The instructions for use position the drug "Trichopol" as an effective antimicrobial and antiproterozoic agent that is used for the treatment of bacterial infections. The medicine is well tolerated by patients and does not have serious side effects.
Composition and release form
It is produced in the form of oral and vaginal tablets (often called suppositories), as well as a solution for infusion in ampoules. The main active ingredient is metronidazole, on which the properties of the drug depend. The list of excipients depending on the form includes:
- citric acid monohydrate;
- crospovidone;
- magnesium stearate;
- povidone;
- sodium chloride;
- gelatin;
- silicon dioxide and other components.
pharmachologic effect
Does Trichopolum help?
Indications for use of the drug are: 
- acute and chronic form of trichomoniasis;
- vaginitis caused by the action of Trichomonas and other microbes;
- stomach and intestinal ulcers (“Trichopol” is treated together with “Amoxicillin” and bismuth-containing drugs);
- giardiasis;
- liver abscesses caused by amoebas;
- prevention of postoperative complications in gynecology, during appendicitis removal, colon surgery;
- infectious pathologies caused by the action of anaerobic bacteria;
- peritonitis;
- inflammation of the ovaries;
- endometritis;
- pneumonia;
- pleural empyema;
- brain abscess;
- suppuration of the liver and abdominal cavity;
- meningitis;
- skin infections.
- inflammation of the fallopian tubes.
Instructions for use
Pills
The drug "Trichopol" for trichomonas infections is taken orally twice a day after meals in a volume of 250 g. Additionally, the insertion of suppositories into the vagina is required. Therapy is carried out for 10 days. For diseases of the reproductive system, both partners need to take the drug.
For peptic ulcers, you need to drink 0.25 g of the drug twice a day after meals. For bacterial vaginitis, the use of 1 g of the drug is prescribed; in the presence of anaerobic bacteria, the dosage is increased to 1.5 g. For patients with dysfunction of the renal parenchyma, the volume of the drug is reduced three times.
How to use Trichopolum suppositories
Instructions for use instruct vaginal tablets to be immersed in boiled water before use. For vaginitis and vaginosis, 1 suppository per day is prescribed, which is used together with tablets for 10 days. The medicine should not be used more than 2-3 times a year.
Application of the solution
The infusion is performed over 30 minutes, introducing 1 g of the drug. More than 4 g should not be used per day. When treating children under 12 years of age, the volume of medication is calculated based on body weight (7.5 mg of the drug should be per 1 kg).
Contraindications
Trichopolum is not prescribed for:
- leukopenia;
- lesions of the central nervous system;
- liver failure;
- epilepsy;
- hypersensitivity to the active component;
- when breastfeeding;
- in the early stages of pregnancy;
- children under 3 years old.
Side effects
Also, when using Trichopolum, nasal congestion, thrombophlebitis, gynecomastia, pustular rashes, fever, itching, and skin rash may occur.
Analogues and price
You can purchase the medicine in tablets for oral use for 90-100 rubles for 20 pieces. Trichopolum suppositories, the price of which is about 180-250 rubles for 10 vaginal tablets, can be purchased at the pharmacy. Analogues of the active ingredient are the drugs "Efloran", "", "".
Conditions of release and storage
In the pharmacy chain, vaginal tablets Trichopolum are dispensed with a doctor's prescription. Their independent use is not allowed, as this can lead to various complications and health consequences.
The shelf life of vaginal tablets Trichopolum is 3 years. They should be stored in the original original packaging, in a dark, dry place, out of reach of children, at an air temperature no higher than +25° C.
Content
Until recently, Trichopolum was used only in the treatment of Trichomonas infections. In modern medical practice, the range of its use has expanded significantly; the medicine is successfully used to treat many infectious diseases. What does Trichopolum treat, what infections is this drug effective against, can it be used in the treatment of children, forms of the drug offered by the pharmaceutical industry?
Indications for use
The action of Trichopol (as well as the biological fungicides trichodermin and trichocin) is based on the biochemical effect of microorganism proteins with the 5-nitro group of metronidazole. Bacterial cells inhibit (slow down) the synthesis of nucleic acids of the substance contained in the drug, and as a result die. Trichopolum simply kills pathogens (bacteria, protozoa).
This property is successfully used in dentistry in the treatment of mixed infections (Trichopolum is part of anti-inflammatory dental ointments), the drug is prescribed in the postoperative period, including after abortion, to prevent complications, and is actively used to eliminate a wide range of infections:
- giardiasis;
- trichomoniasis;
- osteomyelitis;
- stomach ulcer;
- peritonitis;
- etc.
For women
What does Trichopolum help women with? In gynecology, this drug is used to treat inflammation caused by bacterial infections. Trichopolum is prescribed for cystitis, vaginitis (vaginosis), endometritis, colpitis, chlamydia, gonorrhea. The drug is effective in preparation for surgical treatment and in the postoperative period. Trichopolum during pregnancy is prescribed only after the first trimester, since metronidazole, which penetrates the placenta, can provoke fetal development disorders and intrauterine death.
For men
Because Trichopolum and alcohol are incompatible (the drug provokes allergies and worsening well-being), the medicine is used in the treatment of chronic alcoholism as a powerful “brake” that causes a persistent aversion to alcohol. What else does Trichopolum treat men for? In addition to diseases common to patients of both sexes, Trichopolum is effective in the treatment of infections and inflammation of the genitourinary tract caused by them:
- trichomonas urethritis;
- chlamydia;
- gonorrhea;
- giardiasis;
- licheniasis;
- balantidiasis, etc.
For children and teenagers
The annotation stipulates that Trichopolum is prescribed only to patients over six years of age. In the treatment of children, this remedy is used for protozoal infections, for example, giardiasis, bacterial pneumonia, meningitis. The drug is effective in the treatment of cancer when infection is observed in the area of the tumor process. Trichopolum is used for the treatment of teenage acne caused by demodicosis, combining the use of tablets with the use of metronidazole-containing ointment.
Release form and composition of the drug
When choosing Trichopolum or Metronidazole, which is better and more effective, we ask ourselves a rhetorical question, because this is the same drug, produced under different names. Metronidazole is the international name of the drug assigned to it during patenting. It is indicated on the packaging of any other generic (generated drug), which is the Russian Trichopolum.
The main component of this antibiotic is metronidazole. Excipients depend on the form of release: tablets, suppositories (vaginal suppositories), solution for infusion (intravenous infusion). Trichopolum in tablet form contains:
- magnesium stearate;
- starch;
- molasses;
- gelatin.
Trichopolum for vaginal use includes:
- metronidazole;
- cellulose;
- povidone;
- crospovidone;
- silicon dioxide;
- stearic acid.
The solution for intravenous infusion contains:
- metronidazole;
- citric acid monohydrate;
- sodium chloride;
- sodium hydrogen phosphate;
- water.
Instructions for use and dosage
How to take this drug depends on what you are treating with Trichopolum, the form of the drug, and the age of the patient. The exact dosage is determined only by the attending physician. For example, when treating trichomonas infections, the course of therapy is 10 days, two tablets per day. For peptic ulcers, the dosage will be half a gram per day in two doses, for bacterial vaginitis it will increase to one and a half grams, and for patients with liver pathologies it will decrease three times.
Before use, vaginal suppositories must be moistened in water; one tablet is used once every 24 hours for no longer than 10 days. Treatment begins after menstruation, using suppositories with Trichopolum no more than three times a year, combined with the oral form of the drug and other medications. For intravenous infusion, the maximum dose of Trichopolum should not exceed four grams, and for children it is set based on the child’s weight (7.5 ml per 1 kg of weight).
Side effects
Trichopolum is far from a safe drug. In elderly patients, people with pathologies of the liver, nervous system, kidneys, and bone marrow, the use of the drug causes serious side effects. There is dizziness, impaired gait, coordination, and exacerbation of chronic ailments. The use of vaginal suppositories can cause a burning sensation in the genitals and candidiasis. An overdose of Trichopolum provokes the appearance of:
- vomiting;
- dryness, unpleasant taste in the mouth;
- nausea;
- constipation;
- headache;
- diarrhea;
- seizures;
- insomnia;
- allergic rash;
- hearing loss.
Where to buy and how much does Trichopolum cost?
This medicine is considered a prescription drug but is often available over the counter. The average price of tablets varies between 70-90 rubles, the cost of candles ranges from 240 to 400 rubles. Trichopolum solution for infusions (intravenous injections) is sold only by prescription, is rarely found in online pharmacies, and costs approximately 100-120 rubles. When choosing a medicine online, check the delivery cost.
|
Name |
Manufacturer, |
price, rub. |
Salesman |
|
|
"Trichopol", vaginal tablets |
Poland (Polpharma) 500 mg, 10 pcs. |
|||
|
Dobraya Pharmacy on Akademicheskaya |
Moscow, Vinokurova, 5/6, building 3 |
|||
|
Planet Health |
Moscow, 2nd Vladimirskaya, 38 |
|||
|
Piluli (online pharmacy) |
||||
|
Moscow, Kaluzhskaya square, 1/k.1 |
||||
|
"Trichopol", tablets |
250 mg, 20 pcs. |
|||
|
Marko's Pharmacy on Open Highway |
Moscow, Otkrytoe shosse, 21/k.4 |
|||
|
Planet Health |
Moscow, Nakhimovsky prospect, 40 |
|||
|
Samson-Pharma |
Moscow, Frunzenskaya embankment, 36/2 |
|||
|
"Trichopol", solution for intravenous injection |
Samson-Pharma |
Moscow, Nikolskaya, 17/str.1 |
||
|
Pharmacy IFC Dmitrovskaya |
Moscow, Dmitrovskoe highway, 98 |
|||
|
Moscow, st. Dekabristov, 20/ |
This medication can even cure gynecological diseases caused by gram-negative or gram-positive bacteria. Sometimes Trichopolum is used in conjunction with anthelmintic or antibiotic agents.
Trichopolum has a large number of contraindications. That is why in some cases its group analogs are used, which contain other active and auxiliary substances.
Indications for use and pharmacokinetics of the drug
Trichopolum is an antiprotozoal drug with antibacterial activity. The medicine costs 100-140 rubles. The medicine is available without a prescription. Trichopolum is produced in tablet form.
What does Trichopolum treat? This medication is prescribed for trichomoniasis, bacterial vaginosis, periodontitis infections (including ulcerative gingivitis and odontogenic infections). Trichopolum is also used to treat intestinal and extraintestinal amebiasis, giardiasis and anaerobic bacterial infections of the central nervous system (including sepsis, bacteremia, endocartitis).
What diseases of the gastrointestinal tract can Trichopolum cure? This medication is widely used in the treatment of gastric ulcers, which were caused by the bacterium Helicobacter pylori. The drug can also be used in the presence of duodenal ulcer.
It is worth noting that metronidazole does not exhibit bactericidal activity against some anaerobic bacteria and fungi.
The active components of Trichopolum are well adsorbed in the body. Metabolites of the drug are excreted by the kidneys.
Instructions for use of the drug
Trichopolum tablets should be taken with meals. Before taking the drug, it is not recommended to resort to the use of laxatives with irritating or osmotic effects.
The dosage of the medication is selected taking into account the type of disease:
- For trichomoniasis, the dosage is 750 – 1000 mg per day. Adults are recommended to drink 1500-200 mg per day. The frequency of taking the medication is 1-3 times a day. Trichomoniasis should be treated with Trichopolum for 2-7 days. A second course of treatment can be carried out after a month.
- For bacterial vaginosis, the dosage is 500 mg per day. The duration of treatment is 7 days. Also, for bacterial vaginosis, you can use Trichopolum once in a dosage of 2000 mg.
- For amebiasis, the dosage is 750-1000 mg. How much Trichopolum you need to drink is determined by your attending physician. In most cases, the duration of treatment is 7-10 days.
- For giardiasis, the dosage is 450-1000 mg per day. Take the medicine for 5-10 days.
- For infections caused by anaerobic bacteria, the dosage is increased to 1000-1200 mg per day. The duration of the course of treatment is 5-7 days.
- If the Helicobacter pylori bacterium is detected in the body, the dosage will be 750-1100 mg per day. The duration of treatment is 7 days.
Trichopolum has a large number of contraindications for use. This medication is strictly forbidden to be taken by children under 3 years of age, pregnant and lactating women. Trichopolum is also not prescribed to people suffering from hypersensitivity to metronidazole. If a person has progressive leukopenia, organic damage to the central nervous system, or acute liver failure, then taking pills should also not be taken.
Side effects of Trichopolum:
- From the gastrointestinal tract - pain in the epigastric region, vomiting, intestinal colic, diarrhea, impaired taste. With prolonged use of Trichopolum, the patient may develop reversible hepatitis, jaundice or pancreatitis.
- From the central nervous system - headache, impaired coordination of movements, peripheral neuropathy, irritability, convulsions, hallucinations, tremors of the extremities. With long-term use of Trichopolum tablets, a person may develop encephalopathy.
- Pain in the vaginal area.
- Hypersensitivity reactions - itching, urticaria, exudative erythema, nasal congestion, fever, Quincke's edema.
- Myalgia.
- From the hematopoietic system – reversible leukopenia, agranulocytosis, thrombocytopenia. If the dosage is incorrectly selected, Trichopolum can cause progression of pancytopenia.
- The appearance of pustular rashes on the skin.
Group analogues of Trichopolum
If for some reason a person cannot take Trichopolum, then he is prescribed group analogues of this drug. Protozal is considered the best alternative to Trichopolum. This medication costs 150-180 rubles. The medicine is available in tablet form.
Protosal is used in the treatment of trichomoniasis, amoebiasis, and other diseases that progress under the influence of anaerobic bacteria. Also, the medication can be used as a prophylactic agent in the presence of any surgical complications.
The dosage of the drug is selected taking into account the characteristics of the patient and the type of disease. For trichomoniasis, the dosage is 500-1000 mg per day, for amebiasis - 1000-1500 mg, for giardiasis - 1000-1300 mg. The duration of treatment is 3-7 days. A second course of drug therapy can be carried out no earlier than after a month.
Protosal is not prescribed to people suffering from hypersensitivity to ornidazole or the auxiliary components of the drug. Also, the drug should not be taken by children weighing up to 20 kg, pregnant and lactating women. In addition, diseases such as epilepsy, acute renal failure, multiple sclerosis, and organic lesions of the central nervous system are contraindications for use.
Among the side effects of Protozal are:
- Disturbances in the functioning of the central nervous system. They manifest themselves in the form of fainting, headaches, drowsiness, and increased fatigue. If the dosage is incorrectly selected, a person may experience tremors of the limbs, impaired coordination of movements, and convulsions.
- Gastrointestinal disorders. They manifest themselves in the form of heartburn, loss of taste, abdominal pain, and diarrhea. In rare cases, liver enzyme levels increase.
- Allergic reactions - Quincke's edema, itching, urticaria, anaphylactic shock. They occur only if a person takes the medicine for a long time.
Tagera is considered another good analogue of Trichopolum. This medication costs 250-300 rubles. The medicine is available by prescription. Tagera is produced in tablet form.
The average daily dosage of the drug is usually as follows:
- For acute amoebiasis - 2 grams once.
- For liver amebiasis - 1.5 grams for 5-6 days.
- For bacterial vaginosis – 2 grams once.
- For giardiasis - 1-1.5 grams once.
Tagera is not prescribed to children under 12 years of age, people intolerant to secnidazole, and pregnant women. If a person has progressive acute liver failure, severe leukopenia or organic damage to the central nervous system, then taking this medication is strictly prohibited. The drug is sometimes prescribed to women during lactation. However, in this case, it is recommended to stop breastfeeding for a while.
While taking the product, it is strictly forbidden to drink alcoholic beverages. Otherwise, the risk of reversible hepatitis, fatty hepatosis and acute liver failure increases.
Side effects of Tagera:
- Dyspeptic phenomena. They manifest themselves in the form of vomiting, diarrhea, nausea. With long-term use of Tagera, a person may develop glossitis, gastralgia or stomatitis.
- Dysfunction of the hematopoietic system. It was found that when consuming increased dosages of Tagera, a person may develop reversible leukopenia.
- Allergic reactions. They manifest themselves in the form of urticaria, itching, and skin rash. In severe cases, Quincke's edema or anaphylactic shock develops.
- Disturbances in the functioning of the central nervous system. They manifest themselves in the form of headaches and dizziness. With long-term use of Tagera, ataxia, impaired coordination of movements, and polyneuropathy may occur.
If the above side effects occur, you need to stop the course of treatment and perform gastric lavage with a solution of potassium permanganate. To relieve allergic reactions, it is better to resort to the use of antihistamines.
Trichopolum is a drug that belongs to the category of antimicrobial and antiprotozoal drugs and is highly effective in the treatment of many bacterial infections. In most
cases, the pharmacological agent is well tolerated by the human body and does not cause negative reactions. But, since Trichopolum has a wide list of contraindications for use, before using it you should definitely read the manufacturer’s instructions.
Trichopolum. Release form
The antibacterial pharmacological agent Trichopolum is presented on the market in tablet form, in the form of vaginal suppositories and a solution for external application. Tablets are whitish or yellow in color, elongated, elongated in shape, packaged in blister packs and cardboard packs. The pack contains 10 tablets.
Trichopolum in medicinal solution form is produced in glass bottles of 100 ml, as well as ampoules with a dosage of 20 ml. The color of the medicine varies from clear to yellow-green.
Trichopolum composition
The active substance contained in the medicine and ensuring its pharmacological effectiveness is metronidazole. It has a detrimental effect on many simple organisms, including aerobes and anaerobes. A Trichopolum capsule contains 250 mg of metronidazole. 100 ml of product for external application contains 500 mg of the main component. Other ingredients contained: sodium hydrogen phosphate, citric acid monohydrate, sodium chloride, distilled water.
Gynecological suppositories are packaged in aluminum blisters; one suppository contains 500 mg of active metronidazole.
What does Trichopolum treat?
Trichopolum belongs to the category of pharmacological agents used to treat pathologies of infectious-inflammatory origin, provoked by pathogens with sensitivity to the drug.
The main indications for the use of Trichopolum:
- Vaginosis of bacterial nature.
- Nonspecific vaginitis, other gynecological diseases.
- Trichomoniasis.
- Giardiasis.
- Infections caused by the bacterium Helicobacter pylori.
- Peritonitis.
- Hepatic and intestinal amebiasis, which occurs in severe form.
- Gas gangrene.
- Abscesses in the brain, pelvis or other internal organs.
- Sepsis.
Trichopolum - what does it treat? This question arises for many patients who are prescribed this pharmacological drug. The instructions from the manufacturer emphasize that the drug is widely used in the treatment of many gynecological pathologies caused by microorganisms sensitive to Trichopolum.
The pharmacological drug belongs to the group of nitro-5-imidazoles with pronounced antiprotozoal and antibacterial properties. Trichopolum actively affects the DNA of the cells of microorganisms that are causative agents of infectious and inflammatory diseases. This leads to their gradual destruction.
Trichopolum instructions for use
If a patient is prescribed Trichopolum, the instructions for use emphasize that the method of taking the drug depends on the specific disease, age and gender of the patient, as well as the individual characteristics of the body.
: depending on the severity of the disease, the patient may be prescribed Trichopolum 1 tablet three times a day or 2 tablets twice a day. After this, you should take a break from treatment for 4 weeks, after which, if necessary, continue therapy. Additionally, vaginal suppositories with antibacterial properties may be prescribed.
Amebiasis: treatment of the pathology consists of taking 3 tablets of the drug three times a day, the duration of the treatment course varies between 5-6 days.
If vaginal suppositories are used to treat gynecological diseases, it is recommended to dip them in water before use and then insert them as deep as possible into the vagina. It is not recommended to use medicinal suppositories more than 3 times every 12 months. For gynecological diseases, additional treatment of the sexual partner is not necessary.
The medicinal solution is used for intravenous injections. The dosage and frequency of administration are determined by the doctor individually for each patient.
Contraindications for use
The drug has several contraindications for use, so be sure to carefully read the instructions before using it.
The main contraindications to taking Trichopolum:
- all trimesters of pregnancy and breastfeeding;
- renal and liver failure;
- pathologies in the functioning of the brain and nervous system;
- presence of epilepsy;
- leukopenia;
- individual intolerance to the active ingredients included in the drug.
In such cases, it is recommended to abandon the use of Trichopolum or replace it with a pharmacological agent with a similar principle of action.
The drug is prohibited for use during the first trimester of pregnancy and breastfeeding. Taking Trichopolum in the second and third trimester is permitted only as prescribed by a doctor, under his strict supervision, and only in cases where there is a serious risk to the life and health of the expectant mother.
Breastfeeding women are also not recommended to use the drug. The active substances contained in Trichopolum penetrate into breast milk, after which they enter the child’s body. If you use the medication, you will have to stop breastfeeding. You can return to lactation no earlier than 2 days after completing the course of treatment with Trichopolum.
Trichopolum is prohibited for use in the treatment of children under 3 years of age. While taking the medication, it is strictly forbidden to drink any alcoholic beverages, since in combination with alcohol, the medicine can cause unwanted side effects.
Tablets or vaginal suppositories must be used regardless of the menstrual cycle - this means that the course of treatment should not be stopped even during menstruation. But the manufacturer emphasizes that it is best to avoid intimate relationships during therapy.
Side effects
In rare cases, taking Trichopolum can provoke side effects in the form of loss of appetite, attacks of nausea and vomiting, and stool disorders. Also, the use of the drug can cause the development of anorexia, severe headaches and dizziness.
During treatment with Trichopolum, the patient may notice such unpleasant consequences as confusion, sudden mood swings from excitement to depression, depression, weakness, loss of strength, sleep disturbances - from constant drowsiness to insomnia.
In extremely rare situations, Trichopolum can cause side effects in the form of increased body temperature, thrush of the oral cavity or genitals, discomfort, burning and itching in the urinary tract, allergic rashes on the skin of the face or body.
Also, the use of Trichopolum tablets can cause urine to turn brown or red, which is the result of the metabolism of the active component metronidazole.
To date, no cases of overdose of this drug have been recorded in medical practice.
Trichopolum price
Trichopolum is one of the inexpensive drugs. Its cost, depending on the pharmacy chain, varies between 80-150 rubles. The medication is dispensed only with a medical prescription.
Trichopolum analogues
In case of individual intolerance to Trichopolum, it can be replaced with a drug with a similar principle of action. The main active ingredient in the medication is metronidazole. Its analogues include drugs that also contain this component.
The main analogues of Trichopolum:
- Metronidazole.
- Trichosept.
- Orvagil.
- Klion.
- Flagyl.
- Metroseptol.
- Batsimex.
- Deflamon.
- Rosex.
- Trichobrol.
The decision to replace a drug and choose an analogue should be made only by the attending physician, based on the severity and individual characteristics of the development of the disease.
Trichopolum is an effective medication with pronounced antibacterial and antiprotozoal properties. Experts emphasize that the medicine can be combined with antibiotics, as well as drugs from the category of sulfonamides.
Also, Trichopolum should not be taken simultaneously with medications from the category of anticoagulants and muscle relaxants. This significantly enhances the effect of pharmacological agents.
One of the main side effects of the drug is the appearance of severe headaches, attacks of dizziness and confusion. Therefore, during treatment with Trichopolum, it is strictly not recommended to drive vehicles or complex production mechanisms, as this can be dangerous to human life.
In most cases, Trichopol tablets and vaginal suppositories are well tolerated by the human body and do not cause side effects - they develop only in rare cases.
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Perhaps one of the most common diseases in gynecology is inflammatory processes in the genital organs. Therefore, they require adequate and complete therapy aimed at eliminating the cause of the pathology. Among the agents that act on infectious agents, Trichopolum is widely used. And to find out what role it plays in treatment, why and how it is used, you need to read the instructions for use. And the gynecologist will answer any additional questions.
Characteristics
The active ingredient of the drug Trichopolum is metronidazole. This substance belongs to nitroimidazole derivatives and belongs to the group of antimicrobial agents. All properties of a drug are determined by the characteristics of the active component and its molecule. The nitro group is able to integrate into the respiratory chain of microbes, which disrupts their vital functions and leads to death, including due to the suppression of nucleic acid (DNA) synthesis.
Action
Trichopolum has a fairly wide spectrum of antimicrobial action. It is active against many protozoa and various anaerobic bacteria. Metronidazole helps get rid of the following microorganisms:
- Trichomonas.
- Gardnerellas.
- Giardia.
- Amoebas.
- Clostridia.
- Bacteroides.
- Fusobacteria.
- Peptococcus.
- Peptostreptococcus.
Therefore, this drug is also called antiprotozoal, trichomonacid and antibacterial. In addition, it has shown activity against Helicobacter pylori infection. An additional property of Trichopolum is an increased sensitivity to alcohol (Antabuse-like syndrome), which contributes to the formation of an aversion to it.
Distribution in the body
After oral administration, the drug is well absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1.5–3 hours. Its bioavailability is at a fairly high level - at least 80% of the administered amount. Having entered the plasma, 15% of metronidazole is bound to transport proteins, and the rest of the substance is in free form. The drug is able to penetrate well into the biological fluids of the body, including vaginal secretions, passes through biological barriers, and is found in breast milk.
When used systemically, Trichopolum is half metabolized in the liver, undergoing conjugation, oxidation and hydroxylation reactions. Moreover, the substance formed after the breakdown of the main molecule also has antimicrobial properties. The half-life of the drug averages 8 hours. 80% of it is excreted by the kidneys with urine, and the rest is excreted through the intestines with feces. During hemodialysis, it is quickly removed from the plasma along with its metabolites.
The metabolism of metronidazole in the body is greatly influenced by the condition of the liver and kidneys. This must be monitored when prescribing it to patients.
Indications
Instructions for the use of Trichopolum in gynecology indicate that both systemic and vaginal use is acceptable. In the latter case, the following conditions will be indications for prescribing medication:
- Bacterial vaginosis (gardnerellosis).
- Trichomonas vaginitis and urethritis.
- Nonspecific colpitis.
- Tuboovarian abscess.
- Infections of the vaginal vault.
- Pelvioperitonitis.
In addition, metronidazole is used to prevent complications after gynecological operations and as a complex therapy for adnexitis or endometritis. It can also be prescribed for concomitant diseases, for example, peptic ulcer with a confirmed role of Helicobacter pylori infection (together with amoxicillin) or various tumors as a substance that increases the sensitivity of malignant cells to radioactive radiation.
Application
Any medications, including Trichopolum, must be prescribed by a doctor. By taking medications without the consent of a specialist, a woman exposes herself to unjustified risk due to the inability to correctly select the dosage, course of administration and take into account possible side effects.
Method of use
The drug is used in the form of dosage forms for systemic or local use. The first are injection solutions or tablets, and the second are most often represented by vaginal suppositories. Sexually transmitted diseases, in particular trichomoniasis, are mainly treated with oral forms. The tablets are taken after meals, without chewing. The treatment regimen may vary:
- 2 tablets twice a day (5–7 days).
- 1 tablet three times a day (10 days).
- 8 tablets once.
Both partners need to undergo this course of treatment. Women are additionally prescribed Trichopolum in vaginal suppositories for a more pronounced local effect. During drug therapy, you should refrain from sexual intercourse, and after it, you must conduct a control study - a smear from the vagina for flora during the next three menstrual cycles. For severe infections, the dosage and course of administration change. But in such cases, injectable forms of metronidazole are used.
Side effects
There is no drug that is free from side effects. These are phenomena that are undesirable, but can still occur in patients during treatment. The most common with Trichopolum are the following:
- Gastrointestinal: nausea, vomiting, flatulence, diarrhea, abdominal pain, dryness and unpleasant taste in the mouth.
- Neuropsychiatric: headaches and dizziness, coordination disorders, anxiety, disturbances of consciousness, depression, insomnia, peripheral neuropathies.
- Dysuric: increased frequency of urination, pain, incontinence.
- Allergic: rash, itching, urticaria, redness of the skin, rhinitis.
When used vaginally, local reactions such as burning, itching and dryness are possible. A mucous discharge from the vagina may appear (white or clear, odorless). Candidiasis is likely to appear after stopping the use of suppositories. Similar signs occur in the sexual partner.
Do not be afraid of the side effects of Trichopolum. The doctor will try to minimize the effect of the drug on the body.
Restrictions
Before prescribing metronidazole, it should be determined whether the patient has factors limiting its use. This can only be done after a preliminary diagnosis, the results of which will make it clear what concomitant conditions the woman has and what should be done to eliminate the risks.
Contraindications
- Individual hypersensitivity to nitroimidazole derivatives.
- Diseases of the central nervous system (including epilepsy).
- Leukopenia (deficiency of white blood cells).
- Liver and kidney failure.
- Early pregnancy (first trimester).
- Breastfeeding a child.
In these situations, it is better to stop using Trichopolum and replace it with other drugs. Otherwise, the risk to the woman and her child may exceed the expected benefit.
Precautionary measures
Given the antabuse effect of metronidazole, alcohol consumption is not allowed during its treatment. If you don’t know this, you may experience nausea and vomiting, abdominal pain, and facial redness. Treatment should be carried out under the control of the blood picture. If severe side effects occur, stop taking the drug and consult your doctor.
Possible interactions
Trichopolum may interact with other medications. Therefore, a woman should warn her doctor if she is taking any medications. Most often this concerns anticoagulants, which, under the influence of metronidazole, obtain a more pronounced effect; disulfiram, which, when administered simultaneously, provokes various neurological disorders; muscle relaxants and astemizole, which contribute to the development of cardiovascular disorders (rhythm disturbances, blockades, syncope). It should also be remembered that the antimicrobial activity of Trichopolum is enhanced by the influence of sulfonamides and cimetidine, and weakened by the parallel use of anticonvulsants (carbamazepine and phenobarbital).
Trichopolum is a widely used drug in gynecology. Its antimicrobial effect helps eliminate inflammatory processes of a specific and nonspecific nature. But to obtain a pronounced and stable therapeutic effect, it is necessary to adhere to the treatment regimen and doctor’s recommendations. This way you can avoid many undesirable phenomena and minimize possible risks.
