This article allows you to familiarize yourself with the instructions for the use of an anesthetic drug. Novigan.. The reviews of the site visitors - consumers of this medicine are presented, as well as the opinions of medical professionals on the use of Novigan in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of Novigan in the presence of available structural analogues. Use for the treatment of head and dental pain during menstruation in adults, children, as well as in pregnancy and breastfeeding. Composition of the drug.
Novigan. - The combined drug, has an analgesic, anti-inflammatory and antispasmodic effect. Suppresses the synthesis of prostaglandins. The drug includes a non-steroidal anti-inflammatory agent (NSAID) of ibuprofen, a myotropic antispasmodic agent of Pitophenone hydrochloride and a M-choline-blocking agent of the central and peripheral effect of the phenpymeric bromide.
Ibuprofen is a phenylpropionic acid derivative. It has analgesic, anti-inflammatory and antipyretic effect (reduces increased body temperature). The main mechanism of action is the oppression of the synthesis of prostaglandins - fragments of pain sensitivity, thermoregulation and inflammation in the CNS and peripheral tissues. Women with primary dismenoria reduces the elevated level of prostaglandins in myiometry and due to this reduces the intrauterine pressure and the frequency of uterine contractions.
Pitophenone hydrochloride has a direct motropic effect on the smooth muscles of the internal organs and causes it relaxation.
Fenpiverine Bromide due to the cholinoblocking action has an additional relaxing effect on the smooth muscles.
The combination of the three components of the drug leads to a mutual strengthening of their pharmacological action.
Structure
Ibuprofen + Pitoophenone hydrochloride + phenpymeric bromide + excipients.
Pharmacokinetics
When taking inside the components of the drug Novigan are well absorbed into the gastrointestinal tract. The main component of the ibuprofen preparation is 99% associated with blood plasma proteins, accumulates in a synovial fluid. Ibuprofen is metabolized in the liver and is excreted by 90% with urine in the form of metabolites and conjugates. A small part of ibuprofen is excreted with biliary.
Indications
- weakly or moderately expressed pain syndrome in spasms smooth muscles of internal organs: renal and bile colic, dyskinesia biliary tract, intestinal colic;
- dysmenorrhea;
- headache, incl. migraine nature;
- short-term symptomatic treatment with pains in joints, neuralgia, Ishiagia, Malgia.
Forms of release
Tablets covered with a shell of 400 mg + 5 mg + 100 μg.
Instructions for use and dosing mode
Inside, 1 hour before or after 3 hours after meals. In order to avoid annoying action on the stomach, you can take the drug immediately after eating or drink milk.
In the absence of special prescriptions, Novyan's doctor is recommended to take in spastic pains of 1 tablet to 3 times a day. Maximum daily dose - 3 tablets. Do not exceed the specified dose!
The course of treatment with Novigan, without consulting a doctor, should not exceed 5 days. A longer use is possible under the supervision of a physician with the control of the performance of peripheral blood and the functional state of the liver.
Side effect
- NPVP gastropathy (abdominal pain, nausea, vomiting, heartburn, decreased appetite, diarrhea, meteorism, constipation, ulceration of the gastrointestinal mucous membrane, which, in some cases, are complicated by perforation and bleeding; irritation or dryness of the oral mucous membrane, pain in the mouth, ulceration of the gum mucosa, aphthosal stomatitis);
- pancreatitis;
- hepatitis;
- dyspnea;
- bronchospasm;
- headache;
- dizziness;
- insomnia;
- anxiety;
- nervousness and irritability;
- psychomotor excitation;
- drowsiness;
- depression;
- confusion of consciousness;
- hallucinations;
- aseptic meningitis (more often in patients with autoimmune diseases);
- hearing impairment;
- reduction of hearing;
- tinnitus;
- violation of vision (toxic lesion of the optic nerve, the fuzziness of visual perception, scotoma, dryness and irritation of the eyes, edema of conjunctiva and age (allergic genesis), accommodation paresis);
- heart failure;
- tachycardia;
- increased blood pressure;
- acute renal failure;
- allergic jade;
- nephrotic syndrome (swelling);
- oliguria, Anuria, Polyuria;
- proteinuria;
- cystitis;
- staining urine in red;
- skin rash (usually erytematous or urticaria);
- skin itch;
- swelling quinque;
- anaphyactoid reactions;
- anaphylactic shock;
- bronchospasm or dysnae;
- fever;
- multiform exudative erythema (incl. Stevens-Johnson syndrome);
- toxic epidermal necrolis (Layella syndrome);
- eosinophilia;
- allergic rhinitis;
- anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia;
- strengthening or reducing sweating.
Contraindications
- erosive-ulcerative changes in the mucous membrane of the stomach or duodenal intestine, active gastrointestinal bleeding;
- inflammatory bowel disease in the aggravation phase, incl. ulcerative colitis;
- anamnestic data on the attack of broncho-referee, rhinitis, urticaria, after taking acetylsalicylic acid or other NSAIDs (full or incomplete syndrome of the amcetylsalicylic acid intolerance - rinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
- liver failure or active liver disease;
- renal failure (QC less than 30 ml / min), progressive kidney disease;
- confirmed hypercalemia;
- hemophilia and other blood coagulation disorders (including, hypocoagulation), hemorrhagic diathesis;
- the period after conducting the aortocortonary shunting;
- acute interspersed porphyria;
- granulocyptopenia;
- blood breeding;
- deficiency of glucose-6-phosphate dehydrogenase;
- tahiaritimia;
- clotted glaucoma;
- diseases of the optic nerve;
- prostate hyperplasia;
- intestinal obstruction;
- pregnancy;
- lactation period (breastfeeding);
- age up to 16 years;
- increased sensitivity to any component of the drug.
Carefully:
- elderly age;
- stagnant heart failure;
- cerebrovascular diseases;
- arterial hypertension;
- ischemic heart disease (IBS);
- dyslipidemia / hyperlipidemia;
- diabetes;
- peripheral arterial diseases;
- nephrotic syndrome;
- Kk less than 30-60 ml / min;
- hyperbilirubinemia;
- ulcerative ulcer of the stomach and duodenal intestine (in history);
- the presence of Helicobacter Pylori infection;
- gastritis, enteritis, colitis;
- long-term use of NSAIDs;
- blood diseases unclear etiology (leukopenia, anemia);
- smoking;
- frequent use of alcohol (alcoholism);
- severe somatic diseases;
- concomitant therapy with the following drugs: anticoagulants (for example, warfarin), anti-aggregants (for example, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (GKS) (for example, prednisone), selective inhibitors of serotonin reverse seizure (for example, cytalopram, fluoxetine, paroxetine, sertraline).
Application in pregnancy and breastfeeding
The drug Novigan is contraindicated during pregnancy and during lactation (breastfeeding).
Application in children
Contraindicated to children under the age of 16.
Application in elderly patients
With caution, you should use the drug in elderly patients.
special instructions
With long-term use, the picture of the peripheral blood and the functional state of the liver and kidneys is necessary.
To reduce the risk of developing unwanted phenomena by the gastrointestinal gastrointestinal dose. With the appearance of gastropathy symptoms, careful control is shown, comprising carrying out esophagastroduodenoscopy, blood tests with the determination of hemoglobin and hematocrit, feces for hidden blood.
If necessary, the determination of 17-ketosteroids, the drug should be canceled 48 hours before the study.
During the treatment period, you should refrain from taking alcohol.
Impact on the ability to driving vehicles and control mechanisms
During the period of treatment, the patient must refrain from practicing potentially hazardous activities requiring increased concentration and speed of psychomotor reactions.
Medicinal interaction
In therapeutic doses, the drug Novigan does not enter into significant interactions with widespread drugs.
Inductors of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, fluecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the products of hydroxylated active metabolites, increasing the risk of severe intoxication.
Microsomal oxidation inhibitors reduce the risk of hepatotoxic action.
The drug reduces the hypotensive activity of vasodilators and the sodium systemic effect of furosemide and hydrochlorothiazide.
Reduces the effectiveness of uricozeuric drugs.
Enhances the effect of indirect anticoagulants, antiagregants, fibrinolithics (which increases the risk of bleeding).
Enhances the side effects of mineralocorticoids, glucocorticoids (the risk of gastrointestinal bleeding increases), estrogen, ethanol (alcohol).
Enhances the hypoglycemic effect of sulfonylurea derivatives.
Antacids and swiveralities reduce the absorption of ibuprofen.
The drug increases the concentration of digoxin, lithium preparations, methotrexate in the blood.
Enhances the effect of M-cholinoblocators, histamine-receptor histamine blockers, buthrofenons, phenothiazines, amantadine and quinidine.
The simultaneous purpose of other NSAIDs increases the frequency of side effects.
Caffeine enhances analgesic effect.
With a simultaneous purpose reduces the anti-inflammatory and anti-aggregative effect of acetylsalicylic acid (it is possible to increase the frequency of the development of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiagregative agent, after the beginning of the reception of the drug Novigan).
Cephamandol, cefoperazazon, cefethean, valproic acid, Plikamycin increase the frequency of the hypoprothrombinemia while simultaneously intended.
Myelotoxic drugs enhance the manifestations of the hematotoxicity of the drug.
Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increase in nephrotoxicity.
Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.
Drugs that block the tubular secretion reduce the elimination and increase the plasma concentration of ibuprofen.
Analogs of the drug Novigan
Structural analogues for the acting substance:
- Novospaz.
Analogs on therapeutic effect (means for the treatment of migraine):
- Amigrenine;
- Amitriptyline;
- Analgin;
- Anaprilin;
- Andipal;
- Askofen;
- Betalki;
- Vasogrammed;
- Voltaren;
- Diclofenac;
- Dimphosbon;
- Zomig;
- Ibufen;
- Inderal;
- Ipronal;
- Kaffetin;
- Ketonal;
- Contempt;
- Corgard;
- Xanthinola nicotinate;
- Kudvita;
- Lexotan;
- Metovit;
- Metoprolol;
- MiG 200;
- Nazila;
- Flap;
- Naltezin;
- Nex;
- Nilogrin;
- Non-drug;
- Novopalsit;
- Nomigren;
- Nooofen;
- Nooofen for children;
- Obizant;
- Oaron;
- Ormidol;
- Panadein;
- Panadol;
- Paracetamol;
- Pentalgin;
- Peritol;
- Picikalon;
- Plivalgin;
- Propranolol;
- Revalgin;
- Redergin;
- Rudotel;
- Salpadein;
- Starbonon;
- Summigren;
- Topamax;
- Uppsar Ops;
- Soothing (sedative) collection;
- Faspik;
- Febrcenet;
- Fesame;
- Flamaks;
- Heirumat;
- Cefecon D;
- Zinnarizin;
- Citrap;
- Egilov;
- Estecore;
- Efalkon.
In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.
SPAGOANALGETIK
Preparation: Novigan®
The active substance of the drug:
Fenpiverinium Bromide, Ibuprofen, Pitofenone
ATH encoding: M01AE51
KFG: Spasopanalgesic
Registration number: P №008846
Registration date: 04/28/06
Owner reg. Entrepreneur: DR. Reddy`s Laboratories Ltd. (India)
Form of release Novigan, packaging of the drug and composition.
Pills covered with a shell of white color, round, double-screw, embossed "novigan".
1 tab.
ibuprofen.
400 mg
Pitopenone hydrochloride
5 mg
Fenpiverine Bromide
100 μg
Auxiliary substances: microcrystalline cellulose, corn, glycerol starch, glycerol, silicon colloidoid, talc peeled, magnesium stearate, hyprontellose, macrogol 6000, titanium dioxide, polysorbate 80, sorbic acid, dimethicone.
10 pieces. - Blister (2) - cardboard boxes.
10 pieces. - Blister (10) - cardboard boxes.
10 pieces. - blisters (20) - cardboard boxes.
Pharmacological action Novigan
Novigan is a new combined anesthetic and antispasmodic preparation consisting of three components:
1. ibuprofen - non-steroidal anti-inflammatory drug (NSAID);
2. ketone - papaverine-like spasmodics of peripheral action;
3. Amide - cholinolics with a central and peripheral mechanism of action.
All components of Novigan have a different mechanism of action and potentiate anesthetic and antispasmodic effects of each other.
Ibuprofen - like all NSAIDs, inhibiting prostaglandin - synthetia, reduces the synthesis of prostaglandins, which are responsible for the development of pain, inflammation and fever. In women with primary dysmenorrhea, Ibuprofen reduces the elevated level of prostaglandins in the uterus and thereby reduces the intrauterine pressure and the frequency of uterine contractions. Ibuprofen prevents the synthesis of thrombooxane, which causes the aggregation of platelets.
Ketone - as a papaverinopod-like drug acts on the smooth muscle muscles of hollow organs, relaxing it.
Amide - cholinolitic of the central and peripheral action, blocks cholinoreceptors and relaxes a smooth muscles.
Pharmacokinetics of the drug.
Novigan is quickly absorbed in the gastrointestinal tract, the peak of the plasma concentration is achieved after 1-2 hours. The removal of the drug happens quickly, the half-life is 2 hours.
If Novyan is accepted after eating, then suction is noticeably reduced and slows down, but the bioavailability of the drug does not change significantly.
Most of the new Novigan is displayed with urine in 24 hours, the content of ibuprofen metabolites reaches 90%. A small part of the drug is distinguished with bile.
Novigan is firmly and intensively associated with blood plasma proteins. The concentration of the free drug in the blood plasma is approximately 20% of the adopted dose. In this regard, there is no significant interaction with other drugs.
Indications for use:
- renal colic
- hepatic colic, dyskinesia biliary tract
- spasms of various gastrointestinal departments, accompanied by pain
- syndrome, Tenezms
- spastic dysmenorrhea
- headache, including Migraine
- pain of other origin associated with the spasm of smooth muscles.
Dosage and method of use of the drug.
In the absence of special prescriptions, the following approximate doses are recommended:
Adults in spastic pains of 1-2 tablets up to 4 times a day (maximum daily dose of ibuprofen 3200 mg).
With a dynamo 1 tablet every 4 hours.
Since food intake affects Novigan's absorption, take the drug should take 1 hour before or 3 hours after meals. If from the head of the gastrointestinal tract there will be any unpleasant feeling, you can take the drug after eating or milk.
Side effect Novigan:
Since Novigan is not a drug for long-term use and is shown, mainly for episodic use, the side effects are extremely rare and are associated with increased sensitivity to the components of the drug.
Contraindications for the drug:
- erosive-ulcerative lesions of the gastrointestinal tract in the stage of exacerbation;
- increased sensitivity to Ibuprofenu and other NSAIDs;
- aspirinically dependent bronchial asthma syndrome;
- blood breeding;
- diseases of the optic nerve;
- pronounced violations of the liver and kidney function.
Special guidance on applying Novigan.
Since Ibuprofen enters the composition of Novigan, caution should be taken when it is prescribed in patients with diseases of the kidneys, liver, with chronic heart failure, ulcerative disease of the stomach and duodenal intestine in history, violation of the coagulation system of blood, bronchial asthma.
The interaction of Novyan with other drugs.
With a simultaneous appointment with a furosemide, a decrease in the diuretic effect may be observed.
Novigan is an anti-inflammatory drug.
Pharmacological action Novigan
The drug has an anesthetic, antispasmodic (removal of spasms), and anti-inflammatory effect. These processes occur due to the entry into the composition of the medicinal product ibuprofen, pitophenone hydrochloride, as well as the phentiversity of bromide.
Ibuprofen is a non-steroidal anti-inflammatory agent that removes pain and heat. Pitophenone hydrochloride, as well as Fenpiverine Bromide is designed to relax the smooth muscles of human internal organs.
The above three substances in combination enhance each other's action.
Form release
Tablets Novigan are sold in pharmacies.
Indications for the application of Novigan
The drug is used to remove weak, or moderate pain in the spasms of smooth muscles of internal organs. It is recommended to use with biliary, renal colic, dyskinesia of biliary ducts, as well as with strong menstrual pains.
In addition, Novigan is effective in Malgia, radiculitis, neuralgia, moderate, or strong pain in the joints, bursite, tend. The drug quickly removes the toothaches, headache (migraine is included in this list).
Positive feedback Novyan received in the treatment of colds, infectious inflammatory diseases. This remedy reduces the temperature and reduces the heat.
Method of application and dosage
Tablets Novigan should take 1-2 pieces about 4 times a day. The exact dose should determine the specialist. The maximum daily dose is 6 tablets per day.
If the patient has menstrual pains that are caused by the pathologies of the female genital inflammatory organs, it is necessary to take 1 tablet every 4 hours.
In order to warn the IRMINATION of the gastrointestinal tract, the drug should be dried with milk.
Side effects of Novigan
According to Novyan reviews, in rare cases, it may cause allergies, a disruption of renal function, oliguria, anouria, jade, dry oral cavity, tachycardia. In addition, the patient may have urine delay, parires, accommodation.
After applying Novigan, experts mark urine staining in red.
In the case of taking high doses, the drug can cause nausea, vomiting, violation of vision. To cure intoxication, wash the stomach, take the adsorbent, conduct standard symptomatic treatment.
Contraindications
According to the NOVIGA instructions, it should not be used in pronounced disorders of the kidney or liver function, the pathologies of the optic nerve, the closed-coronal glaucoma, tachycardia. Also, the drug should not be prescribed in the hyperplasia of the prostate gland, bronchial asthma (aspirin), lesions of the gastrointestinal tract of ulcerative and erosive nature, acute intestinal obstruction.
In case of detection of hypersensitivity to the drug, its reception should be stopped. With extreme caution, the drug should be prescribed to people with chronic heart failure, an ulcer of the gastrointestinal tract, with violations of blood coagulation, as well as with a tendency to bronchospasm.
Novyan tablets are designed to reduce the diuretic effects of furosemide, hypothiazide. They increase the activity of fibrinolithics, insulin, antiagregants and hypoglycemic agents used orally.
Ibuprofen absorption reduce swiveramin and antacids. In the case of a combination of a drug with potassium-saving means, an increase in the risk of developing hypercalemia, with other non-steroids - negative reactions from the gastrointestinal tract.
Judging by the reviews, Novyan affects the mental, physical reactions of the body and enhances the effect of alcoholic beverages.
Patients often offer the drug Novigan. What helps to get rid of this medicine? What properties do you have? Are there side effects from his reception? These questions will be interesting to many.
Preparation "Novigan": composition
This is a combined medicine that includes several active ingredients:
- Ibuprofen is a non-steroidal anti-inflammatory agent.
- Amide is a cholinolitic that affects both the central and peripheral nervous system.
- Keton - peripheral antispolytic.
Properties of the drug
Due to the unique composition, the medicine helps to solve several problems at once. So what are the main properties of the drug "Novigan"? What does he help? First, it should be noted that ibuprofen reduces the number of prostaglandins, which, in turn, eliminates pain, stops the inflammatory process and relieves fever. This substance has strong anesthetic properties and less dangerous than analgesics.
Keton affects the smooth muscles of the internal organs, removing spasm. Amid blocks cholinoreceptors and contributes to the relaxation of smooth muscle tissues.
"Novigan": what does it help?
In fact, the range of use of this medicine is quite wide. In many cases, doctors include namely "Novigan" into therapy. What does the drug help? The indications for its use are as follows:
- liver colic;
- pain caused by dyskinesia biliary tract;
- pain that is connected with the spasm of any department of the gastrointestinal tract;
- effectively medicine "Novigan" from including chronic migraines;
- dysmenorrhea, accompanied by spasm;
- any diseases accompanied by spasm of smooth muscles and strong pains.
Tablets are desirable to take or three hours after meals, or half an hour before meals. As for the dosage, only a doctor can define it. Adolescents over 15 years old and adult patients can be taken 1-2 tablets 3-4 times a day.
Contraindications and side effects
This medicine is not prescribed to patients with increased sensitivity to any of the components. In particular, if the patient has an allergy to ibuprofen or any other non-steroidal anti-inflammatory medicine, it is better to exclude "Novigan" from the treatment regimen. Tablets are also not recommended to take during the exacerbation of the ulcer of the stomach. Pregnancy is considered contraindications.
It should be noted that the long-term intake of ibuprofen (regularly for 3-6 months) can lead to the development of the ulcer of the stomach or intestine. On the other hand, the reception in small courses is almost completely safe.
Side effects also include allergic reactions that can be accompanied by skin rash, itching and swelling of soft tissues. With a worsening of well-being, it is best to immediately consult a doctor.
PN008846-220911Tradename: Novigan. ®
International non-proprietary or group name of the drug
ibuprofen + Pitoophenon + Fenpiverine Bromide
Dosage form
tablets covered with film shell
Structure
Each tablet covered with film shell contains:
Active substances:ibuprofen 400 mg, Pitoophenone hydrochloride 5 mg, phenpymeric bromide 0.1 mg bromide.
Excipients:cellulose microcrystalline 55 mg, corn starch 76 mg, glycerol 2.9 mg, silicon colloidal dioxide 5 mg, talc 12 mg, magnesium stearate 4 mg; shell:halpRellos 6 CPS 5,686 mg, macrogol 6000 1,124 mg, Talc 1.957 mg, titanium Dioxide 1.059 mg, polysorbate 80 0.058 mg, sorbic acid 0.058 mg, Dimeticone 0.058 mg.
Description
Round bicow-screw tablets covered with a film shell of white color, embossed noviganne one side. View on cross-cut: from white to almost white.
Pharmacotherapeutic Group:
Analgesic antispasmodic combined.ATH code: MO1AE51
Pharmacological properties
Pharmacodynamics
The combined drug, has an analgesic, anti-inflammatory and antispasmodic effect. Suppresses the synthesis of prostaglandins (PG). The drug includes a non-steroid anti-inflammatory tool of ibuprofen, a myotropic antispasmodic agent of Pitophenone hydrochloride and a M-choline-blocking agent of the central and peripheral effect of the phenpymeric bromide.
Ibuprofen. It is a phenylpropionic acid derivative. It has an painful, anti-inflammatory and antipyretic effect. The main mechanism of action is the oppression of the biosynthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation in the central nervous system and peripheral tissues. Women with primary dismenoria reduces the elevated level of prostaglandins in myiometry, due to which reduces intrauterine pressure and the frequency of uterine contractions.
Pitopenone hydrochloride , like papaverine, there is a direct motropic effect on the smooth muscles of the internal organs and causes it relaxation.
Fenpiverine Bromidedue to the M-cholinoblocking effect, has an additional relaxing effect on the smooth muscles.
The combination of the three components of the drug leads to a mutual strengthening of their pharmacological action.
Pharmacokinetics
Components of the drug Novigan. ® Well absorbed in the gastrointestinal tract. The peak of the concentration in the blood plasma is achieved, approximately 1-2 hours after receiving the drug. The main component of the drug ibuprofen is 99% connected to the blood plasma proteins, can accumulate in the synovial fluid, is metabolized in the liver and is removed by 90% with urine in the form of metabolites and conjugates. A small part of the drug is excreted with biliary. The half-life of blood plasma is 2 hours.
Indications for application
Weakly or moderately expressed pain syndrome in spasms smooth muscles of internal organs: renal and bile colic, dyskinesia biliary tract, intestinal colic.
Gynecological diseases: Dysmenorrhea.
Headache, including a migraine nature.
Short-term symptomatic treatment with pains in joints, neuralgia, Ishiagia, Malgia.
Contraindications for application
Hypersensitivity to any of the ingredients that are part of the drug; erosive-ulcerative changes in the mucous membrane of the stomach or duodenal intestine, active gastrointestinal bleeding; inflammatory bowel disease in the aggravation phase, including ulcerative colitis; Anamnestic data on the attack of broncho-referee, rhinitis, urticaria, after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drug - NSAIDs (full or incomplete syndrome of the intolerance of acetylsalicylic acid - rinosinusitis, urticaria, nasal mucosa polyps, bronchial asthma); liver failure or active liver disease; renal failure (creatinine clearance less than 30 ml / min), progressive kidney disease; confirmed hypercalemia; hemophilia and other disorders of blood clotting (including hypocoagulation), hemorrhagic diathesis; the period after the aorto-coronary shunting; acute "interspersed" porphyria; granulocyptopenia; Blood breeding; deficiency of glucose-6-phosphate dehydrogenase; Tahiaritmia; Clotted glaucoma; diseases of the optic nerve; prostate hyperplasia; intestinal obstruction; Pregnancy and breastfeeding period, age up to 16 years.
Precautions when applied
Elderly age, stagnant heart failure, cerebrovascular diseases, arterial hypertension, coronary heart disease, dyslipidemia / hyperlipidemia, diabetes, diseases of peripheral arteries, nephrotic syndrome, creatinine clearance less than 30-60 ml / min, hyperbilirubinemia, ulcerative and duodenal ulcer ( In history), the presence of infection Helicobacter. pylori., gastritis, enteritis, colitis, long-term use of the NSAID, blood disease obscure etiology (leukopenia, anemia), smoking, frequent alcohol use (alcoholism), severe somatic diseases concomitant therapy with the following drugs: anticoagulants (for example, warfarin), anti-aggregants (for example, Acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (for example, prednisone), selective inhibitors of serotonin reverse seizure (for example, cytalopram, fluoxetine, paroxetine, sertraline).
Method of application and dosing mode
Inside, 1 hour before or after 3 hours after meals. In order to avoid annoying action on the stomach, you can take the drug immediately after eating or drink milk.
Course of treatment with Novigan ® , without consulting a doctor, should not exceed 5 days. A longer use is possible under the supervision of a physician with the control of the performance of peripheral blood and the functional state of the liver.
Symptoms of overdose, Measures to assist in overdose
Do not exceed the specified dose. If you exceed a dose, immediately consult a doctor or to the nearest medical institution. Take with you packaging of the drug.
Symptoms: Stomach pain, nausea, vomiting, storage, drowsiness, depression, headache, ears, metabolic acidosis, coma, acute renal failure, reduction in blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory stop.
Treatment: Washing the stomach (only for an hour after taking), activated carbon, alkaline drink, forced diuresis, symptomatic therapy (correction of the acid-base condition, blood pressure). No specific antidote.
Possible side effects when using the drug
From the gastrointestinal tract: NPVP gastropathy (abdominal pains, nausea, vomiting, heartburn, decreased appetite, diarrhea, meteorism, constipation; ulceration of the mucous membrane of the gastrointestinal tract, which, in some cases, are complicated by perforation and bleeding; irritation or dryness of the oral mucosa, Pain in the mouth, the ulceration of the gum mucosa, aphodny stomatitis, pancreatitis.
From the hepatobiliary system: hepatitis.
From the respiratory system: shortness of breath, bronchospasm.
From the senses: Hearing disorders: Hearing reduction, ringing or noise in the ears; Violation of vision: toxic lesion of the optic nerve, fuzziness of visual perception, scotoma, dryness and irritation of the eyes, edema of conjunctiva and century (allergic genesis), accommodation paresis.
From the central and peripheral nervous system: Headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor arousal, drowsiness, depression, confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases).
From the cardiovascular system: Heart failure, tachycardia, enhancement of blood pressure.
From the urinary system: Acute renal failure, allergic jade, nephrotic syndrome (swelling), oliguria, anouria, polyuria, proteinuria, cystitis, urine coloring in red.
Allergic reactions: skin rash (usually erythematous or urticap), skin itching, swelling, anaphylactoid reactions, anaphylactic shock, bronchospasm or dynake, fever, multifilament exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necroliz (Layella syndrome), Eosinophilia, allergic rhinitis.
From the blood formation organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
Others: Strengthening or decreased by sweating.
From the laboratory indicators: Bleeding time (can increase), serum glucose concentration (can decrease), creatinine clearance (can decrease), hematocrit or hemoglobin (may decrease), serum concentration of creatinine (may increase), the activity of "liver" transaminase (may increase).
If the drug has caused a change in your conventional state, stop accepting it and immediately consult a doctor.
Interaction with other drugs and (or) food
In therapeutic doses, the drug Novigan Ò does not enter into significant interactions with widespread drugs.
Inductors of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, fluecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the products of hydroxylated active metabolites, increasing the risk of severe intoxication.
Microsomal oxidation inhibitors reduce the risk of hepatotoxic action.
Reduces the hypotensive activity of vasodilators and the sodium systemic effect of furosemide and hydrochlorothiazide.
Reduces the effectiveness of uricozeuric drugs. Enhances the effect of indirect anticoagulants, antiagregants, fibrinolithics (which increases the risk of bleeding).
Enhances the side effects of mineralocorticosteroids, glucocorticosteroids (the danger of gastrointestinal bleeding increases), estrogen, ethanol; Enhances the hypoglycemic effect of sulfonylurea derivatives.
Antacids and swiveralities reduce the absorption of ibuprofen.
Increases the concentration in the blood of digoxin, drugs of lithium and methotrexate.
Enhances the effect of M-cholinoblockers, H1-histamine blockers, buthrofenons, phenothiazines, amantadine and quinidine.
The simultaneous purpose of other NSAIDs increases the frequency of side effects.
Caffeine enhances analgesic (anesthetic) effect.
With a simultaneous purpose, an anti-inflammatory and anti-aggregative effect of acetylsalicylic acid decreases (it is possible to increase the frequency of the development of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiagregative agent, after the start of receiving the drug Novigan Ò).
Cephamandol, cefoperazazon, cefethean, valproic acid, Plikamycin increase the frequency of the hypoprothrombinemia while simultaneously intended.
Myelotoxic drugs enhance the manifestations of the hematotoxicity of the drug.
Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increase in nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.
Drugs that block the tubular secretion reduce the elimination and increase the plasma concentration of ibuprofen.
special instructions
With long-term use, the picture of the peripheral blood and the functional state of the liver and kidneys is necessary.
To reduce the risk of developing undesirable phenomena from the gastrointestinal tract, use the minimum effective dose. With the appearance of gastropathy symptoms, careful control is shown, comprising conducting esophagastroduodenoscopy, a blood test with the definition of hemoglobin and hematocrit, feces analysis on hidden blood.
If necessary, the determination of 17-ketosteroids, the drug should be canceled 48 hours before the study.
During the treatment period, you should refrain from taking alcohol.
Impact on the ability to control vehicles, mechanisms
During the period of treatment, the patient must refrain from practicing potentially hazardous types of activities requiring increased concentration and speed of psychomotor reactions.
Form release
Tablets covered with film shell. 10 tablets in PVC / aluminum blister. 1 or 2 blisters with instructions for use in a packboard pack.
Storage conditions
In a dry, light-protected place at a temperature not higher than 25 ° C.
Keep out of the reach of children!
Shelf life
5 years. Do not use after the expiration date indicated on the package.
Conditions of vacation from pharmacies
Without recipe.
Manufacturer
Dr. Reddness Laboratories LTD.
g. Heiderabad, Andhra Pradesh, India.
Address of the place of production
Plots No. 137, 138 and 146, Cooperative-industrial complex Sri Vencatheswara, Bollars, Ginararam Mandal, Area Medk, Andhra Pradesh, India.
Consumer claims to send to the address:
Representation of the company "Dr. Reddness Laboratories LTD."
115035, Moscow, Ovchinnikovskaya Nab., \u200b\u200bD.20, p. 1
