not give this drug to a child younger than 6 years old without doctor's advice.
How should I take Claritin?
Use Claritin exactly as directed on the label or as directed by your doctor. Do not use the drug in larger or smaller quantities or for longer than recommended.
Cold or allergy medications are usually taken for a short time until your symptoms go away.
Do not give this medicine to a child younger than 2 years old. Always ask your doctor before giving your child cough or cold medicine. Death may occur if cough or cold medicines are abused by very young children.
Claritin is usually taken once a day. Follow your doctor's directions.
Do not crush, chew, or break the regular tablet. Swallow the tablet whole.
Measure liquid medication using a dosing syringe or a special dosing spoon or medicine cup. If you do not have a dose measuring device, ask your doctor for one.
The chewable tablet must be chewed before swallowing.
Use of tablets that disintegrate in the mouth (Claritin RediTab, Alavert):
Keep the tablet in the blister until you are ready to use the medication. Open the package and open the foil. Do not squeeze the tablet through the foil or you may damage the tablet.
Use dry hands to remove the tablet and place it in your mouth.
Do not swallow the tablet whole. Let it dissolve in your mouth without chewing. If desired, you can drink water to help you swallow the dissolved tablet.
Call your doctor if your symptoms do not improve or if your health condition worsens.
The medicine should be stored at room temperature, away from dampness and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the dose you forgot to take if it is almost time for your next scheduled dose. Do not take several tablets of the medicine at a time to make up for missed doses.
What happens in case of a drug overdose?
Call emergency medical assistance.
Symptoms of overdose may include headache, drowsiness, and fast or pounding heartbeat.
What should I avoid while taking Claritin?
Follow your doctor's instructions about any dietary, drinking, or activity restrictions.
Claritin side effects
Seek emergency medical care if you have signs of an allergic reaction to Claritin: allergic rash; dyspnea; swelling of the tongue, throat, face or lips.
Stop using Claritin and call your doctor immediately if you experience the following symptoms:
- fast or uneven heart rate;
- severe headache; or
- dizziness, as if you are going to faint;
Common side effects from taking Claritin may include:
- headache;
- feeling tired or drowsy;
- abdominal pain, vomiting;
- dry mouth; or
- feeling nervous or hyperactive.
Not shown here full list side effects that may happen. Ask your doctor about possible side effects.
Claritin dosage information
Usual Adult Dose of Claritin for Allergic Rhinitis:
10 mg orally once daily
Usual Adult Dose for Urticaria:
10 mg orally once daily
Usual Pediatric Dose for Allergic Rhinitis:
Usual Pediatric Dose for Urticaria:
2 to 5 years: 5 mg orally once daily (syrup)
6 years and older: 10 mg orally once daily (tablets, gelatin capsule, and lozenges)
Medicines that affect medicinal effect Claritin
Other drugs may interact with loratadine, including prescription and over-the-counter drugs, vitamins, and foods plant origin. Do not hesitate to tell all your doctors about all the medications you are currently taking and any medications you are planning to start or have recently stopped taking.
Claritin Side Effects
For the buyer
Loratadine dosage forms: oral combination tablets, oral disintegrating tablets, oral solution, oral tablets
Side effects include:
Children aged 2-5 years receiving oral solution: Diarrhea, epistaxis, pharyngitis, flu-like symptoms, fatigue, stomatitis, dental dysfunction, ear pain, viral infection, rash.
Children aged 6-12 years receiving oral solution: Nervousness, wheezing, fatigue, hyperkinesis, abdominal pain, conjunctivitis, dysphonia, upper respiratory tract infection.
Adults and children ≥12 years of age receiving regular or disintegrating tablets: Headache, drowsiness, fatigue, dry mouth.
Combination drug loratadine (active ingredient in Claritin) pseudoephedrine sulfate drugs: Insomnia, dry mouth, headache, doubtfulness, increased excitability, dizziness, fatigue.
For professional doctors
Dosage forms of the drug loratadine: oral capsule, oral syrup, tablet for oral administration, chewable oral tablets, disintegrating oral tablets
General
The most commonly reported side effects included headache, drowsiness, irritability, and fatigue.
Nervous system
Very common (10% of cases or more often): Headache (up to 12%)
Common (1% to 10% of cases): Sedation/doubtfulness
Very rare (less than 0.01%): Dizziness, convulsions
Frequency not reported: Syncope, paresthesia
Psychiatric
Common (1% to 10% of cases): Nervousness
Rare (0.1% to 1%): Insomnia
Frequency not reported: Depression, nightmares
Other
Common (1% to 10% of cases): Fatigue
Frequency not reported: Fever, viral infection, tinnitus, malaise
Gastrointestinal
Common (1% to 10% of cases): Dry mouth
Very rare (less than 0.01%): Nausea, gastritis
Incidence not reported: Dyspepsia, diarrhea, constipation, abdominal/stomach pain, altered taste, increased salivation
Metabolic
Rare (0.1% to 1%): Increased appetite
Dermatological
Very rare (less than 0.01%): Angioedema, rash, baldness
Frequency not reported: Itching, rash on face
Genitourinary
Frequency not reported: Increased frequency of urination, discoloration of urine, delayed menstruation
Cardiovascular
Very rare (less than 0.01%): Tachycardia, rapid pulsation
Frequency not reported: High blood pressure, arterial hypotension, chest pain
Increased sensitivity
Very rare (less than 0.01%): Allergic reactions, anaphylaxis
Hepatic
Very rare (less than 0.01%): pathological condition liver
Respiratory
Frequency not reported: Epistaxis, nasal dryness, pharyngitis, cough
Musculoskeletal
Frequency not reported: Myalgia
Pharmacodynamics. Claritin is an antihistamine, a selective blocker of peripheral H1-histamine receptors. Clinical studies have shown that improvement in the condition of most patients began within the first 30 minutes of using Claritin. The antiallergic effect develops during the first 30 minutes after taking the drug, reaches a maximum within 8-12 hours and lasts 24 hours. Loratadine and its metabolites do not penetrate the BBB. Claritin does not affect the central nervous system, does not exhibit anticholinergic or sedative effects, and does not affect the speed of psychomotor reactions. When conducting clinical trial, in which Claritin was used for 90 days at a dose that was 4 times higher than the therapeutic dose, a clinically significant prolongation of the interval Q-T was not detected on the ECG.
Pharmacokinetics. Claritin is rapidly absorbed into the gastrointestinal tract. The time to reach the maximum concentration of loratadine in the blood plasma is 1-1.3 hours, and the time to reach the maximum concentration of the main metabolite, desloratadine, is approximately 2.5 hours. Eating increases the time to reach the maximum concentration of loratadine and desloratadine by 1 hour. The maximum concentration of loratadine and desloratadine is not affected by food intake. The maximum concentration increases in elderly patients, patients with chronic renal failure or alcoholic liver damage.
In almost all cases, the level of influence of metabolites is higher than the level of influence of the parent substance. Determinable concentrations appear in the blood plasma within 15 minutes after taking the drug orally. A comparative study of the use of Claritin syrup and tablets in adequate doses showed that the plasma concentration profile of desloratadine for both dosage forms is comparable.
When researching in vitro human liver microsomes, it was revealed that loratadine is metabolized into desloratadine mainly under the influence of cytochrome P450 3A4 (CYP 3A4) and to a lesser extent cytochrome P450 2D6 (CYP 3D6). The half-life is 8.4 hours for loratadine, 28 hours for its metabolites. About 27% of the administered dose is excreted in the urine during the first 24 hours. In the presence of ketoconazole, a CYP3A4 inhibitor, loratadine is converted to desloratadine primarily by CYP3D6. The half-life increases with alcoholic liver damage and does not change in the presence of chronic renal failure.
The pharmacokinetics of Claritin in children aged 1-2 years when prescribed a single dose of 2.5 mg does not differ from those in adults and older children.
Indications for use of the drug Claritin
Seasonal (polynosis) and year-round allergic rhinitis and allergic conjunctivitis- elimination of symptoms associated with these diseases: sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching of the eyes, lacrimation. Chronic idiopathic urticaria. Skin diseases of allergic origin.
Use of the drug Claritin
Pills
Adults and children ≥12 years old - 10 mg (1 tablet) 1 time per day;
children aged 2-12 years with a body weight of 30 kg - 10 mg (1 tablet) 1 time per day, with a body weight ≤30 kg - 5 mg (1/2 t tablet) 1 time per day;
children aged 1-2 years - 2.5 mg (1/4 t tablet) Claritin 1 time per day.
Syrup
Adults and children aged ≥12 years - 10 mg (2 scoops - 10 ml syrup) 1 time per day;
children aged 2-12 years with body weight ≥30 kg - 10 mg (2 measuring spoons - 10 ml of syrup) 1 time per day, ≤30 kg - 5 mg (1 measuring spoon - 5 ml of syrup) 1 time per day;
children aged 1-2 years - 2.5 mg (1/2 measuring spoon - 2.5 ml of syrup) 1 time per day.
Contraindications to the use of the drug Claritin
Hypersensitivity (or idiosyncrasy) to any of the components of the drug.
Side effects of the drug Claritin
The incidence of side effects with Claritin is approximately the same as with placebo. The following were noted side effects such as fatigue, headache, drowsiness, dry mouth, gastrointestinal disorders (nausea, gastritis), allergic rash. During the studies, isolated cases of alopecia, anaphylaxis, liver dysfunction, tachycardia and palpitations were observed.
Special instructions for the use of Claritin
Claritin does not have a clinically significant sedative effect when used in recommended doses (10 mg once daily). Claritin does not potentiate the effects of alcohol. At recommended doses does not affect the ability to drive vehicles or work with complex mechanisms.
Claritin should be discontinued at least 48 hours before skin diagnostic allergy tests are performed to prevent false results.
For patients with severe liver dysfunction, the initial dose should be reduced due to possible reduction clearance of loratadine (an initial dose of 5 mg once daily or 10 mg every other day is recommended).
Use in children. The effectiveness and safety of Claritin in children under 1 year of age have not been proven. It should be noted that the pharmacokinetics of Claritin in children aged 1-2 years when prescribed a single dose of 2.5 mg does not differ from the pharmacokinetics of adults and older children.
Use during pregnancy and lactation. The safety of using the drug during pregnancy has not been established, therefore Claritin should be used only if the benefits of its use for the mother outweigh the potential risk to the fetus. Since loratadine is excreted in breast milk, a choice must be made between taking the drug and breastfeeding.
Drug interactions Claritin
When loratadine was taken simultaneously with ketoconazole, erythromycin, cimetidine, an increase in the concentration of loratadine in the blood plasma was noted, but this increase did not manifest itself clinically, including according to ECG data.
Claritin overdose, symptoms and treatment
In case of overdose, drowsiness, tachycardia and headache may occur. With a single dose of 160 mg, no side effects were noted (including ECG changes). In case of overdose, symptomatic and supportive treatment is recommended. Standard measures are recommended to remove unabsorbed drug from the stomach: gastric lavage, taking activated carbon. Loratadine is not eliminated by hemodialysis. After rendering emergency care the patient must remain under medical supervision.
Storage conditions for the drug Claritin
In a dry place at a temperature not exceeding 25 °C.
List of pharmacies where you can buy Claritin:
- Saint Petersburg
Name: Claritine
Release form:
— Claritin tablets. Tablets of 10 mg, packaged in 7; 10 or 30 pieces (blister pack). The tablets are white or almost white, marked with the number “10” on one side and the manufacturer’s trademark (flask and bowl) on the other, and have a score on one side.
— Claritin syrup. Syrup in dark glass bottles of 60 or 120 ml. The kit includes a dosage spoon with markings. Yellowish or colorless syrup without foreign impurities.
pharmachologic effect
Claritin is an antihistamine, a selective H1 receptor blocker. The active ingredient of the drug is loratadine (a tricyclic compound). After taking 10 mg (one dose) or several doses of the drug, based on histamine skin tests, it was found that a pronounced antihistamine effect develops after 1-3 hours and reaches a peak value in the range of 8 to 12 hours from the onset of action. The antihistamine effect continues throughout the day. There was no development of resistance even when taking the drug for 28 days.
When studying the effect of the drug on the duration of the QT interval during an electrocardiographic study, Claritin was used at a dose 4 times higher than the average therapeutic dosage of the drug for 90 days. However, no clinically significant increase in the interval on the ECG was recorded.
Metabolized by hepatocytes using the enzyme CYPZA4 to desloratadine. To a lesser extent, the CYP2D6 isoenzyme takes part in the metabolism of the substance. Eliminated in bile and urine. The half-life of loratadine is 3 to 20 hours (approximately 8.4 hours). The half-life of the desloratadine metabolite ranges from 8 to 92 hours (average 28 hours).
Indications for use
- for seasonal (as well as year-round) allergic origin to relieve signs of the disease (itching of the nasal mucosa, sneezing, rhinorrhea, itching and burning in the eyes);
- allergic skin diseases, including urticaria (including for children over 2 years of age);
- for: insect bites, snake bites, etc.
Contraindications
- intolerance to loratadine or other ingredients of Claritin;
- period of breastfeeding;
- age up to 2 years.
Pregnancy
Prescribed for pregnant women only when absolutely necessary. Experimental studies have not revealed a teratogenic effect on the fetus.
The active substance of Claritin and its metabolite (descarboethoxyloratadine) pass into breast milk easily, and the concentration of these substances in breast milk is at the plasma level. Therefore, when prescribing the drug to lactating women, breastfeeding must be stopped.
Mode of application
The drug is prescribed orally, regardless of food intake.
For adults(including elderly patients) and adolescents over the age of 12 years, it is recommended to take Claritin at a dose of 10 mg (1 tablet or 2 teaspoons /10 ml/ syrup) 1 time / day.
Children aged 2 to 12 years The dose of Claritin is recommended to be prescribed depending on body weight: for body weight less than 30 kg - 5 mg (½ tablet or 1 teaspoon /5 ml/ syrup) 1 time / day, for body weight 30 kg or more - 10 mg (1 tablet or 2 teaspoons /10 ml/ syrup) 1 time/day.
For adults and children weighing more than 30 kg with severe liver dysfunction, the initial dose is 10 mg (1 tablet or 2 teaspoons /10 ml/ syrup) every other day, with a body weight of 30 kg or less - 5 mg (1 teaspoon /5 ml/ syrup) every other day.
In elderly patients and in patients with chronic renal failure no dose adjustment is required.
Side effects
The incidence of the following side effects when taking Claritin did not differ from that when taking placebo.
Digestive system (reported in adults): , dry mouth, ; in rare cases – .
Immune system (reported in adults): anaphylactic reactions (rare) and rash.
Central nervous system: increased fatigue, drowsiness (in adults); sedative effect, nervousness.
Skin reactions: isolated cases of alopecia have been identified in adults.
Overdose
Increased heart rate, headaches, drowsiness in adult patients. Similar symptoms developed only when the dosage of Claritin was significantly exceeded (40-180 mg versus the recommended 10 mg).
When children weighing up to 30 kg took a dosage greater than 10 mg, extrapyramidal disorders and tachycardia developed.
To remove Claritin from the gastrointestinal tract, gastric lavage is used with isotonic sodium chloride solution, and adsorbents are prescribed.
Treatment is supportive and symptomatic therapy. It is not eliminated from the body by hemodialysis. There is no information about the possibility of peritoneal dialysis.
Interaction of Claritin with other drugs
Combination with cimetidine, ketoconazole and erythromycin causes an increase in plasma concentrations of loratadine. However, this does not lead to clinically significant changes in electrocardiography.
Storage conditions
The shelf life of the syrup is 3 years; tablets – 4 years. Store at a temperature of 2-30°C. Claritin is approved for sale without a prescription.
Synonyms
" ", "Vero-Loratadine", "Loratadine-Hemofarm", "Loratadine-Verte", "Lomilan", "Lotaren", "Clallergin", "Clarisens", "Claridol", "Clarifarm", "Clarotadine", " Klarifer", "Klarfast", "Loragexal", "Alerpriv", "Klargotil", "Erolin".
Compound
Claritin tablets:
Active ingredient (in 1 tablet): loratadine (10 mg).
Excipients: lactose, corn starch, magnesium stearate.
Claritin syrup:
Active ingredient (in 5 ml of syrup): loratadine (5 mg).
Excipients: glycerol, propylene glycol, sodium benzoate, citric acid, granulated sucrose, artificial flavor (peach), water.
Additionally
To avoid distorting the results of skin tests, they are carried out no later than 2 days after the last dose of the drug. There was no increase in the effect of alcohol when taken simultaneously with Claritin.
The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate. Before you start using Claritine, you should consult your doctor. *Dobro-est.com is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
