The instructions for use describe “Pancreatin 25 units” as an enzymatic digestive drug that is used to treat diseases associated with insufficiency of the exocrine functions of the pancreas.
In what form is it produced?
This medicine takes the form of tablets coated with a special coating that is soluble in the intestinal environment. Sold in cardboard packages, each containing two, three or six blisters. One plate contains ten tablets. Also, these tablets can be sold in dark glass jars containing 60 pills.
Composition of the drug
The instructions for use describe “Pancreatin 25 IU” as a very effective drug, which includes the following components: active substance - pancreatin, gelatin, milk sugar, calcium stearate, titanium dioxide, petroleum jelly, azorubine dye, potato starch, cellacephate and polysorbate.
Many patients ask the question: what does the abbreviation ED stand for? It actually stands for a unit of action.
In what cases can it be used?
"Pancreatin 25 units", the instructions for use of which are described in detail in this article, are very popular among different groups of people, since the product is quite effective and relatively affordable.
Most often, doctors prescribe this drug in the following cases:
For pancreatitis, dyspepsia, after chemical irradiation. That is, in cases where replacement therapy is needed for conditions and ailments associated with imperfect exocrine function of the pancreas;
The drug is very effective in eliminating the symptoms of diarrhea of non-infectious origin, as well as flatulence and (gastrocardiac phenomenon);
In case of improper absorption of food entering the body. This is especially true for the condition after removal of the stomach or small intestine;
The drug can improve digestion. This question is especially relevant for those people who eat poorly, have bad habits, consume a lot of fried, fatty foods and fast foods, as well as for those who lead a sedentary lifestyle;
The medicine is indicated for people who have abnormalities in chewing function, as well as for long-term immobilization.
In some cases, doctors advise using Pancreatin 25 IU tablets, instructions for use for which are included in each cardboard box, for people who are overweight. The active components of the drug promote proper digestion of food and also improve metabolism.
Are there any contraindications for use?
Tablets "Pancreatin Belmed 25 units" instructions for use do not allow everyone to use them. However, there are actually not that many contraindications. Please note the cases in which this product is not recommended for use:
You should not take the drug if you have diseases such as acute or chronic pancreatitis;
The tablets should not be given to children under six years of age;
Do not use the medication under any circumstances if you have noticed hypersensitivity to at least one component included in its composition.
Use for pregnant and lactating women
“Pancreatin 25 units” (instructions for use, reviews are described in this article) is not recommended for use by pregnant women, since there is very little clinical data confirming the safety of the drug for this group of people. Tablets can be prescribed only if the risk to the fetus is not very great.
This medication can be used by breastfeeding women. But in this case, a mandatory consultation with the attending physician is necessary.
"Pancreatin", tablets 25 units: instructions for use
The tablets are usually taken orally with or immediately after meals. The pill should be washed down with plenty of plain water or juice. Do not chew the tablets under any circumstances; swallow them whole.
The dosage is selected individually, and only an experienced specialist can do this, depending on your case.
However, the instructions for use for adults recommend using the drug “Pancreatin 25 units” as follows: from three to six applications per day, two to four tablets. The maximum daily dose is sixteen tablets.
For children, three applications per day will be enough, using one tablet at a time.
The duration of use of this medication depends on each case. If you need to improve digestion without concomitant serious diseases, then a short course of treatment of a few days will be enough.
If your body needs constant replacement therapy, then doctors may prescribe this remedy for you for several months or even years.
It would be useful to say once again that you should not take Pancreatin 25 IU tablets without the recommendation of your doctor. Of course, they are relatively safe, but you must understand the reasons for your poor condition. After all, no one knows, maybe a more serious disease is hidden behind ordinary diarrhea.
Side effects
“Pancreatin 25 units” (the instructions for use allow children to take the drug) in some cases can cause adverse reactions.
Please note that this medication contains components that can lead to allergic reactions. This is especially important to take into account for people suffering from seasonal allergies.
Very rarely, this medication may cause side effects from the digestive system. Some patients experienced nausea, diarrhea, vomiting and abdominal pain. However, the reason for the occurrence of such effects has not been clarified.
In patients suffering from cystic fibrosis, when using the drug "Pancreatin 25 units" in excessively large dosages, strictures in the colon may develop.
Excessive use of the medication can lead to hyperuricosuria and hyperuricemia.
It is very important to choose the correct dosage for children, as otherwise the mucous membranes of the oral cavity may begin to become irritated, and there is also a risk of perianal irritation.
Important instructions
The drug "Pancreatin 25 units" (instructions for use, analogues are listed in this article) cannot be taken in large doses by patients suffering from cystic fibrosis. In this case, there is a high probability of stricture formation.
To determine the correct dosage, you need to take into account the amount of enzymes needed to absorb fats, as well as the quantity and quality of all food consumed. During treatment, it is recommended to follow a diet.
Please note that the drug “Pancreatin 25 units” can reduce the content of iron and folic acid in the body.
Analogs and reviews
This drug is very effective and in demand, so many doctors prescribe it to their patients. However, in some cases, this medicine is not advisable to use, so the patient may be prescribed its substitutes.
The most popular analogues are:
- “Creon 10,000.”
- “Panzim Forte”.
- “Penzital”.
- “Panzikam.”
According to patient reviews, this remedy is very well tolerated and has an amazing effect not only during long-term treatment, but also during express therapy.
In some cases, patients experienced allergic reactions and treatment had to be stopped. There are very rare cases of side effects from the digestive system.
In general, reviews about the drug are positive. Only sometimes patients did not notice the positive effect of treatment. In any case, before using the tablets, consult your doctor and he will help you solve the problem. Don't neglect your health.
Replacement therapy for exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, cystic fibrosis, Shwachman-Diamond syndrome, condition after an attack of acute pancreatitis upon resumption of oral nutrition. Flatulence, diarrhea of non-infectious origin, Roemheld syndrome (gastrocardiac syndrome). Impaired digestion of food (condition after resection of the stomach and small intestine); to improve food digestion in persons with normal gastrointestinal tract (gastrointestinal tract) function in case of dietary errors (eating fatty foods, large amounts of food, irregular meals) and in cases of chewing dysfunction, sedentary lifestyle, prolonged immobilization. Preparation for x-ray examination and ultrasound (ultrasound examination) of the abdominal organs.
Contraindications Pancreatin tablets 25 units
Hypersensitivity to the components of the drug. Acute pancreatitis. Exacerbation of chronic pancreatitis. Lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome. Use during pregnancy and breastfeeding. Pregnancy: There are no clinical data on the treatment of pregnant women with drugs containing pancreatic enzymes. Animal studies have not revealed the absorption of pancreatic enzymes of porcine origin, therefore toxic effects on reproductive function and fetal development are not expected. The drug should be prescribed to pregnant women with caution if the expected benefit to the mother outweighs the potential risk to the fetus. Breastfeeding Period: Based on animal studies in which no systematic negative effects of pancreatic enzymes were observed, no harmful effects on the infant through breast milk are expected. Pancreatic enzymes can be taken by women during breastfeeding.
Directions for use and dosage: Pancreatin tablets 25 units
The drug is taken orally, without chewing, with plenty of liquid (water, fruit juices), during or after meals. Adults and children over 14 years of age: 2-4 tablets (50-100 units) 3-4 times a day. Children - as prescribed by a doctor. Single doses for children: 6-7 years old - 1 tablet (25 units), 8-9 years old - 1-2 tablets (25-50 units), 10-14 years old - 2 tablets (50 units). The duration of treatment can vary from several days (if the digestive process is disrupted due to errors in the diet) to several months or years (if constant replacement therapy is necessary).
enteric-coated tablets
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BIOSINTEZ, JSC
International Classification of Diseases (ICD-10)
E84 Cystic fibrosis K30 Dyspepsia K59.1 Functional diarrhea K86.1 Other chronic pancreatitis K90.3 Pancreatic steatorrhea K91.1 Syndromes of the operated stomach K91.2 Malabsorption after surgery, not elsewhere classified Z51.4 Preparatory procedures for subsequent treatment, not classified elsewherePharmacological group
Enzyme preparation
pharmachologic effect
A digestive enzyme agent that compensates for the insufficiency of the secretory function of the pancreas and the biliary function of the liver, improves food digestion, and has proteolytic, amylolytic and lipolytic effects.
The pancreatic enzymes included in the composition (lipase, alpha-amylase, trypsin, chymotrypsin) help break down proteins into amino acids, fats into glycerol and fatty acids, starch into dextrins and monosaccharides.
Trypsin suppresses stimulated pancreatic secretion, producing an analgesic effect.
The enzyme hemicellulase promotes the breakdown of plant fiber, which also improves digestive processes and reduces the formation of gases in the intestines. Bile extract has a choleretic effect, promotes emulsification of fats, improves the absorption of fats and fat-soluble vitamins, and increases lipase activity.
Pharmacokinetics
Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, because protected from the action of gastric juice by an enteric coating.
The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.
Replacement therapy for exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, cystic fibrosis; flatulence, diarrhea of non-infectious origin;
Impaired digestion of food (condition after resection of the stomach and small intestine);
To improve the digestion of food in people with normal gastrointestinal function in case of errors in nutrition (eating fatty foods, large amounts of food, irregular meals) and in cases of chewing dysfunction, sedentary lifestyle, prolonged immobilization;
Roemheld syndrome (gastrocardiac syndrome);
Preparation for X-ray examination and ultrasound examination of the abdominal organs.
Acute pancreatitis;
Exacerbation of chronic pancreatitis;
Liver failure;
Hepatitis;
Obstructive jaundice;
Cholelithiasis;
Empyema of the gallbladder;
Intestinal obstruction;
Children's age (up to 3 years);
Hypersensitivity to the components of the drug.
Allergic reactions, rarely - diarrhea or constipation, nausea, discomfort in the epigastric region, abdominal pain, decreased endogenous synthesis of bile acids. With long-term use in high doses - hyperuricosuria; when using high doses in patients with cystic fibrosis - strictures in the ileocecal region and in the ascending colon, manifested by symptoms of intestinal obstruction.
Overdose
Symptoms: With long-term use in high doses - hyperuricosuria. when using high doses in patients with cystic fibrosis, strictures in the ileocecal region and in the ascending colon. Hyperuricemia. Children have constipation.
Treatment: drug withdrawal, symptomatic therapy.
special instructions
In case of cystic fibrosis, the drug should be prescribed with caution because the dose must be adequate to the quantity and quality of food consumed.
With long-term use in cases of digestive disorders (with normal pancreatic function), iron supplements should be prescribed at the same time.
In case of liver dysfunction
Contraindicated in liver failure, hepatitis.
Use during pregnancy and breastfeeding
During pregnancy and lactation, the drug is prescribed only if the expected benefit to the mother outweighs the potential risk to the fetus or child.
Drug interactions
When used simultaneously with Pancreatin Forte, the absorption of PAS, sulfonamides, and antibiotics is enhanced.
Reduces iron absorption (especially with long-term use).
Antacids containing calcium carbonate and/or magnesium hydroxide may reduce the effectiveness of Pancreatin Forte.
Orally, swallow whole (without chewing), during or immediately after meals, with plenty of liquid (alkaline if possible: water, fruit juices). The dose of the drug is set individually (in terms of lipase) and depends on the age and degree of pancreatic insufficiency.
Average dose for adults- 150 thousand units/day; at complete insufficiency of exocrine pancreatic function- 400 thousand units/day, which corresponds to the daily requirement of an adult for lipase.
The duration of treatment can vary from a single dose or several days (if the digestive process is disrupted due to errors in the diet) to several months and even years (if constant replacement therapy is necessary). Adults- 3-4 tablets each. 3 times/day. Higher doses are prescribed by your doctor. 2 tablets each. 2-3 times/day for 2-3 days before X-ray or ultrasound examination.
Children over 3 years old- 100 thousand units/day (for lipase), divided into 3-4 doses.
Storage conditions and shelf life
Store in a dry place, at a temperature not exceeding 20°C. Keep out of reach of children. Shelf life: 2 years. Do not use after expiration date.
Release from pharmacies
The drug is approved for use as a means of OTC.
Considerable attention in medical practice, especially in the field of gastroenterology, is paid to enzyme therapy. Drugs to improve digestion are prescribed for diseases of the stomach, pancreas, intestines, and bile ducts. Indicated for disorders of food digestion and motor activity of the gastrointestinal tract.
The unit of measurement for enzyme activity is the amount that contributes to the breakdown of a nutrient per minute under specified conditions.
Designated ME or ED.
What do they mean?
Among modern enzyme medicines, the main groups are distinguished:
- containing only pancreatic enzymes
- in addition to pancreatic ones, they additionally include bile components.
The dosage of drugs is influenced by the units of enzyme activity in their composition. The preparations contain lipase, amylase, protease in optimal proportions.
Pancreatic enzyme preparations are labeled by lipase activity, since lipase is the most critical enzyme in digestion, and when the pancreas is malfunctioning, lipase deficiency occurs predominantly.
400,000 IU is the daily requirement of lipase, ensuring the normal digestion process. For adults, an average meal requires about 40 thousand units.
How do Creon units differ from the domestic “Pancreatin” units?
Russian Pancreatin 25 units produced by Irbitsky HVZ, "Biosynthesis", "Avexima" - an old drug, identical in composition to pancreatic juice, includes 125-250 mg of active ingredient in total and approximately 25 units of protease.
That is, essentially 25 units. domestic "Pancreatin" are related either to the weight of the tablet (250 mg) or to protease activity (25 IU), and not to lipase units of activity (as is designated by modern drugs).
"Pancreatin" contains much fewer lipase units than modern products: Creon, Panzinorm, Pangrol, Ermital and others (full).
Creon, Ermital, Pangrol- pancreatin in the form of minimicrospheres in an enteric coating that allows it to dissolve at the beginning of the small intestine. Thanks to the small particle size, the availability of the drug increases. They have several dosages:
- “10000”: 10000 IU - lipase, 8000 IU - amylase, 600 IU - protease.
- “25000”: 25000 IU - lipase, 18000 IU - amylase, 1000 IU - protease.
- “36000”: 36000 IU - lipase, 18000 IU - amylase, 1200 IU - protease.
Inside the capsules are enteric microspheres. The capsule shell dissolves in the stomach, the microsphere shell dissolves in the small intestine. Creon contains more active substances, provides gradual release of enzymes and mixing, and, accordingly, better efficiency.
What are the USP, FCC and FIP units of lipase?
This designation is often found on foreign enzyme preparations or complex supplements containing enzymes. They usually have the amount of lipase listed in the USP, FCC or FIP Units. These abbreviations do not indicate quantity, but only the standard by which the units are counted.
- USP (United States Pharmacopeia) is an American pharmacopoeial standard used in the United States to measure the mass of a vitamin or drug based on its expected biological effects. Typically, USP units are equal to International Units (IU).
- FIP (Federation International Pharmaceutical) is an organization founded in Holland to unify and simplify international interaction in the field of pharmaceuticals and health. When applied to lipase, 1 FIP unit is approximately equal to 1 USP unit, and therefore the international lipase unit (LU).
- FCC (Food Chemicals Codex) and FCCVIII (the last four characters are not letters, but Roman numerals, that is, they should be read as FCC 8th edition) - another standard for calculating the beneficial effects of nutrients adopted in the West.
Pancreatin is an enzyme that stimulates the liver and pancreas, improving food digestion.
Improves the process of breakdown of proteins, fats and carbohydrates. Reduces the amount of gas in the intestines. Promotes the absorption of fats and has a choleretic effect. The tablets are coated to protect them from gastric juice so that dissolution begins in the small intestine. The drug is sold freely in pharmacies, without a prescription.
In this article we will look at why doctors prescribe Pancreatin, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Pancreatin can be read in the comments.
Release form and composition
Pancreatin is available in the form of enteric-coated tablets (10 pieces in blisters, 2, 3 or 6 blisters in a cardboard box; 60 pieces in dark glass jars or polymer bottles, 1 jar or bottle in a cardboard box).
1 tablet contains:
- Active substance: pancreatin – 25 or 30 units (unit of action);
- Excipients: lactose (milk sugar), gelatin, potato starch, calcium stearate, cellulose acetylphthalyl (cellacephate), titanium dioxide (titanium dioxide), liquid paraffin (petrolatum), polysorbate (Tween-80), acid red 2C (azorubine dye) .
What does Pancreatin help with?
The use of the drug Pancreatin helps in the following situations and diseases:
- Chronic inflammation of the pancreas;
- Congenital or chronic deficiency of pancreatic enzymes;
- Hereditary diseases of the digestive system;
- Blockage of the pancreatic ducts;
- Inflammatory diseases of the digestive system;
- Rehabilitation therapy after removal of the pancreas;
- Impaired chewing of food.
Pancreatin tablets also help to reduce the severity of symptoms accompanying enzyme deficiency: pain in the left hypochondrium and epigastrium after eating, bloating, nausea, loss of appetite, and frequent bowel movements.
pharmachologic effect
Pancreatin belongs to the pharmacological group “Enzymes and antienzymes” and is a multienzyme drug, the action of which is aimed at replenishing the deficiency of pancreatic enzymes in the body and facilitating the digestion of protein, fatty and carbohydrate-containing foods entering the body. As a result, the latter are absorbed more quickly and more completely in the small intestinal tract.
Instructions for use
In accordance with the instructions for use of Pancreatin, this product is intended exclusively for oral administration. It is recommended to take the tablets during meals or immediately after finishing a meal, with a sufficient amount of water. The dose (in terms of lipase) depends on age and the degree of pancreatic insufficiency.
- The average dose for adults is 150,000 units/day. In case of complete insufficiency of the exocrine function of the pancreas – 400,000 units/day, which corresponds to the daily requirement of an adult for lipase.
- The maximum daily dose is 15,000 units/kg.
- Children under 1.5 years old – 50,000 units/day; over 1.5 years – 100,000 units/day.
The duration of treatment can vary from several days (if the digestive process is disrupted due to errors in the diet) to several months and even years (if constant replacement therapy is necessary).
Contraindications
The drugs Pancreatin forte, Lect, 8,000 and 10,000 have the following contraindications for use:
- acute pancreatitis and at the stage of exacerbation of chronic;
- intestinal obstruction;
- severe liver disease;
- individual intolerance to the components included in the drug;
- children up to 3 years old.
Side effects
The annotation states that the drug "Pancreatin" is well tolerated by patients. Their reviews confirm this fact. In some situations, side effects may still occur. The medication may cause:
- diarrhea;
- nausea;
- improper absorption of folic acid;
- discomfort in the stomach;
- allergic reactions;
- constipation;
- perianal irritation.
Local reactions may develop due to hypersensitivity to the drug. With prolonged and excessive use, the development of hyperrusuria or hyperuricemia is likely.
Pregnancy and lactation
The safety of using pancreatin during pregnancy has not been sufficiently studied. Use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Experimental studies have shown that pancreatin does not have a teratogenic effect.
Analogs
Analogues of pancreatin are the drugs Biozym, Zimet, Creon, Lycreaza, Mezim (Mezim Forte), Micrazim, Pangrol, Panzinorm, Pancreazim, Kirschner's Pancreaal, Pancreatin-ICN, Pancretin LekT, Pancreatin Forte, Pancreatin 8000, Pancreatin 25 units (Belmed preparations), Pancreatin for children, Pancreatin-Zdorovye Forte 14000; Pankrenorm, Pankreon, Prolipase, Triferment, Uni-Festal, Festal (Festal N), Enzistal, Ermital, etc.
Attention: the use of analogues must be agreed with the attending physician.
Prices
The average price of PANCREATIN in pharmacies (Moscow) is 20 rubles.
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