Papaverine suppositories. Papaverine - an effective and inexpensive antispasmodic Papaverine rectal suppositories instructions for use

Papaverine suppositories are prescribed not only to relieve discomfort in various forms of hemorrhoids, but also to eliminate uterine hypertonicity during pregnancy, as well as to normalize blood pressure.

It is important to consider a number of contraindications to the use of the medication in order to avoid the development of complications.

Composition and effect of Papaverine for hemorrhoids

Papaverine hydrochloride (an opium alkaloid) eliminates spasms that occur in the lower abdomen. The active substance weakens the contractions of muscle fibers in the intestinal walls, which helps eliminate painful sensations in the anorectal area.

Pharmacological properties

Pharmacodynamics

The drug reduces the severity of angina pectoris.

In surgery, Papaverine suppositories are used for drug preparation body to anesthesia.

Pharmacokinetics

After insertion into the rectum, the suppository melts. The active component of the drug is quickly absorbed from the intestines and enters the systemic circulation. Papaverine is excreted from the body by the kidneys in the form of intermediate metabolic products (metabolites).

Why are Papaverine suppositories prescribed?

The drug is indicated for use:

To relieve excessive tension in the bladder muscles due to cystitis.
For inflammation of the gallbladder.
For bronchitis to prevent swelling of the mucous membrane.
To eliminate discomfort during prostatitis.
In order to increase potency. The active component of the product increases blood circulation in the pelvic organs.
For headaches.
To relieve pain during menstruation.
In order to dilate blood vessels and improve blood circulation, which helps lower blood pressure (hypotensive effect).

Is it possible to take Papaverine suppositories for hemorrhoids?

Chronic

The medication is not used as a means to prevent hemorrhoids. But suppositories are often used to relieve intestinal hypertonicity, which can cause constipation.

Solid feces damage the rectal mucosa, provoking an exacerbation of the pathology. Therefore, Papaverine in this case will help normalize stool.

During exacerbation

Application of Papaverine suppositories

It is important to follow the instructions for use of the product to achieve the maximum possible therapeutic effect.

Where are papaverine candles placed?

How to insert

It is necessary to take a lying position on your side, bending your knees towards your body. Smoothly and without sudden movements insert the candle into the anus.

How long to lie down after insertion

How many times a day

You can use the drug no more than 4 times a day.

How many days to put

The course of treatment with Papaverine is about 2 weeks.

Contraindications to the use of papaverine suppositories

The drug cannot be used:

Side effects

The following undesirable reactions of the body are possible:

gagging;
drowsiness;
arterial hypotension;
hyperhidrosis ( increased sweating);
upset stool (diarrhea);
liver dysfunction.

Overdose

It is necessary to purify the blood in case of overdose.

special instructions

It is important to consider that:

compatibility of alcohol and Papaverine is negative;
Smoking is prohibited while using the product, because the effectiveness of the therapeutic effect of the drug decreases;
It is undesirable to use the drug for people whose activities involve high concentration of attention.

Use in childhood

From 10 years of age it is allowed to use 1 suppository twice a day. Papaverine is contraindicated for newborns. Treatment of infants with the drug is carried out from 6 months under the strict supervision of a doctor.

There are no children's suppositories with papaverine.

During pregnancy and lactation

It is important to consider a number of such features:

on early stages(in the 1st trimester) Papaverine is prescribed simultaneously with Duphaston in order to maintain pregnancy;
in the 2nd trimester (20 weeks) suppositories are used in case of constipation and nagging pain in the lower abdomen;
in the later stages (at 40 weeks), the drug is prescribed to soften the cervix before childbirth;
When breastfeeding, the use of suppositories is contraindicated.

After embryo transfer during IVF, women are also often prescribed Papaverine as a pain reliever.

Drug interactions

Papaverine suppositories can be combined with No-shpa and Platyffilin to achieve the maximum possible antispasmodic effect.

Analogues

For bloating, constipation and intestinal colic, you can use Riabal. And in case of illness genitourinary system, which are accompanied by spasms of the smooth muscles of the organs, it is recommended to use Spasmolysin.

Terms and conditions of storage

It is necessary to limit the access of young children to the drug. The product should be used within 2 years.

Conditions for dispensing from pharmacies

No doctor's prescription required.

How much are

The price of Nizhpharm suppositories is 25 rubles.

Papaverine is an effective antispasmodic that is widely used in medical practice for various diseases. Papaverine suppositories are used for pathologies accompanied by spasm of the smooth muscles of hollow organs, for example, cholecystitis, renal colic, spastic colitis, bronchospasm, endarteritis, migraines and many other diseases. When administered rectally, the drug is quickly absorbed and active ingredients enter the bloodstream. The therapeutic effect occurs quite quickly.

Compound

Papaverine is available in several dosage forms. These are tablets, injection solution and rectal suppositories. Many experts claim that Papaverine suppositories are the safest form of release. One suppository contains 20 mg of the active ingredient – papaverine hydrochloride.

Properties of the drug

Papaverine hydrochloride suppositories, after administration into the rectum, affect the smooth muscles of the bronchi, lungs, large and small intestines, stomach, and uterus. However, the effect of the drug does not apply to the muscles of the skeleton and heart. After the product enters the body, these muscles work as usual.

Properties of the drug:

elimination of smooth muscle tone in various pathologies;
lowering blood pressure, dilating blood vessels;
increased blood flow in all internal organs;
normalization of heart rate;
providing a sedative effect.

During childbirth, women are prescribed Papaverine suppositories to relieve cervical hypertonicity. Many people are interested in how to administer the drug vaginally or rectally? Papaverine suppositories are inserted into the patient's anus.

Indications

What is the medicine used for? Papaverine suppositories are used for many diseases that are accompanied by pain. The drug is widely used in gynecology, urology, and surgery.

Main indications:

all types and stages of hemorrhoids;
headaches caused by vasospasm;
pain syndrome in various diseases digestive system;
renal colic;
pathology urinary tract– pyelonephritis, cystitis, urolithiasis disease, urethritis;
bronchitis, pneumonia;
pain in women during menstruation.

Papaverine helps relieve spasms in various diseases

Papaverine suppositories have a positive effect on the gastrointestinal tract during constipation and help normalize stool. The drug effectively fights migraines. For bronchitis, the medicine relieves spasm from the bronchi and helps prevent swelling of the mucous membrane.

Mechanism of action

The therapeutic effect of Papaverine suppositories is ensured by suppressing the phosphodiesterase enzyme. Thanks to this, it is possible to relieve muscle spasms and relax muscle fibers. The medicine has an effect on the human genitourinary, digestive, and hepatobiliary systems, and also relieves vasospasm. The active component papaverine hydrochloride increases the lumen of blood vessels, thereby normalizing systemic blood pressure. After administration of the drug, its active component quickly penetrates the bloodstream. Papaverine hydrochloride is evenly distributed throughout the body, affecting the central nervous system.

Important! During use during pregnancy, the drug can penetrate the placenta to the fetus and enter milk during breastfeeding.

Contraindications

The instructions for use include a number of contraindications that must be taken into account when using the medicine. These include:

presence of allergies to the components of the drug;
increased intraocular pressure in glaucoma and other diseases;
liver failure, accompanied by severe course;
blockade of the heart muscle;
old age of the patient;
children's age up to 12 years.

Papaverine is prescribed by a doctor who must study the patient’s medical history and exclude all possible contraindications.

How to light candles

Where to insert Papaverine and how often can it be done? Suppositories should be used only as prescribed by a doctor. Typically, adults are administered 20 - 40 mg of the drug 2-3 times throughout the day. Sometimes a specialist may adjust the dosage depending on the diagnosis. Considering the question of how long the drug takes to act, it should be noted that on average the effect occurs after 30 – 40 minutes. Sometimes you have to wait longer for results. It depends on the characteristics of the disease and individual qualities body.

The suppository should be administered according to the instructions.

With uterine hypertonicity

Increased uterine tone threatens premature birth. Papaverine suppositories help relieve spasms and relax smooth muscles. According to the doctor’s recommendation, a woman is given 2–3 suppositories throughout the day to tone the uterus. It is advisable for every pregnant woman to have home medicine cabinet This is a medicine, because when a spasm occurs, this drug will become an emergency aid. The drug should be used carefully during treatment with other vaginal and rectal suppositories.

Sometimes the medicine is used among women in labor during false labor. During this period, the woman experiences pain in the uterus and lower back, but this condition is only a harbinger of an imminent birth. To make a woman feel better, suppositories can be prescribed.

Treatment of prostatitis

For prostatitis, Papaverine helps eliminate pain and unpleasant pulling sensations. During the period of exacerbation, 1-2 suppositories are inserted into the anus. three times a day. Before starting treatment, it is important to make sure that you are not allergic to any of the components of the product.

Papaverine for hemorrhoids

How to place Papaverine suppositories for hemorrhoids? As with other diseases, suppositories are used rectally. The dosage for a particular patient is selected by the doctor, taking into account the characteristics of the course of the disease, the type and stage of the disease. Typically the dosage of medication is varicose veins veins in the anal area is 1 - 2 suppositories three times throughout the day. The duration of therapy depends on the achieved therapeutic effect.

Use of Papaverine among children

Papaverine for children is used under the strict supervision of the attending physician. The instructions for use say that the medicine is prescribed to children over the age of 12, but in some cases a specialist may prescribe the medicine to a child under this age.

The drug should be used with caution among children

Possible side effects

Negative phenomena associated with the use of suppositories are extremely rare. This is evidenced by numerous positive reviews from patients and doctors who have tested the drug in practice. Sometimes during treatment with the product, minor itching and irritation occurs in the anal area. If the dose is greatly exceeded, the patient may experience the following complications:

heart rhythm disturbance;
dizziness;
apathy and drowsiness;
difficulty urinating and defecating;
nausea, less often vomiting.

Treatment of the complications described above consists of blood purification and symptomatic treatment of the patient.

Important! If alarming signs develop during therapy with Papaverine, you should stop taking the drug and immediately visit a doctor.

Combination with other medications

With the simultaneous use of Papaverine with antihypertensive drugs, the effect of the latter is enhanced. The antispasmodic effect of papaverine hydrochloride increases when taking barbiturates. The hypotensive effect of the drug increases when administered simultaneously with drugs such as tricyclic antidepressants, Quinidine, Procainamide, Reserpine.

special instructions

When starting treatment with the drug, you should carefully study the instructions for use. It includes several special instructions which must be observed. These include:

the medicine should be used with extreme caution in severe renal failure;
During treatment with suppositories, it is important to stop drinking alcohol;
During pregnancy and lactation, suppositories are used under the strict supervision of a doctor. To date, there is not enough information about the safety of using the drug during this period;
the active component of the drug can have a relaxing effect on the central nervous system, therefore, among people whose work activity requires increased concentration, the drug is used carefully.

In addition, if the patient is taking any other medications, be sure to inform the doctor.

Before starting treatment, it is important to read the instructions for the drug

Analogues of the drug

How to replace Papaverine suppositories? Among the analogues of the drug, the following drugs can be distinguished:

No-Shpa is a medicine that is used for diseases associated with spasm of the smooth muscles of internal organs and blood vessels, as well as for the treatment of periodic pain;
Spazmolysin suppositories - inserted into the anus when pain syndrome occurring against the background of diseases of the gastrointestinal tract and other organs, with cholecystitis, pancreatitis, cystitis and other pathologies;
Spascuprel - used to relax the smooth muscles of internal organs in diseases of the stomach, intestines, pancreas, kidneys and other organs;
Theophedrine ІС – used for bronchial asthma, obstructive bronchitis to eliminate bronchospasm and ease the patient’s breathing;
GastroComfort is an antispasmodic and carminative drug that is prescribed to patients with diseases of the digestive system;
Niaspam - used for irritable bowel syndrome, renal and hepatic colic, and other pathologies of the digestive system.

You should take any of the analogues only after examination by a doctor.

Self-medication often causes serious negative consequences.

Terms of sale and storage

Papaverine suppositories are available from pharmacies with a doctor's prescription. It is recommended to store the medicine in a place where sunlight does not penetrate. Shelf life is 3 years, provided that the recommendations for storing the drug are followed. After this period, the product cannot be used.

The medicine has a mild hypotensive, analgesic effect and is prescribed for adults and children.

Composition of the drug

The composition of Papaverine tablets includes: medicinal substance as papaverine hydrochloride. Each tablet contains 10 mg of the active ingredient and excipients (stearic acid, talc, sugar, potato starch).

Release form

Tablets are one of the forms of release of Papaverine. In addition, the drug is produced in the form rectal suppositories and ampoules with solution for injection. Suppositories and injections have the same effect as the remedy oral administration. Tablets are produced in 10 pieces in one blister, placed in a cardboard package. Each package contains instructions for using Papaverine tablets, from which you can find out detailed information about the medication.

pharmachologic effect

Let's look at what Papaverine tablets are used for and what effect the drug has on the body. For adults and children, the medicine is prescribed to eliminate spasms and pain in various conditions. In addition, the medicine has a mild vasodilator effect, which can lower blood pressure.

The tablets help relieve spasm of the smooth muscles of the uterus, stomach, intestines, gallbladder, bronchi, larynx, kidneys, bladder, blood vessels and some other organs.

After the active component penetrates the blood, the activity of the phosphodiesterase enzyme is inhibited, which leads to a decrease in the amount of calcium in the human body, as a result of which the ability of smooth muscles to contract decreases and this process slows down.

Indications

The drug should be taken only with the permission of a doctor. It is strictly forbidden to carry out treatment with this remedy yourself, as it has some contraindications. Papaverine tablets are recommended for the treatment of the following conditions:

renal colic;
inflammatory process of the gallbladder, accompanied by spasm and pain;
spastic colitis;
hepatic colic;
to relieve uterine tone;
V complex therapy bronchospasms;
treatment of angina pectoris, recovery after heart attack, stroke.

Papaverine eliminates spasms and has a mild analgesic effect

More often, Papaverine is prescribed as a complex therapy for self-treatment the drug is used less frequently, as it only relieves the symptoms of a particular pathology.

Contraindications

Papaverine should be used in strict accordance with the instructions for use or according to the regimen prescribed by the doctor. Violation of the method of administration and dose of the drug can cause severe complications and side effects.

child's age up to six months;
elderly age. Among patients over 65 years of age, it is recommended to use the drug under the strict supervision of a specialist;
persistent hypotension;
the presence of an allergic reaction to the active component of the drug or its excipients;
precoma or coma;
disturbance of atrioventricular conduction;
glaucoma.

Dosage and methods of administration

Papaverine should be taken according to a regimen selected by the doctor based on the patient’s diagnosis. Tablets are intended for oral administration. It is recommended to take the medicine with water. The standard dosage regimen for adults is 3 tablets throughout the day. For children, the dosage is 1–2 tablets, depending on weight, age and other individual characteristics. The duration of therapy is selected for each patient separately.

The dose and regimen of the drug are selected by the doctor

Use by pregnant women

How should pregnant women take the medicine? Papaverine during pregnancy is prescribed to patients by a leading physician in the presence of indications such as increased uterine tone, high blood pressure and some other conditions accompanied by spasm of smooth muscles. The dose of the drug is selected according to individually, usually 3 tablets throughout the day. The duration of treatment depends on the symptoms and the demonstrated therapeutic effect. In late pregnancy, the medicine is used to lower blood pressure in uncomplicated gestosis.

Papaverine in pediatrics

For what and in what dosage is the drug prescribed to small patients? Papaverine is prescribed to children from the age of six months, if there is a medical indication for it. Patients under 4 years of age are usually prescribed half a tablet 1-2 times a day. From 4 to 6 years – 1 tablet, from 6 to 9 – 1.5–2 tablets. The duration of treatment for children is selected by the doctor depending on the diagnosis and clinical picture of the patient.

Side effects

Papaverine has mostly positive reviews. Side effects are extremely rare. The cause of negative consequences is a violation of the dosage and regimen of medication.

The main side effects while taking the medication:

nausea;
rarely vomiting;
severe decrease in pressure;
rashes on the body of an allergic nature;
eosinophilia;
increased sweating;
dyspeptic disorders;
heart block.

Side effects include headache, nausea and other symptoms

Taking too large a dose of the drug can cause cardiac dysfunction, drowsiness, and double vision. If these symptoms appear, the patient should be immediately taken to a hospital, where gastric lavage and other medical measures are performed.

Analogues

Papaverine analogues, similar in their indications and areas of application, are as follows:

Riabal is indicated for patients with diseases of the digestive system, accompanied by pain and spasm of smooth muscles. The drug is widely used for diseases of the urinary system;
Dibazol is an antispasmodic drug that has a mild analgesic, vasodilator, and hypotensive effect. Among the indications for use of the drug are pathologies that cause spasms of blood vessels, exacerbation of hypertension, diseases of the digestive system accompanied by spasms, and other conditions. The drug is available in the form of tablets and solution for intravenous administration;
Platiphylline is a drug that has a sedative, antispasmodic, and analgesic effect on the body. The medicine is used for stomach cramps, gastritis, ulcers, acute and chronic pancreatitis, cholecystitis, bronchospasms, as well as to reduce blood pressure in hypertension and other diseases of cardio-vascular system;
No-Shpa is a widely used drug used as complementary therapy for many pathologies. No-Shpa is prescribed to eliminate spasms of internal organs and blood vessels. The medicine helps relieve pain in gastrointestinal pathologies, diseases of the respiratory system, heart and blood vessels, diseases of the genitourinary system and other organs;
GastroComfort is a herbal medicine that includes cumin, dill, fennel and other components. The drug is prescribed to patients with diseases of the digestive system. Among the main indications are pain, spasms of the stomach and intestines, flatulence and other manifestations.

Dibazol is one of the analogues of Papaverine

Important! Each of the analogues has its own contraindications, so they can only be used with the permission of a doctor.

Drug interactions

In combination with other medications, the effect of Papaverine may increase or, conversely, decrease.

Strengthen the effect of the medicine:

Before using Papaverine, you should inform your doctor about any medications that the patient is taking or took the day before.

The drug Papaverine is prescribed exclusively by a doctor. The specialist selects the dose and regimen of the medication. The course of therapy usually lasts from 7 to 14 days until pain is completely eliminated.

Give medicine to children with extreme caution. If the child has not learned to swallow the tablet, it is recommended to crush it into powder, mix it with a small amount of water, and give it to the baby.

It is strictly forbidden to combine Papaverine with alcoholic beverages

In case of acute pain syndrome caused by severe diseases of the gastrointestinal tract, respiratory system and cardiovascular system, Papaverine tablets should be replaced with injections.

The drug does not affect concentration and memory, so it can be prescribed to patients with various professional activities.

Terms of sale and price of the product

The drug is dispensed from the pharmacy according to a doctor's prescription, as it is a myotropic antispasmodic. It is recommended to store the medicine at room temperature in places protected from children. The approximate cost of Papaverine tablets ranges from 25 to 35 rubles.

Patient reviews

Veronica, Volgograd

“I suffer from peptic ulcer disease, which is constantly getting worse. I take it in combination with other drugs during severe pain Papaverine tablets. The product is cheap, but very good. Within 15 minutes after consumption, relief occurs. For several years of taking it there were no negative consequences. I consider this medicine to be the best antispasmodic in terms of price and quality.”

Valeria, Izhevsk

“I was diagnosed with hypertension at a fairly young age. I often experience headaches, weakness, apathy and other unpleasant symptoms. The attending physician prescribed me Papaverine as an adjuvant. Since then I always carry the pills with me. The drug helps relieve pressure and relieves pain. The price of the medicine and its effect suit me quite well.”

Elizaveta, Minsk

“I take Papaverine for abdominal pain. I don’t trust imported expensive products, because I believe that they are made on the basis of the same active ingredients, but are much more expensive. Papaverine quickly eliminates spasms and alleviates the condition. I recommend this drug to everyone."

Maxim, Cheboksary

“Several years ago I was diagnosed with urolithiasis. Since then, the pebbles periodically come out on their own, as they are small in size. Papaverine helps me cope with pain during this period. The process of removing the stone becomes less painful. To be fair, I want to say that I would not advise self-medication, because renal colic may occur. It is best to carry out treatment under the supervision of a physician."

“This drug was prescribed to my father during the recovery period after a heart attack to normalize blood pressure. The product is cheap, but works great. At least we didn't have any problems with him. There were no side effects or complications."

Papaverine instructions for use, composition, indications, analogues and reviews

The drug Papaverine is a drug whose main active substance which is papaverine hydrochloride. This active substance has an effect on smooth muscle elements, causing them to relax, therefore the drug is classified as a myotropic antispasmodic.

Composition and release form

Medicine release form:

Pills.
Rectal suppositories.

The medicine is available in tablets of 10 mg and 40 mg, packaged in cellular contour blisters of 10 pieces. The tablets have White color, bitterish taste, do not have any odor.

Also common is a solution of Papaverine for injection, produced in ampoules of 2 ml. The cardboard packaging of the drug contains 10 pieces. You can also find Papaverine suppositories or rectal suppositories, which are intended for insertion into the rectum. The mass of each suppository is 20 mg.

Papaverine - instructions for use in various dosage forms

Papaverine: use in tablet form

Instructions for use of Papaverine provide for the possibility of using the drug by adults and children in different dosages. The dose of the oral form of the drug will depend on the person's age. The following treatment regimen is used:

From 0.5 to 2 years – dosage of 0.005 g;
From 3 to 4 years – 0.005-0.01 g;
From 5 to 6 years – 0.01 g;
From 7 to 9 years – use 0.01-0.015 g;
From 10 to 14 years – 0.015-0.02 g;
Over 14 years old – 0.04-0.08 g.

How to use Papaverine and take it as an injection solution

The active component of the drug has high bioavailability, so injections can be made intramuscularly and subcutaneously or intravenously. At the same time, the therapeutic abilities of Papaverine do not suffer, and there is also no effect on final result. At the same time, subcutaneous injections of Papaverine should not be given in the distal part of the forearm, but rather in the outer surface of the thigh or shoulder, because the frequency of administration often leads to the occurrence of a hematoma.

Intramuscular injections of Papaverine can be performed according to the traditional scheme using the upper lateral quadrant of the buttock. Before administering intravenous injections, the amount of the drug prescribed by the doctor must be divided into sml. isotonic solution sodium chloride. It should be recalled that Papaverine should be administered slowly so that the person does not experience any discomfort during the injection process. The contents of one ampoule are usually injected subcutaneously.

The dosage of Papaverine solution for intramuscular and intravenous administration is as follows:

For adults: 0.3 g daily and 0.1 g once;
For children: up to 0.2 g daily and up to 0.06 g once (depending on age).

Use of Papaverine for hemorrhoids

Papaverine suppositories are used to treat hemorrhoids. Hemorrhoids themselves are directly related to inflammatory processes, thrombosis, pathological dilatation of blood vessels that surround the lumen of the rectal outlet. Suppositories can alleviate the condition and cure the disease.

According to the instructions, it is necessary to begin the course of treatment with 0.02 g of the drug, gradually increasing the dosage to 0.04 g (but only in cases where a smaller amount of the drug does not provide the necessary therapeutic effect). The instructions for use note that it is undesirable to use more than 3 suppositories in one day, because this can lead to the development of adverse effects, or cause an overdose, because the medicinal components are absorbed too well in the rectal area.

It is best to place Papaverine suppositories in the morning and evening, before bedtime. If necessary, an additional candle can be placed at lunchtime. It is also not recommended to light candles too often.

Indications, contraindications, side effects of Papaverine

Indications for use of Papaverine

Papaverine's instructions include the following indications for use of the drug:

Spasm of smooth muscles (especially common with spastic colitis, cholecystitis, pylorospasm);
Hypertensive crisis (with combined conservative treatment);
Endarteritis;
Renal colic;
Spasm of the peripheral vascular bed;
Reduction of the lumen of brain vessels due to contraction of the muscular layer of the arteries;
Bronchospasm;
Angina;
reduction in renal arterial inflow of vascular origin;
Urinary retention due to spasms of the urinary tract;
Hemorrhoids, large hemorrhoids.

Papaverine is also often used before surgical interventions associated with urological or proctological manipulations in the abdominal cavity. The drug allows you to relax smooth muscle elements.

Contraindications for the use of Papaverine

The following contraindications to taking Papaverine can be identified:

Individual intolerance to the components of the drug;
Violation of intracardiac conduction (especially atrioventricular block);
High sensitivity to the drug;
Severe form of liver failure;
Glaucoma;
Old age (there is a high risk of developing hypertensive syndrome);
Children's age (up to 0.5 years).

The following conditions are additional restrictions on the use of Papaverine (the drug can be used with regular supervision by experienced doctors):

Presence of recent traumatic brain injury;
Chronic renal failure;
Hypothyroidism;
Shock conditions;
Benign pancreatic hyperplasia;
Supraventricular tachycardia;
Insufficiency of adrenal gland functionality.

From the cardiovascular system, atrioventricular ventricular block may occur. A decrease in blood pressure and tachycardia is also often observed. In addition, according to the instructions, the main side effects of Papaverine include nausea, constipation, bloating, increased activity of liver transminases, and impaired passage through the digestive tube. There may also be allergic reactions, drowsiness, eosinophilia.

How long can Papaverine be used?

The duration of the course of treatment is usually short, because immediately after the cessation of symptoms and elimination of painful conditions, the drug is completed. The instructions for use of Papaverine state that the drug can be used for a long time, in accordance with the courses prescribed by the attending physician.

Papaverine: use for children

Papaverine in various forms (tablets, suppositories, injections) is actively used in pediatric practice in many countries around the world, starting from 6 months of age.

Medicinal effects of the drug Papaverine

The mechanism of the therapeutic effect of the substance is to influence the messengers (secondary messengers) of the transmission of muscle excitation. Papaverine inhibits phosphodiesterase, due to which cycloadenosine monophosphate begins to accumulate in cells. There is also a decrease in the level of calcium ions. Smooth muscles, in response to such biochemical changes, begin to relax, which is accompanied by a decrease in their tone.

The active component of the drug is completely and quickly absorbed when in different ways introducing medicine into the body. When it enters the bloodstream, the substance begins to bind to plasma proteins, due to which it passes through histohematic barriers with ease. Subject to biotransformation in the liver. The half-life after taking the drug is from 30 to 120 minutes (the duration will depend on the additional components of the drug). It is excreted mainly by the kidneys in the form of metabolic products.

Compatibility of Papaverine with No-shpa

No-Shpa interacts well with Papaverine, as with many of its analogues. The drug will have a therapeutic effect on the smooth muscle elements of the human body. The combined use of Papaverine and No-Shpa is most often found in gynecological and obstetric hospitals with high uterine tone, a serious threat of miscarriage, or when labor is too active ahead of schedule.

No-Shpa and Papaverine can be used in combination for any conditions that are associated with serious pain. The use of No-Shpa is not allowed if there are certain contraindications.

Among Papaverine analogues, many different pharmaceutical forms can be distinguished medicines. The well-known drug Drotaverine Hydrochloride, which is more common in our country under the name No-Shpa, can have a similar antispasmodic effect. In general, analogues of this medicine include any drugs that provide antispasmodic and anti-inflammatory effects.

Price of the drug in pharmacies

Check out the price of Papaverine in 2018 and cheap analogues >>> The cost of Papaverine in different pharmacies can vary significantly. This is due to the use of cheaper components in the drug, and pricing policy pharmacy network. But the important thing is that the price difference between foreign and Russian analogues remains virtually unchanged.

What kind of medicine is Papaverine and how does it work?

What is Papaverine? This medicinal product, known for a very long time. It is used as an antispasmodic in many countries. In the language of professionals, it is called Papaverine hydrochloride. It can be purchased at pharmacies in several medicinal forms. These can be tablets, suppositories or a solution. Its shelf life is 2 years. When visiting a pharmacy, you must take into account that suppositories and tablets are freely available, and to purchase a solution you will need a prescription confirming the prescription.

How does the product work?

Papaverine can be prescribed in two cases:

to reduce pressure in the body;
to relieve muscle pain when spasms occur.

Its main substance is able to influence certain enzymes, so the muscles of the internal organs relax. This helps relieve pain in the digestive organs, blood vessels or lungs. The pain goes away and the pressure begins to drop. If the dose of the drug is slightly increased, a calming effect will also appear. Very often it is used when preparing a person for an operation that will take place under general anesthesia.

When Papaverine is consumed, it quickly spreads in the body through the blood, regardless of the form used. The breakdown products of this drug are excreted through the urine.

It is usually prescribed to patients with various diseases. The form that is most convenient for use is chosen.

But sometimes they prefer injections:

with a sharp change in blood pressure;
with severe intestinal upset;
if body temperature increases sharply;
when a patient loses consciousness and requires urgent assistance.

for stomach pain;
for intestinal and stomach colic;
in case of constipation or disorders;
for menstrual pain;
with spasms in the bladder or inflammation;
with a sharp contraction of the muscles of the bronchial wall;
in case of vascular spasms in the brain area.

Depending on your individual needs, your doctor may use this drug:

with colic in the kidneys;
with inflammation of the gallbladder;
for pain in the chest area.

Sometimes it can be prescribed together with Dibazol. This helps reduce blood pressure. In this case, you need to give an injection intravenously or intramuscularly.

It is also prescribed together with Analgin in ampoules. This helps normalize body temperature and relieve the patient from pain. Such prescriptions will be relevant for patients who have undergone surgery.

How to use depends on the shape:

The tablet form is used if necessary at any time and washed down well with plain water.
Injections with Papaverine can be done subcutaneously or into the muscle. It is best for this to be done by a medical professional in a hospital, subject to all sanitary standards. If it is administered intravenously, it must be diluted with saline solution.
Suppositories are usually used for pain in the pelvic area. They need to be inserted into the anus.

So, Papaverine is an antispasmodic that is available in three different forms (tablets, rectal suppositories and solution in ampoules). The choice in favor of one form or another is made by the doctor based on a number of parameters.

Dosage and possible contraindications

Papaverine has strict restrictions on its intake. It should not be used on small children less than 6 months of age. The same rule applies to people over 65 years of age.

Who else is contraindicated with Papaverine:

in case of kidney dysfunction;
if the liver is not functioning properly;
with the development of glaucoma;
with heart block;
with rapid heartbeat;
in case of malfunction of the thyroid gland;
for brain injuries.

The dosage must be determined by the doctor in each specific case. Usually the product is not used for a long time, but only when necessary. If the desired result is not achieved and if the pain does not stop, then be sure to go to the hospital.

For adult patients, the dose should not exceed 60 mg; if necessary, it can be no more than 240 mg at a time and 720 mg per day.

For medicinal purposes, the doctor may prescribe:

3 or 4 tablets per day;
2 or 3 candles per day;
2 or 4 injections per day.

The form of choice depends on a set of conditions.

Use by pregnant women and children

Sometimes the drug is used to treat children.

The description of the drug establishes the dosage depending on age:

from 6 months to 2 years you can take no more than 5 mg;
from 2 to 7 years, the dose should not exceed 10 mg;
upon reaching 10 years of age, it can be no more than 15 mg;
from 10 to 14 years it can increase to 20 mg.

For convenience, you can purchase tablets with a dosage of 10 mg. If you need to use candles, they can be divided in half. For adults, Papaverine 40 mg is suitable.

During pregnancy, it can only be used as prescribed by a doctor. Papaverine is not able to affect the course of pregnancy, but it is still better not to take risks, especially in the later stages.

Sometimes a large amount of Papaverine can cause vision deterioration and a double effect.

Papaverine - instructions for use, reviews, analogs and release forms (tablets 40 mg, suppositories 20 mg, injections (in injection ampoules)) of a drug for the treatment of spasms in adults, children and pregnancy

In this article you can read the instructions for use of the drug Papaverine. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Papaverine in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Papaverine analogues in the presence of existing structural analogues. Use for the treatment of spasms in adults, children, as well as during pregnancy and breastfeeding.

Papaverine is a myotropic antispasmodic. Reduces the tone of smooth muscles of internal organs (gastrointestinal tract, respiratory, urinary, reproductive systems) and blood vessels. Causes dilation of arteries, increases blood flow, incl. cerebral. Has a hypotensive effect.

In high doses, it reduces the excitability of the heart muscle and slows down intracardiac conduction.

When used in average therapeutic doses, the effect on the central nervous system is weak.

Bioavailability is 54%. It is well distributed in the body and penetrates histohematic barriers. Metabolized in the liver. Excreted by the kidneys in the form of metabolites. It is completely removed from the blood during dialysis.

spasms of smooth muscles of organs abdominal cavity, bronchi, peripheral vessels, cerebral vessels, kidneys;
angina pectoris (as part of combination therapy).

As an adjuvant for premedication.

Suppositories for rectal use 40 mg.

Solution for injection (injections in ampoules) 20 mg/ml.

Instructions for use and dosage

Inside - pomg 3-5 times a day. Rectally - pomg 2-3 times a day.

When administered intramuscularly, subcutaneously or intravenously single dose for adults is mg; the interval between injections is at least 4 hours. For elderly patients, the initial single dose is no more than 10 mg. For children aged 1 to 12 years, the maximum single dose is mg/kg.

nausea;
constipation;
drowsiness;
increased sweating;
arterial hypotension;
development of AV blockade, heart rhythm disturbances (with rapid administration).

AV block;
glaucoma;
severe liver failure;
old age (risk of developing hyperthermia);
children up to 6 months;
hypersensitivity to papaverine.

Use during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding), the safety and effectiveness of papaverine has not been established.

Use with caution in conditions after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, hyperplasia prostate gland, supraventricular tachycardia, shock states.

Intravenously should be administered slowly and under the supervision of a physician.

During the treatment period, alcohol consumption should be avoided.

When used simultaneously with anticholinergic drugs, the anticholinergic effects may be enhanced.

It is believed that when used concomitantly with alprostadil for intracavernosal administration, there is a risk of developing priapism.

There are reports of a decrease in the effectiveness of levodopa when used simultaneously.

Reduces the hypotensive effect of methyldopa.

Analogues of the drug Papaverine

Structural analogues of the active substance:

Papaverine bufus;
Papaverine hydrochloride;
Papaverine hydrochloride MS;
Papaverine hydrochloride solution for injection 2%;
Papaverine hydrochloride tablets for children 0.01 g;
Suppositories with papaverine hydrochloride 0.02.

Used to treat diseases: spasm, angina pectoris

How long does it take for papaverine to be absorbed?

Almost every pregnant woman is familiar with the term “hypertonicity of the uterus.” Although this phenomenon is quite common, it is not a normal option and poses a danger to the course of pregnancy, including its premature termination. Fortunately, modern medicine has a large arsenal of drugs that can effectively relieve tension in the uterine muscles. Among them are the long-known and widely used Papaverine suppositories. Like any medicine, this drug can be used by a pregnant woman only as prescribed by a doctor, however, it is useful for every expectant mother to know all the nuances of its effect on the body and the basic rules of use.

Papaverine rectal suppositories are the most popular doctor’s prescription for uterine hypertonicity

Although Papaverine hydrochloride is actively prescribed by gynecologists to pregnant women for both outpatient and inpatient treatment, the instructions for the drug interpret its use during gestation (bearing a child) ambiguously. According to the recommendations provided by the manufacturer, the safety of using Papaverine by expectant mothers has not been established. Of course, this circumstance, combined with a doctor’s prescription that has already been received, will confuse a woman who is conscious about the use of medications during pregnancy.

It should be noted that clinical studies of the effectiveness and safety of the use of the drug Papaverine in pregnant women have not really been conducted. Nevertheless, the long-term practice of using Papaverine clearly demonstrates its positive effect on the course of pregnancy and, at the same time, complete safety for the fetus.

Papaverine suppositories are prescribed at any stage of pregnancy if a woman has or is suspected of having the following conditions:

Uterine hypertonicity is the most common diagnosis made during pregnancy. Hypertonicity is tension in the myometrium (the muscular layer of the uterus), which can occur for a number of reasons (stress, excessive physical activity, hormonal reasons, etc.) and can lead to premature termination of pregnancy. Arterial hypertension- persistent increase in blood pressure is a fairly common phenomenon in late pregnancy. Colic (liver, kidney, intestinal, etc.) - sudden cramping pain caused by muscle spasm. Bronchospasm is a pathological narrowing of the bronchi. Severe increase in body temperature (in such cases, Papaverine is used as part of a lytic mixture).

Papaverine can also have a positive effect on constipation if it is caused by muscle spasms (spastic constipation). For atonic constipation, which is caused by a decrease in intestinal muscle tone, Papaverine will only worsen the situation.

The drug Papaverine is produced in several pharmaceutical forms:

solution for injections; rectal suppositories; pills.

During pregnancy, Papaverine is most often prescribed in the form of suppositories. This form has a number of advantages:

convenience and versatility of independent use by a woman; complete and rapid absorption of the drug through the rectum; increased therapeutic effect due to the proximity of the uterus.

Each Papaverine rectal suppository contains 20 mg of active ingredient.

The active substance of this product is papaverine hydrochloride, an antispasmodic with myotropic action. In this regard, the drug acts in two directions:

Relieving tension in the smooth muscles of internal organs (the product affects not only the uterus, but also the organs of other systems - urinary, digestive, respiratory). Vasodilation and increased blood flow, due to which the drug is able to reduce blood pressure (hypotensive effect).

With regular use of Papaverine, women note its calming effect - the level of anxiety is significantly reduced and stabilized. heartbeat, which could not have had a more positive effect on the course of pregnancy.

The mechanism of action of the drug in the form of rectal suppositories is as follows:

The suppository, after being placed in the rectum, melts under the influence of body temperature. The active substance is instantly absorbed into the blood. In blood plasma, papaverine binds to proteins. The bloodstream carries papaverine to all systems and organs of a woman, including muscle tissue uterus. The active substance of the drug has a relaxing effect on smooth muscles. Papaverine is excreted from the body by the kidneys in the form of metabolites (metabolic intermediate products).

The treatment regimen with Papaverine during pregnancy is prescribed only by a doctor in accordance with the individual characteristics of the woman’s body and the diagnosis. As a rule, the duration of taking the drug is 2–3 weeks, the daily dose is 2–4 suppositories. The doses of the drug are distributed evenly throughout the day.

It is important to remember that Papaverine suppositories are produced only for rectal use - they should under no circumstances be used vaginally

The rules for administering rectal suppositories are as follows:

Before inserting the suppository, you must wash your hands thoroughly. Since candles melt very quickly upon contact with your hands, before opening the blister, you can hold the unopened candle in the refrigerator or under running cold water for some time. It is convenient to use disposable gloves or finger caps to administer the suppository. It is better to administer the drug while lying on your side. The candle must be placed behind the muscle sphincter, pushing it 2.5–5 cm deep. After administering the product, it is better to lie on your side for a few more minutes to avoid leakage. After completing the procedure, you should wash your hands thoroughly.

It is most convenient to insert rectal suppositories in a lying position

As a rule, suppositories with Papaverine are easily tolerated by pregnant women, however, in isolated cases (with prolonged and uncontrolled use), the following side effects may occur:

redness and itching of the skin (allergic reaction); drowsiness; dizziness; heart rhythm disturbances; increased sweating; decreased blood pressure; constipation; nausea.

Rectal suppositories with Papaverine are contraindicated in the presence of the following conditions and diseases:

individual intolerance to the components of the drug; glaucoma; liver or kidney failure; heart rhythm disturbances; AV block (atrioventricular block).

Papaverine should be used with caution in cases of adrenal dysfunction, hypothyroidism and arterial hypotension (low blood pressure).

The only complete analogues of rectal suppositories with Papaverine are preparations of other pharmaceutical forms of release - tablets and solution for injection. If we talk about drugs with similar effects, then in modern gynecology such drugs as No-shpa, Magne B6, Utrozhestan are used. Their effect is based on the antispasmodic properties of other active ingredients.

When administered rectally, the drug is quickly absorbed and its active components enter the bloodstream. The therapeutic effect occurs quite quickly.

Compound

Properties of the drug

elimination of smooth muscle tone in various pathologies;
lowering blood pressure, dilating blood vessels;
increased blood flow in all internal organs;
normalization of heart rate;
providing a sedative effect.

Indications

What is the medicine used for? Papaverine suppositories are used for many diseases that are accompanied by pain. The drug is widely used in gynecology, urology, and surgery.

all types and stages of hemorrhoids;
headaches caused by vasospasm;
pain syndrome in various diseases of the digestive system;
renal colic;
pathologies of the urinary tract – pyelonephritis, cystitis, urolithiasis, urethritis;
bronchitis, pneumonia;
pain in women during menstruation.

Papaverine helps relieve spasms in various diseases

Mechanism of action

Contraindications

The instructions for use include a number of contraindications that must be taken into account when using the medicine. These include:

presence of allergies to the components of the drug;
increased intraocular pressure in glaucoma and other diseases;
liver failure, accompanied by severe course;
blockade of the heart muscle;
old age of the patient;
children's age up to 12 years.

Papaverine is prescribed by a doctor who must study the patient’s medical history and exclude all possible contraindications.

How to light candles

Where to insert Papaverine and how often can it be done? Suppositories should be used only as prescribed by a doctor. Typically, adults are administered mg 2-3 times throughout the day. Sometimes a specialist may adjust the dosage depending on the diagnosis. Considering the question of how long the drug takes to act, it should be noted that on average the effect occurs after 30 – 40 minutes. Sometimes you have to wait longer for results. This depends on the characteristics of the disease and the individual qualities of the body.

The suppository should be administered according to the instructions.

With uterine hypertonicity

Increased uterine tone threatens premature birth. Papaverine suppositories help relieve spasms and relax smooth muscles. According to the doctor’s recommendation, a woman is given 2–3 suppositories throughout the day to tone the uterus. It is advisable for every pregnant woman to have this medicine in her home medicine cabinet, since when a spasm occurs, this drug will become an ambulance. The drug should be used carefully during treatment with other vaginal and rectal suppositories.

Treatment of prostatitis

Papaverine for hemorrhoids

How to place Papaverine suppositories for hemorrhoids? As with other diseases, suppositories are used rectally. The dosage for a particular patient is selected by the doctor, taking into account the characteristics of the course of the disease, the type and stage of the disease. Typically, the dose of medication for varicose veins in the anal area is 1 - 2 suppositories three times a day. The duration of therapy depends on the achieved therapeutic effect.

Use of Papaverine among children

The drug should be used with caution among children

Possible side effects

heart rhythm disturbance;
dizziness;
apathy and drowsiness;
difficulty urinating and defecating;
nausea, less often vomiting.

Treatment of the complications described above consists of blood purification and symptomatic treatment of the patient.

Combination with other medications

special instructions

When starting treatment with the drug, you should carefully study the instructions for use. It includes several special instructions that must be followed. These include:

the medicine should be used with extreme caution in cases of severe renal failure;
During treatment with suppositories, it is important to stop drinking alcohol;
During pregnancy and lactation, suppositories are used under the strict supervision of a doctor. To date, there is not enough information about the safety of using the drug during this period;
the active component of the drug can have a relaxing effect on the central nervous system, therefore, among people whose work activity requires increased concentration, the drug is used carefully.

In addition, if the patient is taking any other medications, be sure to inform the doctor.

Before starting treatment, it is important to read the instructions for the drug

Analogues of the drug

How to replace Papaverine suppositories? Among the analogues of the drug, the following drugs can be distinguished:

No-Shpa is a medicine that is used for diseases associated with spasm of the smooth muscles of internal organs and blood vessels, as well as for the treatment of periodic pain;
Spazmolysin suppositories - inserted into the anus for pain syndrome arising from diseases of the gastrointestinal tract and other organs, cholecystitis, pancreatitis, cystitis and other pathologies;
Spascuprel - used to relax the smooth muscles of internal organs in diseases of the stomach, intestines, pancreas, kidneys and other organs;
Theophedrine ІС – used for bronchial asthma, obstructive bronchitis to eliminate bronchospasm and ease the patient’s breathing;
GastroComfort is an antispasmodic and carminative drug that is prescribed to patients with diseases of the digestive system;
Niaspam - used for irritable bowel syndrome, renal and hepatic colic, and other pathologies of the digestive system.

You should take any of the analogues only after examination by a doctor.

Self-medication often causes serious negative consequences.

Terms of sale and storage

Patient reviews

Stanislav, Cheboksary

“I was prescribed suppositories for exacerbation of hemorrhoids. The drug works quite quickly, relief occurs within 15 to 20 minutes. Papaverine is easy to find in any pharmacy, its cost is affordable. Over the course of several courses of therapy, I did not notice any side effects.”

Anastasia, Prokopyevsk

“I was prescribed suppositories during pregnancy, when there was a threat of miscarriage. I lit one candle at night. In the ward where I was lying, this drug was prescribed to many girls. Papaverine does not cause side effects and relaxes the uterus well. The main advantage of candles is their low cost and availability.”

Marina, Cherkessk

“I started menstruating at the age of 13. This period is always very painful. Passed a lot medical examinations, but the doctors did not find any abnormalities. Papaverine suppositories save me. In the first days of menstruation, I put one candle in the morning and in the evening. Thanks to the drug, critical days pass easily. I haven't noticed any consequences yet. I recommend to everyone".

Natalia, Minsk

“For many years I have been suffering from chronic cholecystitis, the disease is often accompanied by pain and other unpleasant sensations. One of the components of complex therapy prescribed by the attending physician is Papaverine suppositories. Despite its inexpensive cost, the medicine works great. The pain goes away within 10 minutes. I have been using the product for many years and suppositories have never let me down. “I heard a lot of negative feedback about the medicine, but I didn’t experience any side effects myself.”

Papaverine hydrochloride is an antispasmodic drug, that is, its mechanism of action is to relax smooth muscle cells. It affects blood vessels and all organs and systems that contain smooth muscles. This is one of the few drugs that is widely used to treat pregnant women. Not only does it not have a negative effect on the growth and development of the baby, but if indicated, it also reduces the tone of the uterus and improves blood flow in the uteroplacental system.

Indications

and, as a consequence, the threat of miscarriage. This is the most common reason prescribing papaverine to pregnant women. It is available in various dosage forms, which allows you to change the dosage of the drug and the route of its administration depending on the severity of hypertonicity;
Arterial hypertension, isolated or as part of It gently reduces blood pressure without having a negative effect on the fetus;
Various types of colic (hepatic, renal, intestinal). Papaverine relaxes spasmodic excretory ducts, relieving pain and restoring the function of the damaged organ;
. Under the influence of the medicine, the bronchi relax, breathing is restored and the condition improves;
high temperature as a component of a lytic mixture.

Mode of application

Papaverine is available in the form of rectal suppositories, tablets and solution for injection. The choice of dosage form is determined depending on the indication and severity of symptoms. The duration of treatment can range from several days to 2 – 3 weeks, and sometimes more:

It is recommended to insert into the previously cleaned rectum 2 – 4 times a day at regular intervals.
also take no more than 4 times a day 2 hours before meals.
usually prescribed for more pronounced manifestations of uterine hypertonicity or other symptoms. The drug may cause a significant decrease in blood pressure and a slowdown in heart rate, so this procedure should only be carried out in a medical facility under the constant supervision of staff. Intramuscular and intradermal injections can be done at home, but only after they are prescribed by a doctor.

Side effects

Despite all the positive aspects, you should still not overuse Papaverine. After all, like any medicine, it has side effects, which may occur more often in pregnant women than in other people.

We list the most common of them:

Redness and itching of the skin due to excessive vasodilatation;
Dizziness, feeling of drowsiness;
Reduced blood pressure below acceptable values;
Heart rhythm disturbances;
Nausea, abdominal discomfort, constipation.

Contraindications

Papaverine should not be used for the following conditions:

Allergy to one of the components of the drug;
Glaucoma (increased intraocular pressure);
Atrioventricular block and heart rhythm disturbances with tachycardia;
Severe renal or liver failure.

Use during lactation

There is no reliable data on the use of papaverine in women during breastfeeding. Therefore, if treatment with this drug is necessary, it is better to wean the child off the breast for a while, and after recovery, resume breastfeeding.

Papaverine analogs

The well-known drug no-spa (active ingredient drotoverine hydrochloride) has a similar antispasmodic effect. It is also often prescribed to pregnant women in the treatment of threatened miscarriage and premature birth to relieve the tone of the uterine muscles. No-shpa can also be used as a painkiller for headaches or intestinal cramps.

Always before using any drug, especially if you are pregnant, you should consult your doctor and carefully read the instructions.

Papaverine hydrochloride is an excellent antispasmodic that perfectly relaxes muscles and reduces blood pressure. The medicine papaverine hydrochloride is produced in various forms:

Suppositories with papaverine during pregnancy

It is a rare woman during nine months of pregnancy who does not use papaverine in suppositories at least once. Some save them from increased uterine tone during the entire period of waiting for the baby, others use them only periodically, for example, after being on their feet for a long time or having worked too hard at work or at home, without making allowance for their interesting position.

Be that as it may, suppositories with papaverine are among medications that are not the most desirable for pregnancy. But what does he say? official instructions to this drug regarding its use during such a crucial period as pregnancy? The wording of the answer to this question is as follows: safety and effectiveness during pregnancy have not been established, which sounds rather strange given the many years of use of this drug by pregnant women. Although there is even information about clinical studies in this direction, during which no negative consequences for the pregnant woman and fetus were found. However, the manufacturer leaves the last word for a doctor, and thousands of pregnant women have both used and continue to use papaverine suppositories when they are concerned about the tone of the uterus during pregnancy.

How do suppositories with papaverine work during pregnancy?

The main active ingredient is papaverine hydrochloride, which is an antispasmodic with myotropic action. Its effect in the body is directed not only to the uterine muscles, but also to the smooth muscles of other organs - and these are the urinary, respiratory and reproductive systems, as well as the gastrointestinal tract. In addition, papaverine hydrochloride also has an effect on blood vessels, promoting their expansion and increasing blood flow, which is also associated with the hypotensive effect (lowering blood pressure) of this drug. Therefore, initially the drug is intended to eliminate spasms of smooth muscles of the abdominal cavity, blood vessels of the brain and kidneys, as well as bronchi and peripheral vessels.

The candle melts under the influence of body temperature, and the active substance from the drug is absorbed into the blood and enters all organs and systems of the body and into circulatory system including the uterus. Thus, under the influence of papaverine, the excitability of the uterine muscles decreases, the overall tone decreases, tension and pain associated with it disappear, and due to the ability to lower blood pressure, papaverine suppositories will bring double benefit to expectant mothers who additionally suffer from high blood pressure, which is often found in late pregnancy. stages of pregnancy.

It is worth noting that suppositories with papaverine have only one route of administration into the body - rectal, that is, through the rectum, from where they are absorbed by the body. There can be no question of any vaginal insertion.

Contraindications and side effects

As far as we know, the instructions for most medications certainly describe some side effects and contraindications for use. Papaverine suppositories are no exception in this regard. Due to their moderate hypotensive effect, these suppositories may not be recommended for low blood pressure in a pregnant woman. Also among the contraindications is an eye disease such as glaucoma. Conditions such as adrenal insufficiency or hypothyroidism also require caution in the use of papaverine suppositories.

In addition, side effects such as constipation, nausea, increased sweating, and drowsiness are possible.

To summarize all of the above, it should be noted that despite the absence of harmful effects on the fetus and the body of a pregnant woman as a whole, you should not arbitrarily “prescribe yourself” papaverine suppositories, because this is within the competence of the doctor who is observing the pregnancy and who knows your body.

Suppositories with papaverine during pregnancy

Pregnancy is wonderful and at the same time difficult period in a woman’s life, which is characterized not only by joy and pleasant chores, but also by some health difficulties. It is quite difficult to get rid of various physical problems, because you don’t really want to take medications for fear of harming the baby. In this article we will talk about the safest drug - papaverine hydrochloride suppositories during pregnancy.

What kind of medicine is this?

Papaverine belongs to the group of antispasmodics. It is able to lower blood pressure in the arteries and relieve tension that occurs in the smooth muscles of internal organs. Taking the drug in large quantities has a mild sedative effect on the nervous system and reduces the heart rate. The medicine goes on sale in the form of ampoules with injection solution, tablets and suppositories. Injections can only be given in a hospital setting, while a woman can use suppositories with papaverine during pregnancy at home. This is a very convenient form of the drug that does not require medical supervision.

Why are suppositories with papaverine prescribed for pregnant women?

The most common diagnosis requiring the use of this medication is increased muscle tone of the uterine walls. This rather unpleasant phenomenon increases the risk of premature birth and miscarriage. With the tone of the uterus, papaverine suppositories enable the organ to “relax” somewhat and provide the baby with all the conditions for normal development. Regular use also has a positive effect on the psycho-emotional state of the pregnant woman.

Contraindications for papaverine suppositories during pregnancy

There is an opinion that it is extremely undesirable to use this drug during pregnancy. However, such information is absolutely groundless, and there are corresponding scientific and medical studies. According to medical observations, all women who used papaverine suppositories became mothers of healthy, strong and full-fledged children. Experience shows that this drug not only does not harm the fetus or the pregnant woman, but also makes it possible to carry a child to term normally and without problems, without fear of miscarriage due to the tone of the uterus.

Possible side effects

The use of papaverine suppositories during pregnancy can sometimes provoke such responses from the body as:

nausea;
profuse sweating;
constipation;
the appearance of signs of allergies;
decrease in blood pressure.

As a rule, such symptoms are isolated and are completely determined by the individual characteristics of the body.

Dosage of papaverine suppositories during pregnancy

The amount of the drug produced in the form of suppositories usually reaches one or two pieces per day. It is worth maintaining an equal interval between the administration of the medication so that the body copes with its intake. You should definitely read the instructions for papaverine hydrochloride suppositories, since this drug also has its contraindications, such as:

improper liver function;
high eye pressure;
tachycardia;
thyroid dysfunction.

All this leads to the fact that you should not prescribe suppositories with papaverine before childbirth on your own. Only the doctor observing the pregnancy should recommend the drug, as well as distribute its dosage, and not a friend or acquaintance. The release form of this medication is quite convenient, which does not require special skills in its use. When administered rectally, suppositories with papaverine very quickly begin to act almost immediately, thereby reducing the risk of damage to the fetus.

Suppositories with papaverine during pregnancy

While carrying a baby, the expectant mother tries with special care to protect herself from all sorts of negative factors that can cause pregnancy complications. These include any diseases, painful conditions, or stressful situations that pose a certain threat to bearing a baby. And yet, sometimes, despite all the efforts of a pregnant woman, it happens that such conditions still overtake her. Some of them require the use of medications to correct them, which makes the expectant mother even more worried.

It is known that the pregnancy period should, if possible, exclude the use of any medications - in order to avoid negative consequences for the pregnancy itself and the rapidly developing baby. However, there are medications that have been tested by time and experience, which, if necessary, can only benefit the mother and alleviate certain conditions, without harming the baby in any way. One of these remedies is papaverine: an antispasmodic drug that relaxes and eliminates painful conditions.

Papaverine today can be found in the form of tablets, rectal suppositories, and injection solution. However, during pregnancy, in most cases, suppositories with papaverine are prescribed. This universal and easy-to-use remedy can save the expectant mother from many misfortunes that threaten pregnancy. For example, the most common use of a suppository with papaverine during pregnancy is if a woman has a condition such as uterine hypertonicity.

Read also: Suppositories with glycerin during pregnancy

With hypertonicity, the muscles of the uterus, which is the “house” of the baby, are in constant tension, which is fraught with premature termination of pregnancy. In order to avoid miscarriage, it is necessary to relax the muscles of the uterus and give the baby the opportunity to develop without risks. Suppositories with papaverine during pregnancy can cope with uterine hypertonicity, since this medicine has a pronounced antispasmodic effect: suppositories lower blood pressure and relieve tension in the smooth muscles of internal organs. In addition, with regular use of suppositories, a slight sedative effect is felt: the woman becomes calmer, and even the heart rate slows down: the heart stops pounding and causing anxiety.

Despite the fact that many sources indicate that it is supposedly undesirable to use papaverine when carrying a child, however, the long-term use of this medicine indicates exactly the opposite. Almost all mothers who used suppositories with papaverine during pregnancy carried them to term and gave birth to strong babies without any negative consequences. Many years of experience in using papaverine proves that suppositories with papaverine have absolutely no effect on the baby, and at the same time neutralize the threat of involuntary abortion associated with uterine hypertonicity. The only thing is that suppositories with papaverine during pregnancy in some in some cases may cause some side effects for the mother. Among them are nausea, drowsiness, increased sweating, and constipation. The use of suppositories can provoke allergic reactions or a drop in blood pressure - but all this is only in isolated cases. In general, suppositories with papaverine during pregnancy are tolerated relatively easily, and can even be used for quite a long time.

Despite the fact that suppositories do not pose a threat to the fetus, self-medication is not permissible: suppositories with papaverine should be used during pregnancy only after consultation with a doctor, who determines the dosage. As a rule, suppositories are prescribed at the rate of 2-3 suppositories per day at equal intervals. The form of the drug is convenient to use: women can administer suppositories with papaverine during pregnancy on their own, and they begin to act almost immediately after dissolution. Contraindications to the use of suppositories with papaverine during pregnancy include problems with expectant mother with the liver, tachycardia, increased intraocular pressure, thyroid dysfunction.

How long does it take for papaverine injections and suppositories to work?

The effect of the drug, administered rectally, manifests itself quickly, within a few minutes.

If, when using the medicine Papaverine, you use suppositories that are administered rectally, then the effect will of course be achieved very quickly, usually it takes a few minutes.

Naturally, when using an injection, the action will be almost instantaneous, since the drug immediately enters the blood.

Instructions for use of the drug Papaverine for pregnant women - composition, indications, release form and price

Doctors prescribe Papaverine during pregnancy in ampoules or suppositories to achieve relaxation of the walls and contraction of the uterus. It also helps relieve muscle tone. When carrying a fetus, spasms of the muscles, smooth muscles of the uterus and internal genital organs of a woman are suppressed under the influence of the hormone progesterone, preventing miscarriage. If it is not enough, there is a risk of miscarriage, miscarriage or premature birth. This is what Papaverine helps with.

Why is Papaverine taken?

To improve the situation with uterine tone and relieve spasms, papaverine suppositories are prescribed during pregnancy. This antispasmodic agent reduces blood pressure, improves blood circulation, relaxes the muscles of the uterus, and has a positive effect on the fetus, preventing the threat of miscarriage. If you take a large dose, a sedative effect of the central nervous system is felt, and the rhythm of the heart muscle decreases. Other indications for the use of Papaverine are:

cholecystitis, pylorospasm;
spastic colitis, renal colic;
haemorrhoids;
endarteritis.

Effect on the fetus

Papaverine for pregnant women relieves muscle spasms and may cause some side effects for the mother. The product is completely safe for the fetus because it does not penetrate the placental barrier. For several decades, women have been taking suppositories and ampoules when carrying a baby and, according to reviews, do not observe a negative effect on the child’s body.

Papaverine in early pregnancy

In the first trimester, taking papaverine suppositories is useful if the doctor has detected the initial stage of gestation. This is accompanied by increased uterine tone, and the active components of the medicine eliminate this pathology and vascular spasms. In the second trimester, indications for prescribing medication include high blood pressure and intrauterine pain. At this stage, Papaverine is prescribed as part of complex therapy with magnesium preparations.

In the later stages

The third trimester of pregnancy is characterized in women by an excess of tension in the uterine walls and hardness of the abdomen, which is eliminated with suppositories and ampoules. Before childbirth, the drug may be prescribed to relax and prepare the cervix for dilatation. During childbirth, the medication alleviates spasmodic pain from contractions. If you follow the instructions and dosage of the suppositories, there will be no harm from them.

Release form and composition

The drug is available in the form of rectal suppositories, tablets and ampoules for intravenous administration. Papaverine injections and suppositories are prescribed more often during pregnancy; tablets are contraindicated for women expecting a baby. The composition varies depending on the form:

Active component papaverine hydrochloride, concentration

Injection

Methionine, disodium edetate, purified water

Sugar, potato starch, stearic acid, talc

0.02 g per 1 candle weighing 1.25 g

Emulsifier, cosmetic stearin, tallow

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Tablets weighing 0.01 or 0.04 g are produced in contour cell blisters of 10 pieces. They have a bitter taste, white color, and no odor. The injection solution is in the format of 2% ampoules of 2 ml in a cardboard package of 10 pieces. Rectal suppositories for insertion into the rectum contain 0.02 g of the active ingredient each, secured in PVC blisters or foil packaging of 10 pieces.

Instructions for use

The active ingredient of the drug is papaverine hydrochloride, which is an opium alkaloid that acts on smooth muscle elements. It causes relaxation, therefore, according to the pharmacological classification, it belongs to myotropic antispasmodics. The component inhibits some enzymes, lowers the level of calcium ions, and reduces vascular and muscle tone.

In large doses, it eliminates cardiac excitability, slows intracardiac conduction, and has a hypotensive and sedative effect. In combination with barbiturates, it enhances the antispasmodic effect. When taken simultaneously with tricyclic antidepressants, procainamide, reserpine, quinidine, the drug enhances the hypotensive effect.

Suppositories with papaverine during pregnancy

To prevent the product from causing harm, the pregnant woman should follow the instructions for its use. Rectal suppositories should be inserted into the anus after bowel movements. It is better to do this lying on your side. The course of treatment begins with concentration active substance in a suppository in the amount of 0.02 g, gradually increasing to 0.04 g. It is allowed to use no more than three suppositories per day.

Injection

The active component of the pharmaceutical product is characterized by high bioavailability, which allows subcutaneous, intramuscular or intravenous injections. Subcutaneous injections are given in the shoulder or outer thigh, but not in the forearm, because the risk of hematoma increases. Intramuscular injections are administered into the upper lateral quadrant of the buttock. Before the injection, the contents of the ampoule are dissolved ml saline solution, is introduced very slowly. A single dosage is 0.1 g, the daily dosage does not exceed 0.3.

Contraindications

According to the instructions for use, rectal suppositories and ampoules for administration are not prescribed if there are contraindications:

problems with thyroid gland, liver, adrenal glands, kidneys;
increased intraocular pressure, glaucoma;
tachycardia;
rectal diseases;
bronchial dysfunction;
hypersensitivity to components;
intracardiac conduction disturbance, atrioventricular block;
self-prescription of the drug;
with caution in case of recent traumatic brain injury, shock, hypothyroidism, supraventricular tachycardia.

Side effects and overdose

Go to properties side effect The drug includes allergic reactions, decreased blood pressure, constipation (constipation), atrioventricular block, bloating, nausea, impaired movement of food through the esophagus, and increased activity of liver enzymes. With increased doses, symptoms of drowsiness, nausea, dizziness, sweating, and eosinophilia are possible.

If intravenous ampoules are administered too quickly, the heart rhythm is disrupted. Symptoms of overdose are double vision, weakness, and increased fatigue. You can get rid of them through detoxification, symptomatic therapy. Gastric lavage and the use of sorbents help effectively, plus it is important to support blood pressure with special means.

Terms of sale and storage

The drug is dispensed according to a prescription, stored in a dry place, protected from light and children, at an air temperature of up to 25 degrees. The shelf life is two years.

Analogues

According to the active substance, pharmacological action and the possibility of use during pregnancy, the following analogues of Papaverine, domestic or foreign produced, are distinguished:

Spasmol;
No-Shpa;
Drotaverine and Drotaverine Forte;
Dolce;
Nokhshaverin;
Pantestin;
Spazoverine;
Ple-Spa;
Drotaverine or Papaverine hydrochloride.

How long does it take for papaverine injections and suppositories to work?

How long does it take for papaverine to start working?

How long does it take for a papaverine injection to work?

How long does it take for papaverine suppositories to take effect?

How long does it take for papaverine in suppositories to work?

Papaverine is an antispasmodic, vasodilator, antihypertensive drug. Available in the form of tablets, injection solution, rectal suppositories.

The effect of the drug administered rectally manifests itself quickly, within a few minutes.

An immediate effect from the administration of papaverine can be achieved by making injections (subcutaneously, intramuscularly or intravenously).

Papaverine during pregnancy

It’s rare for a woman to go through nine months of pregnancy without pills and medications. This is influenced by the terrible ecology, hereditary diseases and poor nutrition. In recent years, if a woman has developed uterine hypertonicity, doctors strongly advise taking papaverine during pregnancy to avoid negative consequences and relieve pain.

The drug papaverine for expectant mothers

Papaverine hydrochloride is an excellent antispasmodic that perfectly relaxes muscles and reduces blood pressure.

The medicine papaverine hydrochloride is produced in various forms:

Why is papaverine prescribed during pregnancy?

In any form, papaverine has a positive effect on the body of a pregnant woman; when taken regularly, the following occurs:

Reduced blood pressure
Improving blood supply and relaxing the muscles of the uterus;
The threat of miscarriage associated with uterine hypertonicity is prevented.

It does not harm the health of the unborn child, but on the contrary has a positive effect on him. Several generations of children have already grown up whose mothers took papaverine, and no side effects not detected on them. Doctors consider it the most universal and most convenient medication to use.

Often, papaverine can be prescribed during the first trimester of pregnancy, when other medications are under control. strict ban, usually suppositories are prescribed at this time.

Taking papaverine, a pregnant woman notices that her anxiety stops, she begins to feel much calmer, her heart no longer beats wildly, as its rhythms slow down. But you can take this medicine if your doctor has prescribed it.

Sometimes injections are prescribed, they are done carefully, papaverine is slowly injected into a vein. Only a specialist should give injections.

Papaverine tablets are usually not prescribed during pregnancy, since they are almost insoluble in aqueous solutions, and only half of the dose taken orally is absorbed into the gastrointestinal tract. Pills do not act as quickly and effectively as injections or rectal suppositories.

What does papaverine contain and how does it work?

Papaverine hydrochloride is a substance that weakens the contraction of muscle fibers located in the walls of internal organs. This hormone is obtained artificially. It was synthesized in the fifties of the 20th century, and all the time it helps women safely bear a child. On its basis, a more effective drug no-spa was created.

It does not affect skeletal muscles, so those taking papaverine do not feel weak. This drug helps reduce uterine spasms, reduces calcium levels in muscle cells. It also helps to relax the walls of blood vessels, which lowers blood pressure.

How are papaverine suppositories used?

When a woman is prescribed suppositories with papaverine during pregnancy, when she buys them, she sees that instructions are attached to them. You need to read it carefully and find out from your doctor all the answers to your questions. This form of medication is very convenient, as it is easy to administer independently. The suppositories begin to act immediately after dissolution, instantly relieving painful symptoms. They help the expectant mother get rid of many troubles that threaten normal course pregnancy.

It should be borne in mind that papaverine during pregnancy can cause side effects, which can manifest themselves in the form of:

Allergies
Nausea
Lower blood pressure
Difficulty with bowel movements
Drowsiness
Increased eosinophils in the blood.

When not to take medicine

The instructions attached to the medicine contain a section of contraindications under which papaverine hydrochloride should not be taken. The woman should read it carefully, and if they concern her personally, tell the doctor about it.

It is forbidden to take papaverine during pregnancy when a woman has or has previously had problems:

with the thyroid gland
with liver;
increased intraocular pressure
tachycardia

The need to take and discontinue papaverine is determined only by a doctor.

The effect of papaverine hydrochloride is reduced if the woman does not quit smoking or drinks alcohol.

Prevention of uterine hypertonicity

When a pregnant woman has uterine hypertonicity, she must not only insert suppositories with papaverine during pregnancy and take various medications, but also follow a certain lifestyle. She must provide a gentle regimen for the future baby and herself, and learn relaxation techniques that are simply vital for every pregnant woman.

If there are the slightest signs of increased uterine tone, the woman should tell her gynecologist about them. When a pregnant woman feels discomfort in the lower abdomen, physical activity is completely contraindicated. It is advisable to lie more in a relaxed state. If you have hypertension, sex is prohibited so as not to provoke a miscarriage. Such simple measures are not difficult to follow, but they perfectly help reduce the tone of the uterus and give birth to a baby on time.

How to properly use suppositories with papaverine?

Suppositories with papaverine are an alkaloid drug with an antispasmodic, hypotensive effect on the rectal area.

The drug helps to relax smooth muscle cells, relieve spasms in the intestines, eliminate constipation, normalize stool, and have a beneficial effect on blood vessels and systems in the body.

This is one of the few drugs approved for use by women during pregnancy and breastfeeding. However, there are contraindications and side effects. Before use, it is important to read the instructions and follow the doctor’s recommendations.

Release form, composition and packaging

Suppositories with papaverine are an opium alkaloid with a derivative active substance – isoquinol.

ATX code - A03AD01. Produced by Russian manufacturers, the Dalkhimfarm company, JSC Biosintez.

tablets 0.01-0.04 mg in blisters of 10 pieces;
solutions for injections (2%);
ampoules (2 ml) in cardboard packaging of 10 pieces for subcutaneous, intramuscular, intravenous administration;
rectal suppositories (0.02 g) torpedo-shaped with a smooth white surface for insertion into the rectum.

Packaging - contour cells. In addition, instructions for use are included.

Contains the active ingredient Papaverine hydrochloride.

The drug has found wide use in gynecology, pediatrics, and proctology in the treatment of diseases accompanied by smooth muscle spasms:

With rectal administration of suppositories, a rapid effect and absorption of the active components into the bloodstream are observed.

According to experts, suppositories with papaverine are the safest form of release.

One piece contains 20 mg of papaverine hydrochloride (active ingredient) and auxiliary components: sugar, stearic acid, potato starch.

pharmachologic effect

Regardless of the method of administration and release form, the drug quickly penetrates the body, is absorbed into the bloodstream, binds to plasma proteins up to 90%, passes without difficulty through the histohematic barrier and is transformed in liver cells.

It is excreted within 0.5 - 1 hour by the kidneys in the form of metabolic products.

The active substances are quickly absorbed into the blood, evenly distributed throughout the tissues. They even penetrate into the structures of the central nervous system, affecting arterial vessels, urogenital tract, muscles of the hepatobiliary and digestive systems.

Quickly acting, papaverine suppositories:

expand the lumen of the rectal cavity;
relieve spasms of smooth muscles;
reduce blood pressure levels;
reduce the excitability of the heart muscle.

Suppositories with papaverine have an excellent effect on arterial vessels, the hepatobiliary system, and the structures of the urogenital tract.

They lead to a decrease in the concentration of adenosine monophosphate of calcium ions in the intracellular space, leading to the elimination of spasms in muscle fibers.

Indications for use

Papaverine is widely used in proctology and gynecology in the treatment of diseases as a single agent or in combination with other drugs.

Due to the antispasmodic effect, suppositories are often prescribed in gynecology to women in the prenatal period during excruciatingly painful contractions to relieve spasms, inflammation, hypertonicity of the uterus and softening the cervix, which creates the threat of miscarriage.

Suppositories with papaverine normalize uterine blood flow and pressure indicators, have an antispasmodic effect on blood vessels, eliminate spasms, colic and pain.

bronchospasms;
renal colic;
endotheritis;
spasms of smooth muscles of the peritoneal cavity;
spastic colitis;
hypertensive crisis;
migraine;
urinary retention due to spasms in the urinary tract;
heat bodies;
high blood pressure;
diseases of the urinary system (cystitis, pyelonephritis);
back pain;
hemorrhoids regardless of the stage of development;
painful menstruation;
inflammation in the rectal cavity;
urological diseases (cystitis, prostatitis);
with IVF;
V postpartum period or if there is a threat of miscarriage;
for men to treat potency, enhance erection.

Suppositories with papaverine can be prescribed before surgery to relax smooth muscle structures during abdominal prostatectomy.

The recommended form of papaverine is suppositories for the treatment of diseases: hemorrhoids, cholecystitis, spastic colitis, spasms of the urinary tract. Suppositories have fewer contraindications and side effects, unlike other forms of release of drugs containing Papaverine.

Contraindications for use

Main contraindications to the use of this drug:

infants up to 6 months;
allergy to the components of the composition;
excessive sensitivity to active substances;
liver failure;
glaucoma disease;
kidney disease;
traumatic brain injury;
loss of consciousness;
thyroid diseases;
hyperthermia with elevated temperature bodies.

It is not recommended to use the medicine in combination with nicotine and alcoholic beverages, which can lead to side effects, toxicosis, fainting, increased hypotonic reaction and decreased analgesic effect.

So, for smokers, when treating hemorrhoids, papaverine may become completely useless and not lead to the desired result.

Side effects

It is important to make sure before using suppositories that there are no contraindications.

Side effects from the respiratory, immune, and digestive systems in older people are common:

rash, itching, skin hyperemia;
allergy;
diarrhea;
vomit;
constipation;
dryness, sore mouth;
arterial hypertension;
ventricular extrasystole;
arrhythmia;
dizziness;
darkening of the eyes;
heart rhythm failure;
decrease in blood pressure;
abdominal discomfort;
increased sweating;
excessive dilation of blood vessels.

During pregnancy, it is important for women to take into account all the recommendations of a specialist and not to neglect the doses and method of using suppositories. It must be used for its intended purpose and administered correctly if necessary to relieve tension in the uterus.

Instructions for use

It is important to consider age, release form, dosage, regimen and method of administration.

Method of inserting suppositories into the rectum

When used rectally, it is advisable to use suppositories before bedtime and insert them into the rectum (lumen) with caution, for which:

wash your hands with soap;
lie on your side, tuck your legs towards your stomach;
unpack the candle and insert the straight tip deeper into the anus;
lie down for 0.5 hours without getting up immediately to avoid partial leakage of the candle due to rapid melting.

If inserted correctly into the anus, the therapeutic effect of the suppository will begin in approximately 25 minutes.

The dosage per day should not exceed 120 mg. The temporary treatment period is on average 10 days, but for extension it should be discussed with a doctor individually.

Until the desired result is achieved, it is possible to extend the course up to 2 months as necessary.

With anal rectal administration, the effect and impact on the inflamed lesion is observed much faster, in contrast to the tablet form of Papaverine. Overdoses are excluded. The drug is well tolerated and rarely leads to side effects.

Rectal suppositories contain a lower dose of papaverine hydrochloride. The main thing is to take into account the dosage and clean the rectum before administering the drug by performing an enema.

When using tablets, the permissible dose for children is:

2-4 years - 10 mg 4 times a day;
5-6 years - 10 mg 3 times a day;
7-10 years - 15 mg 4 times a day;
10-14 years - 20 mg 4 times a day.

For rectal administration, the applicable dosage of suppositories with papaverine for adults is 40 mg 2-3 times a day.

A single dose should not exceed 40 mg when administered in solutions (injections) intramuscularly or subcutaneously. When giving injections to children - a maximum of 100 mg of a 5% solution and observing a 4-hour interval between injections.

The maximum dose per day should not exceed 500 ml of papaverine solution or 300 mg for children, but taking into account weight and age.

2 years - 20 mg;
4 years - 30 mg;
7-9 years - 60 mg 3 ml solution;
10-14 years 100 mg or 5 ml of solution by intramuscular, intravenous administration.

When treating prostatitis in men and inserting suppositories into the urethra, the average dose is 40 mg 2 times a day. For older people, a single dose should not exceed 100 mg per day. The course of treatment is 10 days with the possibility of extension, but after consultation with the attending physician.

On a note! Women during pregnancy are not recommended to insert suppositories into the vagina. Only rectal administration of papaverine hydrochloride is permissible, which is unable to show negativity towards the fetus and provoke a miscarriage. Sometimes Papaverine injections are prescribed for medicinal purposes, but therapy should be carried out exclusively under the supervision of the attending physician.

Suppositories with papaverine are the safest form of the drug and are often prescribed to women during pregnancy to relieve uterine hypertonicity and prevent premature birth. later pregnancy, early miscarriage.

It is the overstrain of the uterine cavity that leads to negative consequences.

normalization of blood circulation in the uterine muscles;
heart rate stabilization;
decreased abdominal pressure;
relieving muscle tension;
weakening of the muscles of internal organs.

As the fetus grows in the mother's body, one way or another leads to stretching of the walls of the uterus and muscle tension.

It is suppositories with papaverine that will lead to weakening of the uterine muscles, while the muscles can no longer relax on their own as the fetus grows.

Suppositories with papaverine can be a real salvation for women during pregnancy. However, dosages, advice and recommendations of doctors cannot be neglected.

Overdose

drowsiness;
excessive fatigue;
double vision;
weakness;
decreased blood pressure;
intoxication of the body;
disturbance of the rhythm of heart contractions;
attacks of arrhythmia;
nausea, vomiting.

The stomach should be rinsed immediately, drink a glass of milk, take activated charcoal if side effects are observed 1-2 hours after taking papaverine hydrochloride. It is also important to measure your blood pressure.

In case of excessive drop in indicators, vomiting and dizziness, it is better to call an ambulance without waiting for your health to worsen.

Interaction with other drugs

The combined use of papaverine with other drugs can reduce or enhance the therapeutic effect:

So, compatibility may be without negative reactions subsequently in combination with the following drugs: Dibazol, Prostodin.
The hypotensive stable effect of papaverine is observed when combined with Quinidine, Reserpine, Novocainamide, Procainamide.
An enhanced antispasmodic effect is possible when the drug is combined with barbiturates: Analgin, Diphenhydramine, Diphenhydramine.
Papaverine in combination with Dibazol will help relieve a hypertensive crisis in patients with diabetes and hypertension. Platyfillin will help provide a sedative, vasolytic effect.
Medicines similar to Papaverine in pharmacological properties for the purpose of pain relief and relaxation of smooth muscle elements: No-shpa, Drotaverine.

Often, drugs are prescribed by obstetricians-gynecologists for hypertonicity of the uterus, excessive activation of labor, pain in the lower abdomen, and the threat of miscarriage.

If you need to replace Papaverine with another analogue, you must first consult with a qualified doctor.

Use during pregnancy and lactation

Suppositories with papaverine are suitable for women during pregnancy for the following purposes:

risk of miscarriage;
arterial hypertension;
spasms in the bronchi;
heat;
hypertonicity of the uterus;
colic (renal, intestinal, hepatic) to relax the excretory ducts, restore functions in the body, and relieve pain.

According to the instructions for use, the dosage of the drug, taking into account the duration of pregnancy, differs slightly:

1st trimester - pregnancy is in progress initial stage, the placental barrier is formed and many medications are prohibited. It is papaverine suppositories (an antispasmodic) that can become an essential medicine for pregnant women. The main purposes of the drug: increased uterine tone, threat of miscarriage. Candles have a prolonging effect and quickly relieve uterine tension. Moreover, this week it can be used in combination with No-shpa.
2nd trimester, suppositories with papaverine are also approved for use as a drug with an immediate response to pressure surges and abdominal cramps. The drug will have an antispasmodic effect and will help maintain the well-being of the expectant mother until the doctors arrive, since you should not count on a long-term effect.
The 3rd trimester and the reason for using suppositories may be excessive overexertion, the uterus remaining in good shape, creating a threat of premature birth. Candles can serve as an indicator for false contractions. If after use the contractile activity of the uterus begins to decline, it means that the due date has not yet arrived. In particular, in the third trimester, it is possible to prescribe suppositories to soften the uterine cavity, relieve colic, overexertion, and pain during contractions.

Use in childhood

Main indications for use:

for babies under 1 year of age – renal colic, cholecystitis, endotheritis, angina pectoris, intestinal colic, cerebral vascular spasms;
children over 3 years old - urethral spasms, hepatic colitis, pancreatitis, bronchospasms, hyperthermia with vascular spasms in the periphery, high body temperature as an antipyretic.

Sometimes Papaverine is prescribed to children before surgery.

There are contraindications when using Papaverine tablets:

children under 6 months;
liver failure;
excessive hypersensitivity to the active substance.

The dosage for children should be observed taking into account age. If tablets are used, it is not advisable to chew them. It is important to swallow them whole. washed down with water. If injections are used, then a single dose for children over one year of age is 300 mg.

Administration should be done slowly enough to avoid blockade and failure of the heart muscle.

Acceptable dosages for children based on age:

0.5 - 2 years - 5 mg, 1/4 tablet;
3-4 years – 10 mg, 1/2 tablet;
5-6 years - 12 mg, 1 tablet;
7-9 years - 15 mg, 1.5 tablets;
10-14 years - 20 mg, 2 tablets.

special instructions

Papaverine suppositories contain active ingredients with quick impact on the central nervous system, therefore, for the period of treatment it is recommended to avoid driving a car and work that requires increased concentration.

Papaverine suppositories require careful use for the following disorders in the body:

adrenal hyperplasia;
hyperthyroidism of the thyroid gland;
chronic renal failure;
violation of the functional activity of the kidneys;
tachycardia;
enlargement of the prostate gland in men;
multiple organ failure.

Pregnant women should use the drug with caution unless the degree of benefit and safety for the fetus has been determined. In particular, when breastfeeding, it is not advisable to use the medicine yourself without a prescription from a specialist.

Storage conditions and shelf life

Suppositories with papaverine must be stored in a tight container, dry, protected from contact sun rays. Optimum temperature + 25 degrees.

After the expiration date, candles must be thrown away; they also cannot be stored open for a long time, without packaging.

The average price for 1 package of tablets is 10 rubles. Injections, ampoules of 2 ml - 10 ampoules rub.

Analogues

You can replace suppositories with papaverine with similar drugs containing drotaverine hydrochloride with the following:

No-spa for relieving spasms, relaxing the smooth muscles of blood vessels and internal organs. This is an excellent antispasmodic recommended for women during pregnancy at any stage. Contains the active ingredient (drotaverine hydrochloride). Indications for use: failure of the immune, digestive and cardiovascular systems. Do not take if you have liver, heart or kidney failure. The cost of the drug is rub. per package (10 pieces).
Drotaverine with active ingredient (drotaverine). Release form: tablets. Indications for use: disorders of the cardiovascular, nervous, and respiratory systems. Contraindications: renal and liver failure. Price – 110 rubles for 1 pack.
Spasmolysin for pain in the anus, treatment of diseases: cystitis, cholecystitis, pancreatitis, colitis. Release form: suppositories. Cost, rub.
Spascuprel for relaxing the smooth muscle muscles of internal organs, in the treatment of diseases of the kidneys, intestines, stomach, pancreas. Price, rub.
Niaspam is prescribed for IBS, colic in the intestines, liver, kidneys, treatment of pathologies of the digestive system. Cost, rub.

These analogues should be used only with the permission of the attending physician and only after an examination and tests.

Despite the safety of suppositories with papaverine, self-medication is excluded. Incorrect dosages and uncontrolled methods of use can cause an ambiguous reaction in the body and lead to negative side effects.

Composition and release form of the drug

◊ Rectal suppositories from white to white with a yellowish or creamy tint, torpedo-shaped.

Excipients: solid fat (Vitepsol, Supposir) - to obtain a suppository weighing 1.25 g.

5 pieces. - contour cell packaging (2) - cardboard packs.

pharmachologic effect

Dosage

Orally - 40-60 mg 3-5 times/day. Rectally - 20-40 mg 2-3 times/day.

With intramuscular, subcutaneous or intravenous administration, a single dose for adults is 10-20 mg; the interval between injections is at least 4 hours. For elderly patients, the initial single dose is no more than 10 mg. For children aged 1 to 12 years, the maximum single dose is 200-300 mcg/kg.

Side effects

Maybe: nausea, constipation, drowsiness, increased sweating, arterial hypotension, increased activity of liver transaminases.

With rapid intravenous administration, as well as when used in high doses: development of AV block, rhythm disturbances.

Drug interactions

When used simultaneously with anticholinergic drugs, the anticholinergic effects may be enhanced.

It is believed that when used concomitantly with alprostadil for intracavernosal administration, there is a risk of developing priapism.

There are reports of a decrease in the effectiveness of levodopa when used simultaneously.

Reduces the hypotensive effect.

special instructions

Use with caution in conditions after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock conditions.