When the body is hypersensitive to certain substances, an inadequate reaction of the immune system occurs - an allergy. To stop an attack, most people use various tablets. One of the most effective tablets is Cetrin, which is prescribed for the treatment of both children and adults. The product has many analogues with varying therapeutic efficacy.
General information about the drug
In recent years, the number of patients diagnosed with allergies has begun to increase. Increasingly, the population suffers not only from plant pollen and animal hair, but also from an atypical increased sensitivity to temperature changes (frost). The unpleasant symptoms that accompany the pathological condition develop against the background of increased histamine production. The phenomenon can be eliminated and the patient’s condition can be normalized only with the help of antihistamines. “Cetrin” has a powerful anti-edematous and antipruritic effect.
What do these pills help with? The antiallergic drug belongs to the second generation and can relieve the patient from the discomfort caused by the disease. The drug belongs to the group of selective histamine blockers.
Release form
An Indian pharmaceutical company produces Cetrin in the form of tablets and liquid (syrup). The latter type is often used in pediatric practice due to the ability to clearly calculate the dosage and the sweetish taste of the medicine. The volume of the bottle can be 30 or 60 ml. In tablet form, the drug is used for older children and adults. The package contains 10, 20 or 30 tablets on blisters. The drug has no other forms of release.
What does it contain?
The main active ingredient is cetirizine, a substance that blocks H1-histamine receptors and reduces the manifestations of an allergic reaction. One tablet contains 10 mg of this component. Does not cause pronounced effects like many antihistamines.
"Cetrin" also contains excipients: corn starch, magnesium stearate, lactose, povidone. The syrup contains a larger number of additional components.
Therapeutic effect
The therapeutic effect is due to the presence of cetirizine in the substance, which can prevent the connection of histamine with receptors and, thereby, eliminate the symptoms of an allergic reaction: tearing, redness of certain areas of the skin, itching, swelling.
Cetrin can also be used to prevent the development of allergies. What these tablets are for is described in the instructions, but only a doctor should prescribe the medicine.
An antihistamine can eliminate various skin reactions, including those to cold. In the mild stage of bronchial asthma, the drug reduces histamine-induced bronchoconstriction.
"Cetrin" belongs to the 2nd generation antiallergic drugs, which are characterized by a reduced effect on the functioning of the nervous system. That is, the tablets practically do not cause drowsiness, but at the same time they are less effective in relieving an allergic reaction. The drugs of the previous generation, which have a powerful inhibitory effect on the central nervous system, have a more pronounced therapeutic effect.
Cetrin tablets for allergies can significantly reduce the number of eosinophils, which leads to a decrease in the severity of the late stage of the reaction to hypersensitivity. The inhibitory effect on cytokines causes an anti-inflammatory effect and reduces the negative reaction of the immune system.
When is it prescribed?
A direct indication for the use of the drug "Cetrin" is the presence in the patient's medical history of information about hypersensitivity to certain substances. You can eliminate allergy symptoms using tablets in the following cases:
- Seasonal rhinitis.
- Hay fever.
- Eczema.
- Bronchial asthma.
- Allergic conjunctivitis.
- Quincke's edema.
- Hives.
- Dermatosis (allergic dermatitis or neurodermatitis).
- All year round rhinitis of allergic type.
The drug is recommended to be taken as an anti-inflammatory drug to prevent and prevent deterioration of the condition. For example, Citrine significantly reduces the number of asthma attacks during the treatment and prevention of bronchial disease.
How to use?
Cetrin tablets are taken regardless of food intake. Take the medicine with a small amount of water. The dosage depends on the severity of the patient's condition and age group. Adults and children can be prescribed 10 mg of the drug per day (1 tablet) or 0.5 mg twice a day. Relief of symptoms is observed within 15-20 minutes after taking an antihistamine. The therapeutic effect lasts for 24 hours. During this period, the patient practically does not observe signs characteristic of allergies.
A day after taking the pill, allergy symptoms will begin to recur, which indicates the need to re-use the drug. Before taking Cetrin, you should read the official instructions and get recommendations from an allergist regarding the treatment of the disease. The specialist will help you understand the dosage of the drug and may prescribe additional therapy.
For patients with renal or hepatic insufficiency, the dosage should be selected strictly by a doctor. Usually it is half the daily requirement - 5 mg.
Can the drug be given to children?
Starting from 6 years of age, Cetrin tablets can be used to treat allergic manifestations in children. Doctors recommend using syrup for young patients. Liquid medicine is suitable for children 2-6 years old. The dosage is determined based on the child’s condition and the severity of symptoms.
There is a practice of prescribing for babies in the first year of life. The product in syrup form should be used only after consulting a doctor. The daily amount of the drug should not exceed 2.5 ml. Experts say that the prevention of such a pathological phenomenon is also within the power of the medicine “Cetrin”. The dosage of the drug should not be determined independently. Only if the specialist’s prescriptions are followed, the patient’s condition can be alleviated.
The antihistamine gently affects the activity of the baby’s nervous system, allowing him to calm down and fall asleep. Allergic skin reactions can be treated at home in most cases. In addition to the antihistamine, additional action at the local level will be required.
Contraindications
Relative contraindications for use are renal failure and the age of the patient. In this case, only a specialist can decide on the need for treatment and adjust the individual regimen. Cetrin tablets are contraindicated for children under 6 years of age.
The use of an antihistamine should be avoided if you are intolerant to the components in the composition. The drug is not allowed to be taken during pregnancy and breastfeeding. For pregnant women, doctors select gentler medications that can relieve the unpleasant symptoms of an allergic reaction.
"Cetrin": analogues
The following drug analogues will cost patients less than Cetrin:
- "Loratadine."
- "Diazolin".
- "Cetirizine."
- "Cetirinax".
- "Suprastin".
- "Letizen."
The most optimal substitute for an Indian antihistamine medicine can be selected by the attending physician, taking into account the patient’s medical history and sensitivity to the active ingredients. At the same time, Cetrin is suitable for many patients. Analogs that are cheaper are mainly of the first generation, which do not have pronounced selective activity and cause side effects on the functionality of the nervous system.
Antihistamines belonging to the third generation are considered the most expensive. Drugs tend to act selectively and do not influence the activity of the central nervous system during therapy. Compared to first generation drugs, they have the same powerful therapeutic effect. This group of pharmaceutical products includes drugs such as Erius and Claritin.
"Suprastin" is a proven antiallergic agent
An antihistamine of Hungarian origin has long been used to eliminate and relieve allergy symptoms. The active component of Suprastin is chloropyramine hydrochloride. The drug belongs to the first generation and produces a pronounced sedative effect related to side effects.
When choosing which antihistamine is best suited for treatment - Suprastin or Cetrin - you should carefully read the instructions for each drug. "Suprastin" has an extended list of contraindications: peptic ulcer, prostate hyperplasia, arrhythmia, asthma attacks, myocardial infarction, therapy with MAO inhibitors, urinary retention. There is also an impressive list of side effects, which include:
- Dizziness.
- Increased sleepiness.
- Arrhythmia.
- Attacks of nausea and vomiting.
- Ocular hypertension.
- Dysuria.
- Thrombocytopenia.
- Agranulocytosis.
- Encephalopathy.
- Deterioration of vision.
"Suprastin" can be used to treat infants. The dosage of tablets is calculated by a specialist.
"Zodak"
The popular antihistamine also belongs to the second generation. Available in the form of drops, syrup and tablets. The active ingredient is cetirizine hydrochloride, that is, the product is a complete analogue of Cetrin. Patients say that if the dosage prescribed by the doctor is followed, the drug does not cause a sedative effect and does not affect the functioning of the central nervous system.
Contraindications for the use of the medicine "Zodak" - pregnancy, lactation, children under 1 year of age, hypersensitivity to the substances in the composition.
Side effects of the drug "Cetrin"
To avoid side effects, you should first read the instructions and understand how to take Cetrin. The drug actually rarely causes negative reactions and is normally tolerated by the body. Side effects are possible from the nervous system. The drug causes drowsiness, headache, increased agitation, and weakness. Reactions from the digestive and immune systems are much less common: increased gas formation, constipation, abdominal pain, dyspepsia, skin rashes, itching.
Cetrin tablets are prescribed for courses of therapy. Long-term use of the medication is not advisable. The medicine can be used for the purpose of prevention during periods of danger of developing allergy symptoms.
Tablets "Cetrin": price and reviews
Many people of different age groups experience allergy symptoms. It is most difficult for patients with congenital hypersensitivity to certain irritant substances. Antihistamines help cope with the problem and stop the development of allergic symptoms.
The drug "Cetrin" received positive recommendations. Its cost is affordable for most people who need antiallergic therapy and amounts to 130-170 rubles. for 20 tablets. The drug quickly copes with even severe allergy symptoms. The therapeutic effect lasts for 24 hours, after which you should take a new dose of the medicine. Only in rare cases did Cetrin turn out to be absolutely powerless and did not bring any improvement in the condition. This suggests that each organism is individual.
Cetrin is a 3rd generation antihistamine drug. It is used to combat allergic reactions in patients of various ages. At the moment, this is the most effective and safe anti-allergy drug. Below is an abstract of Cetrin and instructions for its use.
Name: Cetrin Dosage: syrup is available in bottles of 30 and 60 ml. The weight of one tablet is 10 mg, one blister contains 10 tablets, and each cardboard pack contains 2 or 3 blisters. Release form: coated tablets or syrup. Effect group: drug for the respiratory system Pharmacological group: antihistamine. Use orally.
Properties of the drug
Cetrin blocks H1-histamine receptors, providing an antiallergic effect. The drug does not block serotonin and cholinergic receptors.
When used correctly, it does not cause nervous system disorders or drowsiness. Thanks to the active ingredient Cetirizine, the product effectively relieves allergy symptoms at early and late stages, and also reduces the migration of blood cells (eosinophils, basophils and neutrophils). Cetrin can not only quickly relieve allergy symptoms, but also prevent its occurrence. Pharmacological properties of Cetrin tablets also include:
- Reduces smooth muscle spasm and delays the onset of edema
- Reduced capillary permeability
- Elimination of skin reactions to allergens (for example, allergies to cold)
- Reducing the manifestations of bronchial asthma
In most patients, improvement occurs within 60 minutes after taking the drug. Five percent of patients noticed the positive effect of the drug within twenty minutes after use. The duration of action is more than 24 hours. It is not addictive even after a long course of therapy, and after completion of treatment the drug continues to act for 72 hours.
Main components and release form
Cetrin tablets contain lactose, corn starch, sorbic acid, magnesium stearate, dimethicone, titanium dioxide, hypromellose, talc, povidone, polysorbate and macrogol as excipients. Each tablet contains 10 mg of the active substance cetirizine dihydrochloride. The tablets have a round convex shape and are coated with a white coating. The average price for the drug ranges from 140 to 220 rubles.
Cetrin syrup is often colorless, sometimes slightly yellowish, of a uniform structure with a pronounced fruity odor. One milliliter of syrup contains 1 mg of cetirizine. Additional ingredients are purified water, glycerol, sucrose, disodium edetate, benzoic acid, sodium citrate, sorbitol solution and fruit flavor. The cost of syrup is approximately 130 rubles.
Analogues of the drug are Zetrinal, Zirtec, Zodak, Parlazin, Analergin. All of them are available in various forms (tablets, drops and syrups).
Features of application
Cetrin for children in syrup and in tablets for adults is equally well absorbed in the digestive organs. The drug can be taken with food, and the maximum content of the active ingredients of the drug in the blood occurs an hour after administration.
The half-life of the drug from the body is 10 hours, but may increase by half in older people and people with liver problems. In children, the drug is excreted longer (from two years - 3 hours, 2-5 years - 5 hours, up to 12 years - 6 hours). The drug is mainly excreted in the urine, and only a small part of it is excreted during bowel movements. Cetrin tends to penetrate and accumulate in breast milk.
Cetrin is prescribed for the treatment of allergies in the following cases:
- Seasonal or chronic conjunctivitis and rhinitis
- For the treatment of atopic dermatitis and dermatoses accompanied by itching.
- To relieve skin itching, urticaria and Quincke's edema.
- For hay fever, accompanied by sneezing, itching and increased tear production, as well as during atopic bronchial asthma.
Cetrin tablets for the treatment of adults and children over six years of age (daily dose – 10 mg/1 tablet):
- Adults: 1 tablet per day
- Children over 6 years: half a tablet twice a day
- Patients with kidney disease reduce the standard dosage by half.
The medicine should be taken with water.
Cetrin syrup is best taken in the evening, but the drug can be taken at any time of the day, regardless of food. The syrup should be washed down with water.
- Children over six years of age and adults: 10 ml (2 scoops) of syrup once a day. If necessary, the dosage is divided into two doses.
- Children 2-6 years old, people with kidney disease: 5 ml once a day or 2.5 ml twice a day.
The dosage of syrup directly depends on the child’s weight. Children up to 30 kg are prescribed one scoop of the product, and those weighing more than 30 kg - 10 ml or 2 scoops.
Side effects
In most patients, Cetrin does not cause side effects. But in some cases, the following adverse effects may occur:
- Central nervous system disorders: headache, migraine, general weakness, increased drowsiness, nervous agitation, dizziness.
- Digestive organs: pain and discomfort in the abdomen, dry mouth, flatulence.
- Hives, itching, swelling and other manifestations of allergies occur less frequently.
With a severe overdose of the drug (exceeding the therapeutic norm by 30-40 times), pronounced allergy symptoms appear: rash, itching, tachycardia and dry mouth. Exceeding the dose may also be accompanied by urinary retention, constipation, increased weakness and fatigue, and trembling of the limbs.
To eliminate the consequences of an overdose, gastric lavage is performed, and if the patient’s condition is serious, additional symptomatic therapy is performed.
Cetrine and pregnancy
During testing of the drug, no negative effects of Cetrin on the fetus were observed. However, insufficient research into possible risks to the fetus makes Cetrin unsuitable for use during pregnancy and breastfeeding.
Main contraindications
Patients with liver failure are recommended to use Cetrin in limited quantities and only after the dosage has been prescribed by a doctor. Children under one year of age and elderly patients are recommended to use the product only when absolutely necessary and with great caution. Contraindications to the drug also include:
- Pregnancy and lactation
- Individual intolerance or hypersensitivity to the components of the drug
- Children under two years of age (syrup), children under six years of age (tablets).
Use with other medications
Studies have shown that Cetrin does not interact with the following drugs: glipezide, diazepam, ketoconazole, cimetidine and analogues. The simultaneous use of Cetron and theophylline reduces the antihistamine effect of Cetron. The drug should be taken with caution along with sedatives.
Knowing exactly what Cetrin tablets are prescribed for, you can avoid a negative reaction from the body. If the dosage is observed, the drug does not enhance the effect of ethanol, but simultaneous consumption of alcohol is still not recommended.
Cetrin syrup, according to research, does not affect the speed of reaction, but if the dosage is exceeded (10 mg per day), it slows down psychomotor activity. Therefore, Cetrin is prescribed with caution to patients working with machinery, in transport or in production that requires high concentration.
You can also read an article about Cetrin in Ukrainian: “Cetrin tablets, syrup – instructions for use, administration”
Medprice.com.ua
Cetrin indications for use and instructions for use of the drug
In the modern pharmaceutical industry, there are a huge number of different medications that help against a wide variety of diseases. In this article I would like to talk about a medicine such as Cetrin - indications for use, instructions.
When should you use this product?
At the very beginning, it is necessary to understand in what cases this medication has the expected effect. So, Cetrin - indications for use:
- This is an excellent preventive measure for various types of allergic reactions.
- Suitable for treating allergic reactions and relieving main symptoms.
- Effective for allergic dermatitis.
- Helps relieve skin itching.
- Helps cope with hives, including chronic ones.
- Helps with seasonal conjunctivitis and rhinitis, which are allergic in nature.
- Prevents the development of Quincke's edema.
- It is also used in complex therapy in the treatment of bronchial asthma.
Pharmacological action of the drug "Centrin"
It is important to say that the active ingredient in this medicine is cetirizine (this is also the international name of the drug). It helps patients mainly in the first stages of allergies. So, by taking this medication, you can prevent tissue swelling, relieve spasm of smooth muscles, and significantly reduce capillary permeability (which will prevent the allergen from further affecting the body).
If you follow the dosage correctly and take the drug depending on the doctor’s prescription, it does not have a sedative effect (i.e., it does not suppress a person’s consciousness). The first effect is observed approximately 20 minutes after taking the drug (in about half of the patients); in other people, relief occurs within an hour.
The therapeutic effect lasts for two days. After a single dose of the medicine for three days, the patient’s condition will not worsen. It is also worth saying that if the dosages are observed, the drug does not cause addiction to the antihistamine effect of the medication.
Absorption of the drug "Cetrin"
For many patients, an important point will be that this drug is well absorbed by the gastrointestinal tract without damaging the walls of the stomach. Taking the medicine with food will not affect absorption. This medication begins to be eliminated from the body after about 10 hours (for adults), after 6 for children, after 12 hours for older people. Mostly the medicine leaves the body through urine.
Contraindications to the use of Cetrin
We next consider the drug “Cetrin”. Indications for use - everything has already been said about this. However, it is also necessary to talk about for whom this medication is contraindicated. So, the following categories of the population should stop taking it:
- Pregnant women.
- Ladies during lactation.
- For those who have increased sensitivity or intolerance to cetirizine, the active substance.
People with renal failure should be especially careful when taking this drug. As for children, they can take this medicine only on the recommendations of the treating doctor. In such cases, the usual dosage of the drug may be adjusted. As for babies under one year old, there are no reviews about the use of this medication by such patients.
Method of administration, as well as permissible dosages of taking “Cetrina”
We further consider useful information about such a drug as “Cetrin”, indications for use. The instructions strictly instruct you to adhere to the permissible dosages of taking this medicine. Tablet form of the drug:
- The daily dose of this medication is 10 mg, i.e. one tablet per day. If we talk about adults, they are recommended to take one tablet once a day.
- For children over 6 years of age, it is better to take half a tablet twice a day - morning and evening.
- If the patient has problems with kidney function, you can take half a tablet once a day.
It is advisable for the patient to swallow the tablet completely, without chewing, with a small amount of clean water.
How to take Cetrin syrup correctly:
- Adult patients should take no more than 10 mg of syrup per day.
- Children over 6 years old also need to take 10 mg of syrup. However, in this case, you can take 5 mg twice a day - morning and evening, before bed.
- If we are talking about children from 2 to 6 years old, their daily dose is 5 mg. You can take the medicine once, or twice a day - in the morning and before bed.
- If this drug is taken by a patient with kidney problems, he should drink no more than 5 mg per day.
The syrup should be taken orally regardless of meals; if necessary, it can be washed down with a small amount of water. It is best to take this medicine in the morning or before bed.
Side effects from taking the drug "Cetrin"
It is worth saying that this drug is in most cases well tolerated by patients. And side effects are extremely rare. But still, there are:
- The drug may affect the functioning of the gastrointestinal tract. In this case, the patient may experience abdominal pain, flatulence, dyspepsia (various digestive dysfunctions), dry mouth, as well as discomfort in various parts of the gastrointestinal tract.
- Sometimes the drug also affects the functioning of the nervous system. This may manifest itself as headache, migraine, drowsiness, weakness, and slight dizziness.
- Very rarely and mainly in case of individual intolerance to the active substance, an allergic reaction may develop after taking the drug: Quincke's edema, urticaria, itching.
Overdose of the drug "Cetrin"
What else needs to be said when we are talking about a drug like Cetrin? The instructions state that if you adhere to the dosage prescribed above, an overdose will not occur. Only if you exceed the dose of the drug by 30-40 times, urticaria, itching may occur, drowsiness, weakness in the body, and dizziness may also occur.
There may also be a delay in excretion of urine from the body, tremors, constipation, tachycardia and dry mouth. All the above symptoms disappear after gastric lavage. Hemodialysis will not help in this case. Also, there is no drug that would reverse the effect of Cetrin in case of an overdose.
"Cetrin": instructions regarding the interaction of the drug with other drugs
It is worth saying that this drug can be taken simultaneously with various antibiotics. When taken simultaneously with “Theophylline” (a bronchodilator, a diuretic), the effect of “Cetrin” is reduced (the kinetics of “Theophylline” is stable). You should take this drug together with sedatives with caution (it is better to consult your doctor first).
As mentioned above, if the dosage of the drug is observed, it does not affect the patient’s consciousness. However, when taking more than 10 mg of Cetrin per day, the speed of reaction can significantly decrease (according to reviews from most patients). That is why people who drive a car should take this medicine with caution. It is also not recommended to take Cetrin together with ethanol (i.e. alcohol).
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How to take Cetrin - all indications and rules of administration
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Cetrin - contraindications you need to know
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Cetrina tablets contain 10 mg cetirizine hydrochloride , as well as corn starch, lactose, povidone K30, magnesium stearate.
Shell composition pills: hypromellose, titanium dioxide, sorbic acid, talc, macrogol 6000, , polysorbate 80.
IN Cetrin syrup the active substance is contained in a concentration of 1 mg/ml. The auxiliary components of the drug include: benzoic acid, sucrose, glycerin, disodium edetate, sorbitol solution, sodium citrate, ID20181PH fruit flavoring mixture, purified water.
Release form
The manufacturer produces the medicine in the form:
- film-coated tablets 10 mg (packaging No. 20 or No. 30);
- syrup 1 mg/ml (bottles 30 and 60 ml).
Tablets are round, biconvex, film-coated. Their color varies from almost white to white. There is a risk on one side.
Syrup is a transparent, slightly yellowish (or colorless) substance with a pleasant fruity odor. There are no visible particles and the liquid may be slightly opalescent.
pharmachologic effect
Antiallergic .
Pharmacodynamics and pharmacokinetics
Cetirizine selectively blocks H1-type histamine receptors, thereby weakening the effect histamine on blood vessels, reducing swelling and hyperemia. Renders antiexudative And antipruritic effect .
Effective for skin reactions (hyperemia, blister) that develop in response to the introduction of specific allergens , histamine and cooling (at cold urticaria ).
In 50% of patients after taking 10 mg the effect appears within 20 minutes, 95% of patients feel improvement 1 hour after taking the tablet/syrup.
Duration of receptor blockade histamine - more than 24 hours. In children under 2 years of age (including newborns) - approximately 12 hours.
Skin reactivity to histamine restored within three days.
The drug alleviates the condition of , reducing symptoms such as nasal congestion, sneezing, itching, runny nose, and lacrimation.
What does the medicine in syrup help with?
Syrup is the preferred dosage form for pediatric patients. Like the tablets, it is effective for:
- allergic rhinitis/conjunctivitis ;
- accompanied by severe itching allergic skin diseases ;
An additional indication for the use of Cetrin in this dosage form is atopic .
Contraindications
The drug should not be used in patients with known hypersensitivity to cetirizine , hydroxyzine or auxiliary components of syrup/tablets, in pregnant and lactating women.
In pediatrics, syrup is prescribed from the age of two, and tablets from the age of six.
Relative contraindications are old age and chronic . For patients with chronic renal failure and the elderly, the dosage of the drug is selected individually depending on the functional state of the kidneys.
Side effects
Cetrin rarely causes side effects. Sometimes patients experience dry mouth and increased drowsiness. Less common symptoms include:
- headache;
- feeling of discomfort in the stomach/intestines;
- dizziness;
- hypersensitivity reactions (rash, itching, hives , Quincke's edema ).
Instructions for use of Cetrin: how to take tablets and syrup?
Cetrin tablets: instructions for use
The tablets are intended for oral administration. They should be washed down with a glass of water. Food intake does not affect the pharmacokinetics of the drug.
Adults (provided they do not have impaired renal function) should take one 10 mg tablet per day, either in one dose or divided into two doses.
If renal function is reduced, the dose is selected individually.
For kidney damage, in which Clcr is in the range from 30 to 49 ml/min, the daily dose is half a tablet (5 mg). If GFR is reduced so much that Clcr does not exceed 30 ml/min, the indicated dose (5 mg) should be taken every other day.
Instructions for syrup
The syrup is used orally; the time of its administration does not depend on the time of meal.
The daily dose for an adult is 10 mg (corresponding to 10 ml of syrup). Depending on the severity of symptoms, treatment can be started with a dose of 5 mg/day. The highest dose is 20 mg/day.
Elderly people, as well as patients with impaired liver function, provided normal renal function, do not require dose adjustment.
In case of kidney damage, the dosage regimen should be revised.
With a moderate decrease in GFR, when Clcr is in the range from 30 to 49 ml/min, the patient is given 5 ml of syrup per day, if Clcr does not exceed 30 ml/min, this dose is taken every other day. In case of kidney damage with terminal chronic renal failure, in which Clcr does not exceed 10 ml/min, the use of the drug is contraindicated.
Instructions for children
Cetrin tablets for children over six years of age are prescribed to take 2 times a day, 5 mg or 1 time a day, 10 mg (0.5 or 1 tablet per dose, respectively).
The recommended dose of syrup for children under 6 years of age is 2.5 mg 1 time per day. If there are indications (and also taking into account the child’s body weight, the severity of symptoms and the effectiveness of treatment), it can be doubled. In this case, the drug is taken every 12 hours, 2.5 ml per dose.
Children over 6 years old should be given 10 ml of syrup once a day. Your doctor may recommend starting treatment with half the dose.
The dosage of Cetrin for children with impaired renal function is selected individually, depending on body weight and the Clcr value.
How long can you take Cetrin?
How many days to take in a particular case is determined by the attending physician. The duration of the course depends on the nature and severity of the disease.
Overdose
Overdose is mainly due to the influence cetirizine on the nervous system or with effects that may indicate anticholinergic effect .
Taking Cetrin in a dose five times higher than the recommended daily dose provokes:
- increased dry mouth;
- increased fatigue;
- confusion;
- headache;
- dizziness;
- mydriasis ;
- malaise;
- sedation ;
- anxiety;
- drowsiness;
- urinary retention.
Specific antidote cetirizine unknown Treatment for overdose is aimed at maintaining the patient and relieving unwanted symptoms.
At the initial stage of an overdose, it is advisable to perform gastric lavage and induce vomiting. The patient is prescribed laxatives and enterosorbents . Dialysis ineffective. In severe cases, it is necessary to monitor the condition of the patient's respiratory and cardiovascular systems.
Interaction
Conducted studies of interaction with, , Pseudoephedrine , , did not confirm the effect of the listed drugs on the pharmacokinetic profile Cetirizine .
Taking the drug in therapeutic doses does not have a significant effect on the reaction rate, however, drivers and people working with potentially dangerous mechanisms should remember that while using Cetrin, drowsiness may increase in some patients.
Additionally
Most people know the drug thanks to its bright and memorable commercial, which shows the joy of life without allergies .
With this video, the team of the creative agency SmartFarma wanted to convey that spring, which is considered the most difficult time of year for allergy sufferers, like any other season, can be associated with music, songs and dances, and not with unpleasant symptoms.
The girl who sings the song “I’m not afraid of allergies” in the video is a singer, actress, model and TV presenter “Pearl”.
Cetrin's analogs
Level 4 ATX code matches:Analogues with a similar mechanism of action: , Claritin , Xezal , , , , , , , Telfast , Eden .
The price of Cetrin analogues is from 56 rubles. This is the amount it will cost to purchase a package of 10 tablets of the drug. Cetirizine .
Which is better - Cetrin or Zodak?
The main component of the drug is cetirizine . The medicine is produced by the Czech company Zentiva in the form of 10 mg/ml drops, 5 mg/ml syrup and 10 mg tablets.
Application practice and subjective feelings of patients allow us to conclude that there is no fundamental difference between Zodacus And Cetrin No. However, if price plays a decisive role when choosing a product, it is better to choose the latter, since it is much cheaper than its counterpart.
Which is better - Cetrin or Tavegil?
A drug Tavegil is produced by the Austrian company Nycomed Austria GmbH. As an active substance it contains clemastine - one of the most common first generation histamine blockers.
Has high anticholinergic activity , however, it penetrates the BBB in smaller quantities than earlier histamine blockers. In this regard, sedation in patients during its use develops infrequently - in less than 10% of cases. Moreover, the likelihood of sedation increases with parenteral use of the drug
TSmax clemastine - within 2-4 hours, cetirizine - 1 hour. Antihistamine activity clemastine reaches its maximum after an average of 6 hours, the effect lasts up to 12 hours (sometimes during the day). Cetirizine it continues to operate for more than 24 hours.
Thus, the advantages Tavegila are well studied and long-term experience in use, as well as the availability of an injection form and low cost of treatment.
The advantages of Cetrin are a higher affinity for H1-type histamine receptors, a longer duration of action, low permeability through the BBB, no tachyphylaxis , no inactivation of the active substance by food.
Cetirizine is not addictive and sedative effect and, in addition, is practically not metabolized in the body, whereas clemastine biotransforms almost completely (in its pure form the substance is detected in urine in very low concentrations).
Which is better - Claritin or Cetrin?
is a drug from the Belgian company Schering Plow Labo N.V.. It is produced in the form of syrup and tablets, the basis of which is the substance - second generation histamine blocker.
Loratadine does not potentiate the effect of alcohol, is devoid of sedative effect , non-cardiotoxic , almost does not interact with other medications.
In terms of effectiveness, both drugs are comparable, however, Cetrin helps better with skin manifestations of allergies - characteristic feature cetirizine is its ability to penetrate the skin well.
Which is better - Cetrin or Erius?
The basis of the drug Erius is a substance - active metabolite loratadine , III generation H1 blocker. With all the benefits loratadine , it exhibits the highest selectivity for receptors histamine and extremely rarely provokes the development of undesirable reactions.
Application Erius preferably for long-term treatment of allergic diseases such as chronic urticaria or year-round rhinitis .
Affinity desloratadine to H1 receptors 50 times more than cetirizine , That's why Erius - this has been proven both in medical practice and in clinical studies - it is stronger histamine blocker than its counterpart.
Alcohol compatibility
Cetirizine in therapeutic doses does not potentiate the effect of ethanol (if its concentration does not exceed 800 mg/l), however, the manufacturer recommends refraining from drinking alcohol during treatment with Cetrin.
Use during pregnancy
Contraindicated during pregnancy. If used during lactation, the child should be switched to formula for artificial feeding.
When the body is hypersensitive to certain substances, an inadequate reaction of the immune system occurs - an allergy. To stop an attack, most people use various antihistamines. One of the most effective tablets is Cetrin, which is prescribed for the treatment of both children and adults. The product has many analogues with varying therapeutic efficacy.
General information about the drug
In recent years, the number of patients diagnosed with allergies has begun to increase. Increasingly, the population suffers not only from plant pollen and animal hair, but also from atypical increased sensitivity to temperature changes (allergy to the sun, frost). The unpleasant symptoms that accompany the pathological condition develop against the background of increased histamine production. The phenomenon can be eliminated and the patient’s condition can be normalized only with the help of antihistamines. “Cetrin” has a powerful anti-edematous and antipruritic effect.
What do these pills help with? The antiallergic drug belongs to the second generation and can relieve the patient from the discomfort caused by the disease. The drug belongs to the group of selective histamine blockers.
Release form
An Indian pharmaceutical company produces Cetrin in the form of tablets and liquid (syrup). The latter type is often used in pediatric practice due to the ability to clearly calculate the dosage and the sweetish taste of the medicine. The volume of the bottle can be 30 or 60 ml. In tablet form, the drug is used for older children and adults. The package contains 10, 20 or 30 tablets on blisters. The drug has no other forms of release.
What does it contain?
The main active ingredient is cetirizine, a substance that blocks H1-histamine receptors and reduces the manifestations of an allergic reaction. One tablet contains 10 mg of this component. Does not cause a pronounced sedative effect, like many antihistamines.
"Cetrin" also contains excipients: corn starch, magnesium stearate, lactose, povidone. The syrup contains a larger number of additional components.
Therapeutic effect
The therapeutic effect is due to the presence of cetirizine in the substance, which can prevent the connection of histamine with receptors and, thereby, eliminate the symptoms of an allergic reaction: tearing, redness of certain areas of the skin, itching, swelling.
Cetrin can also be used to prevent the development of allergies. What these tablets are for is described in the instructions, but only a doctor should prescribe the medicine.
An antihistamine can eliminate various skin reactions, including those to cold. In the mild stage of bronchial asthma, the drug reduces histamine-induced bronchoconstriction.
"Cetrin" belongs to the 2nd generation antiallergic drugs, which are characterized by a reduced effect on the functioning of the nervous system. That is, the tablets practically do not cause drowsiness, but at the same time they are less effective in relieving an allergic reaction. The drugs of the previous generation, which have a powerful inhibitory effect on the central nervous system, have a more pronounced therapeutic effect.
Cetrin tablets for allergies can significantly reduce the number of eosinophils, which leads to a decrease in the severity of the late stage of the reaction to hypersensitivity. The inhibitory effect on cytokines causes an anti-inflammatory effect and reduces the negative reaction of the immune system.
When is it prescribed?
A direct indication for the use of the drug "Cetrin" is the presence in the patient's medical history of information about hypersensitivity to certain substances. You can eliminate allergy symptoms using tablets in the following cases:
- Seasonal rhinitis.
- Hay fever.
- Eczema.
- Allergic conjunctivitis.
- Quincke's edema.
- Hives.
- Dermatosis (allergic dermatitis or neurodermatitis).
- All year round rhinitis of allergic type.
The drug is recommended to be taken as an anti-inflammatory drug to prevent and prevent deterioration of the condition. For example, Citrine significantly reduces the number of asthma attacks during the treatment and prevention of bronchial disease.
How to use?
Cetrin tablets are taken regardless of food intake. Take the medicine with a small amount of water. The dosage depends on the severity of the patient's condition and age group. Adults and children can be prescribed 10 mg of the drug per day (1 tablet) or 0.5 mg twice a day. Relief of symptoms is observed within 15-20 minutes after taking an antihistamine. The therapeutic effect lasts for 24 hours. During this period, the patient practically does not observe signs characteristic of allergies.
A day after taking the pill, allergy symptoms will begin to recur, which indicates the need to re-use the drug. Before taking Cetrin, you should read the official instructions and get recommendations from an allergist regarding the treatment of the disease. The specialist will help you understand the dosage of the drug and may prescribe additional therapy.
For patients with renal or hepatic insufficiency, the dosage should be selected strictly by a doctor. Usually it is half the daily requirement - 5 mg.
Can the drug be given to children?
Starting from 6 years of age, Cetrin tablets can be used to treat allergic manifestations in children. Doctors recommend using syrup for young patients. Liquid medicine is suitable for children 2-6 years old. The dosage is determined based on the child’s condition and the severity of symptoms.
There is a practice of prescribing an antihistamine to babies in the first year of life. The product in syrup form should be used only after consulting a doctor. The daily amount of the drug should not exceed 2.5 ml. Experts say that the prevention of such a pathological phenomenon as atopic march is also possible with the medicine “Cetrin”. The dosage of the drug should not be determined independently. Only if the specialist’s prescriptions are followed, the patient’s condition can be alleviated.
The antihistamine gently affects the activity of the baby’s nervous system, allowing him to calm down and fall asleep. Allergic skin reactions can be treated at home in most cases. In addition to the antihistamine, additional action at the local level will be required.
Contraindications
Relative contraindications for use are renal failure and the age of the patient. In this case, only a specialist can decide on the need for treatment and adjust the individual regimen. Cetrin tablets are contraindicated for children under 6 years of age.
The use of an antihistamine should be avoided if you are intolerant to the components in the composition. The drug is not allowed to be taken during pregnancy and breastfeeding. For pregnant women, doctors select gentler medications that can relieve the unpleasant symptoms of an allergic reaction.
"Cetrin": analogues
The following drug analogues will cost patients less than Cetrin:
- "Loratadine."
- "Diazolin".
- "Cetirizine."
- "Cetirinax".
- "Letizen."
The most optimal substitute for an Indian antihistamine medicine can be selected by the attending physician, taking into account the patient’s medical history and sensitivity to the active ingredients. At the same time, Cetrin is suitable for many patients. Cheaper analogues mainly refer to first-generation antiallergic drugs, which do not have pronounced selective activity and cause side effects on the functionality of the nervous system.
Antihistamines belonging to the third generation are considered the most expensive. Drugs tend to act selectively and do not influence the activity of the central nervous system during therapy. Compared to first generation drugs, they have the same powerful therapeutic effect. This group of pharmaceutical products includes drugs such as Erius and Claritin.
"Suprastin" is a proven antiallergic agent
An antihistamine of Hungarian origin has long been used to eliminate and relieve allergy symptoms. The active component of Suprastin is chloropyramine hydrochloride. The drug belongs to the first generation and produces a pronounced sedative effect related to side effects.
When choosing which antihistamine is best suited for treatment - Suprastin or Cetrin - you should carefully read the instructions for each drug. "Suprastin" has an extended list of contraindications: peptic ulcer, prostate hyperplasia, arrhythmia, asthma attacks, myocardial infarction, therapy with MAO inhibitors, urinary retention. There is also an impressive list of side effects, which include:
- Dizziness.
- Increased sleepiness.
- Arrhythmia.
- Attacks of nausea and vomiting.
- Ocular hypertension.
- Dysuria.
- Thrombocytopenia.
- Agranulocytosis.
- Encephalopathy.
- Deterioration of vision.
"Suprastin" can be used to treat infants. The dosage of tablets is calculated by a specialist.
"Zodak"
The popular antihistamine also belongs to the second generation. Available in the form of drops, syrup and tablets. The active ingredient is cetirizine hydrochloride, that is, the product is a complete analogue of Cetrin. Patients say that if the dosage prescribed by the doctor is followed, the drug does not cause a sedative effect and does not affect the functioning of the central nervous system.
Contraindications for the use of the medicine "Zodak" - pregnancy, lactation, children under 1 year of age, hypersensitivity to the substances in the composition.
Side effects of the drug "Cetrin"
To avoid side effects, you should first read the instructions and understand how to take Cetrin. The drug actually rarely causes negative reactions and is normally tolerated by the body. Side effects are possible from the nervous system. The drug causes drowsiness, headache, increased agitation, and weakness. Reactions from the digestive and immune systems are much less common: increased gas formation, constipation, abdominal pain, dyspepsia, skin rashes, itching.
Cetrin tablets are prescribed for courses of therapy. Long-term use of the medication is not advisable. The medicine can be used for the purpose of prevention during periods of danger of developing allergy symptoms.
Tablets "Cetrin": price and reviews
Many people of different age groups experience allergy symptoms. It is most difficult for patients with congenital hypersensitivity to certain irritant substances. Antihistamines help cope with the problem and stop the development of allergic symptoms.
Its cost is affordable for most people who need antiallergic therapy and amounts to 130-170 rubles. for 20 tablets. The drug quickly copes with even severe allergy symptoms. The therapeutic effect lasts for 24 hours, after which you should take a new dose of the medicine. Only in rare cases did Cetrin turn out to be absolutely powerless and did not bring any improvement in the condition. This suggests that each organism is individual.
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Zodak tablets contain 10 mg of the active ingredient cetirizine, as well. They can take the drug in the form of syrup or drops. 13 Jun Instructions for use (how to take). You can also find the common name “Cetrin drops” instead of the correct “syrup”, which. Cetrin tablets for allergies (therapeutic effects). The very first pill (!) improved his condition - in the morning he was breathing calmly. . How long can you take it (course), in your opinion? . Once I had an allergy - this applies to any drug, not. May 11, 2016. Remedies for the treatment of allergies Schering-Plough Labo (Belgium) Claritin (tablets) photo. Claritin - indications for use. 2 Jun She follows a diet, goes to the sea, takes pills, but to no avail. At what age can immunotherapy be used? Swallow the tablet whole, without chewing, with a glass of water.
You can take Cetrin ® regardless of food intake (both on an empty stomach and during or. How long should you take Cetrin ®? exacerbation of chronic allergic diseases (allergic rhinitis, dermatitis, etc.); the medicine is presented in tablets in the pharmacy chain (5 mg), coated, as well as drops (5 mg per 10. How long can Erius be taken? March 21, 2017. Allergies can be recognized by an unexpected runny nose. If true, a lotion on the tablet for exceptional problems. May 10. C with the onset of spring, did the allergy make itself felt again?. In it we will tell you how you can reduce allergic reactions without medications or. Do not take pills, but go the other way - change. February 13, 2017. How long can a child take Suprastin. This is not a medicine allergies, and the medicine irritates the throat. Depending on the pharmacy, for one pack of 20 suprastin tablets you will pay from up to rubles. Jan 28. The child has allergies, we give suprastin and neosmectin, but they didn’t tell you. You can only have medicines in the form of solutions and tablets, . Aug 14 I take Desal for allergies, how long can I take it? . D. I tried Dezal tablets for the first time - it was recommended at the pharmacy. 2 07 2001. In the spring-summer period there is a peak in allergic diseases. from 2 to 12 years - 5 mg (5 ml syrup or 1/2 tablet), from 12 years and on. The drug can be prescribed to children, adults, and elderly patients. Is it possible to take suprastin and loratal together? .. Last year I took allergy pills, which made all the symptoms disappear. I'm going to. Allergic diseases are nowadays in one way or another. The drug can be taken once a day, its therapeutic effect. Alerzin anti-allergy drops should be given to children from two years of age. From the age of six, children can take Alerzin tablets. You should not take the product. May 8, 2017. Instructions for use of Cetrin (tablets, drops, syrup) for adults and. How long can you take Cetrin if you have allergies? Cetrin can be used against allergic reactions that occur on. How many tablets to take should be prescribed by your doctor or prescribed independently. In addition, if the allergic reaction does not stop for a long time,... How often can you take allergy pills? Published: 02/13/2017. How to properly cleanse your body of toxins. The most pressing topics from. Let's find out Diazolin or Suprastin, which is better, how to take Diazolin, so. So what are Diazolin tablets for? Diazolin has long been used for... After all, you don’t want to experience itchy skin for a long time or suffer from swelling of the mucous membranes. Within an hour you can feel the maximum effect of this drug. Please note that suprastin does not treat allergies! . Children from 6 to 14 years old - take ½ tablet on average 2-3 times per day. You can also read the instructions for the medications; in particular, the instructions for Enterosgel indicate how to take Enterosgel if you have allergies. Our allergist prescribed ketotifen; we had been taking it for 2 months before. What should I do? Should I take pills or is syrup better? . Or rather: antihistamines are added to it, because... Ketotifen must be taken for a long time, the effect is c. What can a 2.5 year old child do for allergies? like summer - already
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About the release forms and composition of Cetrin
This product is produced by one of the Indian pharmaceutical corporations. There are 2 forms of Cetrin:
- The tablets are round, biconvex, white, film-coated. There is a risk on one side. The active substance of the tablets is cetirizine dihydrochloride, one tablet contains 10 mg. And there are several excipients: povidone, lactose, corn starch, magnesium stearate, hypromellose, talc, titanium dioxide, macrogol, sorbic acid, dimethicone, polysorbate. The package can contain 30, 20 and 10 pieces.
- The syrup is packaged in 60 and 30 ml, the package contains a measuring spoon for easy dosing. The syrup is homogeneous, transparent, uncolored, there may be a slight yellowish tint and opalescence, it has a pleasant, fruity smell. One milliliter of syrup contains 1 mg of cetirizine dihydrochloride. In its production the following is used: sucrose, sorbitol, benzoic acid, fruit flavoring, glycerin, sodium citrate, sodium edetate.
About generations of antiallergic drugs
There are three generations of antihistamines. MirSovetov will give a brief description of these three generations of histamine blockers.
The 1st generation did not have a selective effect on H1 receptors, so when they were taken, histamine receptors located in the central nervous system and organs of the digestive system were blocked. This generation of drugs has a very powerful anti-allergic effect, but there is a significant drawback - drowsiness. We are talking about drugs such as Diazolin, Tavegil, Suprastin, Fenistil.
The 2nd generation has less effect on the central nervous system, since the effect of these drugs is selective. These drugs have a less pronounced antiallergic effect than the first generation. But their advantage is that the feeling of drowsiness is felt to a lesser extent. This characteristic applies to Cetrin, Zyrtec, Zodak, Parlazin
The 3rd generation shows high selectivity of action on histamine receptors. Their therapeutic effect is powerful. There is no effect on the central nervous system, therefore there is no drowsiness. Claritin, Telfast, Erius have such effects.
Who needs Cetrin, how does it work?
Now let’s take a closer look at the medicinal properties of cetirizine. This histamine receptor blocker can bind to these H1 receptors and block them. It turns out that the released histamine is no longer able to contact the receptors and influence them. Let us remember that it is histamine that provokes allergic reactions in the body and their increase - redness, swelling, itching, skin rashes. If the development of allergic reactions is blocked at the cellular level, then their external signs no longer appear in such a significant form. Thanks to Cetrin, the amount of histamine released is reduced, in addition, the migration of eosinophils to the site of allergy is inhibited. Accordingly, the later stages of hypersensitivity will be less pronounced. Cetrin also has a general anti-inflammatory effect, because under its influence the production of cytokines that support the allergic reaction is significantly inhibited. A course of use of Cetrin blunts the readiness of an increase in the allergic reaction in the cells of the bronchi. As a result, the number of attacks decreases in those suffering from bronchial asthma. Cetrin begins to act in the body approximately 20 minutes after taking it. It is stored for 24 hours. Even if the drug is completed, readiness for allergic reactions is restored within three days.
Cetrin is used if necessary:
- relieve itching;
- eliminate existing edema or prevent its development;
- reduce capillary permeability and fluid release into tissue;
- relieve spasm of smooth muscles.
Conditions for which Cetrin is needed:
- runny nose (seasonal and year-round);
- hay fever;
- lacrimation resulting from allergic conjunctivitis;
- itchy dermatoses (atopic dermatitis, neurodermatitis);
- Quincke's edema;
- bronchial asthma;
- eczema.
Instructions for use of Cetrin
Both syrup and tablets are taken once a day, regardless of meal time, with some water. It is advisable to take the tablet or measured amount of syrup in the evening. Syrup can be given to children from the age of two, but tablets can only be given to children over six years of age. The dosages are as follows:
- from two to five years - these children need to drink 5 ml of syrup per day (there are cases when this amount is divided by two);
- For all children over six years old and adults, 10 ml of syrup is measured per day, or they swallow one tablet.
Attention, if you plan to conduct allergy tests, then you must stop using Cetrin three (or four) days in advance, otherwise you may get false negative results. You should not drink alcohol on the days you take this drug. Try to refrain from those activities that require increased reaction speed and close attention.
If the patient takes Theophylline, then the effect of Cetrin is prolonged. If the normal functioning of the kidneys is disrupted, the dose of the drug for patients is reduced by half. The same is done if the patient is elderly. If during the course of treatment one day you forgot to take this medicine, then the next day, be careful, take the drug without increasing the dosage. Another important question arises - how many days should you take Cetrin? And this depends on various factors, including: the nature of the course of the allergy, the degree of its severity. For acute forms of allergies, the course is usually from 10 to 14 days. If allergic manifestations go away earlier, then taking this medication can be stopped before the specified period.
In case of prevention, Cetrin should be taken for 30-45 days, when potential allergens are present in the space around you. For example, if your allergies usually begin during the flowering season of plants, then the time of admission is April and May.
For bronchial asthma, doctors prescribe this remedy as one of the components of treatment. The scheme is as follows: 15-20 days of use, then a seven-day break, after which the use of Cetrin is resumed for another 20 days.
Cases of overdose are recorded if more than 50 milliliters of syrup were drunk at a time (or more than 5 tablets were swallowed). We list the signs of an overdose:
- cessation of urine output;
- dry mouth;
- tachycardia;
- increased irritability, anxiety and restlessness;
- trembling of limbs;
- drowsiness.
Gastric lavage and symptomatic treatment can help here.
About contraindications
Cetrin should not be used throughout pregnancy and during the period when a woman is breastfeeding her baby.
If during treatment with Cetrin there are signs of hypersensitivity to the drug, then it is immediately canceled. If you see a substance in the drug that you are intolerant to, then this product should not be used so as not to cause harm to your health.
mirsovetov.ru
Cetrin - release forms
Cetrin is produced by a pharmaceutical company in India and this medicine is produced in two forms, as a syrup to relieve allergic reactions and in the form of tablets.
The syrup is mainly used in pediatric practice.
It is produced (some refer to this form of drop release) in tinted glass bottles; the packaging is accompanied by a graduated measuring spoon.
In appearance, Cetrin syrup is transparent, slightly yellowish, without foreign impurities, and has a fruity smell.
The tablets are packaged in blisters of 10, 20 or 30 pieces. The top of the biconvex tablets is scored and covered with a white coating.
Chemical composition of Cetrin
The main active substance in both liquid and solid forms of cetrin is cetirizine, it contains 10 mg in a tablet, and 1 mg in 1 ml syrup.
Therefore, when prescribing a treatment regimen with minimal doses of the drug, it is more convenient to use a liquid dosage form.
The syrup, in addition to cetirizine, also contains excipients that improve the absorption of the main component.
These substances include: sucrose, glycerin, sorbitol, sodium citrate, fruit flavoring and several other components.
In addition to cetirizine, the tablets contain starch, lactose, magnesium stearate, and povidone.
Therapeutic effect of using Cetrin
The medicine Cetrin belongs to the second generation of antihistamines.
The group of these drugs is characterized by the least effect on the central nervous system compared to first-generation antihistamines.
Due to this, side effects in the form of drowsiness, lethargy, and inhibition of reactions in Cetrin are expressed only to a small extent.
The anti-allergic effect is also less, in contrast to first-generation antihistamines.
That is, Cetrin can be characterized as an antihistamine with an average antiallergic effect and with the smallest number of possible adverse reactions.
The therapeutic effect when using Cetrin is provided by its main active ingredient - cetirizine.
This chemical is a blocker of inflammatory mediators in allergies - histamine receptors.
As a result of binding and blocking, histamine cannot have an effect on the body. Therefore, an allergic reaction does not yet develop at the cellular level and external symptoms of allergy do not occur, that is, itching, swelling, pain, sneezing.
When an allergic reaction is already developing, Cetrin reduces the amount of histamine produced and also reduces the movement of eosinophils to the site of the allergy.
A decrease in eosinophils leads to a decrease in the late stages of allergic reactions.
In addition to the antihistamine effect, Cetrin also has anti-inflammatory properties.
If you use this drug as a prophylactic agent, you can reduce the susceptibility of bronchial cells to the development of an allergic reaction.
This in turn reduces and reduces the severity of attacks in people with bronchial asthma. The same property of the drug can be used to prevent urticaria and dermographism.
The therapeutic effect after taking Cetrin orally begins to develop after about 20 minutes and continues for a day.
After discontinuation of the drug, its antiallergic effect persists for another three days.
The main therapeutic effects of the drug Cetrin, acting against allergies, include:
- Preventing and reducing swelling.
- Elimination of allergic itching.
- Reduced permeability of capillary walls.
- Relieving spasm from smooth muscles.
Cetrin not only acts as a medicine against allergies, this drug is also used as a prophylactic agent to prevent the development of an intolerance reaction.
Main indications for use of the drug Cetrin
Allergists prescribe tablets and liquid form of the drug Cetrin in case of the following allergic reactions:
- Year-round or periodically occurring seasonal rhinitis.
- Allergic conjunctivitis.
- Pollinosis.
- Hives.
- Dermatosis with intense itching of the skin.
- Eczema.
- Bronchial asthma.
- Quincke's edema.
Features of treatment with Cetrin
When prescribing Cetrin, you can take it regardless of meals. Both the tablets and the drug syrup should be taken with a small amount of water.
Children from the age of two can be treated with syrup; from the age of six they can already use tablets in therapy.
The duration of action of the medicine allows you to take it only once a day and preferably at the same time.
Allergists advise drinking the prescribed dose of the medicine in the evening, so it will not be possible to experience slight drowsiness during the day when using Cetrin.
The dosage of syrup is determined by the person’s age:
- It is recommended to treat children aged two to six years with 5 ml of the drug. In some cases, the daily dosage can be divided equally and you will need to drink 2.5 ml in the morning and in the evening.
- Children over six years of age and adults should be treated with 10 ml of syrup per day; this dose can also be divided into two.
A special dose, according to test indications, is determined for people with renal failure.
An overdose of the drug occurs if you drink more than 50 ml of the drug at one time.
At the same time it appears:
- Dry mouth.
- Drowsiness, lethargy.
- Constipation.
- Reduction, and in severe cases, complete cessation of urine excretion.
- Increased irritability, anxiety.
If an overdose is detected, treatment begins with thorough gastric lavage. Medicines used include drugs that normalize blood pressure, urination, and respiratory function.
Features of using Cetrin tablets.
When prescribing Cetrin tablets, simply swallow them without chewing and wash them down with water.
The duration of the therapeutic effect makes it possible to use this drug once a day during treatment, and it is better to do this in the evening hours, so there will be no discomfort from drowsiness.
The dosage for adults and children over six years of age is the same.
When treating allergies in children, it is better to divide the tablet into two doses - evening and morning.
Patients with impaired renal function take half a tablet per day.
If symptoms of drug hypersensitivity are detected, it should be discontinued and a doctor should be consulted to review the treatment regimen.
Stop taking Cetrin three days before allergy tests are carried out.
You should not drink alcohol while taking this antihistamine.
Due to the possible development of drowsiness with Cetrin during therapy with these drugs, it is necessary to avoid situations in which maximum concentration and high reaction rates are required.
Overdose of Cetrin tablets.
Occurs if you take more than three tablets at a time.
Symptoms of overdose include drowsiness, increased skin itching, rash, anxiety, difficulty urinating, tremors, increased heart rate, and high fatigue.
Elimination of signs of overdose begins with gastric lavage, then symptomatic therapy is used.
Strengthening or weakening of the therapeutic effect of cetrin when taken together with drugs from other groups was not revealed during the tests.
However, Cetrin and sedatives should be combined with caution.
Features of the use of Cetrin in the treatment of children
The use of Cetrin in pediatric practice can quickly relieve a child of many allergy symptoms, including itching.
Skin changes due to allergies, manifested by itching, cause a lot of discomfort to the child and force him to scratch the skin, which can result in the addition of a secondary infection.
Cetrin quickly eliminates the most painful itching, normalizes sleep and prevents the occurrence of infectious lesions on the skin.
With regular use, Cetrin reduces the risk of respiratory failure joining a developing allergy.
In case of intolerance to a certain allergen, it can be expressed by spasm of the bronchi and larynx, difficulty breathing, swelling of the mucous membranes of the respiratory tract, shortness of breath and suffocation.
Thus, Cetrin prevents the transition of skin symptoms in allergies to the respiratory system, that is, the medicine, when used in a timely manner, is a preventive remedy against bronchial asthma and allergic rhinitis.
The dosage of the medicine is always determined taking into account the age of the child. It is advisable to divide the syrup and tablets in the daily dosage into two doses, so the medicine is better tolerated.
To treat small children, it is better to use syrup; it smells good, tastes good and is absorbed faster.
If you miss a dose, you do not need to double it the next time you take it.
Is Cetrin used during pregnancy?
During pregnancy and the entire period of breastfeeding, Cetrin is not used, that is, this drug is contraindicated.
This is due to the penetration of the main active substance through the placenta, which can negatively affect the formation and formation of the spinal cord and brain.
During lactation, Cetrin also enters milk in large quantities, so the baby will also receive the medicine along with it.
Duration of use of Cetrin
The duration of treatment with Cetrin is determined by a whole group of factors. The most important of them are the severity of allergy symptoms and the nature of the intolerance reaction.
- To relieve an acutely developing allergic reaction, the drug is used for a maximum of two weeks. If the symptoms of the disease stop quickly, then stop taking the medication.
- When using Cetrin as a means to prevent allergies, the course of its use can reach one and a half months. Allergists recommend using this drug as a prophylactic throughout the entire period of presence of the allergen in the environment, usually this applies to seasonal hay fever.
- Cetrin also complements the basic therapy for the treatment of bronchial asthma. In this case, the medicine is prescribed for no more than three weeks, then there is a break of one week and the treatment regimen is repeated.
- Children under 7 years of age with a tendency to allergic dermatitis can use Cetrin for two weeks up to four times a year.
Cetrin and its side effects
Both tablets and the liquid form of the drug can cause a number of almost identical side effects, mainly affecting the central nervous system.
Adverse reactions include the following symptoms:
- Headache, periodic dizziness, weakness, drowsiness.
- Dyspeptic symptoms, flatulence, dry mouth, pain in the abdomen.
- Skin rash, itching.
If severe side effects develop, stop taking Cetrin and the doctor prescribes another antihistamine.
Contraindications
There are few contraindications to the use of Cetrin, these are:
- Individual intolerance to the components of the drug.
- Pregnancy and lactation period.
- The syrup is not approved for use in children under two years of age, tablets for children under six.
The drug is used with caution in the treatment of elderly people and patients with renal failure.
Analogs of the drug Cetrin
In the pharmacy chain you can purchase both analogues of Cetrin and drugs with synonymous names.
Synonymous drugs are those drugs that contain cetirizine, but they have different names.
Analogs are medications belonging to the group of antihistamines with different active ingredients in their composition.
Known drugs with cetirizine are:
- Alerza tablets, Allertec, Zirtec, Cetirizine DS, Cetirinax, liquid form and Zodak tablets, Cetrin tablets and syrup.
All synonyms.
Known analogues of Cetrin are:
Tablets Diacin, Dramamine, Ketotifen, LauraGexal, Claritin, Kestin and other antihistamines.
All analogues.
Medicines for allergies should always be selected by a doctor.
But you can independently replace Cetrin with analogue drugs if this medicine is not available in the pharmacy.
Comparison with analogues
Cetrin and Zyrtec.
Both drugs contain one main active ingredient - cetirizine, so these are two drugs.
However, among doctors it is believed that Zyrtec’s cetirizine is better purified, which means it has fewer side effects.
The main factor in this case influencing the choice of a particular drug remains the price.
With cetrin it is much lower, which means you can save on medicine, since everyone knows that the disease does not go away alone.
Cetrin or Suprastin?
Both drugs belong to different generations, Suprastin to the first, and Cetrin to the second.
Therefore, it can be logically assumed that the second generation is better than the first, and this is true.
Cetrin has fewer side effects than Suprastin and this is its main advantage.
However, Suprastin has a greater antiallergic effect and is stronger. But combined with side effects, all these effects may disappear.
Therefore, it is better to take it in a hospital under the supervision of doctors, as side effects can be unpredictable.
This drug is generally contraindicated for children under 12 years of age and people driving.
It is better to take Cetrin at home, which doctors do not prohibit.
Cetrin or Claritin?
The main difference between these drugs is their generation. As we already know, Cetrin belongs to the second generation of antiallergic drugs, and Claritin is already the third.
Claritin has fewer side effects, which means it is safer. Its anti-allergic effect is also stronger, so it is recommended by doctors more often.
But Cetrin is much cheaper than Claritin, so many allergy sufferers decide in its favor.
Cetrin helps against allergies by blocking histamine receptors that irritate the immune system and cause an allergic reaction. The penetration rate through the BBB is so small that the drug does not affect the functioning of the central nervous system. The condition of a neutral effect on the central nervous system and the blood-brain barrier is determined by therapeutic doses; if the medicine is taken in large quantities, a negative reaction may be detected.
Cetrin can be taken by both adults and children over 2 years old. The active ingredients of the product provide relief for both mild and severe allergic reactions. The drug has its own number of contraindications, so before treatment you should read the instructions and consult a doctor.
The main component is cetirizine. It also acts as an H1-histamine blocker, which alleviates the condition when an allergic reaction occurs. One tablet of the drug contains 10 mg of active substance. 1 ml of syrup contains 1 mg of cetirizine.
Also, as binders and additional components in the tablets are:It does not disrupt the functioning of other receptors, being a histamine antagonist. During clinical trials, no pronounced effect on anticholinergic and antiserotin receptors (regulate the functioning of the central nervous system) was revealed. Cetirizine completely suppresses the allergic reaction in the initial stage, prevents the release of inflammatory mediators in advanced forms of allergy.
- starch;
- lactose;
- magnesium;
- povidone;
- talc;
- sorbic acid;
- polysorbate;
- Dimethicone
- sucrose;
- glycerol;
- sorbitol;
- sodium citrate;
- flavorings and additives that impart a fruity taste.
How long does it take for the effect to occur? 20-30 minutes after using the product in half of the patients, and after 50-60 minutes in 92%.
Even if the tablets are no longer used for therapeutic purposes, their effect remains for 72 hours. Blocking the allergic reaction after drinking a Cetrin tablet lasts for a day.
Cetrin quickly enters the bloodstream and spreads throughout the body through the gastrointestinal tract. Food does not in any way affect the degree of absorption of the drug by the digestive tract. The maximum concentration is reached after 0.5-1 hour in an amount of 0.3 μg/ml. The liver interacts with only a small amount of the drug. The standard half-life is 10 hours, but it may be longer if a person has urinary or liver disease.
Sometimes age affects the rate of elimination of ½ of the drug. In 1/3 of the elderly, the half-life reached 15 hours, and the clearance rate from the drug was 30-40% lower.
In children 6-12 years old, partial cleansing of the drug from the body occurs after 5-6 hours. In children under 6 years of age, the half-life is 3-5 hours.
In case of moderate and extreme renal failure, the dosage should be regulated individually by a doctor. In this state, the half-life reaches 20-30 hours, and the clearance rate through the urinary system drops by 40-60%. Using the drug in standard doses can lead to internal intoxication and side effects.
In case of liver failure, the duration of elimination of Cetrin from the body increases by 5 hours, and the cleansing rate through the urinary system drops by 30%. Individual adjustment of the dose of the drug is required if the patient also has renal failure.
Cetirizine as an active ingredient helps stop the external signs of allergies, which reduce the quality of life and interfere with everyday tasks. An allergic reaction, accompanied by a runny nose, lacrimation, swelling, and skin rashes, occurs under the influence of Cetrin.
Cetrin helps with:- Hives.
- Acute atopic conjunctivitis.
- Allergic rhinitis – runny nose, watery eyes, red eyes, swelling of the nasal mucosa.
- Quincke's edema.
- Bronchial asthma.
- Swelling of the larynx, oral cavity of an allergic nature.
- Itchy.
- Allergic dermatoses.
- Eczema.
The tablets help alleviate the condition and prevent the further development of allergies.
Instructions for use indicate the basic dosage regimen, which is accepted for all allergic manifestations. The decision to reduce or increase the dosage is made by the doctor depending on the course of the clinical picture and additional diseases of the patient.
How to take Cetrin for allergies:- Adults. A whole tablet or 1 teaspoon of syrup once a day.
- Children from 6 years old. You need to drink 0.5 tablets or 0.5 tsp of syrup twice a day.
- Children under 6 years old. ½ tablet or 0.5 tsp of syrup once every 24 hours. It is not recommended to treat a child under 2 years of age with Cetrin independently, without a doctor’s prescription.
How many days should you take Cetrin? Standard course – 14-28 days. How long can you take Cetrin without side effects? It is not advisable to take Cetrin for more than a month; the course of the drug can be extended by a doctor based on medical indications.
To achieve the maximum therapeutic effect, an adult needs 10-20 mg of medication (1-2 tablets). Amount exceeding 5 tablets can cause serious harm to the body.
Possible consequences of an overdose:- Dizziness.
- Loss of strength, drowsiness.
- Drowsiness, confusion.
- Nervous excitability, inexplicable feeling of anxiety.
- Convulsions, tremors of limbs.
- Increased or slowed heart rate.
- Repeated loose stools.
- Headache attacks.
The instructions for use indicate that it is impossible to remove excess drug with diuretics, as well as neutralize its negative effects with the help of an antidote. It is necessary to rinse the stomach, provoke vomiting, and drink sorbents.
Numerous testing of the drug has shown that any possible side effect occurs with a frequency of no more than 2-3%. The main side effects are headache, dry mouth, nausea, fatigue, others occur much less frequently.
Rare side effects:- Tachycardia.
- Increase in body mass index.
- Rash, itching, urticaria.
- Vasculitis.
- Depressive state.
- Sleep disorder.
- Hallucinations, confusion.
- Impaired vision clarity.
- Deterioration of memory and hearing.
- Dyskinesia.
- Fainting state.
- Urinary retention.
If a woman took Cetrin during pregnancy, the child may experience disturbances in growth and development.
It is advisable to take this drug during pregnancy only as prescribed by a doctor, in order to avoid complications, miscarriages, and premature birth.
Cetrin is a popular allergy remedy. The easy absorption of the drug by the body helps eliminate allergy symptoms without negative consequences.
